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Protein

HTH-type transcriptional regulator CueR

Gene

cueR

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulates the transcription of the copA and cuiD (cueO) genes. Detects cytoplasmic copper stress and activates transcription in response to increasing copper concentrations (PubMed:17768242).1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi112Copper(1+)By similarity1
Metal bindingi120Copper(1+)By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi4 – 23H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation
LigandCopper, Metal-binding

Enzyme and pathway databases

BioCyciSENT99287:G1FZD-504-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional regulator CueR
Alternative name(s):
Copper efflux regulator
Copper export regulator
Gene namesi
Name:cueR
Synonyms:scr
Ordered Locus Names:STM0499
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000001014 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Disruption phenotypei

Loss of copper-based induction of copA. Causes a mild defect in aerobic growth on CuSO4, strongly impairs survival during anaerobic growth on CuSO4.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000981151 – 138HTH-type transcriptional regulator CueRAdd BLAST138

Proteomic databases

PaxDbiQ93CH6
PRIDEiQ93CH6

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi99287.STM0499

Structurei

3D structure databases

ProteinModelPortaliQ93CH6
SMRiQ93CH6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 69HTH merR-typePROSITE-ProRule annotationAdd BLAST69

Domaini

It contains a N-terminal DNA binding region and a C-terminal metal binding region.By similarity

Phylogenomic databases

eggNOGiENOG4108Z6Z Bacteria
COG0789 LUCA
HOGENOMiHOG000266076
KOiK19591
OMAiYDERAVH
PhylomeDBiQ93CH6

Family and domain databases

CDDicd01108 HTH_CueR, 1 hit
InterProiView protein in InterPro
IPR011789 CueR
IPR009061 DNA-bd_dom_put_sf
IPR000551 MerR-type_HTH_dom
PfamiView protein in Pfam
PF13411 MerR_1, 1 hit
PRINTSiPR00040 HTHMERR
SMARTiView protein in SMART
SM00422 HTH_MERR, 1 hit
SUPFAMiSSF46955 SSF46955, 1 hit
TIGRFAMsiTIGR02044 CueR, 1 hit
PROSITEiView protein in PROSITE
PS00552 HTH_MERR_1, 1 hit
PS50937 HTH_MERR_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q93CH6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNISDVAKKT GLTSKAIRFY EEKGLVTPPL RSENGYRTYT QKHLNELTLL
60 70 80 90 100
RQARQVGFNL EECGELVNLF NDPRRHSADV KKRTLEKVAE IERHISELQS
110 120 130
MRDQLLALAE SCPGDDSADC PIIDNLSGCC HHKAQKPR
Length:138
Mass (Da):15,648
Last modified:December 1, 2001 - v1
Checksum:i20D6D1C23EA6D850
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF409088 Genomic DNA Translation: AAL11724.1
AE006468 Genomic DNA Translation: AAL19453.1
RefSeqiNP_459494.1, NC_003197.2
WP_001026760.1, NC_003197.2

Genome annotation databases

EnsemblBacteriaiAAL19453; AAL19453; STM0499
GeneIDi1252019
KEGGistm:STM0499
PATRICifig|99287.12.peg.533

Similar proteinsi

Entry informationi

Entry nameiCUER_SALTY
AccessioniPrimary (citable) accession number: Q93CH6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2002
Last sequence update: December 1, 2001
Last modified: September 12, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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