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Entry version 153 (16 Oct 2019)
Sequence version 1 (01 Dec 2001)
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Protein

RING-box protein 1a

Gene

RBX1A

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The SCF complex plays a crucial role in regulating response to auxin and is essential for growth and development. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme, to the complex and brings it into close proximity to the substrate. Promotes the neddylation of CUL1.3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi52Zinc 1By similarity1
Metal bindingi55Zinc 1By similarity1
Metal bindingi63Zinc 2By similarity1
Metal bindingi66Zinc 2By similarity1
Metal bindingi78Zinc 2By similarity1
Metal bindingi85Zinc 3By similarity1
Metal bindingi87Zinc 3; via pros nitrogenBy similarity1
Metal bindingi90Zinc 1; via pros nitrogenBy similarity1
Metal bindingi92Zinc 2By similarity1
Metal bindingi104Zinc 3By similarity1
Metal bindingi107Zinc 3By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri63 – 108RING-typePROSITE-ProRule annotationAdd BLAST46

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processUbl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RING-box protein 1a
Alternative name(s):
At-Rbx1;1
Protein RING of cullins 1
RBX1-2
RBX1a-At
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RBX1A
Synonyms:ROC1
Ordered Locus Names:At5g20570
ORF Names:F7C8.160
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT5G20570

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000560192 – 118RING-box protein 1aAdd BLAST117

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1

Keywords - PTMi

Acetylation

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q940X7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed. Expressed in shoot, siliques, meristem, flowers, floral buds, open flowers, leaves, stems, roots, germinal seeds and seedlings in dark. Expressed at a higher level in tissues containing actively dividing cells.2 Publications

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q940X7 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q940X7 AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Part of SCF complexes, which consist of a SKP1-related protein, a cullin, a RBX protein and a F-box protein.

Part of a SCF complex with ASK1 or ASK2 and CUL1.

Part of a SCF complex with CUL1 and TIR1.

Interacts with CUL1 and CUL4.

Component of the CUL4-RBX1-CDD complex.

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
17454, 12 interactors

ComplexPortal: manually curated resource of macromolecular complexes

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ComplexPortali
CPX-1339 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-SKP1A
CPX-1343 SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1A-SKP1A
CPX-1429 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-SKP1B
CPX-1430 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK3
CPX-1431 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK4
CPX-1432 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK5
CPX-1433 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK6
CPX-1434 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK7
CPX-1435 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK8
CPX-1436 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK9
CPX-1437 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK10
CPX-1438 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK11
CPX-1439 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK12
CPX-1440 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK13
CPX-1441 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK14
CPX-1442 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK15
CPX-1443 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK16
CPX-1444 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK17
CPX-1445 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK18
CPX-1446 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK19
CPX-1447 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK20
CPX-1448 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK21
CPX-1471 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1A-SKP1A
CPX-1472 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1A-SKP1B
CPX-1473 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK3
CPX-1474 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK4
CPX-1475 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK5
CPX-1476 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK6
CPX-1477 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK7
CPX-1478 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK8
CPX-1479 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK9
CPX-1480 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK10
CPX-1481 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK11
CPX-1482 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK12
CPX-1483 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK13
CPX-1484 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK14
CPX-1485 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK15
CPX-1486 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK16
CPX-1487 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK17
CPX-1488 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK18
CPX-1489 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK19
CPX-1490 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK20
CPX-1491 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK21
CPX-1515 SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1A-SKP1B
CPX-1516 SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK3
CPX-1517 SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK4
CPX-1518 SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK5
CPX-1519 SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK6
CPX-1520 SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK7
CPX-1521 SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK8
CPX-1522 SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK9
CPX-1523 SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK10
CPX-1524 SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK11
CPX-1525 SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK12
CPX-1526 SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK13
CPX-1527 SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK14
CPX-1528 SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK15
CPX-1529 SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK16
CPX-1530 SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK17
CPX-1531 SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK18
CPX-1532 SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK19
CPX-1533 SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK20
CPX-1534 SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK21
CPX-1557 SCF(TIR1) ubiquitin ligase complex, variant CUL2-RBX1A-SKP1A
CPX-1558 SCF(TIR1) ubiquitin ligase complex, variant CUL2-RBX1A-SKP1B
CPX-1559 SCF(TIR1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK3
CPX-1560 SCF(TIR1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK4
CPX-1561 SCF(TIR1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK5
CPX-1562 SCF(TIR1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK6
CPX-1563 SCF(TIR1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK7
CPX-1564 SCF(TIR1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK8
CPX-1565 SCF(TIR1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK9
CPX-1566 SCF(TIR1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK10
CPX-1567 SCF(TIR1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK11
CPX-1568 SCF(TIR1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK12
CPX-1569 SCF(TIR1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK13
CPX-1570 SCF(TIR1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK14
CPX-1571 SCF(TIR1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK15
CPX-1572 SCF(TIR1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK16
CPX-1573 SCF(TIR1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK17
CPX-1574 SCF(TIR1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK18
CPX-1575 SCF(TIR1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK19
CPX-1576 SCF(TIR1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK20
CPX-1577 SCF(TIR1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK21

Protein interaction database and analysis system

More...
IntActi
Q940X7, 10 interactors

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q940X7

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The RING-type zinc finger domain is essential for ubiquitin ligase activity. It coordinates an additional third zinc ion.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RING-box family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri63 – 108RING-typePROSITE-ProRule annotationAdd BLAST46

Keywords - Domaini

Zinc-finger

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000171951

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q940X7

KEGG Orthology (KO)

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KOi
K03868

Identification of Orthologs from Complete Genome Data

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OMAi
IDKENCT

Database of Orthologous Groups

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OrthoDBi
1587140at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q940X7

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR024766 Znf_RING_H2

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12678 zf-rbx1, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50089 ZF_RING_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 1 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoform i produced by alternative splicing. AlignAdd to basket
Note: A number of isoforms are produced. According to EST sequences.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q940X7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MATLDSDVTM IPAGEASSSV AASSSNKKAK RFEIKKWSAV ALWAWDIVVD
60 70 80 90 100
NCAICRNHIM DLCIECQANQ ASATSEECTV AWGVCNHAFH FHCISRWLKT
110
RQVCPLDNSE WEFQKYGH
Length:118
Mass (Da):13,238
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i19947BF06F442A82
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F4K5K0F4K5K0_ARATH
RING-box 1
RBX1 ATRBX1, HRT1, REGULATOR OF CULLINS-1, RING-BOX 1, RING-box 1
142Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F4K5K1F4K5K1_ARATH
RING-box 1
RBX1 ATRBX1, HRT1, REGULATOR OF CULLINS-1, RING-BOX 1, RING-box 1
136Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AY052401 mRNA Translation: AAL13435.1
AF296833 Genomic DNA No translation available.
CP002688 Genomic DNA Translation: AED92859.1
AK118181 mRNA Translation: BAC42804.1
AY072430 mRNA Translation: AAL62422.1
AY114719 mRNA Translation: AAM48038.1
AY086913 mRNA Translation: AAM64477.1

NCBI Reference Sequences

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RefSeqi
NP_568396.1, NM_122064.3 [Q940X7-1]

Genome annotation databases

Ensembl plant genome annotation project

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EnsemblPlantsi
AT5G20570.1; AT5G20570.1; AT5G20570 [Q940X7-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
832179

Gramene; a comparative resource for plants

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Gramenei
AT5G20570.1; AT5G20570.1; AT5G20570 [Q940X7-1]

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
ath:AT5G20570

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY052401 mRNA Translation: AAL13435.1
AF296833 Genomic DNA No translation available.
CP002688 Genomic DNA Translation: AED92859.1
AK118181 mRNA Translation: BAC42804.1
AY072430 mRNA Translation: AAL62422.1
AY114719 mRNA Translation: AAM48038.1
AY086913 mRNA Translation: AAM64477.1
RefSeqiNP_568396.1, NM_122064.3 [Q940X7-1]

3D structure databases

SMRiQ940X7
ModBaseiSearch...

Protein-protein interaction databases

BioGridi17454, 12 interactors
ComplexPortaliCPX-1339 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-SKP1A
CPX-1343 SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1A-SKP1A
CPX-1429 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-SKP1B
CPX-1430 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK3
CPX-1431 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK4
CPX-1432 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK5
CPX-1433 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK6
CPX-1434 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK7
CPX-1435 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK8
CPX-1436 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK9
CPX-1437 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK10
CPX-1438 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK11
CPX-1439 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK12
CPX-1440 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK13
CPX-1441 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK14
CPX-1442 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK15
CPX-1443 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK16
CPX-1444 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK17
CPX-1445 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK18
CPX-1446 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK19
CPX-1447 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK20
CPX-1448 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK21
CPX-1471 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1A-SKP1A
CPX-1472 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1A-SKP1B
CPX-1473 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK3
CPX-1474 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK4
CPX-1475 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK5
CPX-1476 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK6
CPX-1477 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK7
CPX-1478 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK8
CPX-1479 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK9
CPX-1480 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK10
CPX-1481 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK11
CPX-1482 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK12
CPX-1483 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK13
CPX-1484 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK14
CPX-1485 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK15
CPX-1486 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK16
CPX-1487 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK17
CPX-1488 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK18
CPX-1489 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK19
CPX-1490 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK20
CPX-1491 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK21
CPX-1515 SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1A-SKP1B
CPX-1516 SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK3
CPX-1517 SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK4
CPX-1518 SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK5
CPX-1519 SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK6
CPX-1520 SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK7
CPX-1521 SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK8
CPX-1522 SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK9
CPX-1523 SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK10
CPX-1524 SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK11
CPX-1525 SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK12
CPX-1526 SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK13
CPX-1527 SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK14
CPX-1528 SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK15
CPX-1529 SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK16
CPX-1530 SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK17
CPX-1531 SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK18
CPX-1532 SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK19
CPX-1533 SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK20
CPX-1534 SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK21
CPX-1557 SCF(TIR1) ubiquitin ligase complex, variant CUL2-RBX1A-SKP1A
CPX-1558 SCF(TIR1) ubiquitin ligase complex, variant CUL2-RBX1A-SKP1B
CPX-1559 SCF(TIR1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK3
CPX-1560 SCF(TIR1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK4
CPX-1561 SCF(TIR1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK5
CPX-1562 SCF(TIR1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK6
CPX-1563 SCF(TIR1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK7
CPX-1564 SCF(TIR1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK8
CPX-1565 SCF(TIR1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK9
CPX-1566 SCF(TIR1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK10
CPX-1567 SCF(TIR1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK11
CPX-1568 SCF(TIR1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK12
CPX-1569 SCF(TIR1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK13
CPX-1570 SCF(TIR1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK14
CPX-1571 SCF(TIR1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK15
CPX-1572 SCF(TIR1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK16
CPX-1573 SCF(TIR1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK17
CPX-1574 SCF(TIR1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK18
CPX-1575 SCF(TIR1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK19
CPX-1576 SCF(TIR1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK20
CPX-1577 SCF(TIR1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK21
IntActiQ940X7, 10 interactors

PTM databases

iPTMnetiQ940X7

Genome annotation databases

EnsemblPlantsiAT5G20570.1; AT5G20570.1; AT5G20570 [Q940X7-1]
GeneIDi832179
GrameneiAT5G20570.1; AT5G20570.1; AT5G20570 [Q940X7-1]
KEGGiath:AT5G20570

Organism-specific databases

AraportiAT5G20570

Phylogenomic databases

HOGENOMiHOG000171951
InParanoidiQ940X7
KOiK03868
OMAiIDKENCT
OrthoDBi1587140at2759
PhylomeDBiQ940X7

Enzyme and pathway databases

UniPathwayiUPA00143

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q940X7

Gene expression databases

ExpressionAtlasiQ940X7 baseline and differential
GenevisibleiQ940X7 AT

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR024766 Znf_RING_H2
PfamiView protein in Pfam
PF12678 zf-rbx1, 1 hit
PROSITEiView protein in PROSITE
PS50089 ZF_RING_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRBX1A_ARATH
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q940X7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: December 1, 2001
Last modified: October 16, 2019
This is version 153 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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