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Entry version 135 (07 Apr 2021)
Sequence version 5 (18 Sep 2019)
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Protein

Liprin-beta homolog

Gene

hlb-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in the regulation of synaptic function at neuromuscular junctions (PubMed:19290026). Together with the liprin-alpha protein syd-2, may play a role in regulating the structure of the neuronal region, called the active zone, from which synaptic vesicles send neurotransmitter signals across the synapse (PubMed:19290026). Does not seem to be required for neuronal development (PubMed:19290026). May regulate the disassembly of focal adhesions (By similarity). Does not bind receptor-like tyrosine phosphatases type 2A (By similarity).By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-388844, Receptor-type tyrosine-protein phosphatases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Liprin-beta homologImported
Alternative name(s):
LAR-interacting protein beta
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:hlb-1Imported
ORF Names:T21H8.1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

WormBase

More...
WormBasei
T21H8.1a ; CE37412 ; WBGene00011904 ; hlb-1
T21H8.1b ; CE41339 ; WBGene00011904 ; hlb-1
T21H8.1c ; CE51474 ; WBGene00011904 ; hlb-1
T21H8.1d ; CE51489 ; WBGene00011904 ; hlb-1
T21H8.1e ; CE51430 ; WBGene00011904 ; hlb-1
T21H8.1f ; CE51357 ; WBGene00011904 ; hlb-1
T21H8.1g ; CE51523 ; WBGene00011904 ; hlb-1
T21H8.1h ; CE51532 ; WBGene00011904 ; hlb-1
T21H8.1i ; CE51461 ; WBGene00011904 ; hlb-1
T21H8.1j ; CE51332 ; WBGene00011904 ; hlb-1
T21H8.1k ; CE51249 ; WBGene00011904 ; hlb-1
T21H8.1l ; CE51262 ; WBGene00011904 ; hlb-1
T21H8.1m ; CE51507 ; WBGene00011904 ; hlb-1
T21H8.1n ; CE51376 ; WBGene00011904 ; hlb-1
T21H8.1o ; CE51301 ; WBGene00011904 ; hlb-1
T21H8.1p ; CE18956 ; WBGene00011904 ; hlb-1
T21H8.1q ; CE51549 ; WBGene00011904 ; hlb-1
T21H8.1r ; CE51423 ; WBGene00011904 ; hlb-1
T21H8.1s ; CE51350 ; WBGene00011904 ; hlb-1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Defective locomotion, reduced pumping rate and reduced brood size (PubMed:19290026). Defects in presynaptic and postsynaptic structures and functions in muscle cells (PubMed:19290026). Resistant to the acetylcholinesterase inhibitor aldicarb and to levamisole, an agonist for postsynaptic acetylcholine receptors in muscles (PubMed:19290026). Double knockout with the syd-2 mutant ju37 increases resistance to aldicarb and levamisole (PubMed:19290026).1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001910391 – 1004Liprin-beta homologAdd BLAST1004

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q94071

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q94071

PeptideAtlas

More...
PeptideAtlasi
Q94071

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in pharyngeal muscle, particularly posterior bulb, adjacent to the dorsal and ventral cord (but not in ventral cord neurons), and in body wall muscles.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00011904, Expressed in pharyngeal muscle cell (C elegans) and 4 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q94071, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
46399, 1 interactor

Protein interaction database and analysis system

More...
IntActi
Q94071, 2 interactors

STRING: functional protein association networks

More...
STRINGi
6239.T21H8.1b.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q94071

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini698 – 762SAM 1PROSITE-ProRule annotationAdd BLAST65
Domaini770 – 833SAM 2PROSITE-ProRule annotationAdd BLAST64
Domaini858 – 930SAM 3PROSITE-ProRule annotationAdd BLAST73

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili280 – 328Sequence analysisAdd BLAST49
Coiled coili364 – 396Sequence analysisAdd BLAST33

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi433 – 481Ser-richPROSITE-ProRule annotationAdd BLAST49

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the liprin family. Liprin-beta subfamily.Curated

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502TGDQ, Eukaryota
KOG1899, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00990000203651

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_1526552_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q94071

Identification of Orthologs from Complete Genome Data

More...
OMAi
VETQPCD

Database of Orthologous Groups

More...
OrthoDBi
558442at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q94071

Family and domain databases

Conserved Domains Database

More...
CDDi
cd09563, SAM_liprin-beta1_2_repeat1, 1 hit
cd09566, SAM_liprin-beta1_2_repeat2, 1 hit
cd09569, SAM_liprin-beta1_2_repeat3, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.150.50, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029515, Liprin
IPR030444, Liprin-beta
IPR037617, Liprin-beta_SAM_rpt_1
IPR037618, Liprin-beta_SAM_rpt_2
IPR037619, Liprin-beta_SAM_rpt_3
IPR001660, SAM
IPR013761, SAM/pointed_sf

The PANTHER Classification System

More...
PANTHERi
PTHR12587, PTHR12587, 1 hit
PTHR12587:SF14, PTHR12587:SF14, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00536, SAM_1, 2 hits
PF07647, SAM_2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00454, SAM, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47769, SSF47769, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50105, SAM_DOMAIN, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (19)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 19 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform hImported (identifier: Q94071-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVYSSSSMSN TNIRRRSVPI TIQKSRMDGF AEANQLLSSA LEQLDDIIRN
60 70 80 90 100
GNSTSRSTTT IGSAGPTPII KKSFRDLLPP PPALRSTFSP RIMENGHSNL
110 120 130 140 150
AHKQHINDDI DNGNADDERS SREINRQWIS TDWKHRTDLG SDGSSGVESP
160 170 180 190 200
PSDLPTSSSS LFSPPRVYQE FVKAIDEQTM TERPDLETRL KIMQWVAGRT
210 220 230 240 250
SPSPSMSTVS CPEYPELQDK LHRLAMARDS LQLQVSVLSE QVGAQKEKIK
260 270 280 290 300
DLETVIALKR NNLTSTEELL QDKYHRIDEC QELESKKMDL LAEVSSLKLR
310 320 330 340 350
YATLEREKNE TEKKLRLSQN EMDHVNQSMH GMVVQQQLAH HTNGHSSGGY
360 370 380 390 400
MSPLREHRSE KNDDEMSQLR TAVQRLMADN EHKSLQINTL RNALDEQMRS
410 420 430 440 450
RSQQEDFYAS QRNYTDNFDV NAQIRRILMD EPSDSMSHST SFPVSLSSTT
460 470 480 490 500
SNGKGPRSTV QSSSSYNSSL SAVSPQHNWS SAGAGTPRQL HPIGGNQRVN
510 520 530 540 550
NITSAQYCSP SPPAARQLAA ELDELRRNGN EGANHNYSSA SLPRGVGKAS
560 570 580 590 600
STLTLPSKKL SVASGTSVGE LGGSMSSVAQ PTPKRNYRAQ MNRWINEKLR
610 620 630 640 650
RKRAVSAPNL VESDDEIARG RNLNNATSQS NLKNFSRERT RSSLRNIFSK
660 670 680 690 700
LTRSTSQDQS NSFRRGSAAR STSTARLGST NHLGTVSKRP PLSQFVDWRS
710 720 730 740 750
EQLADWIAEI GYPQYMNEVS RHVRSGRHFL NMSMNEYEGV LNIKNPVHRK
760 770 780 790 800
RVAILLRRIE EDIMEPANKW DVHQTLRWLD DIGLPQYKDV FAENVVDGPL
810 820 830 840 850
LLSLTANDAV EMKVVNAHHY ATLARSIQFL KKADFRFNAM EKLIDQNIVE
860 870 880 890 900
KYPCPDVVVR WTHSATCEWL RKIDLAEFTQ NLLFAGVPGA LMIYEPSFTA
910 920 930 940 950
ESLAEILQMP PHKTLLRRHL TSHFNQLLGP KIIADKRDFL AAGNYPQISP
960 970 980 990 1000
TGRVKVVKKG FSLTRKKAKN EICLEPEELL CPQVLVHKYP TGAGDNSSFE

SSNV
Length:1,004
Mass (Da):112,712
Last modified:September 18, 2019 - v5
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA8F83DF79677EA29
GO
Isoform aImported (identifier: Q94071-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-77: MVYSSSSMSN...PIIKKSFRDL → MYSRHSISDA...APSAGSSCSY
     83-200: ALRSTFSPRI...KIMQWVAGRT → PYRMRGSGGL...DARGASWISL
     569-610: Missing.

Show »
Length:920
Mass (Da):102,674
Checksum:i22A2A59AE94FC19F
GO
Isoform bImported (identifier: Q94071-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-77: MVYSSSSMSN...PIIKKSFRDL → MYSRHSISDA...APSAGSSCSY
     83-200: ALRSTFSPRI...KIMQWVAGRT → PYRMRGSGGL...DARGASWISL

Show »
Length:962
Mass (Da):107,426
Checksum:iFB9ADF59D26AC969
GO
Isoform cImported (identifier: Q94071-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-77: MVYSSSSMSN...PIIKKSFRDL → MYSRHSISDA...APSAGSSCSY
     83-200: ALRSTFSPRI...KIMQWVAGRT → PYRMRGSGGL...DARGASWISL
     273-319: Missing.
     569-610: Missing.

Show »
Length:873
Mass (Da):97,011
Checksum:i31922B4E5A6D4114
GO
Isoform dImported (identifier: Q94071-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-77: MVYSSSSMSN...PIIKKSFRDL → MYSRHSISDA...APSAGSSCSY
     83-200: ALRSTFSPRI...KIMQWVAGRT → PYRMRGSGGL...DARGASWISL
     273-319: Missing.

Show »
Length:915
Mass (Da):101,762
Checksum:i1BFE1CD74ECBB5E8
GO
Isoform eImported (identifier: Q94071-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-321: Missing.
     569-610: Missing.

Show »
Length:641
Mass (Da):71,764
Checksum:i7404BC1E56EB36FF
GO
Isoform fImported (identifier: Q94071-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-321: Missing.

Show »
Length:683
Mass (Da):76,515
Checksum:iCF12408D680ADFDB
GO
Isoform gImported (identifier: Q94071-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     569-610: Missing.

Show »
Length:962
Mass (Da):107,960
Checksum:i14409849FDC1AB96
GO
Isoform iImported (identifier: Q94071-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-26: Missing.
     569-610: Missing.

Show »
Length:936
Mass (Da):104,979
Checksum:i173943B62953E9C5
GO
Isoform jImported (identifier: Q94071-10) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-26: Missing.

Show »
Length:978
Mass (Da):109,730
Checksum:i43DCBCF2DBFF4C7A
GO
Isoform kImported (identifier: Q94071-11) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-92: Missing.
     569-610: Missing.

Show »
Length:870
Mass (Da):97,927
Checksum:i41B465745441F96D
GO
Isoform lImported (identifier: Q94071-12) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-92: Missing.

Show »
Length:912
Mass (Da):102,678
Checksum:i15C2E2F0E987E749
GO
Isoform mImported (identifier: Q94071-13) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-179: Missing.
     569-610: Missing.

Show »
Length:783
Mass (Da):88,205
Checksum:iCCE2268120408FC5
GO
Isoform nImported (identifier: Q94071-14) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-179: Missing.

Show »
Length:825
Mass (Da):92,957
Checksum:iFB61009979831959
GO
Isoform oImported (identifier: Q94071-15) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     201-202: SP → VS
     203-1004: Missing.

Show »
Length:202
Mass (Da):22,473
Checksum:i9B4EC03728BE8523
GO
Isoform pImported (identifier: Q94071-16) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-26: Missing.
     201-202: SP → VS
     203-1004: Missing.

Show »
Length:176
Mass (Da):19,492
Checksum:i4451234A2CB8763F
GO
Isoform qImported (identifier: Q94071-17) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-92: Missing.
     201-202: SP → VS
     203-1004: Missing.

Show »
Length:110
Mass (Da):12,440
Checksum:i68FE4B1BB6C07FCF
GO
Isoform rImported (identifier: Q94071-18) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-200: MVYSSSSMSN...KIMQWVAGRT → MAQRRAKSK
     569-610: Missing.

Show »
Length:771
Mass (Da):86,749
Checksum:i990F07928AD98096
GO
Isoform sImported (identifier: Q94071-19) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-200: MVYSSSSMSN...KIMQWVAGRT → MAQRRAKSK

Show »
Length:813
Mass (Da):91,500
Checksum:i6F0B5F716224074E
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0603001 – 321Missing in isoform e and isoform f. CuratedAdd BLAST321
Alternative sequenceiVSP_0603011 – 200MVYSS…VAGRT → MAQRRAKSK in isoform r and isoform s. CuratedAdd BLAST200
Alternative sequenceiVSP_0603021 – 179Missing in isoform m and isoform n. CuratedAdd BLAST179
Alternative sequenceiVSP_0603031 – 92Missing in isoform k, isoform l and isoform q. CuratedAdd BLAST92
Alternative sequenceiVSP_0603041 – 77MVYSS…SFRDL → MYSRHSISDAYGAVCILPED TLTVSSSQNSHIDAFAALVD RERDSSRSSGSGNIFKDNGS IKRRQALPYVTHYSDSGFGS APSAGSSCSY in isoform a, isoform b, isoform c and isoform d. CuratedAdd BLAST77
Alternative sequenceiVSP_0603051 – 26Missing in isoform i, isoform j and isoform p. CuratedAdd BLAST26
Alternative sequenceiVSP_06030683 – 200ALRST…VAGRT → PYRMRGSGGLSSKPQHKIHR SLSDSKYTASLMTTGVPTLP LLSMTPFNQLQSRDARGASW ISL in isoform a, isoform b, isoform c and isoform d. CuratedAdd BLAST118
Alternative sequenceiVSP_060307201 – 202SP → VS in isoform o, isoform p and isoform q. Curated2
Alternative sequenceiVSP_060308203 – 1004Missing in isoform o, isoform p and isoform q. CuratedAdd BLAST802
Alternative sequenceiVSP_060309273 – 319Missing in isoform c and isoform d. CuratedAdd BLAST47
Alternative sequenceiVSP_060310569 – 610Missing in isoform a, isoform c, isoform e, isoform g, isoform i, isoform k, isoform m and isoform r. CuratedAdd BLAST42

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
BX284606 Genomic DNA Translation: CAB01770.1
BX284606 Genomic DNA Translation: CAB01771.3
BX284606 Genomic DNA Translation: CAO79773.1
BX284606 Genomic DNA Translation: CZR14633.1
BX284606 Genomic DNA Translation: CZR14634.1
BX284606 Genomic DNA Translation: CZR14635.1
BX284606 Genomic DNA Translation: CZR14636.1
BX284606 Genomic DNA Translation: CZR14637.1
BX284606 Genomic DNA Translation: CZR14638.1
BX284606 Genomic DNA Translation: CZR14639.1
BX284606 Genomic DNA Translation: CZR14640.1
BX284606 Genomic DNA Translation: CZR14641.1
BX284606 Genomic DNA Translation: CZR14642.1
BX284606 Genomic DNA Translation: CZR14643.1
BX284606 Genomic DNA Translation: CZR14644.1
BX284606 Genomic DNA Translation: CZR14645.1
BX284606 Genomic DNA Translation: CZR14646.1
BX284606 Genomic DNA Translation: CZR14647.1
BX284606 Genomic DNA Translation: CZR14648.1

Protein sequence database of the Protein Information Resource

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PIRi
A89696
T25087
T25088

NCBI Reference Sequences

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RefSeqi
NP_001123185.1, NM_001129713.2 [Q94071-3]
NP_001309703.1, NM_001322655.1 [Q94071-4]
NP_001309704.1, NM_001322656.1 [Q94071-5]
NP_001309705.1, NM_001322659.1 [Q94071-6]
NP_001309706.1, NM_001322660.1 [Q94071-7]
NP_001309707.1, NM_001322647.1 [Q94071-8]
NP_001309708.1, NM_001322648.1 [Q94071-1]
NP_001309709.1, NM_001322649.1 [Q94071-9]
NP_001309710.1, NM_001322650.1 [Q94071-10]
NP_001309711.1, NM_001322651.1
NP_001309712.1, NM_001322652.1
NP_001309713.1, NM_001322653.1 [Q94071-13]
NP_001309714.1, NM_001322654.1 [Q94071-14]
NP_001309715.1, NM_001322661.1
NP_001309716.1, NM_001322662.1 [Q94071-17]
NP_001309717.1, NM_001322657.1 [Q94071-18]
NP_001309718.1, NM_001322658.1 [Q94071-19]
NP_510311.2, NM_077910.4 [Q94071-2]
NP_510312.1, NM_077911.1

Genome annotation databases

Ensembl metazoan genome annotation project

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EnsemblMetazoai
T21H8.1a.1; T21H8.1a.1; WBGene00011904 [Q94071-2]
T21H8.1a.2; T21H8.1a.2; WBGene00011904 [Q94071-2]
T21H8.1b.1; T21H8.1b.1; WBGene00011904 [Q94071-3]
T21H8.1b.2; T21H8.1b.2; WBGene00011904 [Q94071-3]
T21H8.1c.1; T21H8.1c.1; WBGene00011904 [Q94071-4]
T21H8.1c.2; T21H8.1c.2; WBGene00011904 [Q94071-4]
T21H8.1d.1; T21H8.1d.1; WBGene00011904 [Q94071-5]
T21H8.1d.2; T21H8.1d.2; WBGene00011904 [Q94071-5]
T21H8.1e.1; T21H8.1e.1; WBGene00011904 [Q94071-6]
T21H8.1f.1; T21H8.1f.1; WBGene00011904 [Q94071-7]
T21H8.1g.1; T21H8.1g.1; WBGene00011904 [Q94071-8]
T21H8.1h.1; T21H8.1h.1; WBGene00011904 [Q94071-1]
T21H8.1i.1; T21H8.1i.1; WBGene00011904 [Q94071-9]
T21H8.1j.1; T21H8.1j.1; WBGene00011904 [Q94071-10]
T21H8.1k.1; T21H8.1k.1; WBGene00011904 [Q94071-11]
T21H8.1l.1; T21H8.1l.1; WBGene00011904 [Q94071-12]
T21H8.1m.1; T21H8.1m.1; WBGene00011904 [Q94071-13]
T21H8.1n.1; T21H8.1n.1; WBGene00011904 [Q94071-14]
T21H8.1o.1; T21H8.1o.1; WBGene00011904 [Q94071-15]
T21H8.1p.1; T21H8.1p.1; WBGene00011904 [Q94071-16]
T21H8.1q.1; T21H8.1q.1; WBGene00011904 [Q94071-17]
T21H8.1r.1; T21H8.1r.1; WBGene00011904 [Q94071-18]
T21H8.1s.1; T21H8.1s.1; WBGene00011904 [Q94071-19]

Database of genes from NCBI RefSeq genomes

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GeneIDi
181499

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
cel:CELE_T21H8.1

UCSC genome browser

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UCSCi
T21H8.1b.1, c. elegans
T21H8.5, c. elegans

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284606 Genomic DNA Translation: CAB01770.1
BX284606 Genomic DNA Translation: CAB01771.3
BX284606 Genomic DNA Translation: CAO79773.1
BX284606 Genomic DNA Translation: CZR14633.1
BX284606 Genomic DNA Translation: CZR14634.1
BX284606 Genomic DNA Translation: CZR14635.1
BX284606 Genomic DNA Translation: CZR14636.1
BX284606 Genomic DNA Translation: CZR14637.1
BX284606 Genomic DNA Translation: CZR14638.1
BX284606 Genomic DNA Translation: CZR14639.1
BX284606 Genomic DNA Translation: CZR14640.1
BX284606 Genomic DNA Translation: CZR14641.1
BX284606 Genomic DNA Translation: CZR14642.1
BX284606 Genomic DNA Translation: CZR14643.1
BX284606 Genomic DNA Translation: CZR14644.1
BX284606 Genomic DNA Translation: CZR14645.1
BX284606 Genomic DNA Translation: CZR14646.1
BX284606 Genomic DNA Translation: CZR14647.1
BX284606 Genomic DNA Translation: CZR14648.1
PIRiA89696
T25087
T25088
RefSeqiNP_001123185.1, NM_001129713.2 [Q94071-3]
NP_001309703.1, NM_001322655.1 [Q94071-4]
NP_001309704.1, NM_001322656.1 [Q94071-5]
NP_001309705.1, NM_001322659.1 [Q94071-6]
NP_001309706.1, NM_001322660.1 [Q94071-7]
NP_001309707.1, NM_001322647.1 [Q94071-8]
NP_001309708.1, NM_001322648.1 [Q94071-1]
NP_001309709.1, NM_001322649.1 [Q94071-9]
NP_001309710.1, NM_001322650.1 [Q94071-10]
NP_001309711.1, NM_001322651.1
NP_001309712.1, NM_001322652.1
NP_001309713.1, NM_001322653.1 [Q94071-13]
NP_001309714.1, NM_001322654.1 [Q94071-14]
NP_001309715.1, NM_001322661.1
NP_001309716.1, NM_001322662.1 [Q94071-17]
NP_001309717.1, NM_001322657.1 [Q94071-18]
NP_001309718.1, NM_001322658.1 [Q94071-19]
NP_510311.2, NM_077910.4 [Q94071-2]
NP_510312.1, NM_077911.1

3D structure databases

SMRiQ94071
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi46399, 1 interactor
IntActiQ94071, 2 interactors
STRINGi6239.T21H8.1b.1

Proteomic databases

EPDiQ94071
PaxDbiQ94071
PeptideAtlasiQ94071

Genome annotation databases

EnsemblMetazoaiT21H8.1a.1; T21H8.1a.1; WBGene00011904 [Q94071-2]
T21H8.1a.2; T21H8.1a.2; WBGene00011904 [Q94071-2]
T21H8.1b.1; T21H8.1b.1; WBGene00011904 [Q94071-3]
T21H8.1b.2; T21H8.1b.2; WBGene00011904 [Q94071-3]
T21H8.1c.1; T21H8.1c.1; WBGene00011904 [Q94071-4]
T21H8.1c.2; T21H8.1c.2; WBGene00011904 [Q94071-4]
T21H8.1d.1; T21H8.1d.1; WBGene00011904 [Q94071-5]
T21H8.1d.2; T21H8.1d.2; WBGene00011904 [Q94071-5]
T21H8.1e.1; T21H8.1e.1; WBGene00011904 [Q94071-6]
T21H8.1f.1; T21H8.1f.1; WBGene00011904 [Q94071-7]
T21H8.1g.1; T21H8.1g.1; WBGene00011904 [Q94071-8]
T21H8.1h.1; T21H8.1h.1; WBGene00011904 [Q94071-1]
T21H8.1i.1; T21H8.1i.1; WBGene00011904 [Q94071-9]
T21H8.1j.1; T21H8.1j.1; WBGene00011904 [Q94071-10]
T21H8.1k.1; T21H8.1k.1; WBGene00011904 [Q94071-11]
T21H8.1l.1; T21H8.1l.1; WBGene00011904 [Q94071-12]
T21H8.1m.1; T21H8.1m.1; WBGene00011904 [Q94071-13]
T21H8.1n.1; T21H8.1n.1; WBGene00011904 [Q94071-14]
T21H8.1o.1; T21H8.1o.1; WBGene00011904 [Q94071-15]
T21H8.1p.1; T21H8.1p.1; WBGene00011904 [Q94071-16]
T21H8.1q.1; T21H8.1q.1; WBGene00011904 [Q94071-17]
T21H8.1r.1; T21H8.1r.1; WBGene00011904 [Q94071-18]
T21H8.1s.1; T21H8.1s.1; WBGene00011904 [Q94071-19]
GeneIDi181499
KEGGicel:CELE_T21H8.1
UCSCiT21H8.1b.1, c. elegans
T21H8.5, c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
181499
WormBaseiT21H8.1a ; CE37412 ; WBGene00011904 ; hlb-1
T21H8.1b ; CE41339 ; WBGene00011904 ; hlb-1
T21H8.1c ; CE51474 ; WBGene00011904 ; hlb-1
T21H8.1d ; CE51489 ; WBGene00011904 ; hlb-1
T21H8.1e ; CE51430 ; WBGene00011904 ; hlb-1
T21H8.1f ; CE51357 ; WBGene00011904 ; hlb-1
T21H8.1g ; CE51523 ; WBGene00011904 ; hlb-1
T21H8.1h ; CE51532 ; WBGene00011904 ; hlb-1
T21H8.1i ; CE51461 ; WBGene00011904 ; hlb-1
T21H8.1j ; CE51332 ; WBGene00011904 ; hlb-1
T21H8.1k ; CE51249 ; WBGene00011904 ; hlb-1
T21H8.1l ; CE51262 ; WBGene00011904 ; hlb-1
T21H8.1m ; CE51507 ; WBGene00011904 ; hlb-1
T21H8.1n ; CE51376 ; WBGene00011904 ; hlb-1
T21H8.1o ; CE51301 ; WBGene00011904 ; hlb-1
T21H8.1p ; CE18956 ; WBGene00011904 ; hlb-1
T21H8.1q ; CE51549 ; WBGene00011904 ; hlb-1
T21H8.1r ; CE51423 ; WBGene00011904 ; hlb-1
T21H8.1s ; CE51350 ; WBGene00011904 ; hlb-1

Phylogenomic databases

eggNOGiENOG502TGDQ, Eukaryota
KOG1899, Eukaryota
GeneTreeiENSGT00990000203651
HOGENOMiCLU_1526552_0_0_1
InParanoidiQ94071
OMAiVETQPCD
OrthoDBi558442at2759
PhylomeDBiQ94071

Enzyme and pathway databases

ReactomeiR-CEL-388844, Receptor-type tyrosine-protein phosphatases

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q94071

Gene expression databases

BgeeiWBGene00011904, Expressed in pharyngeal muscle cell (C elegans) and 4 other tissues
ExpressionAtlasiQ94071, baseline and differential

Family and domain databases

CDDicd09563, SAM_liprin-beta1_2_repeat1, 1 hit
cd09566, SAM_liprin-beta1_2_repeat2, 1 hit
cd09569, SAM_liprin-beta1_2_repeat3, 1 hit
Gene3Di1.10.150.50, 3 hits
InterProiView protein in InterPro
IPR029515, Liprin
IPR030444, Liprin-beta
IPR037617, Liprin-beta_SAM_rpt_1
IPR037618, Liprin-beta_SAM_rpt_2
IPR037619, Liprin-beta_SAM_rpt_3
IPR001660, SAM
IPR013761, SAM/pointed_sf
PANTHERiPTHR12587, PTHR12587, 1 hit
PTHR12587:SF14, PTHR12587:SF14, 1 hit
PfamiView protein in Pfam
PF00536, SAM_1, 2 hits
PF07647, SAM_2, 1 hit
SMARTiView protein in SMART
SM00454, SAM, 3 hits
SUPFAMiSSF47769, SSF47769, 2 hits
PROSITEiView protein in PROSITE
PS50105, SAM_DOMAIN, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLIPB_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q94071
Secondary accession number(s): A0A131MBC5
, A0A131MBE2, A0A131MBV4, A0A131MBW2, A0A131MBW4, A0A131MBY3, A0A131MBZ3, A0A131MC19, A0A131MC32, A0A131MCT0, A0A131MD42, A0A131MD54, A0A131MD98, A0A131MDA8, A0A131MDI4, A0A131MDJ4, A7LPI2, Q94075
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: September 18, 2019
Last modified: April 7, 2021
This is version 135 of the entry and version 5 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families
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