UniProtKB - Q93560 (BLMP1_CAEEL)
Protein
B lymphocyte-induced maturation protein 1 homolog
Gene
blmp-1
Organism
Caenorhabditis elegans
Status
Functioni
Transcription factor which binds to enhancer elements in the promoter region of genes (PubMed:26234645). Regulates the expression of the transcription factor bed-3 to control vulval development (PubMed:26234645, PubMed:32417234). Promotes terminal differentiation in the hypodermis and is involved in regulation of gonadal outgrowth and entry into the dauer stage (PubMed:24613396). Regulates the timing of dorsalward migration of the distal tip cells of the hermaphrodite gonad by inhibiting precocious unc-5 and lin-29 expression which in turn prevents early dorsalward turning (PubMed:24968003). Plays a role in male tail tip morphogenesis (PubMed:21408209).4 Publications
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 508 – 530 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 536 – 558 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 564 – 586 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 592 – 614 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 620 – 642 | C2H2-type 5; degeneratePROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- cis-regulatory region sequence-specific DNA binding Source: WormBase
- DNA-binding transcription factor activity Source: GO_Central
- histone deacetylase binding Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- cell fate commitment Source: GO_Central
- dauer entry Source: UniProtKB
- determination of adult lifespan Source: UniProtKB
- hermaphrodite genitalia development Source: UniProtKB
- negative regulation of distal tip cell migration Source: UniProtKB
- negative regulation of transcription by RNA polymerase II Source: UniProtKB
- positive regulation of epidermis development Source: UniProtKB
- positive regulation of nematode male tail tip morphogenesis Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: WormBase
- regulation of gene expression Source: GO_Central
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | Developmental protein |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: B lymphocyte-induced maturation protein 1 homologImported |
Gene namesi | Name:blmp-1Imported ORF Names:F25D7.3Imported |
Organismi | Caenorhabditis elegansImported |
Taxonomic identifieri | 6239 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditina › Rhabditomorpha › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis |
Proteomesi |
|
Organism-specific databases
WormBasei | F25D7.3a ; CE09631 ; WBGene00003847 ; blmp-1 F25D7.3b ; CE43409 ; WBGene00003847 ; blmp-1 |
Pathology & Biotechi
Disruption phenotypei
Gonadal migration defects with premature dorsal turning of distal tip cells in the hermaphrodite gonad (PubMed:24613396, PubMed:24968003). Defective dauer formation, shortened lifespan and retarded terminal differentiation of seam cells with incomplete adult alae synthesis (PubMed:24613396). Suppresses the precocious seam cell terminal differentiation and gonadal migration defects seen in dre-1 mutants (PubMed:24613396). Weak dumpy phenotype and partially penetrant embryonic lethality (PubMed:24968003). Reduced expression of the transcription factor bed-3 which is involved in vulval development and failed division of vulval precursor cell descendents (PubMed:26234645). RNAi-mediated knockdown impairs the expression of several hypodermis-specific genes; reduces levels of clo-124 mRNA and increases levels of lin-29 mRNA (PubMed:32417234). RNAi-mediated knockdown results in the precocious onset of tail tip retraction resulting in over-retracted and shortened adult male tails (also known as the Ore phenotype) (PubMed:21408209).5 Publications
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000430670 | 1 – 817 | B lymphocyte-induced maturation protein 1 homologCuratedAdd BLAST | 817 |
Post-translational modificationi
Ubiquitinated by the SCF(dre-1) complex, leading to its degradation by the proteasome.1 Publication
Keywords - PTMi
Ubl conjugationProteomic databases
EPDi | Q93560 |
PaxDbi | Q93560 |
Expressioni
Tissue specificityi
Expressed in hypodermal, vulval, intestinal and distal tip cells.1 Publication
Developmental stagei
In distal tip cells, expressed from mid-L2 when gonadal outgrowth initiates (PubMed:24613396). By mid-L3, just prior to the dorsal gonadal turn, levels drop dramatically (PubMed:24968003). In seam and hypodermal cells, levels are largely constant throughout larval development except for a transient peak early in L4 (PubMed:24613396).2 Publications
Gene expression databases
Bgeei | WBGene00003847, Expressed in multi-cellular organism and 4 other tissues |
Interactioni
Subunit structurei
GO - Molecular functioni
- histone deacetylase binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 38333, 13 interactors |
IntActi | Q93560, 12 interactors |
STRINGi | 6239.F25D7.3a |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 103 – 241 | SETPROSITE-ProRule annotationAdd BLAST | 139 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 16 – 59 | Ser-richPROSITE-ProRule annotationAdd BLAST | 44 | |
Compositional biasi | 712 – 793 | Gln-richPROSITE-ProRule annotationAdd BLAST | 82 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 508 – 530 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 536 – 558 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 564 – 586 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 592 – 614 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 620 – 642 | C2H2-type 5; degeneratePROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG2461, Eukaryota |
GeneTreei | ENSGT00940000154798 |
HOGENOMi | CLU_018020_0_0_1 |
InParanoidi | Q93560 |
OMAi | AAPKCNS |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q93560 |
Family and domain databases
InterProi | View protein in InterPro IPR001214, SET_dom IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 5 hits |
SMARTi | View protein in SMART SM00317, SET, 1 hit SM00355, ZnF_C2H2, 5 hits |
SUPFAMi | SSF57667, SSF57667, 3 hits |
PROSITEi | View protein in PROSITE PS50280, SET, 1 hit PS00028, ZINC_FINGER_C2H2_1, 4 hits PS50157, ZINC_FINGER_C2H2_2, 5 hits |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1Imported (identifier: Q93560-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGQGSGDDGV PPAPFSSAAA AAHSPPHSPL SVGVSSASSA TSSSSTPPSS
60 70 80 90 100
TSPAGVSASG ARNVETDWKQ SGDENLAELC IFHVPDKSVS LPNPKRAECT
110 120 130 140 150
LPMNLILKSS SKNRKKSSIW SSDHIPRGVR FGPLVGEIRL VDVDTALVCP
160 170 180 190 200
AEASMAGGGP AQEDVPFDEA PEEWKIYSPS GGRLNKTICV KDDARSNWMK
210 220 230 240 250
YVAAAEEEDF QNLVAAQIGN DIYFYTVKKI EANTELSFWF SRDYARKLNY
260 270 280 290 300
STRPYVRVRR PATQLIPSAP PASASTAIAS LAETIVAIDY SVKKLIESPI
310 320 330 340 350
DTLSTDASSA SDEEMIDVEE QESCTRPVAE VTRPNVIQNP VVRPVATKVN
360 370 380 390 400
NFPGIPVRLG NFYASPLVDF KEFMRKSLQL KLVDTSMFVS PVAQTTAAIT
410 420 430 440 450
ATGGRSGQPI DVQPVLAATA GAHFGNYAAI YGSQDFQHEL SKPLYTSASP
460 470 480 490 500
AFGGGGGMGG GFGMGGSAHT SSFHQLPFVN HSSSSHNDSS FNGVPNYVQQ
510 520 530 540 550
QENGKTRYAC KDCNKTFGQL SNLKVHVRTH TGERPFKCEI CTKEFTQLAH
560 570 580 590 600
LQKHHLVHTG ERPHRCDICD KRFSSTSNLK THLRLHNGQK PYTCDVCDAK
610 620 630 640 650
FTQYVHLRLH KRLHANERPY SCGTCGKKYI SPSGLRTHWK TTTCKEEDMK
660 670 680 690 700
DSMRDDLMDI KGEIDEGSMS GSGYGNLGIF ENTLNSELKR PLMPIETIYS
710 720 730 740 750
KYNLPNASLL GQGPSGMQEQ QAPPPTSQQQ QHMMYGNTMG HMGQGSHLQG
760 770 780 790 800
PPPPPQHFQM DHSGMQNGGG IPHQHQLIQG GPSSGSGQQQ HPQHNGIHRL
810
PDLKNPLLPS LGLPHYP
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_057061 | 685 – 700 | Missing in isoform 2. CuratedAdd BLAST | 16 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX284601 Genomic DNA Translation: CAB01695.1 BX284601 Genomic DNA Translation: CAV31771.1 |
PIRi | T21336 |
RefSeqi | NP_001251370.1, NM_001264441.1 [Q93560-1] NP_001251371.1, NM_001264442.1 [Q93560-2] |
Genome annotation databases
EnsemblMetazoai | F25D7.3a.1; F25D7.3a.1; WBGene00003847 [Q93560-1] F25D7.3b.1; F25D7.3b.1; WBGene00003847 [Q93560-2] |
GeneIDi | 172917 |
KEGGi | cel:CELE_F25D7.3 |
UCSCi | F25D7.3, c. elegans [Q93560-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX284601 Genomic DNA Translation: CAB01695.1 BX284601 Genomic DNA Translation: CAV31771.1 |
PIRi | T21336 |
RefSeqi | NP_001251370.1, NM_001264441.1 [Q93560-1] NP_001251371.1, NM_001264442.1 [Q93560-2] |
3D structure databases
SMRi | Q93560 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 38333, 13 interactors |
IntActi | Q93560, 12 interactors |
STRINGi | 6239.F25D7.3a |
Proteomic databases
EPDi | Q93560 |
PaxDbi | Q93560 |
Genome annotation databases
EnsemblMetazoai | F25D7.3a.1; F25D7.3a.1; WBGene00003847 [Q93560-1] F25D7.3b.1; F25D7.3b.1; WBGene00003847 [Q93560-2] |
GeneIDi | 172917 |
KEGGi | cel:CELE_F25D7.3 |
UCSCi | F25D7.3, c. elegans [Q93560-1] |
Organism-specific databases
CTDi | 172917 |
WormBasei | F25D7.3a ; CE09631 ; WBGene00003847 ; blmp-1 F25D7.3b ; CE43409 ; WBGene00003847 ; blmp-1 |
Phylogenomic databases
eggNOGi | KOG2461, Eukaryota |
GeneTreei | ENSGT00940000154798 |
HOGENOMi | CLU_018020_0_0_1 |
InParanoidi | Q93560 |
OMAi | AAPKCNS |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q93560 |
Miscellaneous databases
PROi | PR:Q93560 |
Gene expression databases
Bgeei | WBGene00003847, Expressed in multi-cellular organism and 4 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR001214, SET_dom IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 5 hits |
SMARTi | View protein in SMART SM00317, SET, 1 hit SM00355, ZnF_C2H2, 5 hits |
SUPFAMi | SSF57667, SSF57667, 3 hits |
PROSITEi | View protein in PROSITE PS50280, SET, 1 hit PS00028, ZINC_FINGER_C2H2_1, 4 hits PS50157, ZINC_FINGER_C2H2_2, 5 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | BLMP1_CAEEL | |
Accessioni | Q93560Primary (citable) accession number: Q93560 Secondary accession number(s): B7WN98 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 29, 2014 |
Last sequence update: | February 1, 1997 | |
Last modified: | February 10, 2021 | |
This is version 167 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Caenorhabditis annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Caenorhabditis elegans
Caenorhabditis elegans: entries, gene names and cross-references to WormBase