UniProtKB - Q93CC3 (HOSA_ECOLX)
Protein
Transcriptional regulator HosA
Gene
hosA
Organism
Escherichia coli
Status
Functioni
Involved in the temperature-dependent positive control of flagellum-driven swimming motility and cellular aggregation. Regulates fliC expression by directly interacting with fliC promoter (By similarity).By similarity
Caution
Originally described as slyA, but then it was found that two distinct genes had been named slyA. This gene was renamed hosA. It is not present in strain K12.Curated
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 48 – 71 | H-T-H motifPROSITE-ProRule annotationAdd BLAST | 24 |
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- DNA-binding transcription factor activity Source: InterPro
GO - Biological processi
- pathogenesis Source: UniProtKB-KW
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation, Virulence |
Names & Taxonomyi
Protein namesi | Recommended name: Transcriptional regulator HosA |
Gene namesi | Name:hosA |
Organismi | Escherichia coli |
Taxonomic identifieri | 562 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000054355 | 1 – 135 | Transcriptional regulator HosAAdd BLAST | 135 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 4 – 134 | HTH marR-typePROSITE-ProRule annotationAdd BLAST | 131 |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR000835, HTH_MarR-typ IPR023187, Tscrpt_reg_MarR-type_CS IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF01047, MarR, 1 hit |
PRINTSi | PR00598, HTHMARR |
SMARTi | View protein in SMART SM00347, HTH_MARR, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS01117, HTH_MARR_1, 1 hit PS50995, HTH_MARR_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q93CC3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MALRNKAFHQ LRQLFQQHTA RWQHELPDLT KPQYAVMRAI ADKPGIEQVA
60 70 80 90 100
LIEAAVSTKA TLAEMLARME NRGLVRREHD AADKRRRFVW LTAEGEKVLA
110 120 130
AAIPIGDSVD EEFLGRLSAE EQELFMQLVR KMMNT
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural varianti | 81 | A → P in strain: DEC 9f. | 1 | |
Natural varianti | 81 | A → S in strain: BJ4. | 1 | |
Natural varianti | 98 | V → I in strain: DEC 9f. | 1 | |
Natural varianti | 119 | A → G in strain: DEC 9f and BJ4. | 1 | |
Natural varianti | 121 | E → K in strain: DEC 9f. | 1 | |
Natural varianti | 135 | T → A in strain: DEC 9f and BJ4. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF242209 Genomic DNA Translation: AAG14980.1 AF242210 Genomic DNA Translation: AAG14987.1 AF410776 Genomic DNA Translation: AAL01413.1 |
RefSeqi | WP_001208066.1, NZ_WTRA01000012.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF242209 Genomic DNA Translation: AAG14980.1 AF242210 Genomic DNA Translation: AAG14987.1 AF410776 Genomic DNA Translation: AAL01413.1 |
RefSeqi | WP_001208066.1, NZ_WTRA01000012.1 |
3D structure databases
SMRi | Q93CC3 |
ModBasei | Search... |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR000835, HTH_MarR-typ IPR023187, Tscrpt_reg_MarR-type_CS IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF01047, MarR, 1 hit |
PRINTSi | PR00598, HTHMARR |
SMARTi | View protein in SMART SM00347, HTH_MARR, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS01117, HTH_MARR_1, 1 hit PS50995, HTH_MARR_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | HOSA_ECOLX | |
Accessioni | Q93CC3Primary (citable) accession number: Q93CC3 Secondary accession number(s): Q9EUB1, Q9F8R2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 10, 2005 |
Last sequence update: | May 10, 2005 | |
Last modified: | August 12, 2020 | |
This is version 90 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |