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Entry version 158 (26 Feb 2020)
Sequence version 2 (01 Aug 1998)
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Protein

Glutathione reductase, mitochondrial

Gene

gsr-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Maintains high levels of reduced glutathione in the cytosol (PubMed:23593298). Involved in resistance to oxidative stress and starvation (PubMed:23593298). Together with thioredoxin reductase txtr-1, required for the reduction of disulfide groups in the cuticle during molting (PubMed:21199936).2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

FADBy similarityNote: Binds 1 FAD per subunit.By similarity

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=34.1 µM for glutathione disulfide (at 25 degrees Celsius)1 Publication
  2. KM=12.9 µM for NADPH (at 25 degrees Celsius)1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei456Proton acceptorBy similarity1

    Regions

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi50 – 58FADBy similarity9

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionOxidoreductase
    Biological processStress response
    LigandFAD, Flavoprotein, NADP

    Enzyme and pathway databases

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-CEL-3299685 Detoxification of Reactive Oxygen Species
    R-CEL-499943 Interconversion of nucleotide di- and triphosphates
    R-CEL-5628897 TP53 Regulates Metabolic Genes

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Glutathione reductase, mitochondrialBy similarity (EC:1.8.1.71 Publication)
    Short name:
    GRBy similarity
    Alternative name(s):
    Glutathione disulfide reductaseImported
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:gsr-1Imported
    ORF Names:C46F11.2Imported
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome III

    Organism-specific databases

    WormBase

    More...
    WormBasei
    C46F11.2a ; CE17558 ; WBGene00008117 ; gsr-1
    C46F11.2b ; CE08773 ; WBGene00008117 ; gsr-1

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Cytoplasm, Mitochondrion

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    <p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

    RNAi-mediated knockdown causes a severe decrease in survival upon treatment with oxidants including juglone, paraquat and to a lesser extent, cumen and tert-butylhydroperoxide (tBOOH). Enhances further the production of gamma-glutamylycysteine and glutathione disulfide upon juglone treatment. Increases gst-4 and gcs-1 expression. Reduces lifespan (PubMed:23593298). RNAi-mediated knockdown in a trxr-1 mutant background causes an arrest during larval molting characterized by a partial detachment of the old cuticle and an impaired ability to reduce cuticle components (PubMed:21199936).2 Publications

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – ?Mitochondrion1 Publication
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_0000436306? – 473Glutathione reductase, mitochondrialCurated

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi58 ↔ 63Redox-activeBy similarity

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    Q93379

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q93379

    PeptideAtlas

    More...
    PeptideAtlasi
    Q93379

    2D gel databases

    The World-2DPAGE database

    More...
    World-2DPAGEi
    0020:Q86DB5

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Expressed at all larval stages and in adults in intestine, vulva muscle, pharynx and some cells in the tail.2 Publications

    <p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

    Induced by the oxidant juglone and starvation.1 Publication

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    WBGene00008117 Expressed in germ line (C elegans) and 4 other tissues

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    Protein-protein interaction databases

    Database of interacting proteins

    More...
    DIPi
    DIP-27224N

    STRING: functional protein association networks

    More...
    STRINGi
    6239.C46F11.2a

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    Q93379

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.UniRule annotation

    Keywords - Domaini

    Redox-active center, Transit peptide

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG0405 Eukaryota
    COG1249 LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00940000156986

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q93379

    KEGG Orthology (KO)

    More...
    KOi
    K00383

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    KCAIIEA

    Database of Orthologous Groups

    More...
    OrthoDBi
    581771at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q93379

    Family and domain databases

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    3.30.390.30, 1 hit
    3.50.50.60, 2 hits

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR036188 FAD/NAD-bd_sf
    IPR023753 FAD/NAD-binding_dom
    IPR016156 FAD/NAD-linked_Rdtase_dimer_sf
    IPR006322 Glutathione_Rdtase_euk/bac
    IPR001100 Pyr_nuc-diS_OxRdtase
    IPR004099 Pyr_nucl-diS_OxRdtase_dimer
    IPR012999 Pyr_OxRdtase_I_AS

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR42737 PTHR42737, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF07992 Pyr_redox_2, 1 hit
    PF02852 Pyr_redox_dim, 1 hit

    PIRSF; a whole-protein classification database

    More...
    PIRSFi
    PIRSF000350 Mercury_reductase_MerA, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF51905 SSF51905, 1 hit
    SSF55424 SSF55424, 1 hit

    TIGRFAMs; a protein family database

    More...
    TIGRFAMsi
    TIGR01421 gluta_reduc_1, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS00076 PYRIDINE_REDOX_1, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
    Isoform aImported (identifier: Q93379-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MLRFRCILST SRSIMSGVKE FDYLVIGGGS GGIASARRAR EFGVSVGLIE
    60 70 80 90 100
    SGRLGGTCVN VGCVPKKVMY NCSLHAEFIR DHADYGFDVT LNKFDWKVIK
    110 120 130 140 150
    KSRDEYIKRL NGLYESGLKG SSVEYIRGRA TFAEDGTVEV NGAKYRGKNT
    160 170 180 190 200
    LIAVGGKPTI PNIKGAEHGI DSDGFFDLED LPSRTVVVGA GYIAVEIAGV
    210 220 230 240 250
    LANLGSDTHL LIRYDKVLRT FDKMLSDELT ADMDEETNPL HLHKNTQVTE
    260 270 280 290 300
    VIKGDDGLLT IKTTTGVIEK VQTLIWAIGR DPLTKELNLE RVGVKTDKSG
    310 320 330 340 350
    HIIVDEYQNT SAPGILSVGD DTGKFLLTPV AIAAGRRLSH RLFNGETDNK
    360 370 380 390 400
    LTYENIATVV FSHPLIGTVG LTEAEAVEKY GKDEVTLYKS RFNPMLFAVT
    410 420 430 440 450
    KHKEKAAMKL VCVGKDEKVV GVHVFGVGSD EMLQGFAVAV TMGATKKQFD
    460 470
    QTVAIHPTSA EELVTMRGGV KPE
    Length:473
    Mass (Da):51,467
    Last modified:August 1, 1998 - v2
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE1DAA50758109D80
    GO
    Isoform bImported (identifier: Q93379-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-14: Missing.

    Show »
    Length:459
    Mass (Da):49,802
    Checksum:i78492F3D546A703A
    GO

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0583431 – 14Missing in isoform b. CuratedAdd BLAST14

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    BX284603 Genomic DNA Translation: CAB03763.1
    BX284603 Genomic DNA Translation: CAD88214.1

    Protein sequence database of the Protein Information Resource

    More...
    PIRi
    T19972

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_001021220.1, NM_001026049.5 [Q93379-1]
    NP_001021221.1, NM_001026050.2 [Q93379-2]

    Genome annotation databases

    Ensembl metazoan genome annotation project

    More...
    EnsemblMetazoai
    C46F11.2a.1; C46F11.2a.1; WBGene00008117 [Q93379-1]
    C46F11.2b.1; C46F11.2b.1; WBGene00008117 [Q93379-2]
    C46F11.2b.2; C46F11.2b.2; WBGene00008117 [Q93379-2]
    C46F11.2b.3; C46F11.2b.3; WBGene00008117 [Q93379-2]

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    175467

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    cel:CELE_C46F11.2

    UCSC genome browser

    More...
    UCSCi
    C46F11.2a c. elegans

    Keywords - Coding sequence diversityi

    Alternative splicing

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    BX284603 Genomic DNA Translation: CAB03763.1
    BX284603 Genomic DNA Translation: CAD88214.1
    PIRiT19972
    RefSeqiNP_001021220.1, NM_001026049.5 [Q93379-1]
    NP_001021221.1, NM_001026050.2 [Q93379-2]

    3D structure databases

    SMRiQ93379
    ModBaseiSearch...

    Protein-protein interaction databases

    DIPiDIP-27224N
    STRINGi6239.C46F11.2a

    2D gel databases

    World-2DPAGEi0020:Q86DB5

    Proteomic databases

    EPDiQ93379
    PaxDbiQ93379
    PeptideAtlasiQ93379

    Genome annotation databases

    EnsemblMetazoaiC46F11.2a.1; C46F11.2a.1; WBGene00008117 [Q93379-1]
    C46F11.2b.1; C46F11.2b.1; WBGene00008117 [Q93379-2]
    C46F11.2b.2; C46F11.2b.2; WBGene00008117 [Q93379-2]
    C46F11.2b.3; C46F11.2b.3; WBGene00008117 [Q93379-2]
    GeneIDi175467
    KEGGicel:CELE_C46F11.2
    UCSCiC46F11.2a c. elegans

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    175467
    WormBaseiC46F11.2a ; CE17558 ; WBGene00008117 ; gsr-1
    C46F11.2b ; CE08773 ; WBGene00008117 ; gsr-1

    Phylogenomic databases

    eggNOGiKOG0405 Eukaryota
    COG1249 LUCA
    GeneTreeiENSGT00940000156986
    InParanoidiQ93379
    KOiK00383
    OMAiKCAIIEA
    OrthoDBi581771at2759
    PhylomeDBiQ93379

    Enzyme and pathway databases

    ReactomeiR-CEL-3299685 Detoxification of Reactive Oxygen Species
    R-CEL-499943 Interconversion of nucleotide di- and triphosphates
    R-CEL-5628897 TP53 Regulates Metabolic Genes

    Miscellaneous databases

    Protein Ontology

    More...
    PROi
    PR:Q93379

    Gene expression databases

    BgeeiWBGene00008117 Expressed in germ line (C elegans) and 4 other tissues

    Family and domain databases

    Gene3Di3.30.390.30, 1 hit
    3.50.50.60, 2 hits
    InterProiView protein in InterPro
    IPR036188 FAD/NAD-bd_sf
    IPR023753 FAD/NAD-binding_dom
    IPR016156 FAD/NAD-linked_Rdtase_dimer_sf
    IPR006322 Glutathione_Rdtase_euk/bac
    IPR001100 Pyr_nuc-diS_OxRdtase
    IPR004099 Pyr_nucl-diS_OxRdtase_dimer
    IPR012999 Pyr_OxRdtase_I_AS
    PANTHERiPTHR42737 PTHR42737, 1 hit
    PfamiView protein in Pfam
    PF07992 Pyr_redox_2, 1 hit
    PF02852 Pyr_redox_dim, 1 hit
    PIRSFiPIRSF000350 Mercury_reductase_MerA, 1 hit
    SUPFAMiSSF51905 SSF51905, 1 hit
    SSF55424 SSF55424, 1 hit
    TIGRFAMsiTIGR01421 gluta_reduc_1, 1 hit
    PROSITEiView protein in PROSITE
    PS00076 PYRIDINE_REDOX_1, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

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    ProtoNeti
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    MobiDB: a database of protein disorder and mobility annotations

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    MobiDBi
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    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGSHR_CAEEL
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q93379
    Secondary accession number(s): Q86DB5
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 8, 2016
    Last sequence update: August 1, 1998
    Last modified: February 26, 2020
    This is version 158 of the entry and version 2 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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