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Entry version 169 (26 Feb 2020)
Sequence version 6 (22 Sep 2009)
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Protein

Phosphatidylinositol 3-kinase age-1

Gene

age-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Phosphatidylinositol 3-kinase homolog that regulates longevity and diapause (PubMed:8700226, PubMed:21750263). Promotes cell survival during embryonic development by recruiting akt-1/2 to the plasma membrane through the production of PtdIns(3,4,5)P3 (PubMed:25383666). Could function in the development or neuroendocrine signaling of the dauer pathway (PubMed:8700226). Mediates susceptibility to enteropathogenic E.coli infection (PubMed:16091039). May negatively regulate AYI interneuron neurite outgrowth (PubMed:22069193). Plays a role in aversive olfactory learning when an odor is associated with food deprivation (PubMed:27383131). Regulates this process by promoting the nuclear relocalization of egl-4 in AWC olfactory neurons after odor conditioning (PubMed:27383131).6 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.7.1.137 1045

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-109704 PI3K Cascade
R-CEL-114604 GPVI-mediated activation cascade
R-CEL-1257604 PIP3 activates AKT signaling
R-CEL-1660499 Synthesis of PIPs at the plasma membrane
R-CEL-186763 Downstream signal transduction
R-CEL-392451 G beta:gamma signalling through PI3Kgamma
R-CEL-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-CEL-912631 Regulation of signaling by CBL
R-CEL-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q94125

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Phosphatidylinositol 3-kinase age-1 (EC:2.7.1.137)
Short name:
PI3-kinase age-1
Short name:
PI3K age-1
Short name:
PtdIns-3-kinase age-1
Alternative name(s):
Aging alteration protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:age-1Imported
ORF Names:B0334.8Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome II

Organism-specific databases

WormBase

More...
WormBasei
B0334.8a ; CE43431 ; WBGene00000090 ; age-1
B0334.8b ; CE02940 ; WBGene00000090 ; age-1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi761E → L in am88; extends lifespan, increases pharyngeal pumping, and causes faster body movements. Also increases dauer formation. 1 Publication1
Mutagenesisi842P → S in hx546; increases lifespan. Increases dauer formation. Fails to avoid NaCl after exposure to NaCl under starvation conditions. Defective in aversive olfactory learning. Reduces nuclear enrichment of egl-4 in the AWC neurons after odor conditioning. 4 Publications1
Mutagenesisi862S → N in mg109. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000888071 – 1182Phosphatidylinositol 3-kinase age-1Add BLAST1182

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q94125

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q94125

PeptideAtlas

More...
PeptideAtlasi
Q94125

PRoteomics IDEntifications database

More...
PRIDEi
Q94125

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed both maternally and zygotically.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00000090 Expressed in multi-cellular organism and 4 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
40069, 1 interactor

STRING: functional protein association networks

More...
STRINGi
6239.B0334.8

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q94125

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini74 – 174PI3K-ABDPROSITE-ProRule annotationAdd BLAST101
Domaini266 – 358PI3K-RBDPROSITE-ProRule annotationAdd BLAST93
Domaini425 – 577C2 PI3K-typePROSITE-ProRule annotationAdd BLAST153
Domaini601 – 788PIK helicalPROSITE-ProRule annotationAdd BLAST188
Domaini885 – 1182PI3K/PI4KPROSITE-ProRule annotationAdd BLAST298

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PI3/PI4-kinase family.PROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0904 Eukaryota
COG5032 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000170080

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002191_1_3_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q94125

KEGG Orthology (KO)

More...
KOi
K00922

Identification of Orthologs from Complete Genome Data

More...
OMAi
TLVANKM

Database of Orthologous Groups

More...
OrthoDBi
204282at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q94125

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1070.11, 1 hit
1.25.40.70, 1 hit
2.60.40.150, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024 ARM-type_fold
IPR035892 C2_domain_sf
IPR011009 Kinase-like_dom_sf
IPR000403 PI3/4_kinase_cat_dom
IPR036940 PI3/4_kinase_cat_sf
IPR018936 PI3/4_kinase_CS
IPR001263 PI3K_accessory_dom
IPR042236 PI3K_accessory_sf
IPR003113 PI3K_adapt-bd_dom
IPR002420 PI3K_C2_dom
IPR000341 PI3K_Ras-bd_dom
IPR015433 PI_Kinase
IPR029071 Ubiquitin-like_domsf

The PANTHER Classification System

More...
PANTHERi
PTHR10048 PTHR10048, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00454 PI3_PI4_kinase, 1 hit
PF00792 PI3K_C2, 1 hit
PF02192 PI3K_p85B, 1 hit
PF00794 PI3K_rbd, 1 hit
PF00613 PI3Ka, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00142 PI3K_C2, 1 hit
SM00143 PI3K_p85B, 1 hit
SM00144 PI3K_rbd, 1 hit
SM00145 PI3Ka, 1 hit
SM00146 PI3Kc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 1 hit
SSF54236 SSF54236, 1 hit
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00915 PI3_4_KINASE_1, 1 hit
PS00916 PI3_4_KINASE_2, 1 hit
PS50290 PI3_4_KINASE_3, 1 hit
PS51544 PI3K_ABD, 1 hit
PS51547 PI3K_C2, 1 hit
PS51546 PI3K_RBD, 1 hit
PS51545 PIK_HELICAL, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform aImported (identifier: Q94125-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSMGRSPSTT FRSRTGSHGA RDLIAGHGRN SRRISQMHVN ILHPQLQTMV
60 70 80 90 100
EQWQMRERPS LETENGKGSL LLENEGVADI ITMCPFGEVI SVVFPWFLAN
110 120 130 140 150
VRTSLEIKLS DFKHQLFELI APMKWGTYSV KPQDYVFRQL NNFGEIEVIF
160 170 180 190 200
NDDQPLSKLE LHGTFPMLFL YQPDGINRDK ELMSDISHCL GYSLDKLEES
210 220 230 240 250
LDEELRQFRA SLWARTKKTC LTRGLEGTSH YAFPEEQYLC VGESCPKDLE
260 270 280 290 300
SKVKAAKLSY QMFWRKRKAE INGVCEKMMK IQIEFNPNET PKSLLHTFLY
310 320 330 340 350
EMRKLDVYDT DDPADEGWFL QLAGRTTFVT NPDVKLTSYD GVRSELESYR
360 370 380 390 400
CPGFVVRRQS LVLKDYCRPK PLYEPHYVRA HERKLALDVL SVSIDSTPKQ
410 420 430 440 450
SKNSDMVMTD FRPTASLKQV SLWDLDANLM IRPVNISGFD FPADVDMYVR
460 470 480 490 500
IEFSVYVGTL TLASKSTTKV NAQFAKWNKE MYTFDLYMKD MPPSAVLSIR
510 520 530 540 550
VLYGKVKLKS EEFEVGWVNM SLTDWRDELR QGQFLFHLWA PEPTANRSRI
560 570 580 590 600
GENGARIGTN AAVTIEISSY GGRVRMPSQG QYTYLVKHRS TWTETLNIMG
610 620 630 640 650
DDYESCIRDP GYKKLQMLVK KHESGIVLEE DEQRHVWMWR RYIQKQEPDL
660 670 680 690 700
LIVLSELAFV WTDRENFSEL YVMLEKWKPP SVAAALTLLG KRCTDRVIRK
710 720 730 740 750
FAVEKLNEQL SPVTFHLFIL PLIQALKYEP RAQSEVGMML LTRALCDYRI
760 770 780 790 800
GHRLFWLLRA EIARLRDCDL KSEEYRRISL LMEAYLRGNE EHIKIITRQV
810 820 830 840 850
DMVDELTRIS TLVKGMPKDV ATMKLRDELR SISHKMENMD SPLDPVYKLG
860 870 880 890 900
EMIIDKAIVL GSAKRPLMLH WKNKNPKSDL HLPFCAMIFK NGDDLRQDML
910 920 930 940 950
VLQVLEVMDN IWKAANIDCC LNPYAVLPMG EMIGIIEVVP NCKTIFEIQV
960 970 980 990 1000
GTGFMNTAVR SIDPSFMNKW IRKQCGIEDE KKKSKKDSTK NPIEKKIDNT
1010 1020 1030 1040 1050
QAMKKYFESV DRFLYSCVGY SVATYIMGIK DRHSDNLMLT EDGKYFHIDF
1060 1070 1080 1090 1100
GHILGHGKTK LGIQRDRQPF ILTEHFMTVI RSGKSVDGNS HELQKFKTLC
1110 1120 1130 1140 1150
VEAYEVMWNN RDLFVSLFTL MLGMELPELS TKADLDHLKK TLFCNGESKE
1160 1170 1180
EARKFFAGIY EEAFNGSWST KTNWLFHAVK HY
Length:1,182
Mass (Da):136,873
Last modified:September 22, 2009 - v6
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC82DA6F98A383EAC
GO
Isoform bImported (identifier: Q94125-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1106: Missing.

Show »
Length:76
Mass (Da):8,935
Checksum:i461EB57086F027BC
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC47459 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1046F → V in AAC47459 (PubMed:8700226).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0604741 – 1106Missing in isoform b. CuratedAdd BLAST1106

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U56101 mRNA Translation: AAC47459.1 Frameshift.
BX284602, AL110499 Genomic DNA Translation: CAA91377.3
BX284602 Genomic DNA Translation: CTQ86427.1

Protein sequence database of the Protein Information Resource

More...
PIRi
B88318
S71792

NCBI Reference Sequences

More...
RefSeqi
NP_496462.2, NM_064061.4

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
B0334.8a.1; B0334.8a.1; WBGene00000090

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
174762

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_B0334.8

UCSC genome browser

More...
UCSCi
B0334.8 c. elegans

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U56101 mRNA Translation: AAC47459.1 Frameshift.
BX284602, AL110499 Genomic DNA Translation: CAA91377.3
BX284602 Genomic DNA Translation: CTQ86427.1
PIRiB88318
S71792
RefSeqiNP_496462.2, NM_064061.4

3D structure databases

SMRiQ94125
ModBaseiSearch...

Protein-protein interaction databases

BioGridi40069, 1 interactor
STRINGi6239.B0334.8

Proteomic databases

EPDiQ94125
PaxDbiQ94125
PeptideAtlasiQ94125
PRIDEiQ94125

Genome annotation databases

EnsemblMetazoaiB0334.8a.1; B0334.8a.1; WBGene00000090
GeneIDi174762
KEGGicel:CELE_B0334.8
UCSCiB0334.8 c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
174762
WormBaseiB0334.8a ; CE43431 ; WBGene00000090 ; age-1
B0334.8b ; CE02940 ; WBGene00000090 ; age-1

Phylogenomic databases

eggNOGiKOG0904 Eukaryota
COG5032 LUCA
GeneTreeiENSGT00940000170080
HOGENOMiCLU_002191_1_3_1
InParanoidiQ94125
KOiK00922
OMAiTLVANKM
OrthoDBi204282at2759
PhylomeDBiQ94125

Enzyme and pathway databases

BRENDAi2.7.1.137 1045
ReactomeiR-CEL-109704 PI3K Cascade
R-CEL-114604 GPVI-mediated activation cascade
R-CEL-1257604 PIP3 activates AKT signaling
R-CEL-1660499 Synthesis of PIPs at the plasma membrane
R-CEL-186763 Downstream signal transduction
R-CEL-392451 G beta:gamma signalling through PI3Kgamma
R-CEL-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-CEL-912631 Regulation of signaling by CBL
R-CEL-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
SignaLinkiQ94125

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q94125

Gene expression databases

BgeeiWBGene00000090 Expressed in multi-cellular organism and 4 other tissues

Family and domain databases

Gene3Di1.10.1070.11, 1 hit
1.25.40.70, 1 hit
2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR035892 C2_domain_sf
IPR011009 Kinase-like_dom_sf
IPR000403 PI3/4_kinase_cat_dom
IPR036940 PI3/4_kinase_cat_sf
IPR018936 PI3/4_kinase_CS
IPR001263 PI3K_accessory_dom
IPR042236 PI3K_accessory_sf
IPR003113 PI3K_adapt-bd_dom
IPR002420 PI3K_C2_dom
IPR000341 PI3K_Ras-bd_dom
IPR015433 PI_Kinase
IPR029071 Ubiquitin-like_domsf
PANTHERiPTHR10048 PTHR10048, 1 hit
PfamiView protein in Pfam
PF00454 PI3_PI4_kinase, 1 hit
PF00792 PI3K_C2, 1 hit
PF02192 PI3K_p85B, 1 hit
PF00794 PI3K_rbd, 1 hit
PF00613 PI3Ka, 1 hit
SMARTiView protein in SMART
SM00142 PI3K_C2, 1 hit
SM00143 PI3K_p85B, 1 hit
SM00144 PI3K_rbd, 1 hit
SM00145 PI3Ka, 1 hit
SM00146 PI3Kc, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
SSF54236 SSF54236, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00915 PI3_4_KINASE_1, 1 hit
PS00916 PI3_4_KINASE_2, 1 hit
PS50290 PI3_4_KINASE_3, 1 hit
PS51544 PI3K_ABD, 1 hit
PS51547 PI3K_C2, 1 hit
PS51546 PI3K_RBD, 1 hit
PS51545 PIK_HELICAL, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAGE1_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q94125
Secondary accession number(s): A0A0K3ARF0, Q17482
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: September 22, 2009
Last modified: February 26, 2020
This is version 169 of the entry and version 6 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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