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Protein

P2X purinoceptor 5

Gene

P2RX5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for ATP that acts as a ligand-gated ion channel.

GO - Molecular functioni

  • ATP binding Source: BHF-UCL
  • extracellularly ATP-gated cation channel activity Source: GO_Central
  • ion channel activity Source: ProtInc
  • purinergic nucleotide receptor activity Source: GO_Central
  • transmembrane signaling receptor activity Source: ProtInc

GO - Biological processi

  • blood coagulation Source: Reactome
  • nervous system development Source: ProtInc
  • positive regulation of calcium ion transport into cytosol Source: BHF-UCL
  • positive regulation of calcium-mediated signaling Source: BHF-UCL
  • response to ATP Source: InterPro
  • signal transduction Source: ProtInc

Keywordsi

Molecular functionIon channel, Ligand-gated ion channel, Receptor
Biological processIon transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-139853 Elevation of cytosolic Ca2+ levels
R-HSA-418346 Platelet homeostasis

Names & Taxonomyi

Protein namesi
Recommended name:
P2X purinoceptor 5
Short name:
P2X5
Alternative name(s):
ATP receptor
Purinergic receptor
Gene namesi
Name:P2RX5
Synonyms:P2X5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000083454.21
HGNCiHGNC:8536 P2RX5
MIMi602836 gene
neXtProtiNX_Q93086

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 30CytoplasmicSequence analysisAdd BLAST30
Transmembranei31 – 51Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini52 – 319ExtracellularSequence analysisAdd BLAST268
Transmembranei320 – 340Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini341 – 422CytoplasmicSequence analysisAdd BLAST82

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi5026
OpenTargetsiENSG00000083454
PharmGKBiPA32865

Chemistry databases

ChEMBLiCHEMBL4942

Polymorphism and mutation databases

BioMutaiP2RX5
DMDMi209572778

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001615551 – 422P2X purinoceptor 5Add BLAST422

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi77N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi118 ↔ 169By similarity
Disulfide bondi129 ↔ 152By similarity
Disulfide bondi135 ↔ 163By similarity
Glycosylationi202N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi220 ↔ 229By similarity
Disulfide bondi263 ↔ 272By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ93086
PeptideAtlasiQ93086
PRIDEiQ93086
ProteomicsDBi75715
75716 [Q93086-1]
75717 [Q93086-2]
75718 [Q93086-4]

PTM databases

iPTMnetiQ93086
PhosphoSitePlusiQ93086

Expressioni

Tissue specificityi

Expressed at high levels in brain and immune system.

Gene expression databases

BgeeiENSG00000083454
CleanExiHS_P2RX5
ExpressionAtlasiQ93086 baseline and differential
GenevisibleiQ93086 HS

Organism-specific databases

HPAiHPA021948
HPA067827

Interactioni

Subunit structurei

Functional P2XRs are organized as homomeric and heteromeric trimers.By similarity

Protein-protein interaction databases

BioGridi111065, 30 interactors
IntActiQ93086, 2 interactors
STRINGi9606.ENSP00000225328

Chemistry databases

BindingDBiQ93086

Structurei

3D structure databases

ProteinModelPortaliQ93086
SMRiQ93086
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the P2X receptor family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFJF Eukaryota
ENOG410XR0C LUCA
GeneTreeiENSGT00390000016028
HOGENOMiHOG000232042
HOVERGENiHBG053086
InParanoidiQ93086
KOiK05219
OMAiAGAFFCD
PhylomeDBiQ93086
TreeFamiTF328633

Family and domain databases

Gene3Di2.60.490.10, 1 hit
InterProiView protein in InterPro
IPR003048 P2X5_purnocptor
IPR027309 P2X_extracellular_dom_sf
IPR001429 P2X_purnocptor
PANTHERiPTHR10125 PTHR10125, 1 hit
PTHR10125:SF12 PTHR10125:SF12, 1 hit
PfamiView protein in Pfam
PF00864 P2X_receptor, 1 hit
PIRSFiPIRSF005713 P2X_purinoceptor, 1 hit
PRINTSiPR01312 P2X5RECEPTOR
PR01307 P2XRECEPTOR
TIGRFAMsiTIGR00863 P2X, 1 hit
PROSITEiView protein in PROSITE
PS01212 P2X_RECEPTOR, 1 hit

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q93086-3) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGQAGCKGLC LSLFDYKTEK YVIAKNKKVG LLYRLLQASI LAYLVVWVFL
60 70 80 90 100
IKKGYQDVDT SLQSAVITKV KGVAFTNTSD LGQRIWDVAD YVIPAQGENV
110 120 130 140 150
FFVVTNLIVT PNQRQNVCAE NEGIPDGACS KDSDCHAGEA VTAGNGVKTG
160 170 180 190 200
RCLRRENLAR GTCEIFAWCP LETSSRPEEP FLKEAEDFTI FIKNHIRFPK
210 220 230 240 250
FNFSKSNVMD VKDRSFLKSC HFGPKNHYCP IFRLGSVIRW AGSDFQDIAL
260 270 280 290 300
EGGVIGINIE WNCDLDKAAS ECHPHYSFSR LDNKLSKSVS SGYNFRFARY
310 320 330 340 350
YRDAAGVEFR TLMKAYGIRF DVMVNGKGAF FCDLVLIYLI KKREFYRDKK
360 370 380 390 400
YEEVRGLEDS SQEAEDEASG LGLSEQLTSG PGLLGMPEQQ ELQEPPEAKR
410 420
GSSSQKGNGS VCPQLLEPHR ST
Length:422
Mass (Da):47,205
Last modified:October 14, 2008 - v4
Checksum:iB122027A23B2A240
GO
Isoform 2 (identifier: Q93086-1) [UniParc]FASTAAdd to basket
Also known as: A

The sequence of this isoform differs from the canonical sequence as follows:
     205-206: KS → N

Show »
Length:421
Mass (Da):47,104
Checksum:i6B47307AA14C2A6C
GO
Isoform 3 (identifier: Q93086-2) [UniParc]FASTAAdd to basket
Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
     97-120: Missing.
     205-206: KS → N

Show »
Length:397
Mass (Da):44,430
Checksum:iC3DB8AB55858CEB0
GO
Isoform 4 (identifier: Q93086-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     421-422: ST → LRTPSASPLHQE

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:432
Mass (Da):48,334
Checksum:i53AD66E4F75A69E3
GO
Isoform 5 (identifier: Q93086-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     97-120: Missing.

Show »
Length:398
Mass (Da):44,531
Checksum:i15CA9EC0EC4BB6A4
GO

Sequence cautioni

The sequence AAF43106 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AK307959 differs from that shown. Reason: Frameshift at position 112.Curated
The sequence BAD92860 differs from that shown. Reason: Frameshift at position 112.Curated
The sequence BC028084 differs from that shown. Reason: Frameshift at position 112.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti96Q → E in AAB08577 (Ref. 1) Curated1
Sequence conflicti97 – 98GE → EK in AAB08576 (Ref. 1) Curated2
Sequence conflicti156E → G in AAC51931 (PubMed:9414125).Curated1
Sequence conflicti237 – 238VI → IV in AAC51931 (PubMed:9414125).Curated2
Sequence conflicti251E → R in AAC51931 (PubMed:9414125).Curated1
Sequence conflicti330F → S in AAB08576 (Ref. 1) Curated1
Sequence conflicti330F → S in AAB08577 (Ref. 1) Curated1
Sequence conflicti350K → R in ABB29978 (Ref. 5) Curated1
Sequence conflicti352E → Q in AAB08576 (Ref. 1) Curated1
Sequence conflicti352E → Q in AAB08577 (Ref. 1) Curated1
Sequence conflicti399 – 400KR → NV in AAB08576 (Ref. 1) Curated2
Sequence conflicti399 – 400KR → NV in AAB08577 (Ref. 1) Curated2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00450397 – 120Missing in isoform 3 and isoform 5. 3 PublicationsAdd BLAST24
Alternative sequenceiVSP_035587205 – 206KS → N in isoform 2 and isoform 3. 4 Publications2
Alternative sequenceiVSP_035588421 – 422ST → LRTPSASPLHQE in isoform 4. 1 Publication2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U49395 mRNA Translation: AAB08576.1
U49396 mRNA Translation: AAB08577.1
AF016709 mRNA Translation: AAC51931.1
AF168787 Genomic DNA Translation: AAF43105.1
AF168787 Genomic DNA Translation: AAF43106.1 Sequence problems.
AF070573 mRNA Translation: AAC28645.1
DQ234349 mRNA Translation: ABB29978.1
AK290889 mRNA Translation: BAF83578.1
AK307959 mRNA No translation available.
AB209623 mRNA Translation: BAD92860.1 Frameshift.
AC132942 Genomic DNA No translation available.
CH471108 Genomic DNA Translation: EAW90483.1
BC028084 mRNA No translation available.
BC039015 mRNA Translation: AAH39015.1
CCDSiCCDS11034.1 [Q93086-3]
CCDS11035.1 [Q93086-2]
CCDS56014.1 [Q93086-5]
CCDS56015.1 [Q93086-1]
RefSeqiNP_001191448.1, NM_001204519.1 [Q93086-1]
NP_001191449.1, NM_001204520.1 [Q93086-5]
NP_002552.2, NM_002561.3 [Q93086-3]
NP_778255.1, NM_175080.2 [Q93086-2]
UniGeneiHs.731607

Genome annotation databases

EnsembliENST00000225328; ENSP00000225328; ENSG00000083454 [Q93086-3]
ENST00000345901; ENSP00000342161; ENSG00000083454 [Q93086-5]
ENST00000547178; ENSP00000448355; ENSG00000083454 [Q93086-1]
ENST00000551178; ENSP00000447545; ENSG00000083454 [Q93086-2]
GeneIDi5026
KEGGihsa:5026
UCSCiuc002fwi.4 human [Q93086-3]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiP2RX5_HUMAN
AccessioniPrimary (citable) accession number: Q93086
Secondary accession number(s): G5E981
, O43450, O75540, Q308M5, Q59F38, Q8IXW4, Q93087, Q9NZV0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: October 14, 2008
Last modified: June 20, 2018
This is version 161 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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