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Protein

Translationally-controlled tumor protein homolog

Gene

tct-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in calcium binding and microtubule stabilization.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandCalcium

Names & Taxonomyi

Protein namesi
Recommended name:
Translationally-controlled tumor protein homolog
Short name:
TCTP
Gene namesi
Name:tct-1
ORF Names:F25H2.11
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiF25H2.11 ; CE09656 ; WBGene00009122 ; tct-1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002112811 – 181Translationally-controlled tumor protein homologAdd BLAST181

Proteomic databases

EPDiQ93573
PaxDbiQ93573
PeptideAtlasiQ93573
PRIDEiQ93573

2D gel databases

World-2DPAGEi0020:Q93573

PTM databases

iPTMnetiQ93573

Expressioni

Gene expression databases

BgeeiWBGene00009122

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi38358, 4 interactors
DIPiDIP-26025N
IntActiQ93573, 3 interactors
STRINGi6239.F25H2.11.1

Structurei

Secondary structure

1181
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi2 – 8Combined sources7
Turni10 – 12Combined sources3
Beta strandi14 – 16Combined sources3
Beta strandi21 – 23Combined sources3
Turni24 – 26Combined sources3
Beta strandi27 – 31Combined sources5
Beta strandi34 – 38Combined sources5
Helixi61 – 63Combined sources3
Beta strandi65 – 68Combined sources4
Helixi69 – 72Combined sources4
Turni73 – 75Combined sources3
Beta strandi76 – 79Combined sources4
Helixi81 – 106Combined sources26
Helixi110 – 127Combined sources18
Helixi130 – 133Combined sources4
Beta strandi137 – 141Combined sources5
Helixi142 – 147Combined sources6
Beta strandi153 – 161Combined sources9
Beta strandi164 – 172Combined sources9
Turni173 – 175Combined sources3
Beta strandi176 – 179Combined sources4

3D structure databases

ProteinModelPortaliQ93573
SMRiQ93573
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ93573

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 181TCTPPROSITE-ProRule annotationAdd BLAST181

Sequence similaritiesi

Belongs to the TCTP family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1727 Eukaryota
ENOG4111FVP LUCA
GeneTreeiENSGT00390000006051
HOGENOMiHOG000203361
InParanoidiQ93573
OMAiFKDFEFY
OrthoDBiEOG091G0OTA
PhylomeDBiQ93573

Family and domain databases

Gene3Di2.170.150.10, 1 hit
InterProiView protein in InterPro
IPR011057 Mss4-like_sf
IPR011323 Mss4/transl-control_tumour
IPR034737 TCTP
IPR018103 Translation_control_tumour_CS
IPR018105 Translational_control_tumour_p
PANTHERiPTHR11991 PTHR11991, 1 hit
PfamiView protein in Pfam
PF00838 TCTP, 1 hit
PRINTSiPR01653 TCTPROTEIN
SUPFAMiSSF51316 SSF51316, 1 hit
PROSITEiView protein in PROSITE
PS01002 TCTP_1, 1 hit
PS01003 TCTP_2, 1 hit
PS51797 TCTP_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q93573-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLIYKDIFTD DELSSDSFPM KLVDDLVYEF KGKHVVRKEG EIVLAGSNPS
60 70 80 90 100
AEEGAEDDGS DEHVERGIDI VLNHKLVEMN CYEDASMFKA YIKKFMKNVI
110 120 130 140 150
DHMEKNNRDK ADVDAFKKKI QGWVVSLLAK DRFKNLAFFI GERAAEGAEN
160 170 180
GQVAIIEYRD VDGTEVPTLM LVKEAIIEEK C
Length:181
Mass (Da):20,542
Last modified:February 1, 1997 - v1
Checksum:i112E23374D29DA12
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z79754 Genomic DNA Translation: CAB02099.1
PIRiT21352
RefSeqiNP_492767.1, NM_060366.5
UniGeneiCel.22560

Genome annotation databases

EnsemblMetazoaiF25H2.11; F25H2.11; WBGene00009122
GeneIDi172944
KEGGicel:CELE_F25H2.11
UCSCiF25H2.11.1 c. elegans

Similar proteinsi

Entry informationi

Entry nameiTCTP_CAEEL
AccessioniPrimary (citable) accession number: Q93573
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: July 18, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

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