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UniProtKB - Q93714 (IDH3A_CAEEL)
Protein
Probable isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial
Gene
idha-1
Organism
Caenorhabditis elegans
Status
Functioni
Catalytic activityi
- EC:1.1.1.41
Cofactori
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 108 | SubstrateBy similarity | 1 | |
Binding sitei | 118 | SubstrateBy similarity | 1 | |
Binding sitei | 139 | SubstrateBy similarity | 1 | |
Sitei | 146 | Critical for catalysisBy similarity | 1 | |
Sitei | 193 | Critical for catalysisBy similarity | 1 | |
Metal bindingi | 226 | MagnesiumBy similarity | 1 | |
Binding sitei | 226 | SubstrateBy similarity | 1 | |
Metal bindingi | 250 | MagnesiumBy similarity | 1 | |
Metal bindingi | 254 | MagnesiumBy similarity | 1 |
GO - Molecular functioni
- isocitrate dehydrogenase (NAD+) activity Source: GO_Central
- magnesium ion binding Source: InterPro
- NAD binding Source: InterPro
GO - Biological processi
- isocitrate metabolic process Source: GO_Central
- tricarboxylic acid cycle Source: GO_Central
Keywordsi
Molecular function | Oxidoreductase |
Biological process | Tricarboxylic acid cycle |
Ligand | Magnesium, Manganese, Metal-binding, NAD |
Enzyme and pathway databases
Reactomei | R-CEL-71403, Citric acid cycle (TCA cycle) |
Names & Taxonomyi
Protein namesi | Recommended name: Probable isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial (EC:1.1.1.41)Alternative name(s): Isocitric dehydrogenase subunit alpha NAD(+)-specific ICDH subunit alpha |
Gene namesi | Name:idha-1 ORF Names:F43G9.1 |
Organismi | Caenorhabditis elegans |
Taxonomic identifieri | 6239 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditina › Rhabditomorpha › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis |
Proteomesi |
|
Organism-specific databases
WormBasei | F43G9.1 ; CE34018 ; WBGene00009664 ; idha-1 |
Subcellular locationi
Mitochondrion
- Mitochondrion By similarity
Mitochondrion
- mitochondrion Source: WormBase
Keywords - Cellular componenti
MitochondrionPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – ? | MitochondrionSequence analysis | ||
ChainiPRO_0000014441 | ? – 358 | Probable isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial |
Proteomic databases
EPDi | Q93714 |
PaxDbi | Q93714 |
PeptideAtlasi | Q93714 |
2D gel databases
World-2DPAGEi | 0020:Q93714 |
PTM databases
iPTMneti | Q93714 |
Expressioni
Gene expression databases
Bgeei | WBGene00009664, Expressed in material anatomical entity and 5 other tissues |
Interactioni
Subunit structurei
Heterooligomer of subunits alpha, beta, and gamma in the apparent ratio of 2:1:1.
By similarityProtein-protein interaction databases
BioGRIDi | 38088, 27 interactors |
IntActi | Q93714, 2 interactors |
STRINGi | 6239.F43G9.1 |
Family & Domainsi
Sequence similaritiesi
Belongs to the isocitrate and isopropylmalate dehydrogenases family.Curated
Keywords - Domaini
Transit peptidePhylogenomic databases
eggNOGi | KOG0785, Eukaryota |
GeneTreei | ENSGT00950000182989 |
HOGENOMi | CLU_031953_0_0_1 |
InParanoidi | Q93714 |
OMAi | CVRPCRY |
OrthoDBi | 868374at2759 |
PhylomeDBi | Q93714 |
Family and domain databases
InterProi | View protein in InterPro IPR019818, IsoCit/isopropylmalate_DH_CS IPR004434, Isocitrate_DH_NAD IPR024084, IsoPropMal-DH-like_dom |
Pfami | View protein in Pfam PF00180, Iso_dh, 1 hit |
SMARTi | View protein in SMART SM01329, Iso_dh, 1 hit |
TIGRFAMsi | TIGR00175, mito_nad_idh, 1 hit |
PROSITEi | View protein in PROSITE PS00470, IDH_IMDH, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q93714-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLGKCIKKAS STVGQSIRYS SGDVRRVTLI PGDGIGPEIS ASVQKIFEAA
60 70 80 90 100
DAPIAWDPVD VTPVKGRDGV FRIPSRCIEL MHANKVGLKG PLETPIGKGH
110 120 130 140 150
RSLNLAVRKE FSLYANVRPC RSLEGHKTLY DNVDVVTIRE NTEGEYSGIE
160 170 180 190 200
HEIVPGVVQS IKLITETASR NVASFAFEYA RQNGRKVVTA VHKANIMRQS
210 220 230 240 250
DGLFLSICRE QAALYPDIKF KEAYLDTVCL NMVQDPSQYD VLVMPNLYGD
260 270 280 290 300
ILSDLCAGLV GGLGVTPSGN IGKGAAVFES VHGTAPDIAG QDKANPTALL
310 320 330 340 350
LSAVMMLRYM NLPQHAARIE KAVFDAIADG RAKTGDLGGT GTCSSFTADV
CARVKDLE
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z79755 Genomic DNA Translation: CAB02111.2 |
PIRi | T22149 |
RefSeqi | NP_492330.2, NM_059929.3 |
Genome annotation databases
EnsemblMetazoai | F43G9.1.1; F43G9.1.1; WBGene00009664 F43G9.1.2; F43G9.1.2; WBGene00009664 |
GeneIDi | 172655 |
KEGGi | cel:CELE_F43G9.1 |
UCSCi | F43G9.1.1, c. elegans |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z79755 Genomic DNA Translation: CAB02111.2 |
PIRi | T22149 |
RefSeqi | NP_492330.2, NM_059929.3 |
3D structure databases
AlphaFoldDBi | Q93714 |
SMRi | Q93714 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 38088, 27 interactors |
IntActi | Q93714, 2 interactors |
STRINGi | 6239.F43G9.1 |
PTM databases
iPTMneti | Q93714 |
2D gel databases
World-2DPAGEi | 0020:Q93714 |
Proteomic databases
EPDi | Q93714 |
PaxDbi | Q93714 |
PeptideAtlasi | Q93714 |
Genome annotation databases
EnsemblMetazoai | F43G9.1.1; F43G9.1.1; WBGene00009664 F43G9.1.2; F43G9.1.2; WBGene00009664 |
GeneIDi | 172655 |
KEGGi | cel:CELE_F43G9.1 |
UCSCi | F43G9.1.1, c. elegans |
Organism-specific databases
CTDi | 172655 |
WormBasei | F43G9.1 ; CE34018 ; WBGene00009664 ; idha-1 |
Phylogenomic databases
eggNOGi | KOG0785, Eukaryota |
GeneTreei | ENSGT00950000182989 |
HOGENOMi | CLU_031953_0_0_1 |
InParanoidi | Q93714 |
OMAi | CVRPCRY |
OrthoDBi | 868374at2759 |
PhylomeDBi | Q93714 |
Enzyme and pathway databases
Reactomei | R-CEL-71403, Citric acid cycle (TCA cycle) |
Miscellaneous databases
PROi | PR:Q93714 |
Gene expression databases
Bgeei | WBGene00009664, Expressed in material anatomical entity and 5 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR019818, IsoCit/isopropylmalate_DH_CS IPR004434, Isocitrate_DH_NAD IPR024084, IsoPropMal-DH-like_dom |
Pfami | View protein in Pfam PF00180, Iso_dh, 1 hit |
SMARTi | View protein in SMART SM01329, Iso_dh, 1 hit |
TIGRFAMsi | TIGR00175, mito_nad_idh, 1 hit |
PROSITEi | View protein in PROSITE PS00470, IDH_IMDH, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | IDH3A_CAEEL | |
Accessioni | Q93714Primary (citable) accession number: Q93714 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | April 13, 2004 | |
Last modified: | May 25, 2022 | |
This is version 147 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Caenorhabditis annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Caenorhabditis elegans
Caenorhabditis elegans: entries, gene names and cross-references to WormBase - SIMILARITY comments
Index of protein domains and families