UniProtKB - Q93VM9 (THOC1_ARATH)
Protein
THO complex subunit 1
Gene
THO1
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Functioni
Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export. Contributes to the integrity of the endogenous trans-acting small interfering RNA (ta-siRNA) pathway. May process or transport a long RNA molecule so that it can be a template for secondary siRNA production. May participate in the trafficking of siRNA precursors to the ARGONAUTE catalytic center. Required for the generation of functional messenger ribonucleoproteins (mRNPs). Plays an important roles in plant innate immunity.3 Publications
GO - Molecular functioni
- RNA binding Source: UniProtKB-KW
GO - Biological processi
- defense response to fungus Source: TAIR
- ethylene-activated signaling pathway Source: TAIR
- gene silencing by RNA Source: TAIR
- mRNA export from nucleus Source: TAIR
- mRNA processing Source: UniProtKB-KW
- production of ta-siRNAs involved in RNA interference Source: TAIR
- regulation of DNA-templated transcription, elongation Source: GO_Central
- RNA splicing Source: UniProtKB-KW
Keywordsi
Molecular function | RNA-binding |
Biological process | mRNA processing, mRNA splicing, mRNA transport, Plant defense, RNA-mediated gene silencing, Transport |
Names & Taxonomyi
Protein namesi | Recommended name: THO complex subunit 1Short name: AtTHO1 Alternative name(s): HPR1 homolog Short name: AtHPR1 |
Gene namesi | Name:THO1 Synonyms:EMU, HPR1 Ordered Locus Names:At5g09860 ORF Names:MYH9.7 |
Organismi | Arabidopsis thaliana (Mouse-ear cress) |
Taxonomic identifieri | 3702 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis |
Proteomesi |
|
Organism-specific databases
Araporti | AT5G09860 |
TAIRi | locus:2178183, AT5G09860 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Nucleus
- nucleus Source: TAIR
- THO complex Source: UniProtKB
- THO complex part of transcription export complex Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Disruption phenotypei
Developmental defects as well as reduced levels of endogenous trans-acting small interfering RNA (ta-siRNA).2 Publications
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000425582 | 1 – 599 | THO complex subunit 1Add BLAST | 599 |
Proteomic databases
PaxDbi | Q93VM9 |
PRIDEi | Q93VM9 |
ProteomicsDBi | 234351 [Q93VM9-1] |
PTM databases
iPTMneti | Q93VM9 |
Expressioni
Gene expression databases
ExpressionAtlasi | Q93VM9, baseline and differential |
Genevisiblei | Q93VM9, AT |
Interactioni
Subunit structurei
Component of the THO complex, which is composed of THO1, THO2, THO3, THO5, THO6 and THO7.
1 PublicationProtein-protein interaction databases
BioGRIDi | 16124, 3 interactors |
STRINGi | 3702.AT5G09860.1 |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 72 – 79 | Poly-Asp | 8 |
Phylogenomic databases
eggNOGi | KOG2491, Eukaryota |
HOGENOMi | CLU_027906_1_1_1 |
InParanoidi | Q93VM9 |
OrthoDBi | 403879at2759 |
PhylomeDBi | Q93VM9 |
Family and domain databases
InterProi | View protein in InterPro IPR021861, THO_THOC1 |
PANTHERi | PTHR13265, PTHR13265, 1 hit |
Pfami | View protein in Pfam PF11957, efThoc1, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry describes 1 produced by isoform ialternative splicing. AlignAdd to basketNote: A number of isoforms are produced. According to EST sequences.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q93VM9-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDAFRDAILQ RAPIETFALK TVQHFIQPQK QTKLAQDENQ MLENMLRTLL
60 70 80 90 100
QELVAAAAQS GEQIMQYGQL IDDDDDDDDI HGQIPHLLDV VLYLCEKEHV
110 120 130 140 150
EGGMIFQLLE DLTEMSTMKN CKDVFGYIES KQDILGKQEL FARGKLVMLR
160 170 180 190 200
TCNQLLRRLS KANDVVFCGR ILMFLAHFFP LSERSAVNIK GVFNTSNETK
210 220 230 240 250
YEKDPPKGIS VDFNFYKTFW SLQEYFCNPA SLTSASTKWQ KFSSSLAVVL
260 270 280 290 300
NTFDAQPLSE EEGEANSLEE EAATFNIKYL TSSKLMGLEL KDSSFRRHIL
310 320 330 340 350
LQCLIMFDYL RAPGKNDKDL PSETMKEELK SCEDRVKKLL EITPPKGKEF
360 370 380 390 400
LRAVEHILER EKNWVWWKRD GCPPFEKQPI DKKSPNAGQK KRRQRWRLGN
410 420 430 440 450
KELSQLWRWA DQNPNALTDS QRVRTPDIAD YWKPLAEDMD PSAGIEDEYH
460 470 480 490 500
HKNNRVYCWK GLRFTARQDL EGFSRFTEMG IEGVVPVELL PPEVRSKYQA
510 520 530 540 550
KPNEKAKRAK KEETKGGSHE TEGNQIGVSN SEAEAEGGRG DAETMESDAI
560 570 580 590
ADTPTPEEQQ RLGGSDTENG QEAGQIEDGE TEEAGLMDTD LDHPPMPVS
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketF4KFC9 | F4KFC9_ARATH | Nuclear matrix protein-like protein | THO1 AtHPR1, AtTHO1, HPR1, MYH9.7, MYH9_7 | 598 | Annotation score: |
Sequence cautioni
The sequence BAB09407 differs from that shown. Reason: Erroneous gene model prediction.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 372 | C → Y in AAN33204 (PubMed:14593172).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB016893 Genomic DNA Translation: BAB09407.1 Sequence problems. CP002688 Genomic DNA Translation: AED91456.1 AF424566 mRNA Translation: AAL11560.1 AF428323 mRNA Translation: AAL16253.1 BT000829 mRNA Translation: AAN33204.1 |
RefSeqi | NP_568219.1, NM_121023.4 [Q93VM9-1] |
Genome annotation databases
EnsemblPlantsi | AT5G09860.1; AT5G09860.1; AT5G09860 [Q93VM9-1] |
GeneIDi | 830846 |
Gramenei | AT5G09860.1; AT5G09860.1; AT5G09860 [Q93VM9-1] |
KEGGi | ath:AT5G09860 |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB016893 Genomic DNA Translation: BAB09407.1 Sequence problems. CP002688 Genomic DNA Translation: AED91456.1 AF424566 mRNA Translation: AAL11560.1 AF428323 mRNA Translation: AAL16253.1 BT000829 mRNA Translation: AAN33204.1 |
RefSeqi | NP_568219.1, NM_121023.4 [Q93VM9-1] |
3D structure databases
SMRi | Q93VM9 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 16124, 3 interactors |
STRINGi | 3702.AT5G09860.1 |
PTM databases
iPTMneti | Q93VM9 |
Proteomic databases
PaxDbi | Q93VM9 |
PRIDEi | Q93VM9 |
ProteomicsDBi | 234351 [Q93VM9-1] |
Genome annotation databases
EnsemblPlantsi | AT5G09860.1; AT5G09860.1; AT5G09860 [Q93VM9-1] |
GeneIDi | 830846 |
Gramenei | AT5G09860.1; AT5G09860.1; AT5G09860 [Q93VM9-1] |
KEGGi | ath:AT5G09860 |
Organism-specific databases
Araporti | AT5G09860 |
TAIRi | locus:2178183, AT5G09860 |
Phylogenomic databases
eggNOGi | KOG2491, Eukaryota |
HOGENOMi | CLU_027906_1_1_1 |
InParanoidi | Q93VM9 |
OrthoDBi | 403879at2759 |
PhylomeDBi | Q93VM9 |
Miscellaneous databases
PROi | PR:Q93VM9 |
Gene expression databases
ExpressionAtlasi | Q93VM9, baseline and differential |
Genevisiblei | Q93VM9, AT |
Family and domain databases
InterProi | View protein in InterPro IPR021861, THO_THOC1 |
PANTHERi | PTHR13265, PTHR13265, 1 hit |
Pfami | View protein in Pfam PF11957, efThoc1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | THOC1_ARATH | |
Accessioni | Q93VM9Primary (citable) accession number: Q93VM9 Secondary accession number(s): Q8H134, Q9FIC0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 19, 2014 |
Last sequence update: | December 1, 2001 | |
Last modified: | December 2, 2020 | |
This is version 100 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Arabidopsis thaliana
Arabidopsis thaliana: entries and gene names