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Protein

Rab3 GTPase-activating protein catalytic subunit

Gene

rbg-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable catalytic subunit of a GTPase activating protein that has specificity for Rab3 subfamily. Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Specifically converts active Rab3-GTP to the inactive form Rab3-GDP (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • GTPase activator activity Source: UniProtKB
  • Rab GTPase binding Source: UniProtKB

GO - Biological processi

  • amyloid fibril formation Source: GO_Central
  • autophagy Source: WormBase
  • positive regulation of autophagosome assembly Source: GO_Central
  • positive regulation of GTPase activity Source: GO_Central
  • regulation of GTPase activity Source: UniProtKB

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGTPase activation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-6811436 COPI-independent Golgi-to-ER retrograde traffic
R-CEL-8876198 RAB GEFs exchange GTP for GDP on RABs

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Rab3 GTPase-activating protein catalytic subunit
Alternative name(s):
Rab3 GTPase-activating protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:rbg-1
ORF Names:F20D1.6
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

WormBase

More...
WormBasei
F20D1.6 ; CE09499 ; WBGene00004317 ; rbg-1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001916601 – 915Rab3 GTPase-activating protein catalytic subunitAdd BLAST915

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q93538

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q93538

PeptideAtlas

More...
PeptideAtlasi
Q93538

PRoteomics IDEntifications database

More...
PRIDEi
Q93538

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00004317 Expressed in 5 organ(s), highest expression level in pharyngeal muscle cell (C elegans)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The Rab3 GTPase-activating complex is a heterodimer composed of rbg-1 and rbg-2.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
6239.F20D1.6.2

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q93538

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Rab3-GAP catalytic subunit family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2390 Eukaryota
ENOG410Y2R4 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000006705

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000018297

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q93538

KEGG Orthology (KO)

More...
KOi
K18270

Identification of Orthologs from Complete Genome Data

More...
OMAi
ADFLRWH

Database of Orthologous Groups

More...
OrthoDBi
536022at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q93538

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026147 Rab3-GAP_cat_su

The PANTHER Classification System

More...
PANTHERi
PTHR21422 PTHR21422, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13890 Rab3-GTPase_cat, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q93538-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEIEENTVF EINDFTIVTD MEHFGAAFEG ILQKYEFSSR RPCLSNDVKY
60 70 80 90 100
RLIVTDTNMI SIGENKLRIE LLQPVPASSN PSNDVEFVEA PKDEIEEDAH
110 120 130 140 150
VIPFTVAEEV ANLKHGFEVT DSFLLKFGIR ECIIISPNDS SGTFTDENQV
160 170 180 190 200
NTVMGNIKTI LHSSRCEVPV FCYIKDQSLD MISGYASDGN STYNFSSVVL
210 220 230 240 250
RNINRRHCSM TDLLYLFKEH LGASISAFHE EVRMSSRFTH VVPLKQSKYF
260 270 280 290 300
RNHTVETFGL LATGPTSSLP FDILEIAATW RFFRENSLTE NHSHSDFDIN
310 320 330 340 350
YSSYWNIKMK STKSSLLGVL DEILGVYRED TRKAIRSDLN CALILGKHYT
360 370 380 390 400
QKELPNAFQK LTINSASEVK IGKHAETEDS GTNGPMPPAL MKSWVNFIFN
410 420 430 440 450
EAESDNESLA HELNMLNAAS MSENQLSDDE LVNNVKLDTL FNYKNPKSAN
460 470 480 490 500
TFLAPYKCAK KSTVTWRLAI ALANARVFMS DQPRAEPQLW VEFLLKLREK
510 520 530 540 550
YEKMETVEKV YNGIDHLQCS FSQKMQMLQL CIDARQKRHR MLDSAHSANN
560 570 580 590 600
SDEFFDANES FNAETILEPN NEGRLKLFGL NLVEIPDVPM YIPVTQDACP
610 620 630 640 650
LTDEMIDARN EHLFSLDEED RVHLQMELVK SDMQSFKAAN AGAVFADFLR
660 670 680 690 700
WHSPKDYDEK TNTISERMLI SNNVWVRSWE AALPIPVANQ ARIFNDTKIA
710 720 730 740 750
EEILEIFNNA TLDQVREWMK PTVFAATLER LTEIESSYGV SEEKQKQRTK
760 770 780 790 800
TAKILANATL NNTPMDYNEI SKYCSQIEMI HNMKVHLMQL FENAREKMHP
810 820 830 840 850
PYPSETDVQS AIKQLVNIAV HNLWDNSTDE EPTFVIKPQD PIGRAIAVIG
860 870 880 890 900
KLDELTEQQL INGHRKEYIF NWKHSCPSTT TIPMTHRMYA DLRSDKHSLY
910
FSMANDCNFS NSSYL
Length:915
Mass (Da):104,585
Last modified:February 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0AEAFA63A58F8566
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z78542 Genomic DNA Translation: CAB01748.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T21147

NCBI Reference Sequences

More...
RefSeqi
NP_510490.1, NM_078089.3

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Cel.5670

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
F20D1.6; F20D1.6; WBGene00004317

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
181595

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_F20D1.6

UCSC genome browser

More...
UCSCi
F20D1.6.1 c. elegans

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z78542 Genomic DNA Translation: CAB01748.1
PIRiT21147
RefSeqiNP_510490.1, NM_078089.3
UniGeneiCel.5670

3D structure databases

ProteinModelPortaliQ93538
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.F20D1.6.2

Proteomic databases

EPDiQ93538
PaxDbiQ93538
PeptideAtlasiQ93538
PRIDEiQ93538

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF20D1.6; F20D1.6; WBGene00004317
GeneIDi181595
KEGGicel:CELE_F20D1.6
UCSCiF20D1.6.1 c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
181595
WormBaseiF20D1.6 ; CE09499 ; WBGene00004317 ; rbg-1

Phylogenomic databases

eggNOGiKOG2390 Eukaryota
ENOG410Y2R4 LUCA
GeneTreeiENSGT00390000006705
HOGENOMiHOG000018297
InParanoidiQ93538
KOiK18270
OMAiADFLRWH
OrthoDBi536022at2759
PhylomeDBiQ93538

Enzyme and pathway databases

ReactomeiR-CEL-6811436 COPI-independent Golgi-to-ER retrograde traffic
R-CEL-8876198 RAB GEFs exchange GTP for GDP on RABs

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q93538

Gene expression databases

BgeeiWBGene00004317 Expressed in 5 organ(s), highest expression level in pharyngeal muscle cell (C elegans)

Family and domain databases

InterProiView protein in InterPro
IPR026147 Rab3-GAP_cat_su
PANTHERiPTHR21422 PTHR21422, 1 hit
PfamiView protein in Pfam
PF13890 Rab3-GTPase_cat, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRB3GP_CAEEL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q93538
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: February 1, 1997
Last modified: January 16, 2019
This is version 94 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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