UniProtKB - Q93097 (WNT2B_HUMAN)
Protein Wnt-2b
WNT2B
Functioni
GO - Molecular functioni
- cytokine activity Source: GO_Central
- frizzled binding Source: GO_Central
GO - Biological processi
- canonical Wnt signaling pathway Source: UniProtKB
- cell fate commitment Source: GO_Central
- cellular response to starvation Source: Ensembl
- chondrocyte differentiation Source: UniProtKB
- cornea development in camera-type eye Source: BHF-UCL
- forebrain regionalization Source: UniProtKB
- hematopoietic stem cell proliferation Source: BHF-UCL
- iris morphogenesis Source: BHF-UCL
- lens development in camera-type eye Source: BHF-UCL
- lung induction Source: Ensembl
- male gonad development Source: UniProtKB
- mesenchymal-epithelial cell signaling Source: Ensembl
- neuron differentiation Source: UniProtKB
- positive regulation of branching involved in ureteric bud morphogenesis Source: Ensembl
- Wnt signaling pathway Source: Reactome
Keywordsi
Molecular function | Developmental protein |
Biological process | Wnt signaling pathway |
Enzyme and pathway databases
PathwayCommonsi | Q93097 |
Reactomei | R-HSA-3238698, WNT ligand biogenesis and trafficking R-HSA-373080, Class B/2 (Secretin family receptors) |
SIGNORi | Q93097 |
Names & Taxonomyi
Protein namesi | Recommended name: Protein Wnt-2bAlternative name(s): Protein Wnt-131 Publication |
Gene namesi | Name:WNT2B Synonyms:WNT13 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000134245.17 |
HGNCi | HGNC:12781, WNT2B |
MIMi | 601968, gene |
neXtProti | NX_Q93097 |
Subcellular locationi
Extracellular region or secreted
- extracellular matrix Curated
- Secreted 1 Publication
Extracellular region or secreted
- collagen-containing extracellular matrix Source: BHF-UCL
- extracellular region Source: Reactome
- extracellular space Source: GO_Central
Other locations
- intracellular membrane-bounded organelle Source: HPA
Keywords - Cellular componenti
Extracellular matrix, SecretedPathology & Biotechi
Involvement in diseasei
Diarrhea 9 (DIAR9)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_081727 | 69 – 391 | Missing in DIAR9; diminished staining for the intestinal stem cell marker OLFM4; enteroid cultures generated from patient intestinal epithelium cannot be expanded and do not survive multiple passages; shows a 10-fold increase in LEF1 mRNA and a 100-fold reduction in TLR4 expression compared to controls indicating alterations in canonical Wnt signaling and microbial pattern-recognition signaling. 1 PublicationAdd BLAST | 323 | |
Natural variantiVAR_081728 | 105 – 391 | Missing in DIAR9. 1 PublicationAdd BLAST | 287 |
Keywords - Diseasei
Disease mutationOrganism-specific databases
DisGeNETi | 7482 |
MalaCardsi | WNT2B |
MIMi | 618168, phenotype |
OpenTargetsi | ENSG00000134245 |
PharmGKBi | PA37382 |
Miscellaneous databases
Pharosi | Q93097, Tbio |
Polymorphism and mutation databases
BioMutai | WNT2B |
DMDMi | 14424481 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – ? | Sequence analysis | ||
ChainiPRO_0000041413 | ? – 391 | Protein Wnt-2b |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 107 ↔ 118 | By similarity | ||
Glycosylationi | 117 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Disulfide bondi | 158 ↔ 166 | By similarity | ||
Disulfide bondi | 168 ↔ 188 | By similarity | ||
Disulfide bondi | 237 ↔ 251 | By similarity | ||
Disulfide bondi | 239 ↔ 246 | By similarity | ||
Lipidationi | 243 | O-palmitoleoyl serine; by PORCNBy similarity | 1 | |
Glycosylationi | 283 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Disulfide bondi | 309 ↔ 340 | By similarity | ||
Disulfide bondi | 325 ↔ 335 | By similarity | ||
Disulfide bondi | 339 ↔ 379 | By similarity | ||
Disulfide bondi | 355 ↔ 370 | By similarity | ||
Disulfide bondi | 357 ↔ 367 | By similarity | ||
Disulfide bondi | 362 ↔ 363 | By similarity |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, Glycoprotein, LipoproteinProteomic databases
MassIVEi | Q93097 |
PaxDbi | Q93097 |
PeptideAtlasi | Q93097 |
PRIDEi | Q93097 |
ProteomicsDBi | 75722 [Q93097-1] 75723 [Q93097-2] |
PTM databases
GlyGeni | Q93097, 2 sites |
iPTMneti | Q93097 |
PhosphoSitePlusi | Q93097 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000134245, Expressed in germinal epithelium of ovary and 190 other tissues |
ExpressionAtlasi | Q93097, baseline and differential |
Genevisiblei | Q93097, HS |
Organism-specific databases
HPAi | ENSG00000134245, Tissue enhanced (retina) |
Interactioni
Subunit structurei
Forms a soluble 1:1 complex with AFM; this prevents oligomerization and is required for prolonged biological activity (PubMed:26902720). The complex with AFM may represent the physiological form in body fluids (PubMed:26902720).
Interacts with FZD4 and FZD5 (By similarity).
By similarity1 PublicationGO - Molecular functioni
- cytokine activity Source: GO_Central
- frizzled binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 113319, 4 interactors |
IntActi | Q93097, 1 interactor |
STRINGi | 9606.ENSP00000358698 |
Miscellaneous databases
RNActi | Q93097, protein |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | KOG3913, Eukaryota |
GeneTreei | ENSGT00940000159166 |
HOGENOMi | CLU_033039_1_0_1 |
InParanoidi | Q93097 |
OMAi | HPDIMQA |
OrthoDBi | 745245at2759 |
PhylomeDBi | Q93097 |
TreeFami | TF105310 |
Family and domain databases
Gene3Di | 3.30.2460.20, 1 hit |
InterProi | View protein in InterPro IPR005817, Wnt IPR009140, Wnt2 IPR043158, Wnt_C IPR018161, Wnt_CS |
PANTHERi | PTHR12027, PTHR12027, 1 hit |
Pfami | View protein in Pfam PF00110, wnt, 1 hit |
PRINTSi | PR01842, WNT2PROTEIN PR01349, WNTPROTEIN |
SMARTi | View protein in SMART SM00097, WNT1, 1 hit |
PROSITEi | View protein in PROSITE PS00246, WNT1, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MLRPGGAEEA AQLPLRRASA PVPVPSPAAP DGSRASARLG LACLLLLLLL
60 70 80 90 100
TLPARVDTSW WYIGALGARV ICDNIPGLVS RQRQLCQRYP DIMRSVGEGA
110 120 130 140 150
REWIRECQHQ FRHHRWNCTT LDRDHTVFGR VMLRSSREAA FVYAISSAGV
160 170 180 190 200
VHAITRACSQ GELSVCSCDP YTRGRHHDQR GDFDWGGCSD NIHYGVRFAK
210 220 230 240 250
AFVDAKEKRL KDARALMNLH NNRCGRTAVR RFLKLECKCH GVSGSCTLRT
260 270 280 290 300
CWRALSDFRR TGDYLRRRYD GAVQVMATQD GANFTAARQG YRRATRTDLV
310 320 330 340 350
YFDNSPDYCV LDKAAGSLGT AGRVCSKTSK GTDGCEIMCC GRGYDTTRVT
360 370 380 390
RVTQCECKFH WCCAVRCKEC RNTVDVHTCK APKKAEWLDQ T
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketQ5TEH8 | Q5TEH8_HUMAN | Protein Wnt | WNT2B | 299 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 151 | V → I in CAA96283 (PubMed:8761309).Curated | 1 | |
Sequence conflicti | 182 | D → T in CAA96283 (PubMed:8761309).Curated | 1 | |
Sequence conflicti | 233 | L → V in CAA96283 (PubMed:8761309).Curated | 1 | |
Sequence conflicti | 287 | A → T (PubMed:9441749).Curated | 1 | |
Sequence conflicti | 297 | T → S in CAA96283 (PubMed:8761309).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_081727 | 69 – 391 | Missing in DIAR9; diminished staining for the intestinal stem cell marker OLFM4; enteroid cultures generated from patient intestinal epithelium cannot be expanded and do not survive multiple passages; shows a 10-fold increase in LEF1 mRNA and a 100-fold reduction in TLR4 expression compared to controls indicating alterations in canonical Wnt signaling and microbial pattern-recognition signaling. 1 PublicationAdd BLAST | 323 | |
Natural variantiVAR_081728 | 105 – 391 | Missing in DIAR9. 1 PublicationAdd BLAST | 287 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_006794 | 1 – 61 | MLRPG…DTSWW → MLDGLGVVAISIFGIQLKTE GSLRTAVPGIPTQSAFNKCL QR in isoform 1. 2 PublicationsAdd BLAST | 61 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z71621 mRNA Translation: CAA96283.1 AB045116 mRNA Translation: BAB11984.1 AB045117 mRNA Translation: BAB11985.1 AK312696 mRNA Translation: BAG35575.1 AL354760 Genomic DNA No translation available. AL109932 Genomic DNA No translation available. CH471122 Genomic DNA Translation: EAW56519.1 BC141825 mRNA Translation: AAI41826.1 AF028701 mRNA Translation: AAC39552.1 |
CCDSi | CCDS846.1 [Q93097-2] CCDS847.1 [Q93097-1] |
PIRi | T09612 |
RefSeqi | NP_001278809.1, NM_001291880.1 NP_004176.2, NM_004185.4 [Q93097-2] NP_078613.1, NM_024494.2 [Q93097-1] |
Genome annotation databases
Ensembli | ENST00000369684; ENSP00000358698; ENSG00000134245 [Q93097-1] ENST00000369686; ENSP00000358700; ENSG00000134245 [Q93097-2] |
GeneIDi | 7482 |
KEGGi | hsa:7482 |
UCSCi | uc001eca.4, human [Q93097-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z71621 mRNA Translation: CAA96283.1 AB045116 mRNA Translation: BAB11984.1 AB045117 mRNA Translation: BAB11985.1 AK312696 mRNA Translation: BAG35575.1 AL354760 Genomic DNA No translation available. AL109932 Genomic DNA No translation available. CH471122 Genomic DNA Translation: EAW56519.1 BC141825 mRNA Translation: AAI41826.1 AF028701 mRNA Translation: AAC39552.1 |
CCDSi | CCDS846.1 [Q93097-2] CCDS847.1 [Q93097-1] |
PIRi | T09612 |
RefSeqi | NP_001278809.1, NM_001291880.1 NP_004176.2, NM_004185.4 [Q93097-2] NP_078613.1, NM_024494.2 [Q93097-1] |
3D structure databases
SMRi | Q93097 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 113319, 4 interactors |
IntActi | Q93097, 1 interactor |
STRINGi | 9606.ENSP00000358698 |
PTM databases
GlyGeni | Q93097, 2 sites |
iPTMneti | Q93097 |
PhosphoSitePlusi | Q93097 |
Polymorphism and mutation databases
BioMutai | WNT2B |
DMDMi | 14424481 |
Proteomic databases
MassIVEi | Q93097 |
PaxDbi | Q93097 |
PeptideAtlasi | Q93097 |
PRIDEi | Q93097 |
ProteomicsDBi | 75722 [Q93097-1] 75723 [Q93097-2] |
Protocols and materials databases
Antibodypediai | 20129, 237 antibodies |
Genome annotation databases
Ensembli | ENST00000369684; ENSP00000358698; ENSG00000134245 [Q93097-1] ENST00000369686; ENSP00000358700; ENSG00000134245 [Q93097-2] |
GeneIDi | 7482 |
KEGGi | hsa:7482 |
UCSCi | uc001eca.4, human [Q93097-1] |
Organism-specific databases
CTDi | 7482 |
DisGeNETi | 7482 |
EuPathDBi | HostDB:ENSG00000134245.17 |
GeneCardsi | WNT2B |
HGNCi | HGNC:12781, WNT2B |
HPAi | ENSG00000134245, Tissue enhanced (retina) |
MalaCardsi | WNT2B |
MIMi | 601968, gene 618168, phenotype |
neXtProti | NX_Q93097 |
OpenTargetsi | ENSG00000134245 |
PharmGKBi | PA37382 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3913, Eukaryota |
GeneTreei | ENSGT00940000159166 |
HOGENOMi | CLU_033039_1_0_1 |
InParanoidi | Q93097 |
OMAi | HPDIMQA |
OrthoDBi | 745245at2759 |
PhylomeDBi | Q93097 |
TreeFami | TF105310 |
Enzyme and pathway databases
PathwayCommonsi | Q93097 |
Reactomei | R-HSA-3238698, WNT ligand biogenesis and trafficking R-HSA-373080, Class B/2 (Secretin family receptors) |
SIGNORi | Q93097 |
Miscellaneous databases
BioGRID-ORCSi | 7482, 8 hits in 842 CRISPR screens |
ChiTaRSi | WNT2B, human |
GeneWikii | WNT2B |
GenomeRNAii | 7482 |
Pharosi | Q93097, Tbio |
PROi | PR:Q93097 |
RNActi | Q93097, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000134245, Expressed in germinal epithelium of ovary and 190 other tissues |
ExpressionAtlasi | Q93097, baseline and differential |
Genevisiblei | Q93097, HS |
Family and domain databases
Gene3Di | 3.30.2460.20, 1 hit |
InterProi | View protein in InterPro IPR005817, Wnt IPR009140, Wnt2 IPR043158, Wnt_C IPR018161, Wnt_CS |
PANTHERi | PTHR12027, PTHR12027, 1 hit |
Pfami | View protein in Pfam PF00110, wnt, 1 hit |
PRINTSi | PR01842, WNT2PROTEIN PR01349, WNTPROTEIN |
SMARTi | View protein in SMART SM00097, WNT1, 1 hit |
PROSITEi | View protein in PROSITE PS00246, WNT1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | WNT2B_HUMAN | |
Accessioni | Q93097Primary (citable) accession number: Q93097 Secondary accession number(s): O14903 Q9HDC2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | June 20, 2001 | |
Last modified: | December 2, 2020 | |
This is version 166 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations