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Protein

Transcription factor TCP14

Gene

TCP14

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription factor involved the regulation of plant development. Together with TCP15, modulates plant stature by promoting cell division in young internodes. Represses cell proliferation in leaf and floral tissues (PubMed:21668538). Together with TCP15, acts downstream of gibberellin (GA), and the stratification pathways that promote seed germination. Involved in the control of cell proliferation at the root apical meristem (RAM) by regulating the activity of CYCB1-1 (PubMed:25655823). Involved in the regulation of seed germination. May regulate the activation of embryonic growth potential during seed germination (PubMed:17953649, PubMed:22155632). Acts together with SPY to promote cytokinin responses that affect leaf shape and trichome development in flowers (PubMed:22267487). Transcription factor involved in the regulation of endoreduplication. Represses endoreduplication by activating the gene expression of the key cell-cycle regulators RBR1 and CYCA2-3 (PubMed:25757472). Regulates the expression of the defense gene pathogenesis-related protein 2 (PR2) in antagonism to SRFR1, a negative regulator of effector-triggered immunity (PubMed:24689742). Involved in positive regulation of plant defense. Represses jasmonate (JA) response to promote disease resistance. Regulates the plant immune system by transcriptionally repressing a subset of JA-responsive genes (PubMed:28132837).8 Publications

Miscellaneous

Plants overexpressing TCP14 exhibit altered plant development and occasionally are lethal (PubMed:22267487). Plants overexpressing TCP14 are modestly reduced in size and exhibit enhanced resistance to the bacterial pathogen Pseudomonas syringae pv tomato strain DC3000, and the oomycete Hyaloperonospora arabidopsidis (PubMed:28132837).2 Publications

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • DNA-binding transcription factor activity Source: TAIR

GO - Biological processi

  • cell proliferation Source: TAIR
  • inflorescence development Source: TAIR
  • regulation of defense response Source: TAIR
  • regulation of seed germination Source: TAIR
  • regulation of transcription, DNA-templated Source: TAIR
  • response to abscisic acid Source: TAIR
  • response to cytokinin Source: TAIR
  • response to gibberellin Source: TAIR
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDevelopmental protein, DNA-binding, Repressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor TCP14Curated
Short name:
AtTCP141 Publication
Gene namesi
Name:TCP141 Publication
Ordered Locus Names:At3g47620Imported
ORF Names:F1P2.170Imported
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

AraportiAT3G47620
TAIRilocus:2079202 AT3G47620

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Delayed germination (PubMed:17953649). No visible phenotype under normal growth conditions, but the double mutant plants tcp14 and tcp15 exhibit reduction in inflorescence height and pedicel length (PubMed:21668538).2 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi202 – 207RSAAST → NAAIRS: Unable to interact with the Pseudomonas syringae type III effector HopBB1. 1 Publication6

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003307881 – 489Transcription factor TCP14Add BLAST489

Post-translational modificationi

Ubiquitinated (Probable). Targeted for degradation by the SCF(COI1) E3 ubiquitin ligase-proteasome pathway during jasmonate signaling in response to Pseudomonas syringae infection and the secreted type III effector HopBB1 (PubMed:28132837).1 Publication1 Publication

Keywords - PTMi

Ubl conjugation

Proteomic databases

PaxDbiQ93Z00

PTM databases

iPTMnetiQ93Z00

Expressioni

Tissue specificityi

Expressed in the vascular tissues of the embryo (PubMed:17953649). Expressed in young proliferating tissues (PubMed:21668538).2 Publications

Inductioni

Induced during seed imbibition (PubMed:17953649). Circadian-regulation with the lowest expression in the middle of the dark period (PubMed:17953649).1 Publication

Gene expression databases

ExpressionAtlasiQ93Z00 baseline and differential
GenevisibleiQ93Z00 AT

Interactioni

Subunit structurei

Interacts with DOF3.2 (PubMed:22155632). Interacts with SPY (PubMed:22267487). Interacts with SRFR1 (PubMed:24689742). Interacts with GAI and RGL2 (PubMed:25655823). Interacts with DA1, DAR1 and DAR2 (PubMed:25757472). Interacts with the Pseudomonas syringae type III effector HopBB1 (PubMed:28132837). Interacts with SCE1 (PubMed:29250092). Interacts with MOS1 (PubMed:29086441).8 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi9236, 127 interactors
IntActiQ93Z00, 366 interactors
STRINGi3702.AT3G47620.1

Structurei

3D structure databases

ProteinModelPortaliQ93Z00
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini117 – 171TCPPROSITE-ProRule annotationAdd BLAST55

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi54 – 99Gln-richAdd BLAST46
Compositional biasi318 – 339Ala-richAdd BLAST22
Compositional biasi340 – 364Gly-richAdd BLAST25
Compositional biasi441 – 456His-richAdd BLAST16

Phylogenomic databases

eggNOGiENOG410IX0U Eukaryota
ENOG410YEAM LUCA
HOGENOMiHOG000241759
InParanoidiQ93Z00
OMAiTFPSINT
OrthoDBiEOG09360P5Z
PhylomeDBiQ93Z00

Family and domain databases

InterProiView protein in InterPro
IPR017887 TF_TCP_subgr
IPR005333 Transcription_factor_TCP
PfamiView protein in Pfam
PF03634 TCP, 1 hit
PROSITEiView protein in PROSITE
PS51369 TCP, 1 hit

Sequencei

Sequence statusi: Complete.

Q93Z00-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQKPTSSILN VIMDGGDSVG GGGGDDHHRH LHHHHRPTFP FQLLGKHDPD
60 70 80 90 100
DNHQQQPSPS SSSSLFSLHQ HQQLSQSQPQ SQSQKSQPQT TQKELLQTQE
110 120 130 140 150
ESAVVAAKKP PLKRASTKDR HTKVDGRGRR IRMPALCAAR VFQLTRELGH
160 170 180 190 200
KSDGETIEWL LQQAEPSVIA ATGTGTIPAN FTSLNISLRS SGSSMSLPSH
210 220 230 240 250
FRSAASTFSP NNIFSPAMLQ QQQQQQRGGG VGFHHPHLQG RAPTSSLFPG
260 270 280 290 300
IDNFTPTTSF LNFHNPTKQE GDQDSEELNS EKKRRIQTTS DLHQQQQQHQ
310 320 330 340 350
HDQIGGYTLQ SSNSGSTATA AAAQQIPGNF WMVAAAAAAG GGGGNNNQTG
360 370 380 390 400
GLMTASIGTG GGGGEPVWTF PSINTAAAAL YRSGVSGVPS GAVSSGLHFM
410 420 430 440 450
NFAAPMAFLT GQQQLATTSN HEINEDSNNN EGGRSDGGGD HHNTQRHHHH
460 470 480
QQQHHHNILS GLNQYGRQVS GDSQASGSLG GGDEEDQQD
Length:489
Mass (Da):52,300
Last modified:December 1, 2001 - v1
Checksum:iAC777E2D96FC7586
GO

Sequence cautioni

The sequence CAB61988 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL132955 Genomic DNA Translation: CAB61988.1 Different initiation.
CP002686 Genomic DNA Translation: AEE78308.1
AY058874 mRNA Translation: AAL24261.1
AY103304 mRNA Translation: AAM65356.1
PIRiT45722
RefSeqiNP_190346.2, NM_114630.4
UniGeneiAt.21251

Genome annotation databases

EnsemblPlantsiAT3G47620.1; AT3G47620.1; AT3G47620
GeneIDi823916
GrameneiAT3G47620.1; AT3G47620.1; AT3G47620
KEGGiath:AT3G47620

Similar proteinsi

Entry informationi

Entry nameiTCP14_ARATH
AccessioniPrimary (citable) accession number: Q93Z00
Secondary accession number(s): Q9SN76
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: December 1, 2001
Last modified: September 12, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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