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Entry version 98 (29 Sep 2021)
Sequence version 1 (01 Dec 2001)
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Protein

Histidine kinase

Gene

prlS

Organism
Aeromonas hydrophila
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.ARBA annotation EC:2.7.13.3

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.21.9.2, the solute:sodium symporter (sss) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Histidine kinaseARBA annotation (EC:2.7.13.3ARBA annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:prlSImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAeromonas hydrophilaImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri644 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAeromonadalesAeromonadaceaeAeromonas

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei6 – 25HelicalSequence analysisAdd BLAST20
Transmembranei37 – 58HelicalSequence analysisAdd BLAST22
Transmembranei70 – 92HelicalSequence analysisAdd BLAST23
Transmembranei113 – 138HelicalSequence analysisAdd BLAST26
Transmembranei158 – 177HelicalSequence analysisAdd BLAST20
Transmembranei189 – 216HelicalSequence analysisAdd BLAST28
Transmembranei236 – 260HelicalSequence analysisAdd BLAST25
Transmembranei281 – 301HelicalSequence analysisAdd BLAST21
Transmembranei327 – 355HelicalSequence analysisAdd BLAST29
Transmembranei376 – 399HelicalSequence analysisAdd BLAST24
Transmembranei411 – 432HelicalSequence analysisAdd BLAST22
Transmembranei439 – 464HelicalSequence analysisAdd BLAST26

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei10864-aspartylphosphatePROSITE-ProRule annotation1

Keywords - PTMi

PhosphoproteinPROSITE-ProRule annotationARBA annotation

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini794 – 1014Histidine kinaseInterPro annotationAdd BLAST221
Domaini1036 – 1152Response regulatoryInterPro annotationAdd BLAST117

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. [View classification]ARBA annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisARBA annotation

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00082, HisKA, 1 hit
cd00130, PAS, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1730.10, 1 hit
3.30.565.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011006, CheY-like_superfamily
IPR003594, HATPase_C
IPR036890, HATPase_C_sf
IPR005467, His_kinase_dom
IPR003661, HisK_dim/P
IPR036097, HisK_dim/P_sf
IPR038377, Na/Glc_symporter_sf
IPR001734, Na/solute_symporter
IPR000014, PAS
IPR035965, PAS-like_dom_sf
IPR004358, Sig_transdc_His_kin-like_C
IPR001789, Sig_transdc_resp-reg_receiver

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02518, HATPase_c, 1 hit
PF00512, HisKA, 1 hit
PF00072, Response_reg, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00344, BCTRLSENSOR

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00387, HATPase_c, 1 hit
SM00388, HisKA, 1 hit
SM00448, REC, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47384, SSF47384, 1 hit
SSF52172, SSF52172, 1 hit
SSF55785, SSF55785, 1 hit
SSF55874, SSF55874, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50109, HIS_KIN, 1 hit
PS50283, NA_SOLUT_SYMP_3, 1 hit
PS50110, RESPONSE_REGULATORY, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q93N33-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MHQGWLLIGM SLAYLGLLFL IAFVADKSKR RRLKGQPLLY SLSLAVYCTS
60 70 80 90 100
WTFFGTVGQA SESPWSPVPI YLGPMLVFLF GWRLLARLIL VAKREHITSI
110 120 130 140 150
ADFIAARYGK SQRLAMVITL IAVMGILPYL VLQLKAIVTG LDMLMANSVP
160 170 180 190 200
VGPTGNTGGL ALGVTMILAL FSILFGTRNL DATEHHRGMV VAIAFESLVK
210 220 230 240 250
LLAFMAVGGF ALWLIIAKPS QARTLVASDF LDAVVAVSPG SLLELAIYTL
260 270 280 290 300
VAMCAVICLP RQFHVTVVEN NQGQDLHWAR WVFPLYLFLM GLFIWPLALA
310 320 330 340 350
GKQWVGAGMG SDTYVISLPM SLGYDGMAML AFLGGTSAAT GMVIVCTIAL
360 370 380 390 400
AIMVSNDLVL PVLLRRFWQQ GRDERLMRLL LQVRRGAILL ILLAAWALYL
410 420 430 440 450
WLGDLTSLSR IGYLSFGAVA QFAPALLLGL YWRHGNRKGV YLGLSLGVSL
460 470 480 490 500
WFLTLLAESG LLAGSPLEAL LAPPNWPAFR DLSLGAWCIF ISLLLNLVGY
510 520 530 540 550
VAGSLLSRAA VSERLQAANF VGKPSQDQAA LYQARVSVKE LEMLAARFVG
560 570 580 590 600
SSRVKRAFGR FAGEHGGTLA PQMQASADLI AHTERLLAGV FGTSSARLVL
610 620 630 640 650
ASALQGRNMQ LEEIATIVDE ASDVFRFNRG LLQGAIEHMG QGISVVDREL
660 670 680 690 700
KLVAWNRRYI ELFHYPPGLI QVGRSIEEII RYNAEQGLCG PGELEAHVAR
710 720 730 740 750
RVAFMQRGSP HVSARERPDG RVIEMQGNPM PAGGFVMTFT DITPFRAAER
760 770 780 790 800
VLREANEHLE ARVAERTHEL NRQLLLVNQQ VERANHSKSR FLAAVSHDLT
810 820 830 840 850
QPLNAAKLFT SSLLEMLPGV QGAEQRAEQV RIARHIDDAL GATEDLITDL
860 870 880 890 900
LDISRLEAGK FKAKKLDFAL REVFDNLKAE FGVLAQAGDI QFSVVESKLA
910 920 930 940 950
VYSDVRLLRR VLQNFLTNAF RYNPGGRVLL GCRRLGDKVR IEVWDNGPGI
960 970 980 990 1000
PLDKQEAIFD EFSRLDHSRT AREQGLGLGL AIARGISLVL GHPLSLRSWP
1010 1020 1030 1040 1050
QAGSVFSITL NLATRPVMPT QVAAPAVRDS QLEGIKILCI DNEEDILTAM
1060 1070 1080 1090 1100
HSLLGRWGCE VVCAQSLAQA EDLIAGGFLP RLVLSDYHLD DGKTGLQALH
1110 1120 1130 1140 1150
MIRLAHGNEI GGIIISADRK SELQAQIREH GYGYVSKPVK PLKLRALMNS

LLLPIA
Length:1,156
Mass (Da):126,672
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i30DC9C18DBDF236D
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF388670 Genomic DNA Translation: AAK71637.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF388670 Genomic DNA Translation: AAK71637.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein family/group databases

TCDBi2.A.21.9.2, the solute:sodium symporter (sss) family

Family and domain databases

CDDicd00082, HisKA, 1 hit
cd00130, PAS, 1 hit
Gene3Di1.20.1730.10, 1 hit
3.30.565.10, 1 hit
InterProiView protein in InterPro
IPR011006, CheY-like_superfamily
IPR003594, HATPase_C
IPR036890, HATPase_C_sf
IPR005467, His_kinase_dom
IPR003661, HisK_dim/P
IPR036097, HisK_dim/P_sf
IPR038377, Na/Glc_symporter_sf
IPR001734, Na/solute_symporter
IPR000014, PAS
IPR035965, PAS-like_dom_sf
IPR004358, Sig_transdc_His_kin-like_C
IPR001789, Sig_transdc_resp-reg_receiver
PfamiView protein in Pfam
PF02518, HATPase_c, 1 hit
PF00512, HisKA, 1 hit
PF00072, Response_reg, 1 hit
PRINTSiPR00344, BCTRLSENSOR
SMARTiView protein in SMART
SM00387, HATPase_c, 1 hit
SM00388, HisKA, 1 hit
SM00448, REC, 1 hit
SUPFAMiSSF47384, SSF47384, 1 hit
SSF52172, SSF52172, 1 hit
SSF55785, SSF55785, 1 hit
SSF55874, SSF55874, 1 hit
PROSITEiView protein in PROSITE
PS50109, HIS_KIN, 1 hit
PS50283, NA_SOLUT_SYMP_3, 1 hit
PS50110, RESPONSE_REGULATORY, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ93N33_AERHY
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q93N33
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: December 1, 2001
Last sequence update: December 1, 2001
Last modified: September 29, 2021
This is version 98 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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