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Entry version 107 (22 Apr 2020)
Sequence version 1 (01 Dec 2001)
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Protein

Probable methyltransferase PMT8

Gene

At1g04430

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMethyltransferase, Transferase

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Probable methyltransferase PMT8 (EC:2.1.1.-)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Ordered Locus Names:At1g04430
ORF Names:F19P19.11
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT1G04430

The Arabidopsis Information Resource

More...
TAIRi
locus:2018329 AT1G04430

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 13CytoplasmicSequence analysisAdd BLAST13
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei14 – 34Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini35 – 623LumenalSequence analysisAdd BLAST589

Keywords - Cellular componenti

Golgi apparatus, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003932481 – 623Probable methyltransferase PMT8Add BLAST623

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi204N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi350N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi588N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q940J9

PRoteomics IDEntifications database

More...
PRIDEi
Q940J9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q940J9 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q940J9 AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
24757, 2 interactors

Protein interaction database and analysis system

More...
IntActi
Q940J9, 1 interactor

STRING: functional protein association networks

More...
STRINGi
3702.AT1G04430.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q940J9

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi298 – 303Poly-Leu6

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the methyltransferase superfamily.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IGJA Eukaryota
ENOG410YDXK LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_010485_2_2_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q940J9

Identification of Orthologs from Complete Genome Data

More...
OMAi
CYMERPP

Database of Orthologous Groups

More...
OrthoDBi
288023at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q940J9

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004159 Put_SAM_MeTrfase
IPR029063 SAM-dependent_MTases

The PANTHER Classification System

More...
PANTHERi
PTHR10108 PTHR10108, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03141 Methyltransf_29, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53335 SSF53335, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q940J9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMRGRSDGGL KKRLIASVCV VALFVCFLFM YYGSSSQGAS ALEYGRSLRK
60 70 80 90 100
LGSSYLSGDD DNGDTKQDDS VANAEDSLVV AKSFPVCDDR HSEIIPCLDR
110 120 130 140 150
NFIYQMRLKL DLSLMEHYER HCPPPERRFN CLIPPPSGYK VPIKWPKSRD
160 170 180 190 200
EVWKANIPHT HLAKEKSDQN WMVEKGEKIS FPGGGTHFHY GADKYIASIA
210 220 230 240 250
NMLNFSNDVL NDEGRLRTVL DVGCGVASFG AYLLASDIMT MSLAPNDVHQ
260 270 280 290 300
NQIQFALERG IPAYLGVLGT KRLPYPSRSF EFAHCSRCRI DWLQRDGLLL
310 320 330 340 350
LELDRVLRPG GYFAYSSPEA YAQDEENLKI WKEMSALVER MCWRIAVKRN
360 370 380 390 400
QTVVWQKPLS NDCYLEREPG TQPPLCRSDA DPDAVAGVSM EACITPYSKH
410 420 430 440 450
DHKTKGSGLA PWPARLTSSP PRLADFGYST DMFEKDTELW KQQVDSYWNL
460 470 480 490 500
MSSKVKSNTV RNIMDMKAHM GSFAAALKDK DVWVMNVVSP DGPNTLKLIY
510 520 530 540 550
DRGLIGTNHN WCEAFSTYPR TYDLLHAWSI FSDIKSKGCS AEDLLIEMDR
560 570 580 590 600
ILRPTGFVII RDKQSVVESI KKYLQALHWE TVASEKVNTS SELDQDSEDG
610 620
ENNVVFIVQK KLWLTSESLR DSE
Length:623
Mass (Da):70,508
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i048A3BA631402954
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAB70432 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAM61029 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti190Y → C in AAM10022 (PubMed:14593172).Curated1
Sequence conflicti190Y → C in AAK62456 (PubMed:14593172).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC000104 Genomic DNA Translation: AAB70432.1 Sequence problems.
CP002684 Genomic DNA Translation: AEE27696.1
CP002684 Genomic DNA Translation: AEE27697.1
CP002684 Genomic DNA Translation: ANM58680.1
AY054530 mRNA Translation: AAK96721.1
AY064624 mRNA Translation: AAL47337.1
AF387011 mRNA Translation: AAK62456.1
AY081460 mRNA Translation: AAM10022.1
AY084457 mRNA Translation: AAM61029.1 Different initiation.
AK222007 mRNA Translation: BAD94636.1

Protein sequence database of the Protein Information Resource

More...
PIRi
D86176

NCBI Reference Sequences

More...
RefSeqi
NP_001117225.1, NM_001123753.2
NP_001321096.1, NM_001331478.1
NP_563706.1, NM_100323.7

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT1G04430.1; AT1G04430.1; AT1G04430
AT1G04430.2; AT1G04430.2; AT1G04430
AT1G04430.3; AT1G04430.3; AT1G04430

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
839522

Gramene; a comparative resource for plants

More...
Gramenei
AT1G04430.1; AT1G04430.1; AT1G04430
AT1G04430.2; AT1G04430.2; AT1G04430
AT1G04430.3; AT1G04430.3; AT1G04430

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT1G04430

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC000104 Genomic DNA Translation: AAB70432.1 Sequence problems.
CP002684 Genomic DNA Translation: AEE27696.1
CP002684 Genomic DNA Translation: AEE27697.1
CP002684 Genomic DNA Translation: ANM58680.1
AY054530 mRNA Translation: AAK96721.1
AY064624 mRNA Translation: AAL47337.1
AF387011 mRNA Translation: AAK62456.1
AY081460 mRNA Translation: AAM10022.1
AY084457 mRNA Translation: AAM61029.1 Different initiation.
AK222007 mRNA Translation: BAD94636.1
PIRiD86176
RefSeqiNP_001117225.1, NM_001123753.2
NP_001321096.1, NM_001331478.1
NP_563706.1, NM_100323.7

3D structure databases

SMRiQ940J9
ModBaseiSearch...

Protein-protein interaction databases

BioGridi24757, 2 interactors
IntActiQ940J9, 1 interactor
STRINGi3702.AT1G04430.1

Proteomic databases

PaxDbiQ940J9
PRIDEiQ940J9

Genome annotation databases

EnsemblPlantsiAT1G04430.1; AT1G04430.1; AT1G04430
AT1G04430.2; AT1G04430.2; AT1G04430
AT1G04430.3; AT1G04430.3; AT1G04430
GeneIDi839522
GrameneiAT1G04430.1; AT1G04430.1; AT1G04430
AT1G04430.2; AT1G04430.2; AT1G04430
AT1G04430.3; AT1G04430.3; AT1G04430
KEGGiath:AT1G04430

Organism-specific databases

AraportiAT1G04430
TAIRilocus:2018329 AT1G04430

Phylogenomic databases

eggNOGiENOG410IGJA Eukaryota
ENOG410YDXK LUCA
HOGENOMiCLU_010485_2_2_1
InParanoidiQ940J9
OMAiCYMERPP
OrthoDBi288023at2759
PhylomeDBiQ940J9

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q940J9

Gene expression databases

ExpressionAtlasiQ940J9 baseline and differential
GenevisibleiQ940J9 AT

Family and domain databases

InterProiView protein in InterPro
IPR004159 Put_SAM_MeTrfase
IPR029063 SAM-dependent_MTases
PANTHERiPTHR10108 PTHR10108, 1 hit
PfamiView protein in Pfam
PF03141 Methyltransf_29, 1 hit
SUPFAMiSSF53335 SSF53335, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPMT8_ARATH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q940J9
Secondary accession number(s): P93817
, Q56WM9, Q8LG52, Q94EZ3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 23, 2010
Last sequence update: December 1, 2001
Last modified: April 22, 2020
This is version 107 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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