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Protein

Glutathione S-transferase 1, isoform C

Gene

GstD1

Organism
Anopheles gambiae (African malaria mosquito)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has DDT dehydrochlorinase activity.1 Publication

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.1 Publication
1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane = 1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene + chloride.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei9GlutathioneBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase 1, isoform C (EC:2.5.1.18, EC:4.5.1.1)
Alternative name(s):
AgGst1-alpha
Aggst1-5
DDT-dehydrochlorinase
GST class-theta
Gene namesi
Name:GstD1
Synonyms:GST1a
ORF Names:AGAP004164
OrganismiAnopheles gambiae (African malaria mosquito)
Taxonomic identifieri7165 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraNematoceraCulicoideaCulicidaeAnophelinaeAnopheles
Proteomesi
  • UP000007062 Componentsi: Chromosome 2R, Unassembled WGS sequence

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001859611 – 209Glutathione S-transferase 1, isoform CAdd BLAST209

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ93112
SMRiQ93112
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 80GST N-terminalAdd BLAST80
Domaini86 – 207GST C-terminalAdd BLAST122

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni50 – 52Glutathione bindingBy similarity3
Regioni64 – 66Glutathione bindingBy similarity3

Sequence similaritiesi

Belongs to the GST superfamily. Theta family.Curated

Phylogenomic databases

HOGENOMiHOG000125741
OMAiESNTICR
OrthoDBiEOG091G0MS3

Family and domain databases

InterProiView protein in InterPro
IPR010987 Glutathione-S-Trfase_C-like
IPR036282 Glutathione-S-Trfase_C_sf
IPR004045 Glutathione_S-Trfase_N
IPR004046 GST_C
IPR036249 Thioredoxin-like_sf
PfamiView protein in Pfam
PF00043 GST_C, 1 hit
PF13417 GST_N_3, 1 hit
SUPFAMiSSF47616 SSF47616, 1 hit
SSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS50405 GST_CTER, 1 hit
PS50404 GST_NTER, 1 hit

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform C (identifier: Q93112-1) [UniParc]FASTAAdd to basket
Also known as: 1-5

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDFYYLPGSA PCRAVQMTAA AVGVELNLKL TDLMKGEHMK PEFLKINPQH
60 70 80 90 100
CIPTLVDNGF ALWESRAICT YLAEKYGKDD KLYPKDPQKR AVVNQRMYFD
110 120 130 140 150
MGTLYQRFAD YYYPQIFAKQ PANPENEQKM KDAVGFLNSF LDGHKYVAGD
160 170 180 190 200
SLTIADLSIL ATISTYDVAG FDLAKYQHVA AWYENIRKEA PGAAINQAGI

EEFKKYFEK
Length:209
Mass (Da):23,783
Last modified:May 16, 2006 - v2
Checksum:iED01B322C2715409
GO
Isoform A (identifier: O77462-1) [UniParc]FASTAAdd to basket
Also known as: 1-3
The sequence of this isoform can be found in the external entry O77462.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:186
Mass (Da):21,255
GO
Isoform B (identifier: O77473-1) [UniParc]FASTAAdd to basket
Also known as: 1-4
The sequence of this isoform can be found in the external entry O77473.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:216
Mass (Da):24,492
GO
Isoform D (identifier: Q93113-1) [UniParc]FASTAAdd to basket
Also known as: 1-1, 1-6, 2-1
The sequence of this isoform can be found in the external entry Q93113.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:209
Mass (Da):23,445
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti135G → D in CAB03592 (PubMed:9038148).Curated1
Sequence conflicti139S → T in CAB03592 (PubMed:9038148).Curated1
Sequence conflicti181A → V in CAB03592 (PubMed:9038148).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z81291 mRNA Translation: CAB03592.1
AF071160 Genomic DNA Translation: AAC79993.1
AAAB01008880 Genomic DNA Translation: EAA08605.2
RefSeqiXP_313049.1, XM_313049.4

Genome annotation databases

EnsemblMetazoaiAGAP004164-RA; AGAP004164-PA; AGAP004164 [Q93112-1]
GeneIDi1273988
VectorBaseiAGAP004164-RA; AGAP004164-PA; AGAP004164

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z81291 mRNA Translation: CAB03592.1
AF071160 Genomic DNA Translation: AAC79993.1
AAAB01008880 Genomic DNA Translation: EAA08605.2
RefSeqiXP_313049.1, XM_313049.4

3D structure databases

ProteinModelPortaliQ93112
SMRiQ93112
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiAGAP004164-RA; AGAP004164-PA; AGAP004164 [Q93112-1]
GeneIDi1273988
VectorBaseiAGAP004164-RA; AGAP004164-PA; AGAP004164

Organism-specific databases

CTDi1273988

Phylogenomic databases

HOGENOMiHOG000125741
OMAiESNTICR
OrthoDBiEOG091G0MS3

Family and domain databases

InterProiView protein in InterPro
IPR010987 Glutathione-S-Trfase_C-like
IPR036282 Glutathione-S-Trfase_C_sf
IPR004045 Glutathione_S-Trfase_N
IPR004046 GST_C
IPR036249 Thioredoxin-like_sf
PfamiView protein in Pfam
PF00043 GST_C, 1 hit
PF13417 GST_N_3, 1 hit
SUPFAMiSSF47616 SSF47616, 1 hit
SSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS50405 GST_CTER, 1 hit
PS50404 GST_NTER, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGST1C_ANOGA
AccessioniPrimary (citable) accession number: Q93112
Secondary accession number(s): O76482, Q7PQM5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 16, 2006
Last modified: October 25, 2017
This is version 116 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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