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Protein

Triosephosphate isomerase

Gene

tpiA

Organism
Lactobacillus delbrueckii subsp. lactis
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Seems to be capable of enhancing bacteriocin synthesis.
Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).UniRule annotation

Catalytic activityi

D-glyceraldehyde 3-phosphate = glycerone phosphate.UniRule annotation

Pathwayi: gluconeogenesis

This protein is involved in the pathway gluconeogenesis, which is part of Carbohydrate biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway gluconeogenesis and in Carbohydrate biosynthesis.

Pathwayi: glycolysis

This protein is involved in step 1 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate from glycerone phosphate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Triosephosphate isomerase, Triosephosphate isomerase (tpiA), Triosephosphate isomerase (tpi), Triosephosphate isomerase
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate from glycerone phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei96ElectrophileUniRule annotation1
Active sitei168Proton acceptorUniRule annotation1
Binding sitei174Substrate; via amide nitrogenUniRule annotation1
Binding sitei214SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processGluconeogenesis, Glycolysis

Enzyme and pathway databases

UniPathwayiUPA00109; UER00189
UPA00138

Names & Taxonomyi

Protein namesi
Recommended name:
Triosephosphate isomeraseUniRule annotation (EC:5.3.1.1UniRule annotation)
Short name:
TIMUniRule annotation
Short name:
TPIUniRule annotation
Alternative name(s):
Triose-phosphate isomeraseUniRule annotation
Gene namesi
Name:tpiAUniRule annotation
OrganismiLactobacillus delbrueckii subsp. lactis
Taxonomic identifieri29397 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000902321 – 252Triosephosphate isomeraseAdd BLAST252

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ93GB7
SMRiQ93GB7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni10 – 12Substrate bindingUniRule annotation3
Regioni235 – 236Substrate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the triosephosphate isomerase family.UniRule annotation

Family and domain databases

CDDicd00311 TIM, 1 hit
Gene3Di3.20.20.70, 1 hit
HAMAPiMF_00147_B TIM_B, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR035990 TIM_sf
IPR022896 TrioseP_Isoase_bac/euk
IPR000652 Triosephosphate_isomerase
IPR020861 Triosephosphate_isomerase_AS
PANTHERiPTHR21139 PTHR21139, 1 hit
PfamiView protein in Pfam
PF00121 TIM, 1 hit
SUPFAMiSSF51351 SSF51351, 1 hit
TIGRFAMsiTIGR00419 tim, 1 hit
PROSITEiView protein in PROSITE
PS00171 TIM_1, 1 hit
PS51440 TIM_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q93GB7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRTPIIAGN WKLNMNPKET VEFVNAVKDQ LPDPSKVESV ICAPAVDLDA
60 70 80 90 100
LLKAAEGSNL HVGAENCYWE NSGAFTGETS PAVLKEMGVQ YVIIGHSERR
110 120 130 140 150
DYFHETDEDI NKKAKAIFAN GLTPILCCGE SLEIREAGKE KEWVVSQIKA
160 170 180 190 200
DLEGLTSEQV SKLVIAYEPI WAIGTGKTAS SDQAEEMCKT IRETVKDLYN
210 220 230 240 250
EETAENVRIQ YGGSVKPANI KELMAKPNID GGLVGGASLV PDSYLALVNY

QD
Length:252
Mass (Da):27,481
Last modified:December 1, 2001 - v1
Checksum:i4588520C5B1DC658
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF288619 Genomic DNA Translation: AAL09962.1
RefSeqiWP_002879988.1, NZ_MRBF01000002.1

Similar proteinsi

Entry informationi

Entry nameiTPIS_LACDL
AccessioniPrimary (citable) accession number: Q93GB7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: December 1, 2001
Last modified: April 25, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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