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Protein

Probable inactive E3 ubiquitin-protein ligase SINAT6

Gene

SINAT6

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable inactive E3 ubiquitin-protein ligase that plays a role in regulation of autophagy. Upon starvation, involved in maintaining ATG6 homeostasis by competitively associating with ATG6, a component of the autophagosome complex (PubMed:28351989). Acts as positive regulator of drought stress response. Functions as positive regulator of abscisic acid-mediated stomatal closure (PubMed:24350984).2 Publications

Caution

Lacks the RING-type zinc finger domain that is essential for ubiquitin ligase activity. May not possess E3 ubiquitin-protein ligase activity by itself.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri5 – 74SIAH-typeCuratedAdd BLAST70

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • protein homodimerization activity Source: UniProtKB

GO - Biological processi

  • multicellular organism development Source: InterPro
  • positive regulation of response to water deprivation Source: UniProtKB
  • protein ubiquitination Source: UniProtKB
  • regulation of autophagosome assembly Source: UniProtKB
  • ubiquitin-dependent protein catabolic process Source: InterPro

Keywordsi

LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-ATH-5689880 Ub-specific processing proteases
R-ATH-983168 Antigen processing: Ubiquitination & Proteasome degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Probable inactive E3 ubiquitin-protein ligase SINAT6Curated
Alternative name(s):
Protein SEVEN IN ABSENTIA 21 Publication
Seven in absentia homolog 61 Publication
Gene namesi
Name:SINAT61 Publication
Synonyms:SINA21 Publication
Ordered Locus Names:At3g13672Imported
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

AraportiAT3G13672

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Disruption phenotypei

No visible phenotype under normal growth conditions, but mutant plants are hypersensitive to drought stress.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004423551 – 216Probable inactive E3 ubiquitin-protein ligase SINAT6Add BLAST216

Expressioni

Tissue specificityi

Expressed in roots, rosette leaves, cauline leaves, guard cells and flowers.1 Publication

Inductioni

Induced by abscisic acid (ABA) and salt stress.1 Publication

Gene expression databases

ExpressionAtlasiQ93WE4 baseline and differential

Interactioni

Subunit structurei

Homodimer (PubMed:24350984). Interacts with SINAT1, SINAT2, SINAT3, SINAT4 and SINAT5 (PubMed:24350984). Interacts with ATG6 and TRAF1A (PubMed:28351989).2 Publications

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ93WE4, 3 interactors

Structurei

3D structure databases

ProteinModelPortaliQ93WE4
SMRiQ93WE4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SINA (Seven in absentia) family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri5 – 74SIAH-typeCuratedAdd BLAST70

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3002 Eukaryota
ENOG410XVP0 LUCA
HOGENOMiHOG000231487
PhylomeDBiQ93WE4

Family and domain databases

Gene3Di2.60.210.10, 1 hit
InterProiView protein in InterPro
IPR018121 7-in-absentia-prot_TRAF-dom
IPR004162 SINA-like
IPR008974 TRAF-like
PANTHERiPTHR10315 PTHR10315, 1 hit
PfamiView protein in Pfam
PF03145 Sina, 1 hit
SUPFAMiSSF49599 SSF49599, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q93WE4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEPRINDLQV ESRVHELLDF PVHTNQISSA IYECPNDHIE NPKKKPYNCP
60 70 80 90 100
HSGAKCDVTG DIQRLLLHLR NDHNVEMSDG RSFSHRYVHH DPKHLHHATW
110 120 130 140 150
MLTLLDCCGR KFCLYFEAFH LRKTPMYMAF MQFMGDEEEA MSFSYSLQVG
160 170 180 190 200
GNGRKLTWQG VPRSIRDSHK TVRDSQDGLI ITRKLALFFS TDNNTTDKEL
210
KLKVSGRVWR EQPVSI
Length:216
Mass (Da):25,140
Last modified:December 1, 2001 - v1
Checksum:i2A8D7A17B2CAC361
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F4JDF6F4JDF6_ARATH
E3 ubiquitin-protein ligase
SINA2 At3g13672
243Annotation score:

Sequence cautioni

The sequence BAB01915 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP001307 Genomic DNA Translation: BAB01915.1 Sequence problems.
CP002686 Genomic DNA Translation: AEE75391.1
AF370175 mRNA Translation: AAK43990.1
AY059135 mRNA Translation: AAL15241.1
RefSeqiNP_187978.1, NM_112215.2
UniGeneiAt.19060
At.48655

Genome annotation databases

EnsemblPlantsiAT3G13672.1; AT3G13672.1; AT3G13672
GeneIDi820573
GrameneiAT3G13672.1; AT3G13672.1; AT3G13672
KEGGiath:AT3G13672

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP001307 Genomic DNA Translation: BAB01915.1 Sequence problems.
CP002686 Genomic DNA Translation: AEE75391.1
AF370175 mRNA Translation: AAK43990.1
AY059135 mRNA Translation: AAL15241.1
RefSeqiNP_187978.1, NM_112215.2
UniGeneiAt.19060
At.48655

3D structure databases

ProteinModelPortaliQ93WE4
SMRiQ93WE4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ93WE4, 3 interactors

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT3G13672.1; AT3G13672.1; AT3G13672
GeneIDi820573
GrameneiAT3G13672.1; AT3G13672.1; AT3G13672
KEGGiath:AT3G13672

Organism-specific databases

AraportiAT3G13672

Phylogenomic databases

eggNOGiKOG3002 Eukaryota
ENOG410XVP0 LUCA
HOGENOMiHOG000231487
PhylomeDBiQ93WE4

Enzyme and pathway databases

ReactomeiR-ATH-5689880 Ub-specific processing proteases
R-ATH-983168 Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

PROiPR:Q93WE4

Gene expression databases

ExpressionAtlasiQ93WE4 baseline and differential

Family and domain databases

Gene3Di2.60.210.10, 1 hit
InterProiView protein in InterPro
IPR018121 7-in-absentia-prot_TRAF-dom
IPR004162 SINA-like
IPR008974 TRAF-like
PANTHERiPTHR10315 PTHR10315, 1 hit
PfamiView protein in Pfam
PF03145 Sina, 1 hit
SUPFAMiSSF49599 SSF49599, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSINA6_ARATH
AccessioniPrimary (citable) accession number: Q93WE4
Secondary accession number(s): Q9LID2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2017
Last sequence update: December 1, 2001
Last modified: October 10, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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