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Protein

Probable N-acetyl-gamma-glutamyl-phosphate reductase, chloroplastic

Gene

At2g19940

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH.

Pathwayi: L-arginine biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes N(2)-acetyl-L-ornithine from L-glutamate.
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. Arginine biosynthesis bifunctional protein ArgJ, chloroplastic (At2g37500), Probable amino-acid acetyltransferase NAGS2, chloroplastic (NAGS2), Probable amino-acid acetyltransferase NAGS1, chloroplastic (NAGS1), Arginine biosynthesis bifunctional protein ArgJ, chloroplastic (AXX17_At2g34300)
  2. Acetylglutamate kinase, chloroplastic (NAGK)
  3. Probable N-acetyl-gamma-glutamyl-phosphate reductase, chloroplastic (At2g19940)
  4. Acetylornithine aminotransferase, chloroplastic/mitochondrial (WIN1)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes N(2)-acetyl-L-ornithine from L-glutamate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei205By similarity1

GO - Molecular functioni

GO - Biological processi

  • arginine biosynthetic process Source: UniProtKB-UniPathway
  • response to cadmium ion Source: TAIR

Keywordsi

Molecular functionOxidoreductase
Biological processAmino-acid biosynthesis, Arginine biosynthesis
LigandNADP

Enzyme and pathway databases

UniPathwayi
UPA00068;UER00108

Names & Taxonomyi

Protein namesi
Recommended name:
Probable N-acetyl-gamma-glutamyl-phosphate reductase, chloroplastic (EC:1.2.1.38)
Short name:
AGPR
Alternative name(s):
N-acetyl-glutamate semialdehyde dehydrogenase
Short name:
NAGSA dehydrogenase
Gene namesi
Ordered Locus Names:At2g19940
ORF Names:F6F22.3
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

AraportiAT2G19940
TAIRilocus:2051980 AT2G19940

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chloroplast, Plastid

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 48ChloroplastSequence analysisAdd BLAST48
ChainiPRO_000000206649 – 401Probable N-acetyl-gamma-glutamyl-phosphate reductase, chloroplasticAdd BLAST353

Proteomic databases

PaxDbiQ93Z70
PRIDEiQ93Z70

Expressioni

Gene expression databases

ExpressionAtlasiQ93Z70 baseline and differential
GenevisibleiQ93Z70 AT

Interactioni

Subunit structurei

Homotetramer.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi1868, 1 interactor
IntActiQ93Z70, 1 interactor
STRINGi3702.AT2G19940.1

Structurei

Secondary structure

1401
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ93Z70
SMRiQ93Z70
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ93Z70

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG4354 Eukaryota
COG0002 LUCA
InParanoidiQ93Z70
KOiK00145
OrthoDBiEOG09360B0T
PhylomeDBiQ93Z70

Family and domain databases

HAMAPiMF_00150 ArgC_type1, 1 hit
InterProiView protein in InterPro
IPR023013 AGPR_AS
IPR000706 AGPR_type-1
IPR036291 NAD(P)-bd_dom_sf
IPR000534 Semialdehyde_DH_NAD-bd
IPR012280 Semialdhyde_DH_dimer_dom
PfamiView protein in Pfam
PF01118 Semialdhyde_dh, 1 hit
PF02774 Semialdhyde_dhC, 1 hit
SMARTiView protein in SMART
SM00859 Semialdhyde_dh, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR01850 argC, 1 hit
PROSITEiView protein in PROSITE
PS01224 ARGC, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q93Z70-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSTASAFSSI QGCWFKGERK IRVADKRAKR LTLGSHVASP SSMSFRVSAS
60 70 80 90 100
SSVKPEKDIR IGLLGASGYT GAEIVRLLAN HPHFQVTLMT ADRKAGQSME
110 120 130 140 150
SVFPHLRAQK LPTLVSVKDA DFSTVDAVFC CLPHGTTQEI IKELPTALKI
160 170 180 190 200
VDLSADFRLR NIAEYEEWYG QPHKAVELQK EVVYGLTEIL REDIKKARLV
210 220 230 240 250
ANPGCYPTTI QLPLVPLLKA NLIKHENIII DAKSGVSGAG RGAKEANLYS
260 270 280 290 300
EIAEGISSYG VTRHRHVPEI EQGLSDVAQS KVTVSFTPHL MPMIRGMQST
310 320 330 340 350
IYVEMAPGVR TEDLHQQLKT SYEDEEFVKV LDEGVVPRTH NVRGSNYCHM
360 370 380 390 400
SVFPDRIPGR AIIISVIDNL VKGASGQALQ NLNIMLGYPE TTGLLHQPLF

P
Length:401
Mass (Da):44,136
Last modified:August 30, 2005 - v2
Checksum:i70A1CFECD1EAD162
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1P8B108A0A1P8B108_ARATH
N-acetyl-gamma-glutamyl-phosphate r...
At2g19940, F6F22.3, F6F22_3
389Annotation score:

Sequence cautioni

The sequence AAC62122 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005169 Genomic DNA Translation: AAC62122.2 Sequence problems.
CP002685 Genomic DNA Translation: AEC06946.2
AY058082 mRNA Translation: AAL24190.1
AY090309 mRNA Translation: AAL90970.1
PIRiA84583
RefSeqiNP_849993.5, NM_179662.6
UniGeneiAt.21379

Genome annotation databases

GeneIDi816513
KEGGiath:AT2G19940

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005169 Genomic DNA Translation: AAC62122.2 Sequence problems.
CP002685 Genomic DNA Translation: AEC06946.2
AY058082 mRNA Translation: AAL24190.1
AY090309 mRNA Translation: AAL90970.1
PIRiA84583
RefSeqiNP_849993.5, NM_179662.6
UniGeneiAt.21379

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1XYGX-ray2.19A/B/C/D43-401[»]
2Q49X-ray2.19A/B/C/D43-401[»]
ProteinModelPortaliQ93Z70
SMRiQ93Z70
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi1868, 1 interactor
IntActiQ93Z70, 1 interactor
STRINGi3702.AT2G19940.1

Proteomic databases

PaxDbiQ93Z70
PRIDEiQ93Z70

Protocols and materials databases

DNASUi816513
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi816513
KEGGiath:AT2G19940

Organism-specific databases

AraportiAT2G19940
TAIRilocus:2051980 AT2G19940

Phylogenomic databases

eggNOGiKOG4354 Eukaryota
COG0002 LUCA
InParanoidiQ93Z70
KOiK00145
OrthoDBiEOG09360B0T
PhylomeDBiQ93Z70

Enzyme and pathway databases

UniPathwayi
UPA00068;UER00108

Miscellaneous databases

EvolutionaryTraceiQ93Z70
PROiPR:Q93Z70

Gene expression databases

ExpressionAtlasiQ93Z70 baseline and differential
GenevisibleiQ93Z70 AT

Family and domain databases

HAMAPiMF_00150 ArgC_type1, 1 hit
InterProiView protein in InterPro
IPR023013 AGPR_AS
IPR000706 AGPR_type-1
IPR036291 NAD(P)-bd_dom_sf
IPR000534 Semialdehyde_DH_NAD-bd
IPR012280 Semialdhyde_DH_dimer_dom
PfamiView protein in Pfam
PF01118 Semialdhyde_dh, 1 hit
PF02774 Semialdhyde_dhC, 1 hit
SMARTiView protein in SMART
SM00859 Semialdhyde_dh, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR01850 argC, 1 hit
PROSITEiView protein in PROSITE
PS01224 ARGC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiARGC_ARATH
AccessioniPrimary (citable) accession number: Q93Z70
Secondary accession number(s): O82187
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: August 30, 2005
Last modified: November 7, 2018
This is version 122 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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