Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Transaldolase

Gene

Taldo1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.By similarity

Catalytic activityi

Sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + D-fructose 6-phosphate.

Pathwayi: pentose phosphate pathway

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage).
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Transaldolase (Taldo1), Transaldolase (Taldo1)
  3. no protein annotated in this organism
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei142Schiff-base intermediate with substrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processPentose shunt
LigandSchiff base

Enzyme and pathway databases

ReactomeiR-MMU-163754 Insulin effects increased synthesis of Xylulose-5-Phosphate
R-MMU-71336 Pentose phosphate pathway (hexose monophosphate shunt)
UniPathwayiUPA00115; UER00414

Names & Taxonomyi

Protein namesi
Recommended name:
Transaldolase (EC:2.2.1.2)
Gene namesi
Name:Taldo1
Synonyms:Tal, Taldo
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1274789 Taldo1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001735651 – 337TransaldolaseAdd BLAST337

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei115N6-acetyllysineCombined sources1
Modified residuei219N6-acetyllysineBy similarity1
Modified residuei237PhosphoserineCombined sources1
Modified residuei256PhosphoserineBy similarity1
Modified residuei269N6-acetyllysineBy similarity1
Modified residuei286N6-acetyllysineBy similarity1
Modified residuei321N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ93092
MaxQBiQ93092
PaxDbiQ93092
PeptideAtlasiQ93092
PRIDEiQ93092
TopDownProteomicsiQ93092

2D gel databases

REPRODUCTION-2DPAGEiIPI00124692
Q93092

PTM databases

iPTMnetiQ93092
PhosphoSitePlusiQ93092
SwissPalmiQ93092

Expressioni

Gene expression databases

BgeeiENSMUSG00000025503
CleanExiMM_TALDO1
ExpressionAtlasiQ93092 baseline and differential
GenevisibleiQ93092 MM

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

BioGridi203964, 1 interactor
IntActiQ93092, 2 interactors
MINTiQ93092
STRINGi10090.ENSMUSP00000026576

Structurei

Secondary structure

1337
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi14 – 18Combined sources5
Turni19 – 21Combined sources3
Beta strandi22 – 27Combined sources6
Helixi31 – 33Combined sources3
Turni34 – 37Combined sources4
Beta strandi40 – 43Combined sources4
Helixi46 – 53Combined sources8
Helixi56 – 58Combined sources3
Helixi59 – 72Combined sources14
Helixi76 – 98Combined sources23
Beta strandi103 – 106Combined sources4
Helixi109 – 111Combined sources3
Helixi115 – 131Combined sources17
Helixi136 – 138Combined sources3
Beta strandi139 – 144Combined sources6
Helixi147 – 160Combined sources14
Beta strandi164 – 169Combined sources6
Helixi172 – 181Combined sources10
Beta strandi184 – 190Combined sources7
Helixi191 – 200Combined sources10
Helixi208 – 210Combined sources3
Helixi212 – 226Combined sources15
Beta strandi232 – 236Combined sources5
Helixi241 – 245Combined sources5
Turni246 – 249Combined sources4
Beta strandi250 – 255Combined sources6
Helixi257 – 265Combined sources9
Helixi276 – 279Combined sources4
Helixi291 – 299Combined sources9
Helixi302 – 330Combined sources29

3D structure databases

ProteinModelPortaliQ93092
SMRiQ93092
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ93092

Family & Domainsi

Sequence similaritiesi

Belongs to the transaldolase family. Type 1 subfamily.Curated

Phylogenomic databases

eggNOGiKOG2772 Eukaryota
COG0176 LUCA
GeneTreeiENSGT00390000017361
HOGENOMiHOG000281234
HOVERGENiHBG054014
InParanoidiQ93092
KOiK00616
OrthoDBiEOG091G0FTU
PhylomeDBiQ93092
TreeFamiTF300757

Family and domain databases

CDDicd00957 Transaldolase_TalAB, 1 hit
Gene3Di3.20.20.70, 1 hit
HAMAPiMF_00492 Transaldolase_1, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR001585 TAL/FSA
IPR004730 Transaldolase_1
IPR018225 Transaldolase_AS
PANTHERiPTHR10683 PTHR10683, 1 hit
PTHR10683:SF20 PTHR10683:SF20, 1 hit
PfamiView protein in Pfam
PF00923 TAL_FSA, 1 hit
TIGRFAMsiTIGR00874 talAB, 1 hit
PROSITEiView protein in PROSITE
PS01054 TRANSALDOLASE_1, 1 hit
PS00958 TRANSALDOLASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q93092-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGSPVKRQR MESALDQLKQ FTTVVADTGD FNAIDEYKPQ DATTNPSLIL
60 70 80 90 100
AAAQMPAYQE LVEEAIAYGK KLGGPQEEQI KNAIDKLFVL FGAEILKKIP
110 120 130 140 150
GRVSTEVDAR LSFDKDAMVA RARRLIELYK EAGVGKDRIL IKLSSTWEGI
160 170 180 190 200
QAGKELEEQH GIHCNMTLLF SFAQAVACAE AGVTLISPFV GRILDWHVAN
210 220 230 240 250
TDKKSYEPQE DPGVKSVTKI YNYYKKFGYK TIVMGASFRN TGEIKALAGC
260 270 280 290 300
DFLTISPKLL GELLKDNSKL APALSVKAAQ TSDSEKIHLD EKAFRWLHNE
310 320 330
DQMAVEKLSD GIRKFAADAI KLERMLTERM FSAENGK
Length:337
Mass (Da):37,387
Last modified:July 15, 1998 - v2
Checksum:iB0AD351FD778367F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U67611 mRNA Translation: AAB83955.1
U63158 mRNA Translation: AAB08722.1 Sequence problems.
U63159 mRNA Translation: AAB08723.1 Sequence problems.
BC004754 mRNA Translation: AAH04754.1
BC094277 mRNA Translation: AAH94277.1
CCDSiCCDS22011.1
RefSeqiNP_035658.1, NM_011528.4
UniGeneiMm.29182

Genome annotation databases

EnsembliENSMUST00000026576; ENSMUSP00000026576; ENSMUSG00000025503
GeneIDi21351
KEGGimmu:21351
UCSCiuc009kkv.2 mouse

Similar proteinsi

Entry informationi

Entry nameiTALDO_MOUSE
AccessioniPrimary (citable) accession number: Q93092
Secondary accession number(s): P70358, P70703, Q52KM4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 15, 1998
Last modified: June 20, 2018
This is version 159 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health