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Entry version 106 (23 Feb 2022)
Sequence version 2 (03 May 2011)
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Protein

C2 domain-containing protein At1g53590

Gene

NTMC2T6.1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Ca2+PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi298Calcium 1PROSITE-ProRule annotation1
Metal bindingi298Calcium 2PROSITE-ProRule annotation1
Metal bindingi304Calcium 1PROSITE-ProRule annotation1
Metal bindingi352Calcium 1PROSITE-ProRule annotation1
Metal bindingi352Calcium 2PROSITE-ProRule annotation1
Metal bindingi354Calcium 1PROSITE-ProRule annotation1
Metal bindingi354Calcium 2PROSITE-ProRule annotation1
Metal bindingi359Calcium 2PROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processLipid transport, Transport
LigandCalcium, Lipid-binding, Metal-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
C2 domain-containing protein At1g53590
Alternative name(s):
N-terminal-TM-C2 domain type 6 protein 1
Short name:
NTMC2TYPE6.1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NTMC2T6.1
Ordered Locus Names:At1g53590
ORF Names:F22G10.28, T3F20.10
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT1G53590

The Arabidopsis Information Resource

More...
TAIRi
locus:2024912, AT1G53590

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei2 – 22HelicalSequence analysisAdd BLAST21
Transmembranei26 – 46HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003154041 – 751C2 domain-containing protein At1g53590Add BLAST751

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q93XX4

PRoteomics IDEntifications database

More...
PRIDEi
Q93XX4

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
222824

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q93XX4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q93XX4, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q93XX4, AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
3702.AT1G53590.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q93XX4

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini68 – 262SMP-LTDPROSITE-ProRule annotationAdd BLAST195
Domaini267 – 381C2PROSITE-ProRule annotationAdd BLAST115

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni469 – 519DisorderedSequence analysisAdd BLAST51
Regioni572 – 751DisorderedSequence analysisAdd BLAST180

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili701 – 728Sequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi472 – 486Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi487 – 511Polar residuesSequence analysisAdd BLAST25
Compositional biasi582 – 638Basic and acidic residuesSequence analysisAdd BLAST57
Compositional biasi666 – 685Basic and acidic residuesSequence analysisAdd BLAST20
Compositional biasi692 – 751Basic and acidic residuesSequence analysisAdd BLAST60

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the extended synaptotagmin family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1012, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_017566_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q93XX4

Identification of Orthologs from Complete Genome Data

More...
OMAi
WTVKDIA

Database of Orthologous Groups

More...
OrthoDBi
524702at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.150, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000008, C2_dom
IPR035892, C2_domain_sf
IPR031468, SMP_LBD

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00168, C2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00239, C2, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49562, SSF49562, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50004, C2, 1 hit
PS51847, SMP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q93XX4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MESSLIHHII IVLLLLWFIS SLNRSHAFFY FLALIYLYLV HERYVMRLKR
60 70 80 90 100
KLQFEERKQA NQRRVLSDSE SVRWMNYAVE KIWPICMEQI ASQKILGPII
110 120 130 140 150
PWFLEKYRPW TAKKAVIQHL YMGRNPPLLT DIRVLRQSTG DDHLVLELGM
160 170 180 190 200
NFLAADDMSA ILAVKLRKRL GFGMWTKLHL TGMHVEGKVL IGVKFLRRWP
210 220 230 240 250
FLGRLRVCFA EPPYFQMTVK PIFTHGLDVA VLPGIAGWLD KLLSIAFEQT
260 270 280 290 300
LVQPNMLVVD MEKFVSPTSE NWFFVDEKEP VAHVLVEVFE ASDLKPSDLN
310 320 330 340 350
GLADPYVKGK LGAYRFKTKI QKKTLSPKWH EEFKIPIFTW DSPSILNIEV
360 370 380 390 400
GDKDRFVDDT LGECSVNIEE FRGGQRNDMW LSLQNIKMGR LHLAITVIED
410 420 430 440 450
NAKSSDDPLK KAKLNKEDIQ TSFASDTTNL GSFSSDKSPS VVDNFEPIKI
460 470 480 490 500
DGQEETAIWV QKPGAEVSQI WEPRKGKSRR LDSQIQRTPN DESLSNGSSS
510 520 530 540 550
TDDNQEGSKN PMKSVGRGLR KIGSMFHRNV KKEEFLIGSI EEESQSQSPR
560 570 580 590 600
INLKAVNQKD VGLNFIVDDN LSGPLSGKSL DGESLDAEEN SGKGHMKDVA
610 620 630 640 650
KSFLKQAEKS AKQIKHAFSR KGSMKPRDGH KEIVPESDSG TDSESSDDDD
660 670 680 690 700
AFTCVKNLAT EPGKLTRDGN IERTGDDDHV DSTTLATAKE DSSGDILEDS
710 720 730 740 750
TDVEAKEEKL KEAAESETRD MDTAMNIKTE DEKGDTLKNI EEGEEKESSS

K
Length:751
Mass (Da):84,901
Last modified:May 3, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0AB8219A6B6A81D4
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF78431 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAG51985 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti201F → Y in AAK96876 (PubMed:14593172).Curated1
Sequence conflicti654C → Y in AAK96876 (PubMed:14593172).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC018748 Genomic DNA Translation: AAF78431.1 Sequence problems.
AC024260 Genomic DNA Translation: AAG51985.1 Sequence problems.
CP002684 Genomic DNA Translation: AEE32967.1
AY054685 mRNA Translation: AAK96876.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A96576

NCBI Reference Sequences

More...
RefSeqi
NP_564637.1, NM_104237.4

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT1G53590.1; AT1G53590.1; AT1G53590

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
841794

Gramene; a comparative resource for plants

More...
Gramenei
AT1G53590.1; AT1G53590.1; AT1G53590

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT1G53590

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC018748 Genomic DNA Translation: AAF78431.1 Sequence problems.
AC024260 Genomic DNA Translation: AAG51985.1 Sequence problems.
CP002684 Genomic DNA Translation: AEE32967.1
AY054685 mRNA Translation: AAK96876.1
PIRiA96576
RefSeqiNP_564637.1, NM_104237.4

3D structure databases

SMRiQ93XX4
ModBaseiSearch...

Protein-protein interaction databases

STRINGi3702.AT1G53590.1

PTM databases

iPTMnetiQ93XX4

Proteomic databases

PaxDbiQ93XX4
PRIDEiQ93XX4
ProteomicsDBi222824

Genome annotation databases

EnsemblPlantsiAT1G53590.1; AT1G53590.1; AT1G53590
GeneIDi841794
GrameneiAT1G53590.1; AT1G53590.1; AT1G53590
KEGGiath:AT1G53590

Organism-specific databases

AraportiAT1G53590
TAIRilocus:2024912, AT1G53590

Phylogenomic databases

eggNOGiKOG1012, Eukaryota
HOGENOMiCLU_017566_0_0_1
InParanoidiQ93XX4
OMAiWTVKDIA
OrthoDBi524702at2759

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q93XX4

Gene expression databases

ExpressionAtlasiQ93XX4, baseline and differential
GenevisibleiQ93XX4, AT

Family and domain databases

Gene3Di2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR000008, C2_dom
IPR035892, C2_domain_sf
IPR031468, SMP_LBD
PfamiView protein in Pfam
PF00168, C2, 1 hit
SMARTiView protein in SMART
SM00239, C2, 1 hit
SUPFAMiSSF49562, SSF49562, 1 hit
PROSITEiView protein in PROSITE
PS50004, C2, 1 hit
PS51847, SMP, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiC2D61_ARATH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q93XX4
Secondary accession number(s): Q9C8L5, Q9LPH4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 3, 2011
Last modified: February 23, 2022
This is version 106 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families
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