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Entry version 173 (11 Dec 2019)
Sequence version 4 (14 Oct 2008)
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Protein

P2X purinoceptor 5

Gene

P2RX5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor for ATP that acts as a ligand-gated ion channel.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIon channel, Ligand-gated ion channel, Receptor
Biological processIon transport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-139853 Elevation of cytosolic Ca2+ levels
R-HSA-418346 Platelet homeostasis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
P2X purinoceptor 5
Short name:
P2X5
Alternative name(s):
ATP receptor
Purinergic receptor
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:P2RX5
Synonyms:P2X5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000083454.21

Human Gene Nomenclature Database

More...
HGNCi
HGNC:8536 P2RX5

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
602836 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q93086

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 30CytoplasmicSequence analysisAdd BLAST30
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei31 – 51Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini52 – 319ExtracellularSequence analysisAdd BLAST268
Transmembranei320 – 340Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini341 – 422CytoplasmicSequence analysisAdd BLAST82

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
5026

Open Targets

More...
OpenTargetsi
ENSG00000083454

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA32865

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q93086 Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL4942

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
P2RX5

Domain mapping of disease mutations (DMDM)

More...
DMDMi
209572778

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001615551 – 422P2X purinoceptor 5Add BLAST422

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi77N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi118 ↔ 169By similarity
Disulfide bondi129 ↔ 152By similarity
Disulfide bondi135 ↔ 163By similarity
Glycosylationi202N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi220 ↔ 229By similarity
Disulfide bondi263 ↔ 272By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q93086

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q93086

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q93086

PeptideAtlas

More...
PeptideAtlasi
Q93086

PRoteomics IDEntifications database

More...
PRIDEi
Q93086

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
33860
75715 [Q93086-3]
75716 [Q93086-1]
75717 [Q93086-2]
75718 [Q93086-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q93086

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q93086

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed at high levels in brain and immune system.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000083454 Expressed in 154 organ(s), highest expression level in spleen

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q93086 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q93086 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA021948
HPA067827

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Functional P2XRs are organized as homomeric and heteromeric trimers.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
111065, 31 interactors

Protein interaction database and analysis system

More...
IntActi
Q93086, 25 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000225328

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q93086

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q93086 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q93086

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the P2X receptor family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IFJF Eukaryota
ENOG410XR0C LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182706

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000232042

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q93086

KEGG Orthology (KO)

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KOi
K05219

Identification of Orthologs from Complete Genome Data

More...
OMAi
GIHIEWN

Database of Orthologous Groups

More...
OrthoDBi
1128763at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q93086

TreeFam database of animal gene trees

More...
TreeFami
TF328633

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.490.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003048 P2X5_purnocptor
IPR027309 P2X_extracellular_dom_sf
IPR001429 P2X_purnocptor

The PANTHER Classification System

More...
PANTHERi
PTHR10125:SF12 PTHR10125:SF12, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF005713 P2X_purinoceptor, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01312 P2X5RECEPTOR
PR01307 P2XRECEPTOR

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00863 P2X, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01212 P2X_RECEPTOR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q93086-3) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGQAGCKGLC LSLFDYKTEK YVIAKNKKVG LLYRLLQASI LAYLVVWVFL
60 70 80 90 100
IKKGYQDVDT SLQSAVITKV KGVAFTNTSD LGQRIWDVAD YVIPAQGENV
110 120 130 140 150
FFVVTNLIVT PNQRQNVCAE NEGIPDGACS KDSDCHAGEA VTAGNGVKTG
160 170 180 190 200
RCLRRENLAR GTCEIFAWCP LETSSRPEEP FLKEAEDFTI FIKNHIRFPK
210 220 230 240 250
FNFSKSNVMD VKDRSFLKSC HFGPKNHYCP IFRLGSVIRW AGSDFQDIAL
260 270 280 290 300
EGGVIGINIE WNCDLDKAAS ECHPHYSFSR LDNKLSKSVS SGYNFRFARY
310 320 330 340 350
YRDAAGVEFR TLMKAYGIRF DVMVNGKGAF FCDLVLIYLI KKREFYRDKK
360 370 380 390 400
YEEVRGLEDS SQEAEDEASG LGLSEQLTSG PGLLGMPEQQ ELQEPPEAKR
410 420
GSSSQKGNGS VCPQLLEPHR ST
Length:422
Mass (Da):47,205
Last modified:October 14, 2008 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB122027A23B2A240
GO
Isoform 2 (identifier: Q93086-1) [UniParc]FASTAAdd to basket
Also known as: A

The sequence of this isoform differs from the canonical sequence as follows:
     205-206: KS → N

Show »
Length:421
Mass (Da):47,104
Checksum:i6B47307AA14C2A6C
GO
Isoform 3 (identifier: Q93086-2) [UniParc]FASTAAdd to basket
Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
     97-120: Missing.
     205-206: KS → N

Show »
Length:397
Mass (Da):44,430
Checksum:iC3DB8AB55858CEB0
GO
Isoform 4 (identifier: Q93086-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     421-422: ST → LRTPSASPLHQE

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »
Length:432
Mass (Da):48,334
Checksum:i53AD66E4F75A69E3
GO
Isoform 5 (identifier: Q93086-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     97-120: Missing.

Show »
Length:398
Mass (Da):44,531
Checksum:i15CA9EC0EC4BB6A4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EQ78K7EQ78_HUMAN
P2X purinoceptor
P2RX5
431Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B4DEG2B4DEG2_HUMAN
P2X purinoceptor
P2RX5
362Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YII8H0YII8_HUMAN
P2X purinoceptor 5
P2RX5
286Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YHT9H0YHT9_HUMAN
P2X purinoceptor 5
P2RX5
29Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF43106 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AK307959 differs from that shown. Reason: Frameshift.Curated
The sequence BAD92860 differs from that shown. Reason: Frameshift.Curated
The sequence BC028084 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti96Q → E in AAB08577 (Ref. 1) Curated1
Sequence conflicti97 – 98GE → EK in AAB08576 (Ref. 1) Curated2
Sequence conflicti156E → G in AAC51931 (PubMed:9414125).Curated1
Sequence conflicti237 – 238VI → IV in AAC51931 (PubMed:9414125).Curated2
Sequence conflicti251E → R in AAC51931 (PubMed:9414125).Curated1
Sequence conflicti330F → S in AAB08576 (Ref. 1) Curated1
Sequence conflicti330F → S in AAB08577 (Ref. 1) Curated1
Sequence conflicti350K → R in ABB29978 (Ref. 5) Curated1
Sequence conflicti352E → Q in AAB08576 (Ref. 1) Curated1
Sequence conflicti352E → Q in AAB08577 (Ref. 1) Curated1
Sequence conflicti399 – 400KR → NV in AAB08576 (Ref. 1) Curated2
Sequence conflicti399 – 400KR → NV in AAB08577 (Ref. 1) Curated2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_00450397 – 120Missing in isoform 3 and isoform 5. 3 PublicationsAdd BLAST24
Alternative sequenceiVSP_035587205 – 206KS → N in isoform 2 and isoform 3. 4 Publications2
Alternative sequenceiVSP_035588421 – 422ST → LRTPSASPLHQE in isoform 4. 1 Publication2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U49395 mRNA Translation: AAB08576.1
U49396 mRNA Translation: AAB08577.1
AF016709 mRNA Translation: AAC51931.1
AF168787 Genomic DNA Translation: AAF43105.1
AF168787 Genomic DNA Translation: AAF43106.1 Sequence problems.
AF070573 mRNA Translation: AAC28645.1
DQ234349 mRNA Translation: ABB29978.1
AK290889 mRNA Translation: BAF83578.1
AK307959 mRNA No translation available.
AB209623 mRNA Translation: BAD92860.1 Frameshift.
AC132942 Genomic DNA No translation available.
CH471108 Genomic DNA Translation: EAW90483.1
BC028084 mRNA No translation available.
BC039015 mRNA Translation: AAH39015.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS11034.1 [Q93086-3]
CCDS11035.1 [Q93086-2]
CCDS56014.1 [Q93086-5]
CCDS56015.1 [Q93086-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001191448.1, NM_001204519.1 [Q93086-1]
NP_001191449.1, NM_001204520.1 [Q93086-5]
NP_002552.2, NM_002561.3 [Q93086-3]
NP_778255.1, NM_175080.2 [Q93086-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000225328; ENSP00000225328; ENSG00000083454 [Q93086-3]
ENST00000345901; ENSP00000342161; ENSG00000083454 [Q93086-5]
ENST00000547178; ENSP00000448355; ENSG00000083454 [Q93086-1]
ENST00000551178; ENSP00000447545; ENSG00000083454 [Q93086-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
5026

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:5026

UCSC genome browser

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UCSCi
uc002fwi.4 human [Q93086-3]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

P2X receptor entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U49395 mRNA Translation: AAB08576.1
U49396 mRNA Translation: AAB08577.1
AF016709 mRNA Translation: AAC51931.1
AF168787 Genomic DNA Translation: AAF43105.1
AF168787 Genomic DNA Translation: AAF43106.1 Sequence problems.
AF070573 mRNA Translation: AAC28645.1
DQ234349 mRNA Translation: ABB29978.1
AK290889 mRNA Translation: BAF83578.1
AK307959 mRNA No translation available.
AB209623 mRNA Translation: BAD92860.1 Frameshift.
AC132942 Genomic DNA No translation available.
CH471108 Genomic DNA Translation: EAW90483.1
BC028084 mRNA No translation available.
BC039015 mRNA Translation: AAH39015.1
CCDSiCCDS11034.1 [Q93086-3]
CCDS11035.1 [Q93086-2]
CCDS56014.1 [Q93086-5]
CCDS56015.1 [Q93086-1]
RefSeqiNP_001191448.1, NM_001204519.1 [Q93086-1]
NP_001191449.1, NM_001204520.1 [Q93086-5]
NP_002552.2, NM_002561.3 [Q93086-3]
NP_778255.1, NM_175080.2 [Q93086-2]

3D structure databases

SMRiQ93086
ModBaseiSearch...

Protein-protein interaction databases

BioGridi111065, 31 interactors
IntActiQ93086, 25 interactors
STRINGi9606.ENSP00000225328

Chemistry databases

BindingDBiQ93086
ChEMBLiCHEMBL4942

PTM databases

iPTMnetiQ93086
PhosphoSitePlusiQ93086

Polymorphism and mutation databases

BioMutaiP2RX5
DMDMi209572778

Proteomic databases

jPOSTiQ93086
MassIVEiQ93086
PaxDbiQ93086
PeptideAtlasiQ93086
PRIDEiQ93086
ProteomicsDBi33860
75715 [Q93086-3]
75716 [Q93086-1]
75717 [Q93086-2]
75718 [Q93086-4]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
5026

Genome annotation databases

EnsembliENST00000225328; ENSP00000225328; ENSG00000083454 [Q93086-3]
ENST00000345901; ENSP00000342161; ENSG00000083454 [Q93086-5]
ENST00000547178; ENSP00000448355; ENSG00000083454 [Q93086-1]
ENST00000551178; ENSP00000447545; ENSG00000083454 [Q93086-2]
GeneIDi5026
KEGGihsa:5026
UCSCiuc002fwi.4 human [Q93086-3]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
5026
DisGeNETi5026
EuPathDBiHostDB:ENSG00000083454.21

GeneCards: human genes, protein and diseases

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GeneCardsi
P2RX5
HGNCiHGNC:8536 P2RX5
HPAiHPA021948
HPA067827
MIMi602836 gene
neXtProtiNX_Q93086
OpenTargetsiENSG00000083454
PharmGKBiPA32865

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IFJF Eukaryota
ENOG410XR0C LUCA
GeneTreeiENSGT00950000182706
HOGENOMiHOG000232042
InParanoidiQ93086
KOiK05219
OMAiGIHIEWN
OrthoDBi1128763at2759
PhylomeDBiQ93086
TreeFamiTF328633

Enzyme and pathway databases

ReactomeiR-HSA-139853 Elevation of cytosolic Ca2+ levels
R-HSA-418346 Platelet homeostasis

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
P2RX5

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
5026
PharosiQ93086 Tchem

Protein Ontology

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PROi
PR:Q93086
RNActiQ93086 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000083454 Expressed in 154 organ(s), highest expression level in spleen
ExpressionAtlasiQ93086 baseline and differential
GenevisibleiQ93086 HS

Family and domain databases

Gene3Di2.60.490.10, 1 hit
InterProiView protein in InterPro
IPR003048 P2X5_purnocptor
IPR027309 P2X_extracellular_dom_sf
IPR001429 P2X_purnocptor
PANTHERiPTHR10125:SF12 PTHR10125:SF12, 1 hit
PIRSFiPIRSF005713 P2X_purinoceptor, 1 hit
PRINTSiPR01312 P2X5RECEPTOR
PR01307 P2XRECEPTOR
TIGRFAMsiTIGR00863 P2X, 1 hit
PROSITEiView protein in PROSITE
PS01212 P2X_RECEPTOR, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiP2RX5_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q93086
Secondary accession number(s): G5E981
, O43450, O75540, Q308M5, Q59F38, Q8IXW4, Q93087, Q9NZV0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: October 14, 2008
Last modified: December 11, 2019
This is version 173 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
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