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Protein

Chaperonin CPN60-like 2, mitochondrial

Gene

At3g13860

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Implicated in mitochondrial protein import and macromolecular assembly. May facilitate the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
Biological processStress response
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-ATH-1268020 Mitochondrial protein import

Names & Taxonomyi

Protein namesi
Recommended name:
Chaperonin CPN60-like 2, mitochondrial
Alternative name(s):
HSP60-like 2
Gene namesi
Ordered Locus Names:At3g13860
ORF Names:MCP4.9
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

AraportiAT3G13860
TAIRilocus:2087959 AT3G13860

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 31Mitochondrion1 PublicationAdd BLAST31
ChainiPRO_000004579332 – 572Chaperonin CPN60-like 2, mitochondrialAdd BLAST541

Proteomic databases

PaxDbiQ93ZM7
PRIDEiQ93ZM7

Expressioni

Gene expression databases

ExpressionAtlasiQ93ZM7 baseline and differential
GenevisibleiQ93ZM7 AT

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi5933, 2 interactors
IntActiQ93ZM7, 2 interactors
STRINGi3702.AT3G13860.1

Structurei

3D structure databases

ProteinModelPortaliQ93ZM7
SMRiQ93ZM7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the chaperonin (HSP60) family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0356 Eukaryota
COG0459 LUCA
HOGENOMiHOG000076290
InParanoidiQ93ZM7
KOiK04077
OMAiWTSPKIT
OrthoDBiEOG093606CJ
PhylomeDBiQ93ZM7

Family and domain databases

CDDicd03344 GroEL, 1 hit
Gene3Di1.10.560.10, 2 hits
3.30.260.10, 2 hits
3.50.7.10, 1 hit
HAMAPiMF_00600 CH60, 1 hit
InterProiView protein in InterPro
IPR018370 Chaperonin_Cpn60_CS
IPR001844 Chaprnin_Cpn60
IPR002423 Cpn60/TCP-1
IPR027409 GroEL-like_apical_dom_sf
IPR027413 GROEL-like_equatorial_sf
IPR027410 TCP-1-like_intermed_sf
PfamiView protein in Pfam
PF00118 Cpn60_TCP1, 1 hit
PRINTSiPR00298 CHAPERONIN60
SUPFAMiSSF48592 SSF48592, 2 hits
SSF52029 SSF52029, 1 hit
SSF54849 SSF54849, 1 hit
TIGRFAMsiTIGR02348 GroEL, 1 hit
PROSITEiView protein in PROSITE
PS00296 CHAPERONINS_CPN60, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q93ZM7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYRVLSKLSS SIGSSTSRKL VSGRIISSRN YAAKDISFGI GARAAMLQGV
60 70 80 90 100
SEVAEAVKVT MGPKGRNVII ESSYGGPKIT KDGVTVAKSI SFQAKAKNIG
110 120 130 140 150
AELVKQVASA TNKVAGDGTT CATVLTQAIL IEGCKSVAAG VNVMDLRVGI
160 170 180 190 200
NMAIAAVVSD LKSRAVMIST PEEITQVATI SANGEREIGE LIARAMEKVG
210 220 230 240 250
KEGVITVADG NTLDNELEVV EGMKLARGYI SPYFITDEKT QKCELENPII
260 270 280 290 300
LIHEKKISDI NSLLKVLEAA VKSSRPLLIV AEDVESDALA MLILNKHHGG
310 320 330 340 350
LKVCAIKAPG FGDNRKASLD DLAVLTGAEV ISEERGLSLE KIRPELLGTA
360 370 380 390 400
KKVTVTRDDT IILHGGGDKK LIEERCEELR SANEKSTSTF DQEKTQERLS
410 420 430 440 450
KLSGGVAVFK VGGASESEVG ERKDRVTDAL NATRAAVEEG IIPGGGVALL
460 470 480 490 500
YATKALDNLQ TENEDQRRGV QIVQNALKAP AFTIAANAGY DGSLVVGKLL
510 520 530 540 550
EQDDCNFGFD AAKGKYVDMV KAGIIDPVKV IRTALTDAAS VSLLLTTTEA
560 570
SVLVKADENT PNHVPDMASM GM
Length:572
Mass (Da):60,466
Last modified:January 24, 2006 - v2
Checksum:i7CA7CAF188753805
GO

Sequence cautioni

The sequence AAL09728 differs from that shown. Reason: Frameshift at position 419.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti273 – 274SS → KY in AAL09728 (PubMed:14593172).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB028610 Genomic DNA Translation: BAB02911.1
CP002686 Genomic DNA Translation: AEE75427.1
AY056782 mRNA Translation: AAL09728.1 Frameshift.
AY094453 mRNA Translation: AAM19824.1
BT015923 mRNA Translation: AAU95459.1
RefSeqiNP_566466.1, NM_112240.4
UniGeneiAt.8222

Genome annotation databases

EnsemblPlantsiAT3G13860.1; AT3G13860.1; AT3G13860
GeneIDi820599
GrameneiAT3G13860.1; AT3G13860.1; AT3G13860
KEGGiath:AT3G13860

Similar proteinsi

Entry informationi

Entry nameiCH60C_ARATH
AccessioniPrimary (citable) accession number: Q93ZM7
Secondary accession number(s): Q9LRW0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: January 24, 2006
Last modified: May 23, 2018
This is version 112 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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