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Entry version 112 (11 Dec 2019)
Sequence version 1 (01 Dec 2001)
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Protein

Formyltetrahydrofolate deformylase 1, mitochondrial

Gene

PURU1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Deformylase involved in photorespiration. Prevents excessive accumulation of 5-formyl tetrahydrofolate (THF), a potent inhibitor of the Gly decarboxylase/Ser hydroxymethyltransferase complex.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei267By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase
Biological processOne-carbon metabolism, Photorespiration

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
ARA:GQT-82-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Formyltetrahydrofolate deformylase 1, mitochondrial (EC:3.5.1.10)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PURU1
Ordered Locus Names:At5g47435
ORF Names:MNJ7.1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT5G47435

The Arabidopsis Information Resource

More...
TAIRi
locus:505006677 AT5G47435

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

No visible phenotype. Puru1 and puru2 double mutant shows a 70-fold increase in Gly levels and accumulates elevated levels of 5- and 10-formyl THF. Embryo development arrests between heart and early bent cotyledon stages, and mature seeds are shriveled, accumulate low amounts of lipids, and fail to germinate. Puru1 and puru2 double mutant is only conditionally lethal and is rescued by growth under nonphotorespiratory conditions. Puru1, puru2 and fold1 triple mutant shows no photorespiratory phenotype.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 25MitochondrionSequence analysisAdd BLAST25
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000042434226 – 323Formyltetrahydrofolate deformylase 1, mitochondrialAdd BLAST298

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q93YQ3

PRoteomics IDEntifications database

More...
PRIDEi
Q93YQ3

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q93YQ3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in leaves, cotyledons, roots, seeds and flowers.1 Publication

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q93YQ3 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q93YQ3 AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
20039, 2 interactors

Protein interaction database and analysis system

More...
IntActi
Q93YQ3, 1 interactor

STRING: functional protein association networks

More...
STRINGi
3702.AT5G47435.2

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q93YQ3

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini41 – 124ACTAdd BLAST84

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PurU family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IQK3 Eukaryota
COG0788 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000033576

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q93YQ3

KEGG Orthology (KO)

More...
KOi
K01433

Identification of Orthologs from Complete Genome Data

More...
OMAi
HADHHTD

Database of Orthologous Groups

More...
OrthoDBi
943824at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q93YQ3

Family and domain databases

Conserved Domains Database

More...
CDDi
cd08648 FMT_core_Formyl-FH4-Hydrolase_C, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR041729 Formyl-FH4-Hydrolase_C
IPR002376 Formyl_transf_N
IPR036477 Formyl_transf_N_sf
IPR004810 PurU

The PANTHER Classification System

More...
PANTHERi
PTHR42706 PTHR42706, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00551 Formyl_trans_N, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01575 FFH4HYDRLASE

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53328 SSF53328, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q93YQ3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIRRITERAS GFAKNIPILK SSRFHGESLD SSVSPVLIPG VHVFHCQDAV
60 70 80 90 100
GIVAKLSDCI AAKGGNILGY DVFVPENNNV FYSRSEFIFD PVKWPRSQVD
110 120 130 140 150
EDFQTIAQRY GALNSVVRVP SIDPKYKIAL LLSKQDHCLV EMLHKWQDGK
160 170 180 190 200
LPVDITCVIS NHERASNTHV MRFLERHGIP YHYVSTTKEN KREDDILELV
210 220 230 240 250
KDTDFLVLAR YMQILSGNFL KGYGKDVINI HHGLLPSFKG GYPAKQAFDA
260 270 280 290 300
GVKLIGATSH FVTEELDSGP IIEQMVESVS HRDNLRSFVQ KSEDLEKKCL
310 320
TRAIKSYCEL RVLPYGTNKT VVF
Length:323
Mass (Da):36,452
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA45061CBE8B7C5DB
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB018117 Genomic DNA No translation available.
CP002688 Genomic DNA Translation: AED95511.1
CP002688 Genomic DNA Translation: AED95512.1
AK117593 mRNA Translation: BAC42250.1
AY059833 mRNA Translation: AAL24315.1
AY081459 mRNA Translation: AAM10021.1

NCBI Reference Sequences

More...
RefSeqi
NP_568682.1, NM_124115.4
NP_851145.1, NM_180814.3

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT5G47435.1; AT5G47435.1; AT5G47435
AT5G47435.2; AT5G47435.2; AT5G47435

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
834791

Gramene; a comparative resource for plants

More...
Gramenei
AT5G47435.1; AT5G47435.1; AT5G47435
AT5G47435.2; AT5G47435.2; AT5G47435

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT5G47435

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018117 Genomic DNA No translation available.
CP002688 Genomic DNA Translation: AED95511.1
CP002688 Genomic DNA Translation: AED95512.1
AK117593 mRNA Translation: BAC42250.1
AY059833 mRNA Translation: AAL24315.1
AY081459 mRNA Translation: AAM10021.1
RefSeqiNP_568682.1, NM_124115.4
NP_851145.1, NM_180814.3

3D structure databases

SMRiQ93YQ3
ModBaseiSearch...

Protein-protein interaction databases

BioGridi20039, 2 interactors
IntActiQ93YQ3, 1 interactor
STRINGi3702.AT5G47435.2

PTM databases

iPTMnetiQ93YQ3

Proteomic databases

PaxDbiQ93YQ3
PRIDEiQ93YQ3

Genome annotation databases

EnsemblPlantsiAT5G47435.1; AT5G47435.1; AT5G47435
AT5G47435.2; AT5G47435.2; AT5G47435
GeneIDi834791
GrameneiAT5G47435.1; AT5G47435.1; AT5G47435
AT5G47435.2; AT5G47435.2; AT5G47435
KEGGiath:AT5G47435

Organism-specific databases

AraportiAT5G47435
TAIRilocus:505006677 AT5G47435

Phylogenomic databases

eggNOGiENOG410IQK3 Eukaryota
COG0788 LUCA
HOGENOMiHOG000033576
InParanoidiQ93YQ3
KOiK01433
OMAiHADHHTD
OrthoDBi943824at2759
PhylomeDBiQ93YQ3

Enzyme and pathway databases

BioCyciARA:GQT-82-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q93YQ3

Gene expression databases

ExpressionAtlasiQ93YQ3 baseline and differential
GenevisibleiQ93YQ3 AT

Family and domain databases

CDDicd08648 FMT_core_Formyl-FH4-Hydrolase_C, 1 hit
InterProiView protein in InterPro
IPR041729 Formyl-FH4-Hydrolase_C
IPR002376 Formyl_transf_N
IPR036477 Formyl_transf_N_sf
IPR004810 PurU
PANTHERiPTHR42706 PTHR42706, 1 hit
PfamiView protein in Pfam
PF00551 Formyl_trans_N, 1 hit
PRINTSiPR01575 FFH4HYDRLASE
SUPFAMiSSF53328 SSF53328, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPURU1_ARATH
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q93YQ3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2013
Last sequence update: December 1, 2001
Last modified: December 11, 2019
This is version 112 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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