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Entry version 106 (07 Oct 2020)
Sequence version 1 (01 Dec 2001)
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Protein
Submitted name:

AmphK

Gene

amphK

Organism
Streptomyces nodosus
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

pantetheine 4'-phosphateARBA annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMultifunctional enzymeARBA annotation, TransferaseARBA annotation
Biological processAntibiotic biosynthesisARBA annotation

Protein family/group databases

ESTHER database of the Alpha/Beta-hydrolase fold superfamily of proteins

More...
ESTHERi
strno-AMPHK, Thioesterase

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
AmphKImported
Submitted name:
AmphK polyketide synthaseImported
Submitted name:
Type I polyketide synthaseImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:amphKImported
ORF Names:CP978_03050Imported, SNOD_02650Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiStreptomyces nodosusImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri40318 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000031526 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000325763 Componenti: Chromosome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1698O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1

Keywords - PTMi

PhosphopantetheinePROSITE-ProRule annotationARBA annotation, PhosphoproteinARBA annotation

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1663 – 1738CarrierInterPro annotationAdd BLAST76

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni459 – 479DisorderedSequence analysisAdd BLAST21

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000022_35_2_11

KEGG Orthology (KO)

More...
KOi
K16387

Database of Orthologous Groups

More...
OrthoDBi
1123553at2

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1200.10, 1 hit
3.10.129.110, 1 hit
3.40.366.10, 1 hit
3.40.47.10, 1 hit
3.40.50.1820, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029058, AB_hydrolase
IPR001227, Ac_transferase_dom_sf
IPR036736, ACP-like_sf
IPR014043, Acyl_transferase
IPR016035, Acyl_Trfase/lysoPLipase
IPR032821, KAsynt_C_assoc
IPR018201, Ketoacyl_synth_AS
IPR014031, Ketoacyl_synth_C
IPR014030, Ketoacyl_synth_N
IPR016036, Malonyl_transacylase_ACP-bd
IPR036291, NAD(P)-bd_dom_sf
IPR020801, PKS_acyl_transferase
IPR020841, PKS_Beta-ketoAc_synthase_dom
IPR020807, PKS_dehydratase
IPR042104, PKS_dehydratase_sf
IPR013968, PKS_KR
IPR020806, PKS_PP-bd
IPR020802, PKS_thioesterase
IPR015083, Polyketide_synth_docking
IPR009081, PP-bd_ACP
IPR001031, Thioesterase
IPR016039, Thiolase-like

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00698, Acyl_transf_1, 1 hit
PF08990, Docking, 1 hit
PF16197, KAsynt_C_assoc, 1 hit
PF00109, ketoacyl-synt, 1 hit
PF02801, Ketoacyl-synt_C, 1 hit
PF08659, KR, 1 hit
PF00550, PP-binding, 1 hit
PF14765, PS-DH, 1 hit
PF00975, Thioesterase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00827, PKS_AT, 1 hit
SM00826, PKS_DH, 1 hit
SM00825, PKS_KS, 1 hit
SM00823, PKS_PP, 1 hit
SM00824, PKS_TE, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47336, SSF47336, 1 hit
SSF51735, SSF51735, 2 hits
SSF52151, SSF52151, 1 hit
SSF53474, SSF53474, 1 hit
SSF53901, SSF53901, 1 hit
SSF55048, SSF55048, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00606, B_KETOACYL_SYNTHASE, 1 hit
PS50075, CARRIER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q93NX7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPDESKLVDY LKWVTADLHQ TRRRLQEAES GRHEPVAIVG MACRFPGGVR
60 70 80 90 100
SPEDLWEMLA DGRDAISGFP ADRGWDLETL AGDGAGGSST QEGGFLHDVA
110 120 130 140 150
DFDPGFFDIS PREALAMDPQ QRLLLETAWE AVERAGIAPG SLRGSRTGVF
160 170 180 190 200
VGTNSQDYAH LVLASDDDMG GYAGNGLAAS VMSGRLSFAL GFEGPAVTLD
210 220 230 240 250
TACSSALVAL HLAAQSVRSG EADLALAGGV TVMTTSSSFV GFSLQGGLAT
260 270 280 290 300
DGRCKAFADS ADGTGWSEGV GMILVERLSE ARRKGHPVLA VLRGSAVNQD
310 320 330 340 350
GASNGLSAPN GPAQQRVIRD ALASAGLSPA DVDAVEAHGT GTTLGDPIEA
360 370 380 390 400
QALLATYGQD RDASRPLRLG TVKSNIGHTQ AAAGAAGVIK MVLALRHGLL
410 420 430 440 450
PRTLHIDAPS THVDWDAGHV SLLTEATPWP EGEQTRRAGV SSFGISGTNA
460 470 480 490 500
HVILEEAPAA EEDTDAEQRP EPVVPGAVPW PVSARTADAL DAQLEKVRPL
510 520 530 540 550
AASGADPVAV GHALAVTRTP FEHRALLVAA DGNLTEAARG TVPSGDRPGL
560 570 580 590 600
AVLFSGQGAQ RLGMGRELHA RFPVFAAALD ETLALLDERL GHSLRDVIWG
610 620 630 640 650
EDPVALDDTG HTQPALFAVE VALYRLFASW GLRPDHLAGH SVGEIAAVHV
660 670 680 690 700
AGALSLEDAC TLVAARAGLM RDLPAGGAMV ALRATEAEVR PLLDERVSLA
710 720 730 740 750
SVNGPDSVVV SGAEDAVLAV AEHFRKQDRR TTRLSVSHAF HSPLVDPMLD
760 770 780 790 800
AFRDVVAKLT FGEPSVPVVS TLTGDVVAAE ELATPHYWVC HARQAVRFAD
810 820 830 840 850
AVRTLVDEGA RTFLEVGPGG VLSALVGENT QEAGVSAVPA LRKDQPEEAS
860 870 880 890 900
VLAALGTLWT RGTAADWDAV FEGTLPGRPE SVDLPTYAFQ RGRYWPTVRA
910 920 930 940 950
RSGDPAGLGL GAAGHPLLSA TVTLAEADES VLTGRLSPLT HPWLTEHRVD
960 970 980 990 1000
GRITVPGTAL VEIAVRAGDE NGTPRLDRLD LLAPLTLGDR DAVLLQVRVG
1010 1020 1030 1040 1050
PEDASGRRTL SVHARPATAD DAPWTTYARG VLAPDEGAED TAADLVEWPP
1060 1070 1080 1090 1100
ADARQVPLTE LESEGRALGP LFSGLTGVWR HEGEVFAEAE LPAGPDSGFG
1110 1120 1130 1140 1150
LHPALLSTAL RAAAVLDGTT AGEPAAFEGL TLHATGATAL RVRLSTTGPD
1160 1170 1180 1190 1200
TVDLTAVDPA GNLVLTAETV RLGTPDGTAD TPAATGRGDL FGLKWVPVKA
1210 1220 1230 1240 1250
SERATGTRWA VVGSDELDLG YAMHRADETV TAYAESLGGA IGDSGVAPDV
1260 1270 1280 1290 1300
FLIPLAGEKD AGAEGVHALT TRVLGYLQEW LSEPRLSGTR LVFVTRRAVA
1310 1320 1330 1340 1350
LDDEDVLDPA GAAVWGLVRS AQTENPGSLL LVDLDDTFLS AGVLPDVLTL
1360 1370 1380 1390 1400
DEQQLAVRDY QVRAARLARL PRPADDAPAA DWNPDGTVLI TGGTGGLGAA
1410 1420 1430 1440 1450
LARHLVTSRG ARHLLLASRR GPDAPGTSEL VAELTGLGAQ VTVSACDVGD
1460 1470 1480 1490 1500
RDAVDTLVAS VPAEHPLTAV VHTAGVLDDA LTGSLTPEQL AGVLRPKADA
1510 1520 1530 1540 1550
ALHLHEATLG QDLAAFVLYS SISGVIGGPG QANYAAANAS LDALAHRRRA
1560 1570 1580 1590 1600
AGLPGLSLAW GPWGRGSGMT SQVSDTDLGR MDRGGTPPMS LEDGLALFDA
1610 1620 1630 1640 1650
ALARTEPMVV PTRINVTGLQ VQQTLPALWR DLVPRPRRTA AADRSPKTVL
1660 1670 1680 1690 1700
DGLRTLDTAG REKLLTELVV GFTAGLLGHA DPAAVDPERG FLELGFDSLV
1710 1720 1730 1740 1750
SVSLRNQLGE LLGLRLPTSV VFDSKTPVKL ARHLNEELGD LSASGPASGT
1760 1770 1780 1790 1800
AVAGTTVHPD DTLVGLFHNA VRGGKLVEAM RMLKAVANTR PTFETPADLE
1810 1820 1830 1840 1850
ELSEAVTLAT GPGSPRLIFV SAPGATGGVH QYARIAAHFR GKRHVSAIPL
1860 1870 1880 1890 1900
MGFAPGELLP ATSEAAARIV AESVLMASDG EPFVMVGHST GGSLAYLAAG
1910 1920 1930 1940 1950
VLEDTWGVKP EAVVLLDTAS IRYNPSEGNN LDQTTRFYLA DIDSPSVTLN
1960 1970 1980 1990 2000
SARMSAMAHW FMAMTDIDAP ATTAPTLLLR ATQANNGFML DTSAVPADVV
2010 2020 2030
RDIEADHLSL AMEHSDLTAE AIENWLAELP AGEA
Length:2,034
Mass (Da):212,064
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i83E962B7DC3D5747
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF357202 Genomic DNA Translation: AAK73503.1
CP009313 Genomic DNA Translation: AJE39059.1
CP023747 Genomic DNA Translation: QEV37650.1

NCBI Reference Sequences

More...
RefSeqi
WP_043437281.1, NZ_CP023747.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AJE39059; AJE39059; SNOD_02650

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ag:AAK73503

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF357202 Genomic DNA Translation: AAK73503.1
CP009313 Genomic DNA Translation: AJE39059.1
CP023747 Genomic DNA Translation: QEV37650.1
RefSeqiWP_043437281.1, NZ_CP023747.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein family/group databases

ESTHERistrno-AMPHK, Thioesterase

Genome annotation databases

EnsemblBacteriaiAJE39059; AJE39059; SNOD_02650
KEGGiag:AAK73503

Phylogenomic databases

HOGENOMiCLU_000022_35_2_11
KOiK16387
OrthoDBi1123553at2

Family and domain databases

Gene3Di1.10.1200.10, 1 hit
3.10.129.110, 1 hit
3.40.366.10, 1 hit
3.40.47.10, 1 hit
3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058, AB_hydrolase
IPR001227, Ac_transferase_dom_sf
IPR036736, ACP-like_sf
IPR014043, Acyl_transferase
IPR016035, Acyl_Trfase/lysoPLipase
IPR032821, KAsynt_C_assoc
IPR018201, Ketoacyl_synth_AS
IPR014031, Ketoacyl_synth_C
IPR014030, Ketoacyl_synth_N
IPR016036, Malonyl_transacylase_ACP-bd
IPR036291, NAD(P)-bd_dom_sf
IPR020801, PKS_acyl_transferase
IPR020841, PKS_Beta-ketoAc_synthase_dom
IPR020807, PKS_dehydratase
IPR042104, PKS_dehydratase_sf
IPR013968, PKS_KR
IPR020806, PKS_PP-bd
IPR020802, PKS_thioesterase
IPR015083, Polyketide_synth_docking
IPR009081, PP-bd_ACP
IPR001031, Thioesterase
IPR016039, Thiolase-like
PfamiView protein in Pfam
PF00698, Acyl_transf_1, 1 hit
PF08990, Docking, 1 hit
PF16197, KAsynt_C_assoc, 1 hit
PF00109, ketoacyl-synt, 1 hit
PF02801, Ketoacyl-synt_C, 1 hit
PF08659, KR, 1 hit
PF00550, PP-binding, 1 hit
PF14765, PS-DH, 1 hit
PF00975, Thioesterase, 1 hit
SMARTiView protein in SMART
SM00827, PKS_AT, 1 hit
SM00826, PKS_DH, 1 hit
SM00825, PKS_KS, 1 hit
SM00823, PKS_PP, 1 hit
SM00824, PKS_TE, 1 hit
SUPFAMiSSF47336, SSF47336, 1 hit
SSF51735, SSF51735, 2 hits
SSF52151, SSF52151, 1 hit
SSF53474, SSF53474, 1 hit
SSF53901, SSF53901, 1 hit
SSF55048, SSF55048, 1 hit
PROSITEiView protein in PROSITE
PS00606, B_KETOACYL_SYNTHASE, 1 hit
PS50075, CARRIER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ93NX7_9ACTN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q93NX7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: December 1, 2001
Last sequence update: December 1, 2001
Last modified: October 7, 2020
This is version 106 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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