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Protein

Oxysterol-binding protein

Gene

obr-2

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • lipid binding Source: GO_Central
  • sterol binding Source: GO_Central
  • sterol transporter activity Source: GO_Central

Keywordsi

Biological processLipid transportUniRule annotation, Transport

Enzyme and pathway databases

ReactomeiR-CEL-192105 Synthesis of bile acids and bile salts

Names & Taxonomyi

Protein namesi
Recommended name:
Oxysterol-binding proteinUniRule annotation
Gene namesi
Name:obr-2Imported
ORF Names:CELE_F14H8.1Imported, F14H8.1Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiF14H8.1a ; CE35859 ; WBGene00008832 ; obr-2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

EPDiQ93485
PaxDbiQ93485

Expressioni

Gene expression databases

BgeeiWBGene00008832 Expressed in 5 organ(s), highest expression level in material anatomical entity

Interactioni

Protein-protein interaction databases

STRINGi6239.F14H8.1a

Structurei

3D structure databases

ProteinModelPortaliQ93485
SMRiQ93485
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili358 – 378Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the OSBP family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG1737 Eukaryota
ENOG410XP9E LUCA
GeneTreeiENSGT00760000119155
HOGENOMiHOG000231233
InParanoidiQ93485
OMAiHLIHKAC
OrthoDBiEOG091G07RK
PhylomeDBiQ93485

Family and domain databases

InterProiView protein in InterPro
IPR037239 OSBP_sf
IPR000648 Oxysterol-bd
IPR018494 Oxysterol-bd_CS
PANTHERiPTHR10972 PTHR10972, 1 hit
PfamiView protein in Pfam
PF01237 Oxysterol_BP, 1 hit
SUPFAMiSSF144000 SSF144000, 1 hit
PROSITEiView protein in PROSITE
PS01013 OSBP, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q93485-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVKLFREKKD MGSPKIQNFK RQTVLHKGQR TRLPATYIAP EDVSIWDIIR
60 70 80 90 100
PNLGKDFSRF TVPVFMNEPL SFLQRLSENV QYNYLLEKAA KCSDDMERIE
110 120 130 140 150
YVAAFALATV SANHKRLSKP FNPLLLETFE LERNGVRFLA EQVSHHPPIS
160 170 180 190 200
AVYAESDEFT VEGTVEPTLG FWMTKLLANP HAHLKLTFKK TGETYSWSAP
210 220 230 240 250
KCAIYNVIMG KMYMNFTSHM KIESSGTYDA VFSFDNKGYY NHKGGDVHVE
260 270 280 290 300
GHIFEGKNKI KALYGNWTLF LASCDNEDFK HHRKEYLRMF NETVSEKDQG
310 320 330 340 350
PVVPGSKILW VSNQIPKLFD DQFHFTNFTL SLNEMYPGMS DTVAPTDSRR
360 370 380 390 400
RKDMKALEDG KNDEAEEFKH KYEEEQRERR TTKTGDVPMW FAKNDEGHWA
410 420 430
YKGGYWDRDY SNCLELFESL ENSSTNSSNS SISSVD
Length:436
Mass (Da):50,399
Last modified:July 5, 2004 - v3
Checksum:iCC28E683EF76FDCB
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B2D6P3B2D6P3_CAEEL
Oxysterol-binding protein
obr-2 CELE_F14H8.1, F14H8.1
426Annotation score:
G1K0Y0G1K0Y0_CAEEL
Oxysterol-binding protein
obr-2 CELE_F14H8.1, F14H8.1
264Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284605 Genomic DNA Translation: CAB02934.3
PIRiH89308
T20938
RefSeqiNP_506695.2, NM_074294.3
UniGeneiCel.4083

Genome annotation databases

EnsemblMetazoaiF14H8.1a; F14H8.1a; WBGene00008832
GeneIDi180003
KEGGicel:CELE_F14H8.1
UCSCiF14H8.1b c. elegans

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284605 Genomic DNA Translation: CAB02934.3
PIRiH89308
T20938
RefSeqiNP_506695.2, NM_074294.3
UniGeneiCel.4083

3D structure databases

ProteinModelPortaliQ93485
SMRiQ93485
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.F14H8.1a

Proteomic databases

EPDiQ93485
PaxDbiQ93485

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF14H8.1a; F14H8.1a; WBGene00008832
GeneIDi180003
KEGGicel:CELE_F14H8.1
UCSCiF14H8.1b c. elegans

Organism-specific databases

CTDi180003
WormBaseiF14H8.1a ; CE35859 ; WBGene00008832 ; obr-2

Phylogenomic databases

eggNOGiKOG1737 Eukaryota
ENOG410XP9E LUCA
GeneTreeiENSGT00760000119155
HOGENOMiHOG000231233
InParanoidiQ93485
OMAiHLIHKAC
OrthoDBiEOG091G07RK
PhylomeDBiQ93485

Enzyme and pathway databases

ReactomeiR-CEL-192105 Synthesis of bile acids and bile salts

Gene expression databases

BgeeiWBGene00008832 Expressed in 5 organ(s), highest expression level in material anatomical entity

Family and domain databases

InterProiView protein in InterPro
IPR037239 OSBP_sf
IPR000648 Oxysterol-bd
IPR018494 Oxysterol-bd_CS
PANTHERiPTHR10972 PTHR10972, 1 hit
PfamiView protein in Pfam
PF01237 Oxysterol_BP, 1 hit
SUPFAMiSSF144000 SSF144000, 1 hit
PROSITEiView protein in PROSITE
PS01013 OSBP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ93485_CAEEL
AccessioniPrimary (citable) accession number: Q93485
Entry historyiIntegrated into UniProtKB/TrEMBL: February 1, 1997
Last sequence update: July 5, 2004
Last modified: November 7, 2018
This is version 133 of the entry and version 3 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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