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UniProtKB - Q93088 (BHMT1_HUMAN)

Entry version 180 (11 Dec 2019)
Sequence version 2 (17 Apr 2007)
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Protein

Betaine--homocysteine S-methyltransferase 1

Gene

BHMT

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+Note: Binds 1 zinc ion per subunit.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: betaine degradation

This protein is involved in step 1 of the subpathway that synthesizes sarcosine from betaine.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Betaine--homocysteine S-methyltransferase 1 (BHMT)
  2. Dimethylglycine dehydrogenase, mitochondrial (DMGDH)
This subpathway is part of the pathway betaine degradation, which is itself part of Amine and polyamine degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes sarcosine from betaine, the pathway betaine degradation and in Amine and polyamine degradation.

Pathwayi: L-methionine biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes L-methionine from L-homocysteine (BhmT route).
Proteins known to be involved in this subpathway in this organism are:
  1. cDNA, FLJ96222, highly similar to Homo sapiens betaine-homocysteine methyltransferase (BHMT), mRNA, Betaine-homocysteine methyltransferase, isoform CRA_a (HEL-S-61p), cDNA FLJ54604, highly similar to Betaine--homocysteine S-methyltransferase, S-methylmethionine--homocysteine S-methyltransferase BHMT2 (BHMT2), Betaine--homocysteine S-methyltransferase 1 (BHMT), cDNA, FLJ96586, highly similar to Homo sapiens betaine-homocysteine methyltransferase 2 (BHMT2), mRNA, Methionine synthase (MTR), Betaine-homocysteine methyltransferase 2, isoform CRA_c (BHMT2), Betaine--homocysteine S-methyltransferase 1 (BHMT)
This subpathway is part of the pathway L-methionine biosynthesis via de novo pathway, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-methionine from L-homocysteine (BhmT route), the pathway L-methionine biosynthesis via de novo pathway and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi217Zinc1
Metal bindingi299Zinc1
Metal bindingi300Zinc1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMethyltransferase, Transferase
LigandMetal-binding, Zinc

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		MetaCyc:HS07273-MONOMER

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		2.1.1.5 2681

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1614635 Sulfur amino acid metabolism
R-HSA-6798163 Choline catabolism

SABIO-RK: Biochemical Reaction Kinetics Database

More...SABIO-RKi		Q93088

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q93088

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi		UPA00051;UER00083
UPA00291;UER00432

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Betaine--homocysteine S-methyltransferase 1 (EC:2.1.1.5)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:BHMT
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000145692.14

Human Gene Nomenclature Database

More...HGNCi		HGNC:1047 BHMT

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		602888 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q93088

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		635

Open Targets

More...OpenTargetsi		ENSG00000145692

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA25350

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q93088 Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL4328

Drug and drug target database

More...DrugBanki		DB04272 Citric acid
DB00134 Methionine
DB02337 S-(D-Carboxybutyl)-L-Homocysteine

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		BHMT

Domain mapping of disease mutations (DMDM)

More...DMDMi		145559446

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001146211 – 406Betaine--homocysteine S-methyltransferase 1Add BLAST406

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei40N6-succinyllysineBy similarity1
Modified residuei93N6-succinyllysineBy similarity1
Modified residuei232N6-succinyllysineBy similarity1
Modified residuei241N6-succinyllysineBy similarity1
Modified residuei330PhosphoserineBy similarity1
Modified residuei340N6-succinyllysineBy similarity1
Modified residuei377N6-succinyllysineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q93088

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q93088

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q93088

PeptideAtlas

More...PeptideAtlasi		Q93088

PRoteomics IDEntifications database

More...PRIDEi		Q93088

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		75719

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q93088

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q93088

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Found exclusively in liver and kidney.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000145692 Expressed in 93 organ(s), highest expression level in kidney epithelium

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q93088 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q93088 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA038285
HPA058310

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotetramer.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		107104, 11 interactors

Protein interaction database and analysis system

More...IntActi		Q93088, 7 interactors

Molecular INTeraction database

More...MINTi		Q93088

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000274353

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q93088

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q93088 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1406
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q93088

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q93088

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini11 – 314Hcy-bindingPROSITE-ProRule annotationAdd BLAST304

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1579 Eukaryota
COG0646 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00390000003122

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000231636

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q93088

KEGG Orthology (KO)

More...KOi		K00544

Identification of Orthologs from Complete Genome Data

More...OMAi		AQPLAYH

Database of Orthologous Groups

More...OrthoDBi		731388at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q93088

TreeFam database of animal gene trees

More...TreeFami		TF329202

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.20.20.330, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR017226 Betaine-hCys_S-MeTrfase_BHMT
IPR003726 HCY_dom
IPR036589 HCY_dom_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF02574 S-methyl_trans, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF037505 Betaine_HMT, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF82282 SSF82282, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50970 HCY, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q93088-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPPVGGKKAK KGILERLNAG EIVIGDGGFV FALEKRGYVK AGPWTPEAAV 
        60         70         80         90        100
EHPEAVRQLH REFLRAGSNV MQTFTFYASE DKLENRGNYV LEKISGQEVN 
       110        120        130        140        150
EAACDIARQV ADEGDALVAG GVSQTPSYLS CKSETEVKKV FLQQLEVFMK 
       160        170        180        190        200
KNVDFLIAEY FEHVEEAVWA VETLIASGKP VAATMCIGPE GDLHGVPPGE 
       210        220        230        240        250
CAVRLVKAGA SIIGVNCHFD PTISLKTVKL MKEGLEAARL KAHLMSQPLA 
       260        270        280        290        300
YHTPDCNKQG FIDLPEFPFG LEPRVATRWD IQKYAREAYN LGVRYIGGCC 
       310        320        330        340        350
GFEPYHIRAI AEELAPERGF LPPASEKHGS WGSGLDMHTK PWVRARARKE 
       360        370        380        390        400
YWENLRIASG RPYNPSMSKP DGWGVTKGTA ELMQQKEATT EQQLKELFEK 

QKFKSQ
Length:406
Mass (Da):44,998
Last modified:April 17, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i557855B8CEDD0D54
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E5RJH0E5RJH0_HUMAN
Betaine--homocysteine S-methyltrans...
BHMT
253Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_061345199G → S. Corresponds to variant dbSNP:rs59866108Ensembl.1
Natural variantiVAR_015886239R → Q May decrease risk for coronary artery disease. 2 PublicationsCorresponds to variant dbSNP:rs3733890Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U50929 mRNA Translation: AAC50668.1
AF118378 AF118377 Genomic DNA Translation: AAD22043.1
BC012616 mRNA Translation: AAH12616.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS4046.1

NCBI Reference Sequences

More...RefSeqi		NP_001704.2, NM_001713.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000274353; ENSP00000274353; ENSG00000145692

Database of genes from NCBI RefSeq genomes

More...GeneIDi		635

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:635

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U50929 mRNA Translation: AAC50668.1
AF118378 AF118377 Genomic DNA Translation: AAD22043.1
BC012616 mRNA Translation: AAH12616.1
CCDSiCCDS4046.1
RefSeqiNP_001704.2, NM_001713.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1LT7X-ray2.15A/B1-406[»]
1LT8X-ray2.05A/B1-406[»]
4M3PX-ray1.90A/B/C/D1-406[»]
SMRiQ93088
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi107104, 11 interactors
IntActiQ93088, 7 interactors
MINTiQ93088
STRINGi9606.ENSP00000274353

Chemistry databases

BindingDBiQ93088
ChEMBLiCHEMBL4328
DrugBankiDB04272 Citric acid
DB00134 Methionine
DB02337 S-(D-Carboxybutyl)-L-Homocysteine

PTM databases

iPTMnetiQ93088
PhosphoSitePlusiQ93088

Polymorphism and mutation databases

BioMutaiBHMT
DMDMi145559446

Proteomic databases

EPDiQ93088
MassIVEiQ93088
PaxDbiQ93088
PeptideAtlasiQ93088
PRIDEiQ93088
ProteomicsDBi75719

Genome annotation databases

EnsembliENST00000274353; ENSP00000274353; ENSG00000145692
GeneIDi635
KEGGihsa:635

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		635
DisGeNETi635
EuPathDBiHostDB:ENSG00000145692.14

GeneCards: human genes, protein and diseases

More...GeneCardsi		BHMT
HGNCiHGNC:1047 BHMT
HPAiHPA038285
HPA058310
MIMi602888 gene
neXtProtiNX_Q93088
OpenTargetsiENSG00000145692
PharmGKBiPA25350

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1579 Eukaryota
COG0646 LUCA
GeneTreeiENSGT00390000003122
HOGENOMiHOG000231636
InParanoidiQ93088
KOiK00544
OMAiAQPLAYH
OrthoDBi731388at2759
PhylomeDBiQ93088
TreeFamiTF329202

Enzyme and pathway databases

UniPathwayiUPA00051;UER00083
UPA00291;UER00432
BioCyciMetaCyc:HS07273-MONOMER
BRENDAi2.1.1.5 2681
ReactomeiR-HSA-1614635 Sulfur amino acid metabolism
R-HSA-6798163 Choline catabolism
SABIO-RKiQ93088
SIGNORiQ93088

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		BHMT human
EvolutionaryTraceiQ93088

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		635
PharosiQ93088 Tchem

Protein Ontology

More...PROi		PR:Q93088
RNActiQ93088 protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000145692 Expressed in 93 organ(s), highest expression level in kidney epithelium
ExpressionAtlasiQ93088 baseline and differential
GenevisibleiQ93088 HS

Family and domain databases

Gene3Di3.20.20.330, 1 hit
InterProiView protein in InterPro
IPR017226 Betaine-hCys_S-MeTrfase_BHMT
IPR003726 HCY_dom
IPR036589 HCY_dom_sf
PfamiView protein in Pfam
PF02574 S-methyl_trans, 1 hit
PIRSFiPIRSF037505 Betaine_HMT, 1 hit
SUPFAMiSSF82282 SSF82282, 1 hit
PROSITEiView protein in PROSITE
PS50970 HCY, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBHMT1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q93088
Secondary accession number(s): Q9UNI9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: April 17, 2007
Last modified: December 11, 2019
This is version 180 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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