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Protein

Protein Wnt-2b

Gene

WNT2B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt/beta-catenin signaling pathway. Plays a redundant role in embryonic lung development.By similarity

GO - Molecular functioni

  • frizzled binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processWnt signaling pathway

Enzyme and pathway databases

ReactomeiR-HSA-3238698 WNT ligand biogenesis and trafficking
R-HSA-373080 Class B/2 (Secretin family receptors)
SIGNORiQ93097

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Wnt-2b
Alternative name(s):
Protein Wnt-131 Publication
Gene namesi
Name:WNT2B
Synonyms:WNT13
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000134245.17
HGNCiHGNC:12781 WNT2B
MIMi601968 gene
neXtProtiNX_Q93097

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi7482
MalaCardsiWNT2B
OpenTargetsiENSG00000134245
PharmGKBiPA37382

Polymorphism and mutation databases

BioMutaiWNT2B
DMDMi14424481

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000041413? – 391Protein Wnt-2b
Signal peptidei1 – ?Sequence analysis

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi107 ↔ 118By similarity
Glycosylationi117N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi158 ↔ 166By similarity
Disulfide bondi168 ↔ 188By similarity
Disulfide bondi237 ↔ 251By similarity
Disulfide bondi239 ↔ 246By similarity
Lipidationi243O-palmitoleoyl serine; by PORCNBy similarity1
Glycosylationi283N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi325 ↔ 340By similarity
Disulfide bondi355 ↔ 370By similarity
Disulfide bondi357 ↔ 367By similarity
Disulfide bondi362 ↔ 363By similarity

Post-translational modificationi

Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein

Proteomic databases

PaxDbiQ93097
PeptideAtlasiQ93097
PRIDEiQ93097
ProteomicsDBi75722
75723 [Q93097-2]

PTM databases

iPTMnetiQ93097
PhosphoSitePlusiQ93097

Expressioni

Tissue specificityi

Isoform 1 is expressed in adult heart, brain, placenta, lung, prostate, testis, ovary, small intestine and colon. In the adult brain, it is mainly found in the caudate nucleus, subthalamic nucleus and thalamus. Also detected in fetal brain, lung and kidney. Isoform 2 is expressed in fetal brain, fetal lung, fetal kidney, caudate nucleus, testis and cancer cell lines.2 Publications

Gene expression databases

BgeeiENSG00000134245 Expressed in 176 organ(s), highest expression level in germinal epithelium of ovary
CleanExiHS_WNT2B
ExpressionAtlasiQ93097 baseline and differential
GenevisibleiQ93097 HS

Organism-specific databases

HPAiHPA047274
HPA060696
HPA066368

Interactioni

Subunit structurei

Forms a soluble 1:1 complex with AFM; this prevents oligomerization and is required for prolonged biological activity (PubMed:26902720). The complex with AFM may represent the physiological form in body fluids (PubMed:26902720). Interacts with FZD4 and FZD5 (By similarity).By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi113319, 2 interactors
STRINGi9606.ENSP00000358698

Structurei

3D structure databases

ProteinModelPortaliQ93097
SMRiQ93097
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Wnt family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3913 Eukaryota
ENOG410XQZ1 LUCA
GeneTreeiENSGT00760000118943
HOGENOMiHOG000039529
HOVERGENiHBG001595
InParanoidiQ93097
KOiK00182
OMAiDYCVMDK
OrthoDBiEOG091G0OFF
PhylomeDBiQ93097
TreeFamiTF105310

Family and domain databases

InterProiView protein in InterPro
IPR005817 Wnt
IPR009140 Wnt2
IPR018161 Wnt_CS
PANTHERiPTHR12027 PTHR12027, 1 hit
PfamiView protein in Pfam
PF00110 wnt, 1 hit
PRINTSiPR01842 WNT2PROTEIN
PR01349 WNTPROTEIN
SMARTiView protein in SMART
SM00097 WNT1, 1 hit
PROSITEiView protein in PROSITE
PS00246 WNT1, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 2 (identifier: Q93097-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLRPGGAEEA AQLPLRRASA PVPVPSPAAP DGSRASARLG LACLLLLLLL
60 70 80 90 100
TLPARVDTSW WYIGALGARV ICDNIPGLVS RQRQLCQRYP DIMRSVGEGA
110 120 130 140 150
REWIRECQHQ FRHHRWNCTT LDRDHTVFGR VMLRSSREAA FVYAISSAGV
160 170 180 190 200
VHAITRACSQ GELSVCSCDP YTRGRHHDQR GDFDWGGCSD NIHYGVRFAK
210 220 230 240 250
AFVDAKEKRL KDARALMNLH NNRCGRTAVR RFLKLECKCH GVSGSCTLRT
260 270 280 290 300
CWRALSDFRR TGDYLRRRYD GAVQVMATQD GANFTAARQG YRRATRTDLV
310 320 330 340 350
YFDNSPDYCV LDKAAGSLGT AGRVCSKTSK GTDGCEIMCC GRGYDTTRVT
360 370 380 390
RVTQCECKFH WCCAVRCKEC RNTVDVHTCK APKKAEWLDQ T
Length:391
Mass (Da):43,770
Last modified:June 20, 2001 - v2
Checksum:iBD7BB7F795FB33B1
GO
Isoform 1 (identifier: Q93097-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-61: MLRPGGAEEA...LPARVDTSWW → MLDGLGVVAI...QSAFNKCLQR

Show »
Length:372
Mass (Da):41,830
Checksum:i9D8820B9E42ECA29
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5TEH8Q5TEH8_HUMAN
Protein Wnt
WNT2B
299Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti151V → I in CAA96283 (PubMed:8761309).Curated1
Sequence conflicti182D → T in CAA96283 (PubMed:8761309).Curated1
Sequence conflicti233L → V in CAA96283 (PubMed:8761309).Curated1
Sequence conflicti287A → T (PubMed:9441749).Curated1
Sequence conflicti297T → S in CAA96283 (PubMed:8761309).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0067941 – 61MLRPG…DTSWW → MLDGLGVVAISIFGIQLKTE GSLRTAVPGIPTQSAFNKCL QR in isoform 1. 2 PublicationsAdd BLAST61

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z71621 mRNA Translation: CAA96283.1
AB045116 mRNA Translation: BAB11984.1
AB045117 mRNA Translation: BAB11985.1
AK312696 mRNA Translation: BAG35575.1
AL354760 Genomic DNA No translation available.
AL109932 Genomic DNA No translation available.
CH471122 Genomic DNA Translation: EAW56519.1
BC141825 mRNA Translation: AAI41826.1
AF028701 mRNA Translation: AAC39552.1
CCDSiCCDS846.1 [Q93097-2]
CCDS847.1 [Q93097-1]
PIRiT09612
RefSeqiNP_001278809.1, NM_001291880.1
NP_004176.2, NM_004185.4 [Q93097-2]
NP_078613.1, NM_024494.2 [Q93097-1]
UniGeneiHs.258575

Genome annotation databases

EnsembliENST00000369684; ENSP00000358698; ENSG00000134245 [Q93097-1]
ENST00000369686; ENSP00000358700; ENSG00000134245 [Q93097-2]
GeneIDi7482
KEGGihsa:7482
UCSCiuc001eca.4 human [Q93097-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z71621 mRNA Translation: CAA96283.1
AB045116 mRNA Translation: BAB11984.1
AB045117 mRNA Translation: BAB11985.1
AK312696 mRNA Translation: BAG35575.1
AL354760 Genomic DNA No translation available.
AL109932 Genomic DNA No translation available.
CH471122 Genomic DNA Translation: EAW56519.1
BC141825 mRNA Translation: AAI41826.1
AF028701 mRNA Translation: AAC39552.1
CCDSiCCDS846.1 [Q93097-2]
CCDS847.1 [Q93097-1]
PIRiT09612
RefSeqiNP_001278809.1, NM_001291880.1
NP_004176.2, NM_004185.4 [Q93097-2]
NP_078613.1, NM_024494.2 [Q93097-1]
UniGeneiHs.258575

3D structure databases

ProteinModelPortaliQ93097
SMRiQ93097
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113319, 2 interactors
STRINGi9606.ENSP00000358698

PTM databases

iPTMnetiQ93097
PhosphoSitePlusiQ93097

Polymorphism and mutation databases

BioMutaiWNT2B
DMDMi14424481

Proteomic databases

PaxDbiQ93097
PeptideAtlasiQ93097
PRIDEiQ93097
ProteomicsDBi75722
75723 [Q93097-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000369684; ENSP00000358698; ENSG00000134245 [Q93097-1]
ENST00000369686; ENSP00000358700; ENSG00000134245 [Q93097-2]
GeneIDi7482
KEGGihsa:7482
UCSCiuc001eca.4 human [Q93097-1]

Organism-specific databases

CTDi7482
DisGeNETi7482
EuPathDBiHostDB:ENSG00000134245.17
GeneCardsiWNT2B
HGNCiHGNC:12781 WNT2B
HPAiHPA047274
HPA060696
HPA066368
MalaCardsiWNT2B
MIMi601968 gene
neXtProtiNX_Q93097
OpenTargetsiENSG00000134245
PharmGKBiPA37382
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3913 Eukaryota
ENOG410XQZ1 LUCA
GeneTreeiENSGT00760000118943
HOGENOMiHOG000039529
HOVERGENiHBG001595
InParanoidiQ93097
KOiK00182
OMAiDYCVMDK
OrthoDBiEOG091G0OFF
PhylomeDBiQ93097
TreeFamiTF105310

Enzyme and pathway databases

ReactomeiR-HSA-3238698 WNT ligand biogenesis and trafficking
R-HSA-373080 Class B/2 (Secretin family receptors)
SIGNORiQ93097

Miscellaneous databases

ChiTaRSiWNT2B human
GeneWikiiWNT2B
GenomeRNAii7482
PROiPR:Q93097
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000134245 Expressed in 176 organ(s), highest expression level in germinal epithelium of ovary
CleanExiHS_WNT2B
ExpressionAtlasiQ93097 baseline and differential
GenevisibleiQ93097 HS

Family and domain databases

InterProiView protein in InterPro
IPR005817 Wnt
IPR009140 Wnt2
IPR018161 Wnt_CS
PANTHERiPTHR12027 PTHR12027, 1 hit
PfamiView protein in Pfam
PF00110 wnt, 1 hit
PRINTSiPR01842 WNT2PROTEIN
PR01349 WNTPROTEIN
SMARTiView protein in SMART
SM00097 WNT1, 1 hit
PROSITEiView protein in PROSITE
PS00246 WNT1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiWNT2B_HUMAN
AccessioniPrimary (citable) accession number: Q93097
Secondary accession number(s): O14903
, Q5TEH9, Q5TEI2, Q9HDC1, Q9HDC2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: June 20, 2001
Last modified: November 7, 2018
This is version 152 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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