UniProtKB - Q93092 (TALDO_MOUSE)
Protein
Transaldolase
Gene
Taldo1
Organism
Mus musculus (Mouse)
Status
Functioni
Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.By similarity
Catalytic activityi
- D-glyceraldehyde 3-phosphate + D-sedoheptulose 7-phosphate = β-D-fructose 6-phosphate + D-erythrose 4-phosphateEC:2.2.1.2
: pentose phosphate pathway Pathwayi
This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage).Proteins known to be involved in the 3 steps of the subpathway in this organism are:
- no protein annotated in this organism
- Transaldolase (Taldo1), Transaldolase (Taldo1)
- no protein annotated in this organism
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 142 | Schiff-base intermediate with substrateBy similarity | 1 |
GO - Molecular functioni
- carbohydrate binding Source: MGI
- monosaccharide binding Source: MGI
- sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity Source: MGI
GO - Biological processi
- carbohydrate metabolic process Source: InterPro
- fructose 6-phosphate metabolic process Source: MGI
- glyceraldehyde-3-phosphate metabolic process Source: MGI
- pentose-phosphate shunt Source: MGI
- pentose-phosphate shunt, non-oxidative branch Source: MGI
Keywordsi
Molecular function | Transferase |
Biological process | Pentose shunt |
Ligand | Schiff base |
Enzyme and pathway databases
Reactomei | R-MMU-163754 Insulin effects increased synthesis of Xylulose-5-Phosphate R-MMU-71336 Pentose phosphate pathway |
UniPathwayi | UPA00115;UER00414 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:Taldo1 Synonyms:Tal, Taldo |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1274789 Taldo1 |
Subcellular locationi
Other locations
- Cytoplasm Curated
Cytosol
- cytosol Source: MGI
Nucleus
- nucleoplasm Source: Ensembl
Other locations
- intracellular membrane-bounded organelle Source: MGI
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000173565 | 1 – 337 | TransaldolaseAdd BLAST | 337 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 115 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 219 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 237 | PhosphoserineCombined sources | 1 | |
Modified residuei | 256 | PhosphoserineBy similarity | 1 | |
Modified residuei | 269 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 286 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 321 | N6-acetyllysineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
CPTACi | non-CPTAC-3950 |
EPDi | Q93092 |
jPOSTi | Q93092 |
MaxQBi | Q93092 |
PaxDbi | Q93092 |
PeptideAtlasi | Q93092 |
PRIDEi | Q93092 |
TopDownProteomicsi | Q93092 |
2D gel databases
REPRODUCTION-2DPAGEi | IPI00124692 Q93092 |
PTM databases
iPTMneti | Q93092 |
PhosphoSitePlusi | Q93092 |
SwissPalmi | Q93092 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000025503 Expressed in 298 organ(s), highest expression level in blood |
ExpressionAtlasi | Q93092 baseline and differential |
Genevisiblei | Q93092 MM |
Interactioni
Subunit structurei
Homodimer.
By similarityProtein-protein interaction databases
BioGridi | 203964, 1 interactor |
IntActi | Q93092, 2 interactors |
MINTi | Q93092 |
STRINGi | 10090.ENSMUSP00000026576 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q93092 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q93092 |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG2772 Eukaryota COG0176 LUCA |
GeneTreei | ENSGT00390000017361 |
HOGENOMi | HOG000281234 |
InParanoidi | Q93092 |
KOi | K00616 |
OMAi | ILDWFKA |
OrthoDBi | 1402459at2759 |
PhylomeDBi | Q93092 |
TreeFami | TF300757 |
Family and domain databases
CDDi | cd00957 Transaldolase_TalAB, 1 hit |
Gene3Di | 3.20.20.70, 1 hit |
HAMAPi | MF_00492 Transaldolase_1, 1 hit |
InterProi | View protein in InterPro IPR013785 Aldolase_TIM IPR001585 TAL/FSA IPR004730 Transaldolase_1 IPR018225 Transaldolase_AS |
PANTHERi | PTHR10683 PTHR10683, 1 hit PTHR10683:SF18 PTHR10683:SF18, 1 hit |
Pfami | View protein in Pfam PF00923 TAL_FSA, 1 hit |
TIGRFAMsi | TIGR00874 talAB, 1 hit |
PROSITEi | View protein in PROSITE PS01054 TRANSALDOLASE_1, 1 hit PS00958 TRANSALDOLASE_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q93092-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSGSPVKRQR MESALDQLKQ FTTVVADTGD FNAIDEYKPQ DATTNPSLIL
60 70 80 90 100
AAAQMPAYQE LVEEAIAYGK KLGGPQEEQI KNAIDKLFVL FGAEILKKIP
110 120 130 140 150
GRVSTEVDAR LSFDKDAMVA RARRLIELYK EAGVGKDRIL IKLSSTWEGI
160 170 180 190 200
QAGKELEEQH GIHCNMTLLF SFAQAVACAE AGVTLISPFV GRILDWHVAN
210 220 230 240 250
TDKKSYEPQE DPGVKSVTKI YNYYKKFGYK TIVMGASFRN TGEIKALAGC
260 270 280 290 300
DFLTISPKLL GELLKDNSKL APALSVKAAQ TSDSEKIHLD EKAFRWLHNE
310 320 330
DQMAVEKLSD GIRKFAADAI KLERMLTERM FSAENGK
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A1B0GR11 | A0A1B0GR11_MOUSE | Transaldolase | Taldo1 | 382 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U67611 mRNA Translation: AAB83955.1 U63158 mRNA Translation: AAB08722.1 Sequence problems. U63159 mRNA Translation: AAB08723.1 Sequence problems. BC004754 mRNA Translation: AAH04754.1 BC094277 mRNA Translation: AAH94277.1 |
CCDSi | CCDS22011.1 |
RefSeqi | NP_035658.1, NM_011528.4 |
Genome annotation databases
Ensembli | ENSMUST00000026576; ENSMUSP00000026576; ENSMUSG00000025503 |
GeneIDi | 21351 |
KEGGi | mmu:21351 |
UCSCi | uc009kkv.2 mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U67611 mRNA Translation: AAB83955.1 U63158 mRNA Translation: AAB08722.1 Sequence problems. U63159 mRNA Translation: AAB08723.1 Sequence problems. BC004754 mRNA Translation: AAH04754.1 BC094277 mRNA Translation: AAH94277.1 |
CCDSi | CCDS22011.1 |
RefSeqi | NP_035658.1, NM_011528.4 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2CWN | X-ray | 2.10 | A/B | 13-337 | [»] | |
2E1D | X-ray | 2.00 | A/B | 11-334 | [»] | |
SMRi | Q93092 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGridi | 203964, 1 interactor |
IntActi | Q93092, 2 interactors |
MINTi | Q93092 |
STRINGi | 10090.ENSMUSP00000026576 |
PTM databases
iPTMneti | Q93092 |
PhosphoSitePlusi | Q93092 |
SwissPalmi | Q93092 |
2D gel databases
REPRODUCTION-2DPAGEi | IPI00124692 Q93092 |
Proteomic databases
CPTACi | non-CPTAC-3950 |
EPDi | Q93092 |
jPOSTi | Q93092 |
MaxQBi | Q93092 |
PaxDbi | Q93092 |
PeptideAtlasi | Q93092 |
PRIDEi | Q93092 |
TopDownProteomicsi | Q93092 |
Genome annotation databases
Ensembli | ENSMUST00000026576; ENSMUSP00000026576; ENSMUSG00000025503 |
GeneIDi | 21351 |
KEGGi | mmu:21351 |
UCSCi | uc009kkv.2 mouse |
Organism-specific databases
CTDi | 6888 |
MGIi | MGI:1274789 Taldo1 |
Phylogenomic databases
eggNOGi | KOG2772 Eukaryota COG0176 LUCA |
GeneTreei | ENSGT00390000017361 |
HOGENOMi | HOG000281234 |
InParanoidi | Q93092 |
KOi | K00616 |
OMAi | ILDWFKA |
OrthoDBi | 1402459at2759 |
PhylomeDBi | Q93092 |
TreeFami | TF300757 |
Enzyme and pathway databases
UniPathwayi | UPA00115;UER00414 |
Reactomei | R-MMU-163754 Insulin effects increased synthesis of Xylulose-5-Phosphate R-MMU-71336 Pentose phosphate pathway |
Miscellaneous databases
ChiTaRSi | Taldo1 mouse |
EvolutionaryTracei | Q93092 |
PROi | PR:Q93092 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000025503 Expressed in 298 organ(s), highest expression level in blood |
ExpressionAtlasi | Q93092 baseline and differential |
Genevisiblei | Q93092 MM |
Family and domain databases
CDDi | cd00957 Transaldolase_TalAB, 1 hit |
Gene3Di | 3.20.20.70, 1 hit |
HAMAPi | MF_00492 Transaldolase_1, 1 hit |
InterProi | View protein in InterPro IPR013785 Aldolase_TIM IPR001585 TAL/FSA IPR004730 Transaldolase_1 IPR018225 Transaldolase_AS |
PANTHERi | PTHR10683 PTHR10683, 1 hit PTHR10683:SF18 PTHR10683:SF18, 1 hit |
Pfami | View protein in Pfam PF00923 TAL_FSA, 1 hit |
TIGRFAMsi | TIGR00874 talAB, 1 hit |
PROSITEi | View protein in PROSITE PS01054 TRANSALDOLASE_1, 1 hit PS00958 TRANSALDOLASE_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TALDO_MOUSE | |
Accessioni | Q93092Primary (citable) accession number: Q93092 Secondary accession number(s): P70358, P70703, Q52KM4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | July 15, 1998 | |
Last modified: | November 13, 2019 | |
This is version 169 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Complete proteome, Direct protein sequencing, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways - PDB cross-references
Index of Protein Data Bank (PDB) cross-references