UniProtKB - Q93098 (WNT8B_HUMAN)
Protein
Protein Wnt-8b
Gene
WNT8B
Organism
Homo sapiens (Human)
Status
Functioni
Ligand for members of the frizzled family of seven transmembrane receptors. May play an important role in the development and differentiation of certain forebrain structures, notably the hippocampus.1 Publication
GO - Molecular functioni
- cytokine activity Source: GO_Central
- frizzled binding Source: GO_Central
- receptor ligand activity Source: WormBase
GO - Biological processi
- beta-catenin destruction complex disassembly Source: Reactome
- canonical Wnt signaling pathway Source: WormBase
- cell fate commitment Source: GO_Central
- cellular response to retinoic acid Source: UniProtKB
- determination of dorsal identity Source: BHF-UCL
- gastrulation Source: BHF-UCL
- nervous system development Source: ProtInc
- neuron differentiation Source: UniProtKB
- response to estradiol Source: BHF-UCL
- response to retinoic acid Source: BHF-UCL
- signal transduction Source: ProtInc
- Wnt signaling pathway Source: Reactome
Keywordsi
Molecular function | Developmental protein |
Biological process | Wnt signaling pathway |
Enzyme and pathway databases
PathwayCommonsi | Q93098 |
Reactomei | R-HSA-201681, TCF dependent signaling in response to WNT R-HSA-3238698, WNT ligand biogenesis and trafficking R-HSA-373080, Class B/2 (Secretin family receptors) R-HSA-4641262, Disassembly of the destruction complex and recruitment of AXIN to the membrane |
SIGNORi | Q93098 |
Names & Taxonomyi
Protein namesi | Recommended name: Protein Wnt-8b |
Gene namesi | Name:WNT8B |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000075290.7 |
HGNCi | HGNC:12789, WNT8B |
MIMi | 601396, gene |
neXtProti | NX_Q93098 |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular region Source: Reactome
- extracellular space Source: GO_Central
Keywords - Cellular componenti
Extracellular matrix, SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 7479 |
OpenTargetsi | ENSG00000075290 |
PharmGKBi | PA37390 |
Miscellaneous databases
Pharosi | Q93098, Tbio |
Polymorphism and mutation databases
BioMutai | WNT8B |
DMDMi | 66774217 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 22 | Sequence analysisAdd BLAST | 22 | |
ChainiPRO_0000041450 | 23 – 351 | Protein Wnt-8bAdd BLAST | 329 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 54 ↔ 65 | By similarity | ||
Glycosylationi | 103 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 104 ↔ 112 | By similarity | ||
Disulfide bondi | 114 ↔ 132 | By similarity | ||
Disulfide bondi | 180 ↔ 194 | By similarity | ||
Disulfide bondi | 182 ↔ 189 | By similarity | ||
Lipidationi | 186 | O-palmitoleoyl serineBy similarity | 1 | |
Disulfide bondi | 256 ↔ 294 | By similarity | ||
Glycosylationi | 259 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 272 ↔ 287 | By similarity | ||
Disulfide bondi | 291 ↔ 333 | By similarity | ||
Disulfide bondi | 309 ↔ 324 | By similarity | ||
Disulfide bondi | 311 ↔ 321 | By similarity | ||
Disulfide bondi | 316 ↔ 317 | By similarity |
Post-translational modificationi
Palmitoleoylation is required for efficient binding to frizzled receptors (By similarity). Depalmitoleoylation leads to Wnt signaling pathway inhibition (By similarity).By similarity
Proteolytic processing by TIKI1 and TIKI2 promotes oxidation and formation of large disulfide-bond oligomers, leading to inactivation of WNT8B.By similarity
Keywords - PTMi
Disulfide bond, Glycoprotein, LipoproteinProteomic databases
MassIVEi | Q93098 |
PaxDbi | Q93098 |
PeptideAtlasi | Q93098 |
PRIDEi | Q93098 |
ProteomicsDBi | 75724 |
PTM databases
GlyGeni | Q93098, 2 sites |
iPTMneti | Q93098 |
Expressioni
Tissue specificityi
Expression is restricted to the brain, and more specifically to the forebrain.1 Publication
Gene expression databases
Bgeei | ENSG00000075290, Expressed in adult mammalian kidney and 29 other tissues |
ExpressionAtlasi | Q93098, baseline and differential |
Genevisiblei | Q93098, HS |
Organism-specific databases
HPAi | ENSG00000075290, Tissue enhanced (adrenal gland, parathyroid gland) |
Interactioni
GO - Molecular functioni
- cytokine activity Source: GO_Central
- frizzled binding Source: GO_Central
- receptor ligand activity Source: WormBase
Protein-protein interaction databases
IntActi | Q93098, 2 interactors |
STRINGi | 9606.ENSP00000340677 |
Miscellaneous databases
RNActi | Q93098, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the Wnt family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | KOG3913, Eukaryota |
GeneTreei | ENSGT00940000160584 |
HOGENOMi | CLU_033039_1_2_1 |
InParanoidi | Q93098 |
OMAi | NCGCDDT |
OrthoDBi | 618621at2759 |
PhylomeDBi | Q93098 |
TreeFami | TF105310 |
Family and domain databases
Gene3Di | 3.30.2460.20, 1 hit |
InterProi | View protein in InterPro IPR034311, Protein_Wnt-8B IPR005817, Wnt IPR013301, Wnt8 IPR043158, Wnt_C IPR018161, Wnt_CS |
PANTHERi | PTHR12027, PTHR12027, 1 hit PTHR12027:SF94, PTHR12027:SF94, 1 hit |
Pfami | View protein in Pfam PF00110, wnt, 1 hit |
PRINTSi | PR01892, WNT8PROTEIN PR01349, WNTPROTEIN |
SMARTi | View protein in SMART SM00097, WNT1, 1 hit |
PROSITEi | View protein in PROSITE PS00246, WNT1, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q93098-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MFLSKPSVYI CLFTCVLQLS HSWSVNNFLM TGPKAYLIYS SSVAAGAQSG
60 70 80 90 100
IEECKYQFAW DRWNCPERAL QLSSHGGLRS ANRETAFVHA ISSAGVMYTL
110 120 130 140 150
TRNCSLGDFD NCGCDDSRNG QLGGQGWLWG GCSDNVGFGE AISKQFVDAL
160 170 180 190 200
ETGQDARAAM NLHNNEAGRK AVKGTMKRTC KCHGVSGSCT TQTCWLQLPE
210 220 230 240 250
FREVGAHLKE KYHAALKVDL LQGAGNSAAG RGAIADTFRS ISTRELVHLE
260 270 280 290 300
DSPDYCLENK TLGLLGTEGR ECLRRGRALG RWERRSCRRL CGDCGLAVEE
310 320 330 340 350
RRAETVSSCN CKFHWCCAVR CEQCRRRVTK YFCSRAERPR GGAAHKPGRK
P
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 230 | G → A (PubMed:9536085).Curated | 1 | |
Sequence conflicti | 230 | G → A (PubMed:8661156).Curated | 1 | |
Sequence conflicti | 284 | R → L (PubMed:9536085).Curated | 1 | |
Sequence conflicti | 284 | R → L (PubMed:8661156).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_020310 | 11 | C → S. Corresponds to variant dbSNP:rs3793771Ensembl. | 1 | |
Natural variantiVAR_036288 | 53 | E → Q in a colorectal cancer sample; somatic mutation. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y11094 mRNA Translation: CAA71968.1 Y11108 Genomic DNA Translation: CAA71994.1 AB073637 mRNA Translation: BAB83924.1 AL359759 Genomic DNA No translation available. AL133352 Genomic DNA No translation available. X91940 mRNA Translation: CAA63017.1 |
CCDSi | CCDS7494.1 |
RefSeqi | NP_003384.2, NM_003393.3 |
Genome annotation databases
Ensembli | ENST00000343737; ENSP00000340677; ENSG00000075290 |
GeneIDi | 7479 |
KEGGi | hsa:7479 |
UCSCi | uc001krb.4, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y11094 mRNA Translation: CAA71968.1 Y11108 Genomic DNA Translation: CAA71994.1 AB073637 mRNA Translation: BAB83924.1 AL359759 Genomic DNA No translation available. AL133352 Genomic DNA No translation available. X91940 mRNA Translation: CAA63017.1 |
CCDSi | CCDS7494.1 |
RefSeqi | NP_003384.2, NM_003393.3 |
3D structure databases
SMRi | Q93098 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | Q93098, 2 interactors |
STRINGi | 9606.ENSP00000340677 |
PTM databases
GlyGeni | Q93098, 2 sites |
iPTMneti | Q93098 |
Polymorphism and mutation databases
BioMutai | WNT8B |
DMDMi | 66774217 |
Proteomic databases
MassIVEi | Q93098 |
PaxDbi | Q93098 |
PeptideAtlasi | Q93098 |
PRIDEi | Q93098 |
ProteomicsDBi | 75724 |
Protocols and materials databases
Antibodypediai | 17653, 222 antibodies |
DNASUi | 7479 |
Genome annotation databases
Ensembli | ENST00000343737; ENSP00000340677; ENSG00000075290 |
GeneIDi | 7479 |
KEGGi | hsa:7479 |
UCSCi | uc001krb.4, human |
Organism-specific databases
CTDi | 7479 |
DisGeNETi | 7479 |
EuPathDBi | HostDB:ENSG00000075290.7 |
GeneCardsi | WNT8B |
HGNCi | HGNC:12789, WNT8B |
HPAi | ENSG00000075290, Tissue enhanced (adrenal gland, parathyroid gland) |
MIMi | 601396, gene |
neXtProti | NX_Q93098 |
OpenTargetsi | ENSG00000075290 |
PharmGKBi | PA37390 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3913, Eukaryota |
GeneTreei | ENSGT00940000160584 |
HOGENOMi | CLU_033039_1_2_1 |
InParanoidi | Q93098 |
OMAi | NCGCDDT |
OrthoDBi | 618621at2759 |
PhylomeDBi | Q93098 |
TreeFami | TF105310 |
Enzyme and pathway databases
PathwayCommonsi | Q93098 |
Reactomei | R-HSA-201681, TCF dependent signaling in response to WNT R-HSA-3238698, WNT ligand biogenesis and trafficking R-HSA-373080, Class B/2 (Secretin family receptors) R-HSA-4641262, Disassembly of the destruction complex and recruitment of AXIN to the membrane |
SIGNORi | Q93098 |
Miscellaneous databases
BioGRID-ORCSi | 7479, 4 hits in 845 CRISPR screens |
GeneWikii | WNT8B |
GenomeRNAii | 7479 |
Pharosi | Q93098, Tbio |
PROi | PR:Q93098 |
RNActi | Q93098, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000075290, Expressed in adult mammalian kidney and 29 other tissues |
ExpressionAtlasi | Q93098, baseline and differential |
Genevisiblei | Q93098, HS |
Family and domain databases
Gene3Di | 3.30.2460.20, 1 hit |
InterProi | View protein in InterPro IPR034311, Protein_Wnt-8B IPR005817, Wnt IPR013301, Wnt8 IPR043158, Wnt_C IPR018161, Wnt_CS |
PANTHERi | PTHR12027, PTHR12027, 1 hit PTHR12027:SF94, PTHR12027:SF94, 1 hit |
Pfami | View protein in Pfam PF00110, wnt, 1 hit |
PRINTSi | PR01892, WNT8PROTEIN PR01349, WNTPROTEIN |
SMARTi | View protein in SMART SM00097, WNT1, 1 hit |
PROSITEi | View protein in PROSITE PS00246, WNT1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | WNT8B_HUMAN | |
Accessioni | Q93098Primary (citable) accession number: Q93098 Secondary accession number(s): O00771, Q5VX55, Q8WYK9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | May 24, 2005 | |
Last modified: | December 2, 2020 | |
This is version 167 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations