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Entry version 128 (31 Jul 2019)
Sequence version 1 (01 Dec 2001)
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Protein

Transcription initiation factor TFIID subunit 12b

Gene

TAF12B

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

TAFs are components of the transcription factor IID (TFIID) complex that is essential for mediating regulation of RNA polymerase transcription. Required for the expression of a subset of ethylene-responsive genes. Probably involved in the negative regulation of cytokinin sensitivity.1 Publication

Caution

TAF12B in cv. Lansberg erecta (AC B2C6R6) is 2 amino acids shorter and has been shown to be involved in the negative regulation of cytokinin sensitivity.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Initiation factor
Biological processProtein biosynthesis, Transcription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transcription initiation factor TFIID subunit 12b
Alternative name(s):
Protein CYTOKININ-HYPERSENSITIVE 1
Protein ENHANCED ETHYLENE RESPONSE 4
TBP-associated factor 12b
Short name:
AtTAF12b
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TAF12B
Synonyms:CKH1, EER4
Ordered Locus Names:At1g17440
ORF Names:F28G4.8
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT1G17440

The Arabidopsis Information Resource

More...
TAIRi
locus:2018861 AT1G17440

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004240511 – 683Transcription initiation factor TFIID subunit 12bAdd BLAST683

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q940A7

PRoteomics IDEntifications database

More...
PRIDEi
Q940A7

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q940A7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in roots, leaves, stems, inflorescences and flowers.2 Publications

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Not up-regulated by ethylene.1 Publication

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q940A7 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q940A7 AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the TFIID complex. TFIID is composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs) whose MWs range from 14-217 kDa. Can homodimerize.

Interacts with PP2A1, PP2A5, ERF1B, EIN3, TAF4, TAF4B, TAF5, TAF8, TAF10, TAF11, TAF12, TAF13, TAF14, TAF14B, TAF15 and TAF15B.

2 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
23556, 14 interactors

Protein interaction database and analysis system

More...
IntActi
Q940A7, 15 interactors

STRING: functional protein association networks

More...
STRINGi
3702.AT1G17440.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q940A7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini525 – 598Histone-foldAdd BLAST74

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi7 – 104Ser-richAdd BLAST98
Compositional biasi107 – 482Gln-richAdd BLAST376

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TAF12 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1142 Eukaryota
COG5624 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000238463

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q940A7

KEGG Orthology (KO)

More...
KOi
K03126

Identification of Orthologs from Complete Genome Data

More...
OMAi
AWLKQMQ

Database of Orthologous Groups

More...
OrthoDBi
1227642at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q940A7

Family and domain databases

Conserved Domains Database

More...
CDDi
cd07981 TAF12, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.20.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009072 Histone-fold
IPR037794 TAF12
IPR003228 TFIID_TAF12_dom

The PANTHER Classification System

More...
PANTHERi
PTHR12264 PTHR12264, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03847 TFIID_20kDa, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47113 SSF47113, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q940A7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEPIPSSSL SPKSLQSPNP MEPSPASSTP LPSSSSQQQQ LMTAPISNSV
60 70 80 90 100
NSAASPAMTV TTTEGIVIQN NSQPNISSPN PTSSNPPIGA QIPSPSPLSH
110 120 130 140 150
PSSSLDQQTQ TQQLVQQTQQ LPQQQQQIMQ QISSSPIPQL SPQQQQILQQ
160 170 180 190 200
QHMTSQQIPM SSYQIAQSLQ RSPSLSRLSQ IQQQQQQQHQ GQYGNVLRQQ
210 220 230 240 250
AGLYGTMNFG GSGSVQQSQQ NQQMVNPNMS RAGLVGQSGH LPMLNGAAGA
260 270 280 290 300
AQMNIQPQLL AASPRQKSGM VQGSQFHPGS SGQQLQGMQA MGMMGSLNLT
310 320 330 340 350
SQMRGNPALY AQQRINPGQM RQQLSQQNAL TSPQVQNLQR TSSLAFMNPQ
360 370 380 390 400
LSGLAQNGQA GMMQNSLSQQ QWLKQMSGIT SPNSFRLQPS QRQALLLQQQ
410 420 430 440 450
QQQQQQLSSP QLHQSSMSLN QQQISQIIQQ QQQQSQLGQS QMNQSHSQQQ
460 470 480 490 500
LQQMQQQLQQ QPQQQMQQQQ QQQQQMQINQ QQPSPRMLSH AGQKSVSLTG
510 520 530 540 550
SQPEATQSGT TTPGGSSSQG TEATNQLLGK RKIQDLVSQV DVHAKLDPDV
560 570 580 590 600
EDLLLEVADD FIDSVTSFAC SLAKHRKSSV LEPKDILLHL EKNLHLTIPG
610 620 630 640 650
FSSEDKRQTK TVPTDLHKKR LAMVRALLES SKPETNASNS KETMRQAMVN
660 670 680
PNGPNHLLRP SQSSEQLVSQ TSGPHILQHM TRY
Length:683
Mass (Da):74,805
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCA53B057BE2D9EB8
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF97312 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY463614 mRNA Translation: AAR28016.1
AC007843 Genomic DNA Translation: AAF97312.1 Sequence problems.
CP002684 Genomic DNA Translation: AEE29587.1
CP002684 Genomic DNA Translation: AEE29588.1
AY056144 mRNA Translation: AAL07223.1
AY091423 mRNA Translation: AAM14362.1

NCBI Reference Sequences

More...
RefSeqi
NP_564023.1, NM_101605.5
NP_849680.1, NM_179349.1

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT1G17440.1; AT1G17440.1; AT1G17440
AT1G17440.2; AT1G17440.2; AT1G17440

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
838316

Gramene; a comparative resource for plants

More...
Gramenei
AT1G17440.1; AT1G17440.1; AT1G17440
AT1G17440.2; AT1G17440.2; AT1G17440

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT1G17440

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY463614 mRNA Translation: AAR28016.1
AC007843 Genomic DNA Translation: AAF97312.1 Sequence problems.
CP002684 Genomic DNA Translation: AEE29587.1
CP002684 Genomic DNA Translation: AEE29588.1
AY056144 mRNA Translation: AAL07223.1
AY091423 mRNA Translation: AAM14362.1
RefSeqiNP_564023.1, NM_101605.5
NP_849680.1, NM_179349.1

3D structure databases

SMRiQ940A7
ModBaseiSearch...

Protein-protein interaction databases

BioGridi23556, 14 interactors
IntActiQ940A7, 15 interactors
STRINGi3702.AT1G17440.1

PTM databases

iPTMnetiQ940A7

Proteomic databases

PaxDbiQ940A7
PRIDEiQ940A7

Genome annotation databases

EnsemblPlantsiAT1G17440.1; AT1G17440.1; AT1G17440
AT1G17440.2; AT1G17440.2; AT1G17440
GeneIDi838316
GrameneiAT1G17440.1; AT1G17440.1; AT1G17440
AT1G17440.2; AT1G17440.2; AT1G17440
KEGGiath:AT1G17440

Organism-specific databases

AraportiAT1G17440
TAIRilocus:2018861 AT1G17440

Phylogenomic databases

eggNOGiKOG1142 Eukaryota
COG5624 LUCA
HOGENOMiHOG000238463
InParanoidiQ940A7
KOiK03126
OMAiAWLKQMQ
OrthoDBi1227642at2759
PhylomeDBiQ940A7

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q940A7

Gene expression databases

ExpressionAtlasiQ940A7 baseline and differential
GenevisibleiQ940A7 AT

Family and domain databases

CDDicd07981 TAF12, 1 hit
Gene3Di1.10.20.10, 1 hit
InterProiView protein in InterPro
IPR009072 Histone-fold
IPR037794 TAF12
IPR003228 TFIID_TAF12_dom
PANTHERiPTHR12264 PTHR12264, 2 hits
PfamiView protein in Pfam
PF03847 TFIID_20kDa, 1 hit
SUPFAMiSSF47113 SSF47113, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTA12B_ARATH
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q940A7
Secondary accession number(s): Q9LQJ7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 16, 2013
Last sequence update: December 1, 2001
Last modified: July 31, 2019
This is version 128 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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