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Protein

Rab3 GTPase-activating protein catalytic subunit

Gene

rbg-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Probable catalytic subunit of a GTPase activating protein that has specificity for Rab3 subfamily. Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Specifically converts active Rab3-GTP to the inactive form Rab3-GDP (By similarity).By similarity

GO - Molecular functioni

  • GTPase activator activity Source: UniProtKB
  • Rab GTPase binding Source: UniProtKB

GO - Biological processi

  • amyloid fibril formation Source: GO_Central
  • autophagy Source: WormBase
  • positive regulation of autophagosome assembly Source: GO_Central
  • positive regulation of GTPase activity Source: GO_Central
  • regulation of GTPase activity Source: UniProtKB

Keywordsi

Molecular functionGTPase activation

Enzyme and pathway databases

ReactomeiR-CEL-6811436 COPI-independent Golgi-to-ER retrograde traffic
R-CEL-8876198 RAB GEFs exchange GTP for GDP on RABs

Names & Taxonomyi

Protein namesi
Recommended name:
Rab3 GTPase-activating protein catalytic subunit
Alternative name(s):
Rab3 GTPase-activating protein 1
Gene namesi
Name:rbg-1
ORF Names:F20D1.6
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiF20D1.6 ; CE09499 ; WBGene00004317 ; rbg-1

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001916601 – 915Rab3 GTPase-activating protein catalytic subunitAdd BLAST915

Proteomic databases

EPDiQ93538
PaxDbiQ93538
PeptideAtlasiQ93538
PRIDEiQ93538

Expressioni

Gene expression databases

BgeeiWBGene00004317

Interactioni

Subunit structurei

The Rab3 GTPase-activating complex is a heterodimer composed of rbg-1 and rbg-2.By similarity

GO - Molecular functioni

  • Rab GTPase binding Source: UniProtKB

Protein-protein interaction databases

STRINGi6239.F20D1.6.2

Structurei

3D structure databases

ProteinModelPortaliQ93538
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Rab3-GAP catalytic subunit family.Curated

Phylogenomic databases

eggNOGiKOG2390 Eukaryota
ENOG410Y2R4 LUCA
GeneTreeiENSGT00390000006705
HOGENOMiHOG000018297
InParanoidiQ93538
KOiK18270
OMAiADFLRWH
OrthoDBiEOG091G023S
PhylomeDBiQ93538

Family and domain databases

InterProiView protein in InterPro
IPR026147 Rab3-GAP_cat_su
PANTHERiPTHR21422 PTHR21422, 1 hit
PfamiView protein in Pfam
PF13890 Rab3-GTPase_cat, 1 hit

Sequencei

Sequence statusi: Complete.

Q93538-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEIEENTVF EINDFTIVTD MEHFGAAFEG ILQKYEFSSR RPCLSNDVKY
60 70 80 90 100
RLIVTDTNMI SIGENKLRIE LLQPVPASSN PSNDVEFVEA PKDEIEEDAH
110 120 130 140 150
VIPFTVAEEV ANLKHGFEVT DSFLLKFGIR ECIIISPNDS SGTFTDENQV
160 170 180 190 200
NTVMGNIKTI LHSSRCEVPV FCYIKDQSLD MISGYASDGN STYNFSSVVL
210 220 230 240 250
RNINRRHCSM TDLLYLFKEH LGASISAFHE EVRMSSRFTH VVPLKQSKYF
260 270 280 290 300
RNHTVETFGL LATGPTSSLP FDILEIAATW RFFRENSLTE NHSHSDFDIN
310 320 330 340 350
YSSYWNIKMK STKSSLLGVL DEILGVYRED TRKAIRSDLN CALILGKHYT
360 370 380 390 400
QKELPNAFQK LTINSASEVK IGKHAETEDS GTNGPMPPAL MKSWVNFIFN
410 420 430 440 450
EAESDNESLA HELNMLNAAS MSENQLSDDE LVNNVKLDTL FNYKNPKSAN
460 470 480 490 500
TFLAPYKCAK KSTVTWRLAI ALANARVFMS DQPRAEPQLW VEFLLKLREK
510 520 530 540 550
YEKMETVEKV YNGIDHLQCS FSQKMQMLQL CIDARQKRHR MLDSAHSANN
560 570 580 590 600
SDEFFDANES FNAETILEPN NEGRLKLFGL NLVEIPDVPM YIPVTQDACP
610 620 630 640 650
LTDEMIDARN EHLFSLDEED RVHLQMELVK SDMQSFKAAN AGAVFADFLR
660 670 680 690 700
WHSPKDYDEK TNTISERMLI SNNVWVRSWE AALPIPVANQ ARIFNDTKIA
710 720 730 740 750
EEILEIFNNA TLDQVREWMK PTVFAATLER LTEIESSYGV SEEKQKQRTK
760 770 780 790 800
TAKILANATL NNTPMDYNEI SKYCSQIEMI HNMKVHLMQL FENAREKMHP
810 820 830 840 850
PYPSETDVQS AIKQLVNIAV HNLWDNSTDE EPTFVIKPQD PIGRAIAVIG
860 870 880 890 900
KLDELTEQQL INGHRKEYIF NWKHSCPSTT TIPMTHRMYA DLRSDKHSLY
910
FSMANDCNFS NSSYL
Length:915
Mass (Da):104,585
Last modified:February 1, 1997 - v1
Checksum:i0AEAFA63A58F8566
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z78542 Genomic DNA Translation: CAB01748.1
PIRiT21147
RefSeqiNP_510490.1, NM_078089.3
UniGeneiCel.5670

Genome annotation databases

EnsemblMetazoaiF20D1.6; F20D1.6; WBGene00004317
GeneIDi181595
KEGGicel:CELE_F20D1.6
UCSCiF20D1.6.1 c. elegans

Similar proteinsi

Entry informationi

Entry nameiRB3GP_CAEEL
AccessioniPrimary (citable) accession number: Q93538
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: February 1, 1997
Last modified: April 12, 2017
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

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