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Entry version 155 (08 May 2019)
Sequence version 3 (13 Apr 2004)
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Protein

F-box/WD repeat-containing protein sel-10

Gene

sel-10

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable substrate recognition component of SCF (SKP1-CUL-F-box protein) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:17626846). Regulates synapse elimination in early development in the motor neuron HSNL (PubMed:17626846). Cell autonomous negative regulator of lin-12/Notch-mediated signaling, with respect to lin-12 activity in cell fate decisions and tumorigenesis (PubMed:9389650). May target the intracellular domains of lin-12/Notch proteins for ubiquitin-dependent degradation (PubMed:9389650). Involved in sex determination by promoting female development (PubMed:15306688, PubMed:18718460). Potential regulator of presenilin (PubMed:9861048). May have a role in egg laying (PubMed:8293978, PubMed:15306688). Regulates zyg-1 levels (possibly redundantly with lin-23) to control centrosome duplication during mitosis (PubMed:22623721). Negatively regulates lin-45 activity and protein stability, probably by targeting it for ubiquitination and proteasomal degradation (PubMed:23154983).8 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Sexual differentiation, Ubl conjugation pathway

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-983168 Antigen processing: Ubiquitination & Proteasome degradation

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q93794

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
F-box/WD repeat-containing protein sel-10
Alternative name(s):
Egg laying defective protein 411 Publication
Suppressor/enhancer of lin-12 protein 10
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:sel-10Imported
Synonyms:egl-41Imported
ORF Names:F55B12.3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome V

Organism-specific databases

WormBase

More...
WormBasei
F55B12.3a ; CE25007 ; WBGene00004767 ; sel-10
F55B12.3b ; CE27762 ; WBGene00004767 ; sel-10

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Worms show a weak masculinization phenotype (PubMed:8293978). Moreover sel-10 mutants suppress the egg laying defective (egl) phenotype of the sel-12 mutants (PubMed:8293978). RNAi-mediated knockdown results in increased zyg-1 expression at centrosomes (PubMed:22623721).2 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi567G → E in n1074; masculinizing phenotype. Does not self-interact in vitro or bind to skr-1 protein. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000512121 – 587F-box/WD repeat-containing protein sel-10Add BLAST587

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q93794

PeptideAtlas

More...
PeptideAtlasi
Q93794

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q93794

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in tail and head neurons.1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expression begins at the 50-cell embryonic stage and continues throughout development (PubMed:19528325). Expressed in the HSNL motor neuron from early larval stage L4 to the young adult stage (PubMed:17626846).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00004767 Expressed in 5 organ(s), highest expression level in germ line (C elegans)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Probable component of the SCF(sel-10) E3 ubiquitin-protein ligase complex which includes skr-1 and F-box domain-containing protein sel-10 as a substrate recognition component (PubMed:17626846).

Interacts with fem-1, fem-2, and fem-3 (PubMed:15306688).

Interacts with the intracellular domain of glp-1 and sel-12 (PubMed:9861048).

Interacts with lin-12 (PubMed:9389650).

Interacts with skr-1 (PubMed:18718460).

Interacts with zyg-1 (PubMed:22623721).

6 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
44892, 11 interactors

Protein interaction database and analysis system

More...
IntActi
Q93794, 11 interactors

Molecular INTeraction database

More...
MINTi
Q93794

STRING: functional protein association networks

More...
STRINGi
6239.F55B12.3a

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q93794

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini121 – 167F-boxPROSITE-ProRule annotationAdd BLAST47
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati253 – 291WD 1Add BLAST39
Repeati294 – 333WD 2Add BLAST40
Repeati336 – 373WD 3Add BLAST38
Repeati376 – 415WD 4Add BLAST40
Repeati416 – 455WD 5Add BLAST40
Repeati461 – 498WD 6Add BLAST38
Repeati501 – 539WD 7Add BLAST39

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0274 Eukaryota
ENOG410XRWX LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000174696

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000236264

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q93794

KEGG Orthology (KO)

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KOi
K10260

Identification of Orthologs from Complete Genome Data

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OMAi
MTWKNLC

Database of Orthologous Groups

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OrthoDBi
927943at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q93794

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.130.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036047 F-box-like_dom_sf
IPR001810 F-box_dom
IPR020472 G-protein_beta_WD-40_rep
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12937 F-box-like, 1 hit
PF00400 WD40, 7 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00320 GPROTEINBRPT

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00256 FBOX, 1 hit
SM00320 WD40, 7 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50978 SSF50978, 1 hit
SSF81383 SSF81383, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50181 FBOX, 1 hit
PS00678 WD_REPEATS_1, 5 hits
PS50082 WD_REPEATS_2, 7 hits
PS50294 WD_REPEATS_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform a (identifier: Q93794-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MWPRNDVHMD DGSMTPEDQE PVTDNDMEYN DNGEESSYSN GSSSSYNADK
60 70 80 90 100
LSSSRPLQHK LDLSASPSRN NDLNPRVEHL IALFKDLSSA EQMDAFTRLL
110 120 130 140 150
QESNMTNIRQ LRAIIEPHFQ RDFLSCLPVE LGMKILHNLT GYDLLKVAQV
160 170 180 190 200
SKNWKLISEI DKIWKSLGVE EFKHHPDPTD RVTGAWQGTA IAAGVTIPDH
210 220 230 240 250
IQPCDLNVHR FLKLQKFGDI FERAADKSRY LRADKIEKNW NANPIMGSAV
260 270 280 290 300
LRGHEDHVIT CMQIHDDVLV TGSDDNTLKV WCIDKGEVMY TLVGHTGGVW
310 320 330 340 350
TSQISQCGRY IVSGSTDRTV KVWSTVDGSL LHTLQGHTST VRCMAMAGSI
360 370 380 390 400
LVTGSRDTTL RVWDVESGRH LATLHGHHAA VRCVQFDGTT VVSGGYDFTV
410 420 430 440 450
KIWNAHTGRC IRTLTGHNNR VYSLLFESER SIVCSGSLDT SIRVWDFTRP
460 470 480 490 500
EGQECVALLQ GHTSLTSGMQ LRGNILVSCN ADSHVRVWDI HEGTCVHMLS
510 520 530 540 550
GHRSAITSLQ WFGRNMVATS SDDGTVKLWD IERGALIRDL VTLDSGGNGG
560 570 580
CIWRLCSTST MLACAVGSRN NTEETKVILL DFDAVYP
Length:587
Mass (Da):65,312
Last modified:April 13, 2004 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2D3970B4EFAA1B8C
GO
Isoform b (identifier: Q93794-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     54-55: Missing.

Note: No experimental confirmation available.
Show »
Length:585
Mass (Da):65,068
Checksum:i60F100B591F28D1B
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_00981354 – 55Missing in isoform b. Curated2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF020788 mRNA Translation: AAC47809.1
Z79757 Genomic DNA Translation: CAB02129.2
Z79757 Genomic DNA Translation: CAC42307.1

Protein sequence database of the Protein Information Resource

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PIRi
T22703

NCBI Reference Sequences

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RefSeqi
NP_001023975.1, NM_001028804.2 [Q93794-2]
NP_506421.1, NM_074020.5 [Q93794-1]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
F55B12.3a; F55B12.3a; WBGene00004767 [Q93794-1]
F55B12.3b.1; F55B12.3b.1; WBGene00004767 [Q93794-2]
F55B12.3b.2; F55B12.3b.2; WBGene00004767 [Q93794-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
179878

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
cel:CELE_F55B12.3

UCSC genome browser

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UCSCi
F55B12.3b.1 c. elegans [Q93794-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF020788 mRNA Translation: AAC47809.1
Z79757 Genomic DNA Translation: CAB02129.2
Z79757 Genomic DNA Translation: CAC42307.1
PIRiT22703
RefSeqiNP_001023975.1, NM_001028804.2 [Q93794-2]
NP_506421.1, NM_074020.5 [Q93794-1]

3D structure databases

SMRiQ93794
ModBaseiSearch...

Protein-protein interaction databases

BioGridi44892, 11 interactors
IntActiQ93794, 11 interactors
MINTiQ93794
STRINGi6239.F55B12.3a

PTM databases

iPTMnetiQ93794

Proteomic databases

PaxDbiQ93794
PeptideAtlasiQ93794

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF55B12.3a; F55B12.3a; WBGene00004767 [Q93794-1]
F55B12.3b.1; F55B12.3b.1; WBGene00004767 [Q93794-2]
F55B12.3b.2; F55B12.3b.2; WBGene00004767 [Q93794-2]
GeneIDi179878
KEGGicel:CELE_F55B12.3
UCSCiF55B12.3b.1 c. elegans [Q93794-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
179878
WormBaseiF55B12.3a ; CE25007 ; WBGene00004767 ; sel-10
F55B12.3b ; CE27762 ; WBGene00004767 ; sel-10

Phylogenomic databases

eggNOGiKOG0274 Eukaryota
ENOG410XRWX LUCA
GeneTreeiENSGT00940000174696
HOGENOMiHOG000236264
InParanoidiQ93794
KOiK10260
OMAiMTWKNLC
OrthoDBi927943at2759
PhylomeDBiQ93794

Enzyme and pathway databases

ReactomeiR-CEL-983168 Antigen processing: Ubiquitination & Proteasome degradation
SignaLinkiQ93794

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q93794

Gene expression databases

BgeeiWBGene00004767 Expressed in 5 organ(s), highest expression level in germ line (C elegans)

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR036047 F-box-like_dom_sf
IPR001810 F-box_dom
IPR020472 G-protein_beta_WD-40_rep
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF12937 F-box-like, 1 hit
PF00400 WD40, 7 hits
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00256 FBOX, 1 hit
SM00320 WD40, 7 hits
SUPFAMiSSF50978 SSF50978, 1 hit
SSF81383 SSF81383, 1 hit
PROSITEiView protein in PROSITE
PS50181 FBOX, 1 hit
PS00678 WD_REPEATS_1, 5 hits
PS50082 WD_REPEATS_2, 7 hits
PS50294 WD_REPEATS_REGION, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSEL10_CAEEL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q93794
Secondary accession number(s): O44083, Q95ZT0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: April 13, 2004
Last modified: May 8, 2019
This is version 155 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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