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Protein

Probable NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial

Gene

gas-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).By similarity

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).
NADH + acceptor = NAD+ + reduced acceptor.

Cofactori

[4Fe-4S] clusterBy similarityNote: Binds 1 [4Fe-4S] cluster.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi345Iron-sulfur (4Fe-4S)Sequence analysis1
Metal bindingi351Iron-sulfur (4Fe-4S)Sequence analysis1
Metal bindingi366Iron-sulfur (4Fe-4S)Sequence analysis1

GO - Molecular functioni

GO - Biological processi

  • mitochondrial electron transport, NADH to ubiquinone Source: WormBase
  • response to drug Source: WormBase

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Respiratory chain, Transport
Ligand4Fe-4S, Iron, Iron-sulfur, Metal-binding, NAD, Ubiquinone

Enzyme and pathway databases

ReactomeiR-CEL-6799198 Complex I biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Probable NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial (EC:1.6.5.3, EC:1.6.99.3)
Alternative name(s):
Complex I-49kD
Short name:
CI-49kD
NADH-ubiquinone oxidoreductase 49 kDa subunit
Gene namesi
Name:gas-1
ORF Names:K09A9.5
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiK09A9.5 ; CE11980 ; WBGene00001520 ; gas-1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000019983? – 482Probable NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial
Transit peptidei1 – ?MitochondrionSequence analysis

Proteomic databases

EPDiQ93873
PaxDbiQ93873
PeptideAtlasiQ93873
PRIDEiQ93873

Expressioni

Gene expression databases

BgeeiWBGene00001520

Interactioni

Subunit structurei

Complex I is composed of 45 different subunits. Component of the iron-sulfur (IP) fragment of the enzyme (By similarity).By similarity

Protein-protein interaction databases

STRINGi6239.K09A9.5

Structurei

3D structure databases

ProteinModelPortaliQ93873
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I 49 kDa subunit family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2870 Eukaryota
COG0649 LUCA
GeneTreeiENSGT00390000009529
HOGENOMiHOG000228264
InParanoidiQ93873
KOiK03935
OMAiKKIAWPA
OrthoDBiEOG091G0WWQ
PhylomeDBiQ93873

Family and domain databases

Gene3Di1.10.645.20, 1 hit
HAMAPiMF_01358 NDH1_NuoD, 1 hit
InterProiView protein in InterPro
IPR001135 NADH_Q_OxRdtase_suD
IPR038290 NADH_Q_OxRdtase_suD_sf
IPR014029 NADH_UbQ_OxRdtase_49kDa_CS
IPR022885 NDH1_su_D/H
IPR029014 NiFe-Hase_large
PfamiView protein in Pfam
PF00346 Complex1_49kDa, 1 hit
SUPFAMiSSF56762 SSF56762, 1 hit
TIGRFAMsiTIGR01962 NuoD, 1 hit
PROSITEiView protein in PROSITE
PS00535 COMPLEX1_49K, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q93873-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGRKIAGTC LRANVPSVAA TSSTPATQTR NSHTIWYPDA KFERQFKTGG
60 70 80 90 100
TLGKLWMSER VSDFDEKIGL DKLEKLAYSD PVMSDNYSGK QREKNLENMI
110 120 130 140 150
LNFGPQHPAA HGVLRLVLKL EGEVIIKAIP HIGLLHRATE KLIEHKTYTQ
160 170 180 190 200
ALPYFDRLDY VSMMCNEQAW SLAVEKLLGI DIPTRAKYIR TLMGELTRIQ
210 220 230 240 250
NHIMGITTHA LDVGAMTPFF WMFEEREKLF EFSERVSGAR MHANYVRPGG
260 270 280 290 300
VAWDLPIGLM DDIYDWAIKF PERIDELEDM LTENRIWKAR TIDIGLVSAA
310 320 330 340 350
DALNWGFSGV MVRGSGIKQD VRKTEPYDAY ADMEFDVPIG TKGDCYDRYL
360 370 380 390 400
CRIEEMRQSL NIVHQCLNKM PAGEIKVDDH KVVPPKRAEM KENMESLIHH
410 420 430 440 450
FKFFTEGFQV PPGATYVPIE APKGEFGVYL VADGTGKPYR CFIRAPGFAH
460 470 480
LAAIHDVCYM SLIADIVAVI GTMDIVFGEV DR
Length:482
Mass (Da):54,563
Last modified:January 1, 1998 - v2
Checksum:iACF06535338418B1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z79601 Genomic DNA Translation: CAB01886.1
PIRiT23532
RefSeqiNP_510569.1, NM_078168.4
UniGeneiCel.8011

Genome annotation databases

EnsemblMetazoaiK09A9.5; K09A9.5; WBGene00001520
GeneIDi181646
KEGGicel:CELE_K09A9.5
UCSCiK09A9.5 c. elegans

Similar proteinsi

Entry informationi

Entry nameiNDUS2_CAEEL
AccessioniPrimary (citable) accession number: Q93873
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: March 28, 2018
This is version 142 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

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