UniProtKB - Q94071 (LIPB_CAEEL)
Protein
Liprin-beta homolog
Gene
hlb-1
Organism
Caenorhabditis elegans
Status
Functioni
Involved in the regulation of synaptic function at neuromuscular junctions (PubMed:19290026). Together with the liprin-alpha protein syd-2, may play a role in regulating the structure of the neuronal region, called the active zone, from which synaptic vesicles send neurotransmitter signals across the synapse (PubMed:19290026). Does not seem to be required for neuronal development (PubMed:19290026). May regulate the disassembly of focal adhesions (By similarity). Does not bind receptor-like tyrosine phosphatases type 2A (By similarity).By similarity1 Publication
GO - Biological processi
- neuromuscular junction development Source: WormBase
- positive regulation of locomotion Source: WormBase
- regulation of pharyngeal pumping Source: WormBase
- reproduction Source: WormBase
- synapse organization Source: GO_Central
Enzyme and pathway databases
Reactomei | R-CEL-388844, Receptor-type tyrosine-protein phosphatases |
Names & Taxonomyi
Protein namesi | Recommended name: Liprin-beta homologImportedAlternative name(s): LAR-interacting protein beta |
Gene namesi | Name:hlb-1Imported ORF Names:T21H8.1Imported |
Organismi | Caenorhabditis elegans |
Taxonomic identifieri | 6239 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditina › Rhabditomorpha › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis |
Proteomesi |
|
Organism-specific databases
WormBasei | T21H8.1a ; CE37412 ; WBGene00011904 ; hlb-1 T21H8.1b ; CE41339 ; WBGene00011904 ; hlb-1 T21H8.1c ; CE51474 ; WBGene00011904 ; hlb-1 T21H8.1d ; CE51489 ; WBGene00011904 ; hlb-1 T21H8.1e ; CE51430 ; WBGene00011904 ; hlb-1 T21H8.1f ; CE51357 ; WBGene00011904 ; hlb-1 T21H8.1g ; CE51523 ; WBGene00011904 ; hlb-1 T21H8.1h ; CE51532 ; WBGene00011904 ; hlb-1 T21H8.1i ; CE51461 ; WBGene00011904 ; hlb-1 T21H8.1j ; CE51332 ; WBGene00011904 ; hlb-1 T21H8.1k ; CE51249 ; WBGene00011904 ; hlb-1 T21H8.1l ; CE51262 ; WBGene00011904 ; hlb-1 T21H8.1m ; CE51507 ; WBGene00011904 ; hlb-1 T21H8.1n ; CE51376 ; WBGene00011904 ; hlb-1 T21H8.1o ; CE51301 ; WBGene00011904 ; hlb-1 T21H8.1p ; CE18956 ; WBGene00011904 ; hlb-1 T21H8.1q ; CE51549 ; WBGene00011904 ; hlb-1 T21H8.1r ; CE51423 ; WBGene00011904 ; hlb-1 T21H8.1s ; CE51350 ; WBGene00011904 ; hlb-1 |
Subcellular locationi
Other locations
- presynaptic active zone Source: GO_Central
Pathology & Biotechi
Disruption phenotypei
Defective locomotion, reduced pumping rate and reduced brood size (PubMed:19290026). Defects in presynaptic and postsynaptic structures and functions in muscle cells (PubMed:19290026). Resistant to the acetylcholinesterase inhibitor aldicarb and to levamisole, an agonist for postsynaptic acetylcholine receptors in muscles (PubMed:19290026). Double knockout with the syd-2 mutant ju37 increases resistance to aldicarb and levamisole (PubMed:19290026).1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000191039 | 1 – 1004 | Liprin-beta homologAdd BLAST | 1004 |
Proteomic databases
EPDi | Q94071 |
PaxDbi | Q94071 |
PeptideAtlasi | Q94071 |
Expressioni
Tissue specificityi
Expressed in pharyngeal muscle, particularly posterior bulb, adjacent to the dorsal and ventral cord (but not in ventral cord neurons), and in body wall muscles.1 Publication
Gene expression databases
Bgeei | WBGene00011904, Expressed in pharyngeal muscle cell (C elegans) and 4 other tissues |
ExpressionAtlasi | Q94071, baseline and differential |
Interactioni
Protein-protein interaction databases
IntActi | Q94071, 2 interactors |
STRINGi | 6239.T21H8.1b.1 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 698 – 762 | SAM 1PROSITE-ProRule annotationAdd BLAST | 65 | |
Domaini | 770 – 833 | SAM 2PROSITE-ProRule annotationAdd BLAST | 64 | |
Domaini | 858 – 930 | SAM 3PROSITE-ProRule annotationAdd BLAST | 73 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 280 – 328 | Sequence analysisAdd BLAST | 49 | |
Coiled coili | 364 – 396 | Sequence analysisAdd BLAST | 33 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 433 – 481 | Ser-richPROSITE-ProRule annotationAdd BLAST | 49 |
Sequence similaritiesi
Keywords - Domaini
Coiled coil, RepeatPhylogenomic databases
eggNOGi | ENOG502TGDQ, Eukaryota KOG1899, Eukaryota |
GeneTreei | ENSGT00990000203651 |
HOGENOMi | CLU_1526552_0_0_1 |
InParanoidi | Q94071 |
OMAi | VETQPCD |
OrthoDBi | 558442at2759 |
PhylomeDBi | Q94071 |
Family and domain databases
CDDi | cd09563, SAM_liprin-beta1_2_repeat1, 1 hit cd09566, SAM_liprin-beta1_2_repeat2, 1 hit cd09569, SAM_liprin-beta1_2_repeat3, 1 hit |
Gene3Di | 1.10.150.50, 3 hits |
InterProi | View protein in InterPro IPR029515, Liprin IPR030444, Liprin-beta IPR037617, Liprin-beta_SAM_rpt_1 IPR037618, Liprin-beta_SAM_rpt_2 IPR037619, Liprin-beta_SAM_rpt_3 IPR001660, SAM IPR013761, SAM/pointed_sf |
PANTHERi | PTHR12587, PTHR12587, 1 hit PTHR12587:SF14, PTHR12587:SF14, 1 hit |
Pfami | View protein in Pfam PF00536, SAM_1, 2 hits PF07647, SAM_2, 1 hit |
SMARTi | View protein in SMART SM00454, SAM, 3 hits |
SUPFAMi | SSF47769, SSF47769, 2 hits |
PROSITEi | View protein in PROSITE PS50105, SAM_DOMAIN, 2 hits |
s (19)i Sequence
Sequence statusi: Complete.
This entry describes 19 produced by isoformsialternative splicing. AlignAdd to basketIsoform hImported (identifier: Q94071-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MVYSSSSMSN TNIRRRSVPI TIQKSRMDGF AEANQLLSSA LEQLDDIIRN
60 70 80 90 100
GNSTSRSTTT IGSAGPTPII KKSFRDLLPP PPALRSTFSP RIMENGHSNL
110 120 130 140 150
AHKQHINDDI DNGNADDERS SREINRQWIS TDWKHRTDLG SDGSSGVESP
160 170 180 190 200
PSDLPTSSSS LFSPPRVYQE FVKAIDEQTM TERPDLETRL KIMQWVAGRT
210 220 230 240 250
SPSPSMSTVS CPEYPELQDK LHRLAMARDS LQLQVSVLSE QVGAQKEKIK
260 270 280 290 300
DLETVIALKR NNLTSTEELL QDKYHRIDEC QELESKKMDL LAEVSSLKLR
310 320 330 340 350
YATLEREKNE TEKKLRLSQN EMDHVNQSMH GMVVQQQLAH HTNGHSSGGY
360 370 380 390 400
MSPLREHRSE KNDDEMSQLR TAVQRLMADN EHKSLQINTL RNALDEQMRS
410 420 430 440 450
RSQQEDFYAS QRNYTDNFDV NAQIRRILMD EPSDSMSHST SFPVSLSSTT
460 470 480 490 500
SNGKGPRSTV QSSSSYNSSL SAVSPQHNWS SAGAGTPRQL HPIGGNQRVN
510 520 530 540 550
NITSAQYCSP SPPAARQLAA ELDELRRNGN EGANHNYSSA SLPRGVGKAS
560 570 580 590 600
STLTLPSKKL SVASGTSVGE LGGSMSSVAQ PTPKRNYRAQ MNRWINEKLR
610 620 630 640 650
RKRAVSAPNL VESDDEIARG RNLNNATSQS NLKNFSRERT RSSLRNIFSK
660 670 680 690 700
LTRSTSQDQS NSFRRGSAAR STSTARLGST NHLGTVSKRP PLSQFVDWRS
710 720 730 740 750
EQLADWIAEI GYPQYMNEVS RHVRSGRHFL NMSMNEYEGV LNIKNPVHRK
760 770 780 790 800
RVAILLRRIE EDIMEPANKW DVHQTLRWLD DIGLPQYKDV FAENVVDGPL
810 820 830 840 850
LLSLTANDAV EMKVVNAHHY ATLARSIQFL KKADFRFNAM EKLIDQNIVE
860 870 880 890 900
KYPCPDVVVR WTHSATCEWL RKIDLAEFTQ NLLFAGVPGA LMIYEPSFTA
910 920 930 940 950
ESLAEILQMP PHKTLLRRHL TSHFNQLLGP KIIADKRDFL AAGNYPQISP
960 970 980 990 1000
TGRVKVVKKG FSLTRKKAKN EICLEPEELL CPQVLVHKYP TGAGDNSSFE
SSNV
Isoform cImported (identifier: Q94071-4) [UniParc]FASTAAdd to basket
The sequence of this isoform differs from the canonical sequence as follows:
1-77: MVYSSSSMSN...PIIKKSFRDL → MYSRHSISDA...APSAGSSCSY
83-200: ALRSTFSPRI...KIMQWVAGRT → PYRMRGSGGL...DARGASWISL
273-319: Missing.
569-610: Missing.
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_060300 | 1 – 321 | Missing in isoform e and isoform f. CuratedAdd BLAST | 321 | |
Alternative sequenceiVSP_060301 | 1 – 200 | MVYSS…VAGRT → MAQRRAKSK in isoform r and isoform s. CuratedAdd BLAST | 200 | |
Alternative sequenceiVSP_060302 | 1 – 179 | Missing in isoform m and isoform n. CuratedAdd BLAST | 179 | |
Alternative sequenceiVSP_060303 | 1 – 92 | Missing in isoform k, isoform l and isoform q. CuratedAdd BLAST | 92 | |
Alternative sequenceiVSP_060304 | 1 – 77 | MVYSS…SFRDL → MYSRHSISDAYGAVCILPED TLTVSSSQNSHIDAFAALVD RERDSSRSSGSGNIFKDNGS IKRRQALPYVTHYSDSGFGS APSAGSSCSY in isoform a, isoform b, isoform c and isoform d. CuratedAdd BLAST | 77 | |
Alternative sequenceiVSP_060305 | 1 – 26 | Missing in isoform i, isoform j and isoform p. CuratedAdd BLAST | 26 | |
Alternative sequenceiVSP_060306 | 83 – 200 | ALRST…VAGRT → PYRMRGSGGLSSKPQHKIHR SLSDSKYTASLMTTGVPTLP LLSMTPFNQLQSRDARGASW ISL in isoform a, isoform b, isoform c and isoform d. CuratedAdd BLAST | 118 | |
Alternative sequenceiVSP_060307 | 201 – 202 | SP → VS in isoform o, isoform p and isoform q. Curated | 2 | |
Alternative sequenceiVSP_060308 | 203 – 1004 | Missing in isoform o, isoform p and isoform q. CuratedAdd BLAST | 802 | |
Alternative sequenceiVSP_060309 | 273 – 319 | Missing in isoform c and isoform d. CuratedAdd BLAST | 47 | |
Alternative sequenceiVSP_060310 | 569 – 610 | Missing in isoform a, isoform c, isoform e, isoform g, isoform i, isoform k, isoform m and isoform r. CuratedAdd BLAST | 42 |
Sequence databases
Genome annotation databases
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
3D structure databases
SMRi | Q94071 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | Q94071, 2 interactors |
STRINGi | 6239.T21H8.1b.1 |
Proteomic databases
EPDi | Q94071 |
PaxDbi | Q94071 |
PeptideAtlasi | Q94071 |
Genome annotation databases
Organism-specific databases
CTDi | 181499 |
WormBasei | T21H8.1a ; CE37412 ; WBGene00011904 ; hlb-1 T21H8.1b ; CE41339 ; WBGene00011904 ; hlb-1 T21H8.1c ; CE51474 ; WBGene00011904 ; hlb-1 T21H8.1d ; CE51489 ; WBGene00011904 ; hlb-1 T21H8.1e ; CE51430 ; WBGene00011904 ; hlb-1 T21H8.1f ; CE51357 ; WBGene00011904 ; hlb-1 T21H8.1g ; CE51523 ; WBGene00011904 ; hlb-1 T21H8.1h ; CE51532 ; WBGene00011904 ; hlb-1 T21H8.1i ; CE51461 ; WBGene00011904 ; hlb-1 T21H8.1j ; CE51332 ; WBGene00011904 ; hlb-1 T21H8.1k ; CE51249 ; WBGene00011904 ; hlb-1 T21H8.1l ; CE51262 ; WBGene00011904 ; hlb-1 T21H8.1m ; CE51507 ; WBGene00011904 ; hlb-1 T21H8.1n ; CE51376 ; WBGene00011904 ; hlb-1 T21H8.1o ; CE51301 ; WBGene00011904 ; hlb-1 T21H8.1p ; CE18956 ; WBGene00011904 ; hlb-1 T21H8.1q ; CE51549 ; WBGene00011904 ; hlb-1 T21H8.1r ; CE51423 ; WBGene00011904 ; hlb-1 T21H8.1s ; CE51350 ; WBGene00011904 ; hlb-1 |
Phylogenomic databases
eggNOGi | ENOG502TGDQ, Eukaryota KOG1899, Eukaryota |
GeneTreei | ENSGT00990000203651 |
HOGENOMi | CLU_1526552_0_0_1 |
InParanoidi | Q94071 |
OMAi | VETQPCD |
OrthoDBi | 558442at2759 |
PhylomeDBi | Q94071 |
Enzyme and pathway databases
Reactomei | R-CEL-388844, Receptor-type tyrosine-protein phosphatases |
Miscellaneous databases
PROi | PR:Q94071 |
Gene expression databases
Bgeei | WBGene00011904, Expressed in pharyngeal muscle cell (C elegans) and 4 other tissues |
ExpressionAtlasi | Q94071, baseline and differential |
Family and domain databases
CDDi | cd09563, SAM_liprin-beta1_2_repeat1, 1 hit cd09566, SAM_liprin-beta1_2_repeat2, 1 hit cd09569, SAM_liprin-beta1_2_repeat3, 1 hit |
Gene3Di | 1.10.150.50, 3 hits |
InterProi | View protein in InterPro IPR029515, Liprin IPR030444, Liprin-beta IPR037617, Liprin-beta_SAM_rpt_1 IPR037618, Liprin-beta_SAM_rpt_2 IPR037619, Liprin-beta_SAM_rpt_3 IPR001660, SAM IPR013761, SAM/pointed_sf |
PANTHERi | PTHR12587, PTHR12587, 1 hit PTHR12587:SF14, PTHR12587:SF14, 1 hit |
Pfami | View protein in Pfam PF00536, SAM_1, 2 hits PF07647, SAM_2, 1 hit |
SMARTi | View protein in SMART SM00454, SAM, 3 hits |
SUPFAMi | SSF47769, SSF47769, 2 hits |
PROSITEi | View protein in PROSITE PS50105, SAM_DOMAIN, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | LIPB_CAEEL | |
Accessioni | Q94071Primary (citable) accession number: Q94071 Secondary accession number(s): A0A131MBC5 Q94075 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 16, 2004 |
Last sequence update: | September 18, 2019 | |
Last modified: | December 2, 2020 | |
This is version 134 of the entry and version 5 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Caenorhabditis annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Caenorhabditis elegans
Caenorhabditis elegans: entries, gene names and cross-references to WormBase - SIMILARITY comments
Index of protein domains and families