WNT8B

Functionⁱ

Ligand for members of the frizzled family of seven transmembrane receptors. May play an important role in the development and differentiation of certain forebrain structures, notably the hippocampus.1 Publication

GO - Molecular functionⁱ

frizzled binding Source: GO_Central
receptor ligand activity
Source: WormBase
Inferred from direct assayⁱ
- 28733458

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

beta-catenin destruction complex disassembly Source: Reactome
canonical Wnt signaling pathway
Source: WormBase
Inferred from direct assayⁱ
- 28733458
cell fate commitment Source: GO_Central
cellular response to retinoic acid Source: UniProtKB
determination of dorsal identity
Source: BHF-UCL
Inferred from sequence or structural similarityⁱ
- 7635061
gastrulation
Source: BHF-UCL
Inferred from sequence or structural similarityⁱ
- 7635061
nervous system development
Source: ProtInc
Traceable author statementⁱ
- 9536085
neuron differentiation Source: UniProtKB
response to estradiol
Source: BHF-UCL
Non-traceable author statementⁱ
- 11956596
response to retinoic acid
Source: BHF-UCL
Non-traceable author statementⁱ
- 11956596
signal transduction
Source: ProtInc
Traceable author statementⁱ
- 9536085
Wnt signaling pathway Source: GO_Central

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Developmental protein
Biological process	Wnt signaling pathway

Enzyme and pathway databases

Reactomeⁱ	R-HSA-201681 TCF dependent signaling in response to WNT R-HSA-3238698 WNT ligand biogenesis and trafficking R-HSA-373080 Class B/2 (Secretin family receptors) R-HSA-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane
SIGNORⁱ	Q93098

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Protein Wnt-8b
Gene namesⁱ	Name:WNT8B
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 10

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000075290.7
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:12789 WNT8B
MIMⁱ	601396 gene
neXtProtⁱ	NX_Q93098

Keywords - Cellular componentⁱ

Extracellular matrix, Secreted

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	7479
Open Targets More...OpenTargetsⁱ	ENSG00000075290
PharmGKBⁱ	PA37390

Polymorphism and mutation databases

BioMutaⁱ	WNT8B
DMDMⁱ	66774217

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 22	Sequence analysisAdd BLAST		22
ChainⁱPRO_0000041450	23 – 351	Protein Wnt-8bAdd BLAST		329

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	54 ↔ 65	By similarity
Glycosylationⁱ	103	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	104 ↔ 112	By similarity
Disulfide bondⁱ	114 ↔ 132	By similarity
Disulfide bondⁱ	180 ↔ 194	By similarity
Disulfide bondⁱ	182 ↔ 189	By similarity
Lipidationⁱ	186	O-palmitoleoyl serineBy similarity	1
Disulfide bondⁱ	256 ↔ 294	By similarity
Glycosylationⁱ	259	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	272 ↔ 287	By similarity
Disulfide bondⁱ	291 ↔ 333	By similarity
Disulfide bondⁱ	309 ↔ 324	By similarity
Disulfide bondⁱ	311 ↔ 321	By similarity
Disulfide bondⁱ	316 ↔ 317	By similarity

Post-translational modificationⁱ

Palmitoleoylation is required for efficient binding to frizzled receptors (By similarity). Depalmitoleoylation leads to Wnt signaling pathway inhibition (By similarity).By similarity

Proteolytic processing by TIKI1 and TIKI2 promotes oxidation and formation of large disulfide-bond oligomers, leading to inactivation of WNT8B.By similarity

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Lipoprotein

Proteomic databases

PaxDbⁱ	Q93098
PRIDEⁱ	Q93098
ProteomicsDBⁱ	75724

Expressionⁱ

Tissue specificityⁱ

Expression is restricted to the brain, and more specifically to the forebrain.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000075290 Expressed in 21 organ(s), highest expression level in liver
CleanExⁱ	HS_WNT8B
Genevisibleⁱ	Q93098 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA036570

HPAⁱ

HPA036570

Interactionⁱ

GO - Molecular functionⁱ

frizzled binding Source: GO_Central
receptor ligand activity
Source: WormBase
Inferred from direct assayⁱ
- 28733458

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000340677

STRINGⁱ

9606.ENSP00000340677

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q93098
SMRⁱ	Q93098
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the Wnt family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	KOG3913 Eukaryota ENOG410XQZ1 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00690000101857
HOGENOMⁱ	HOG000039529
HOVERGENⁱ	HBG001595
InParanoidⁱ	Q93098
KEGG Orthology (KO) More...KOⁱ	K00714
OMAⁱ	KWEKRSC
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0B1B
PhylomeDBⁱ	Q93098
TreeFamⁱ	TF105310

Family and domain databases

InterProⁱ	View protein in InterPro IPR034311 Protein_Wnt-8B IPR005817 Wnt IPR013301 Wnt8 IPR018161 Wnt_CS
PANTHERⁱ	PTHR12027 PTHR12027, 1 hit PTHR12027:SF94 PTHR12027:SF94, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00110 wnt, 1 hit
PRINTSⁱ	PR01892 WNT8PROTEIN PR01349 WNTPROTEIN
SMARTⁱ	View protein in SMART SM00097 WNT1, 1 hit
PROSITEⁱ	View protein in PROSITE PS00246 WNT1, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

Q93098-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MFLSKPSVYI CLFTCVLQLS HSWSVNNFLM TGPKAYLIYS SSVAAGAQSG 
        60         70         80         90        100
IEECKYQFAW DRWNCPERAL QLSSHGGLRS ANRETAFVHA ISSAGVMYTL 
       110        120        130        140        150
TRNCSLGDFD NCGCDDSRNG QLGGQGWLWG GCSDNVGFGE AISKQFVDAL 
       160        170        180        190        200
ETGQDARAAM NLHNNEAGRK AVKGTMKRTC KCHGVSGSCT TQTCWLQLPE 
       210        220        230        240        250
FREVGAHLKE KYHAALKVDL LQGAGNSAAG RGAIADTFRS ISTRELVHLE 
       260        270        280        290        300
DSPDYCLENK TLGLLGTEGR ECLRRGRALG RWERRSCRRL CGDCGLAVEE 
       310        320        330        340        350
RRAETVSSCN CKFHWCCAVR CEQCRRRVTK YFCSRAERPR GGAAHKPGRK 

P

Length:351

Mass (Da):38,721

Last modified:May 24, 2005 - v3

Checksum:ⁱDD242070948813F8

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	230	G → A (PubMed:9536085).Curated	1
Sequence conflictⁱ	230	G → A (PubMed:8661156).Curated	1
Sequence conflictⁱ	284	R → L (PubMed:9536085).Curated	1
Sequence conflictⁱ	284	R → L (PubMed:8661156).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_020310	11	C → S. Corresponds to variant dbSNP:rs3793771Ensembl.		1
Natural variantⁱVAR_036288	53	E → Q in a colorectal cancer sample; somatic mutation. 1 Publication		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Y11094 mRNA Translation: CAA71968.1 Y11108 Genomic DNA Translation: CAA71994.1 AB073637 mRNA Translation: BAB83924.1 AL359759 Genomic DNA No translation available. AL133352 Genomic DNA No translation available. X91940 mRNA Translation: CAA63017.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS7494.1
NCBI Reference Sequences More...RefSeqⁱ	NP_003384.2, NM_003393.3
UniGeneⁱ	Hs.421281

Genome annotation databases

Ensemblⁱ	ENST00000343737; ENSP00000340677; ENSG00000075290
GeneIDⁱ	7479
KEGGⁱ	hsa:7479
UCSC genome browser More...UCSCⁱ	uc001krb.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q93098	Protein Wnt		CERAT		353	UniRef90_Q93098
Protein Wnt		RHIRO		353
Protein Wnt		MACFA		353
Protein Wnt		Cebus capucinus imitator		351
Protein Wnt		AOTNA		351
+77

Protein	Similar proteins		Species	Score	Length	Source
Q93098	Protein Wnt-8a		DANRE		359	UniRef50_P51028
Protein Wnt-8a		HUMAN		351
Protein Wnt-8 (Fragment)		THUTH		128
Protein Wnt-8b		XENLA		428
Protein Wnt-8c		CHICK		357
+502

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Y11094 mRNA Translation: CAA71968.1 Y11108 Genomic DNA Translation: CAA71994.1 AB073637 mRNA Translation: BAB83924.1 AL359759 Genomic DNA No translation available. AL133352 Genomic DNA No translation available. X91940 mRNA Translation: CAA63017.1
CCDSⁱ	CCDS7494.1
RefSeqⁱ	NP_003384.2, NM_003393.3
UniGeneⁱ	Hs.421281

3D structure databases

ProteinModelPortalⁱ	Q93098
SMRⁱ	Q93098
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000340677

STRINGⁱ

9606.ENSP00000340677

Polymorphism and mutation databases

BioMutaⁱ	WNT8B
DMDMⁱ	66774217

Proteomic databases

PaxDbⁱ	Q93098
PRIDEⁱ	Q93098
ProteomicsDBⁱ	75724

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	7479
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000343737; ENSP00000340677; ENSG00000075290
GeneIDⁱ	7479
KEGGⁱ	hsa:7479
UCSCⁱ	uc001krb.4 human

Organism-specific databases

CTDⁱ	7479
DisGeNETⁱ	7479
EuPathDBⁱ	HostDB:ENSG00000075290.7
GeneCardsⁱ	WNT8B
HGNCⁱ	HGNC:12789 WNT8B
HPAⁱ	HPA036570
MIMⁱ	601396 gene
neXtProtⁱ	NX_Q93098
OpenTargetsⁱ	ENSG00000075290
PharmGKBⁱ	PA37390
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3913 Eukaryota ENOG410XQZ1 LUCA
GeneTreeⁱ	ENSGT00690000101857
HOGENOMⁱ	HOG000039529
HOVERGENⁱ	HBG001595
InParanoidⁱ	Q93098
KOⁱ	K00714
OMAⁱ	KWEKRSC
OrthoDBⁱ	EOG091G0B1B
PhylomeDBⁱ	Q93098
TreeFamⁱ	TF105310

Enzyme and pathway databases

Reactomeⁱ	R-HSA-201681 TCF dependent signaling in response to WNT R-HSA-3238698 WNT ligand biogenesis and trafficking R-HSA-373080 Class B/2 (Secretin family receptors) R-HSA-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane
SIGNORⁱ	Q93098

Miscellaneous databases

ChiTaRSⁱ	WNT8B human
GeneWikiⁱ	WNT8B
GenomeRNAiⁱ	7479
Protein Ontology More...PROⁱ	PR:Q93098
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000075290 Expressed in 21 organ(s), highest expression level in liver
CleanExⁱ	HS_WNT8B
Genevisibleⁱ	Q93098 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR034311 Protein_Wnt-8B IPR005817 Wnt IPR013301 Wnt8 IPR018161 Wnt_CS
PANTHERⁱ	PTHR12027 PTHR12027, 1 hit PTHR12027:SF94 PTHR12027:SF94, 1 hit
Pfamⁱ	View protein in Pfam PF00110 wnt, 1 hit
PRINTSⁱ	PR01892 WNT8PROTEIN PR01349 WNTPROTEIN
SMARTⁱ	View protein in SMART SM00097 WNT1, 1 hit
PROSITEⁱ	View protein in PROSITE PS00246 WNT1, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	WNT8B_HUMAN
Accessionⁱ	Q93098Primary (citable) accession number: Q93098 Secondary accession number(s): O00771, Q5VX55, Q8WYK9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
	Last sequence update:	May 24, 2005
	Last modified:	September 12, 2018
	This is version 154 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q93098 (WNT8B_HUMAN)

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Protein Wnt-8b

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ