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UniProtKB - Q93353 (IDH3B_CAEEL)
Protein
Probable isocitrate dehydrogenase [NAD] subunit beta, mitochondrial
Gene
idhb-1
Organism
Caenorhabditis elegans
Status
Functioni
Catalytic activityi
- EC:1.1.1.41
Cofactori
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 129 | SubstrateBy similarity | 1 | |
Binding sitei | 161 | SubstrateBy similarity | 1 | |
Sitei | 168 | Critical for catalysisBy similarity | 1 | |
Sitei | 215 | Critical for catalysisBy similarity | 1 | |
Metal bindingi | 248 | MagnesiumBy similarity | 1 | |
Binding sitei | 248 | SubstrateBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 44 – 72 | NADSequence analysisAdd BLAST | 29 |
GO - Molecular functioni
- isocitrate dehydrogenase (NAD+) activity Source: UniProtKB-EC
- magnesium ion binding Source: InterPro
- NAD binding Source: InterPro
GO - Biological processi
- isocitrate metabolic process Source: GO_Central
- tricarboxylic acid cycle Source: GO_Central
Keywordsi
Molecular function | Oxidoreductase |
Biological process | Tricarboxylic acid cycle |
Ligand | Magnesium, Manganese, Metal-binding, NAD |
Enzyme and pathway databases
Reactomei | R-CEL-71403, Citric acid cycle (TCA cycle) |
Names & Taxonomyi
Protein namesi | Recommended name: Probable isocitrate dehydrogenase [NAD] subunit beta, mitochondrial (EC:1.1.1.41)Alternative name(s): Isocitric dehydrogenase subunit beta NAD(+)-specific ICDH subunit beta |
Gene namesi | Name:idhb-1 ORF Names:C37E2.1 |
Organismi | Caenorhabditis elegans |
Taxonomic identifieri | 6239 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditina › Rhabditomorpha › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis |
Proteomesi |
|
Organism-specific databases
WormBasei | C37E2.1 ; CE08620 ; WBGene00007993 ; idhb-1 |
Subcellular locationi
Mitochondrion
- Mitochondrion By similarity
Mitochondrion
- mitochondrion Source: GO_Central
Keywords - Cellular componenti
MitochondrionPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 31 | MitochondrionBy similarityAdd BLAST | 31 | |
ChainiPRO_0000014448 | 32 – 379 | Probable isocitrate dehydrogenase [NAD] subunit beta, mitochondrialAdd BLAST | 348 |
Proteomic databases
EPDi | Q93353 |
PaxDbi | Q93353 |
PeptideAtlasi | Q93353 |
Expressioni
Gene expression databases
Bgeei | WBGene00007993, Expressed in material anatomical entity and 5 other tissues |
Interactioni
Subunit structurei
Heterooligomer of subunits alpha, beta, and gamma in the apparent ratio of 2:1:1.
By similarityProtein-protein interaction databases
BioGRIDi | 46427, 7 interactors |
DIPi | DIP-27476N |
IntActi | Q93353, 1 interactor |
STRINGi | 6239.C37E2.1.1 |
Family & Domainsi
Sequence similaritiesi
Belongs to the isocitrate and isopropylmalate dehydrogenases family.Curated
Keywords - Domaini
Transit peptidePhylogenomic databases
eggNOGi | KOG0784, Eukaryota |
GeneTreei | ENSGT00950000182989 |
HOGENOMi | CLU_031953_0_1_1 |
InParanoidi | Q93353 |
OMAi | TCAHKAN |
OrthoDBi | 868374at2759 |
PhylomeDBi | Q93353 |
Family and domain databases
InterProi | View protein in InterPro IPR019818, IsoCit/isopropylmalate_DH_CS IPR004434, Isocitrate_DH_NAD IPR024084, IsoPropMal-DH-like_dom |
Pfami | View protein in Pfam PF00180, Iso_dh, 1 hit |
SMARTi | View protein in SMART SM01329, Iso_dh, 1 hit |
TIGRFAMsi | TIGR00175, mito_nad_idh, 1 hit |
PROSITEi | View protein in PROSITE PS00470, IDH_IMDH, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q93353-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLSRTVSSLS RVAPQTLGAV NAASSRQYSI TAPRPPTELN QKLKVTIIPG
60 70 80 90 100
DGVGPELIYT VQDIVKQTGI PIEFEEIFLS EVHYTRSSSI ENAVESIGRN
110 120 130 140 150
NNVALKGAIE ESAVLHTEGE LQGLNMRLRR SLDLFANVVH IKTLDGIKTR
160 170 180 190 200
HGKQLDFVIV REQTEGEYSS LEHELVPGVI ECLKISTRTK AERIAKFAFD
210 220 230 240 250
YATKTGRKKV TAVHKANIMK LGDGLFLRTC EGVAKQYPKI QFESMIIDNT
260 270 280 290 300
CMQLVSKPEQ FDVMVMPNLY GNIIDNLAAG LVGGAGVVPG QSVGRDFVIF
310 320 330 340 350
EPGSRHSFQE AMGRSIANPT AMILCAANML NHLHLDAWGN SLRQAVADVV
360 370
KEGKVRTRDL GGYATTVDFA DAVIDKFRI
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z81046 Genomic DNA Translation: CAB02822.1 |
PIRi | T19810 |
RefSeqi | NP_510362.1, NM_077961.5 |
Genome annotation databases
EnsemblMetazoai | C37E2.1.1; C37E2.1.1; WBGene00007993 C37E2.1.2; C37E2.1.2; WBGene00007993 |
GeneIDi | 181528 |
KEGGi | cel:CELE_C37E2.1 |
UCSCi | C37E2.1.2, c. elegans |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z81046 Genomic DNA Translation: CAB02822.1 |
PIRi | T19810 |
RefSeqi | NP_510362.1, NM_077961.5 |
3D structure databases
AlphaFoldDBi | Q93353 |
SMRi | Q93353 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 46427, 7 interactors |
DIPi | DIP-27476N |
IntActi | Q93353, 1 interactor |
STRINGi | 6239.C37E2.1.1 |
Proteomic databases
EPDi | Q93353 |
PaxDbi | Q93353 |
PeptideAtlasi | Q93353 |
Genome annotation databases
EnsemblMetazoai | C37E2.1.1; C37E2.1.1; WBGene00007993 C37E2.1.2; C37E2.1.2; WBGene00007993 |
GeneIDi | 181528 |
KEGGi | cel:CELE_C37E2.1 |
UCSCi | C37E2.1.2, c. elegans |
Organism-specific databases
CTDi | 181528 |
WormBasei | C37E2.1 ; CE08620 ; WBGene00007993 ; idhb-1 |
Phylogenomic databases
eggNOGi | KOG0784, Eukaryota |
GeneTreei | ENSGT00950000182989 |
HOGENOMi | CLU_031953_0_1_1 |
InParanoidi | Q93353 |
OMAi | TCAHKAN |
OrthoDBi | 868374at2759 |
PhylomeDBi | Q93353 |
Enzyme and pathway databases
Reactomei | R-CEL-71403, Citric acid cycle (TCA cycle) |
Miscellaneous databases
PROi | PR:Q93353 |
Gene expression databases
Bgeei | WBGene00007993, Expressed in material anatomical entity and 5 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR019818, IsoCit/isopropylmalate_DH_CS IPR004434, Isocitrate_DH_NAD IPR024084, IsoPropMal-DH-like_dom |
Pfami | View protein in Pfam PF00180, Iso_dh, 1 hit |
SMARTi | View protein in SMART SM01329, Iso_dh, 1 hit |
TIGRFAMsi | TIGR00175, mito_nad_idh, 1 hit |
PROSITEi | View protein in PROSITE PS00470, IDH_IMDH, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | IDH3B_CAEEL | |
Accessioni | Q93353Primary (citable) accession number: Q93353 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1998 |
Last sequence update: | February 1, 1997 | |
Last modified: | May 25, 2022 | |
This is version 137 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Caenorhabditis annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Caenorhabditis elegans
Caenorhabditis elegans: entries, gene names and cross-references to WormBase - SIMILARITY comments
Index of protein domains and families