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UniProtKB - Q93074 (MED12_HUMAN)

Protein

Mediator of RNA polymerase II transcription subunit 12

Gene

MED12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. This subunit may specifically regulate transcription of targets of the Wnt signaling pathway and SHH signaling pathway.3 Publications

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionActivator, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-1989781 PPARA activates gene expression
R-HSA-212436 Generic Transcription Pathway
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation
SignaLinkiQ93074
SIGNORiQ93074

Names & Taxonomyi

Protein namesi
Recommended name:
Mediator of RNA polymerase II transcription subunit 12
Alternative name(s):
Activator-recruited cofactor 240 kDa component
Short name:
ARC240
CAG repeat protein 45
Mediator complex subunit 12
OPA-containing protein
Thyroid hormone receptor-associated protein complex 230 kDa component
Short name:
Trap230
Trinucleotide repeat-containing gene 11 protein
Gene namesi
Name:MED12
Synonyms:ARC240, CAGH45, HOPA, KIAA0192, TNRC11, TRAP230
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000184634.15
HGNCiHGNC:11957 MED12
MIMi300188 gene
neXtProtiNX_Q93074

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Opitz-Kaveggia syndrome (OKS)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionX-linked disorder characterized by mental retardation, relative macrocephaly, hypotonia and constipation.
See also OMIM:305450
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_033112961R → W in OKS. 1 PublicationCorresponds to variant dbSNP:rs80338758EnsemblClinVar.1
Lujan-Fryns syndrome (LUJFRYS)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionClinically, Lujan-Fryns syndrome can be distinguished from Opitz-Kaveggia syndrome by tall stature, hypernasal voice, hyperextensible digits and high nasal root.
See also OMIM:309520
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0375341007N → S in LUJFRYS. 1 PublicationCorresponds to variant dbSNP:rs80338759EnsemblClinVar.1
Ohdo syndrome, X-linked (OHDOX)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA syndrome characterized by mental retardation, feeding problems, and distinctive facial appearance with coarse facial features, severe blepharophimosis, ptosis, a bulbous nose, micrognathia and a small mouth. Dental hypoplasia and deafness can be considered as common manifestations of the syndrome. Male patients show cryptorchidism and scrotal hypoplasia.
See also OMIM:300895
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0697701148R → H in OHDOX. 1 PublicationCorresponds to variant dbSNP:rs387907360EnsemblClinVar.1
Natural variantiVAR_0697711165S → P in OHDOX. 1 PublicationCorresponds to variant dbSNP:rs387907361EnsemblClinVar.1
Natural variantiVAR_0697721729H → N in OHDOX. 1 PublicationCorresponds to variant dbSNP:rs387907362EnsemblClinVar.1

Keywords - Diseasei

Disease mutation, Mental retardation

Organism-specific databases

DisGeNETi9968
GeneReviewsiMED12
MalaCardsiMED12
MIMi300895 phenotype
305450 phenotype
309520 phenotype
OpenTargetsiENSG00000184634
Orphaneti293707 Blepharophimosis-intellectual disability syndrome, MKB type
93932 FG syndrome type 1
776 X-linked intellectual disability with marfanoid habitus
777 X-linked non-syndromic intellectual disability
PharmGKBiPA36645

Polymorphism and mutation databases

BioMutaiMED12
DMDMi209572775

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000963591 – 2177Mediator of RNA polymerase II transcription subunit 12Add BLAST2177

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei80N6-acetyllysineBy similarity1
Modified residuei166PhosphotyrosineCombined sources1
Modified residuei635PhosphoserineCombined sources1
Modified residuei665PhosphoserineCombined sources1
Modified residuei698PhosphoserineCombined sources1
Modified residuei700PhosphoserineCombined sources1
Modified residuei1258PhosphoserineCombined sources1
Modified residuei1269PhosphoserineCombined sources1
Modified residuei1798N6-acetyllysineBy similarity1
Modified residuei1899Asymmetric dimethylarginine; alternateBy similarity1
Modified residuei1899Omega-N-methylarginine; alternateBy similarity1
Modified residuei1910Omega-N-methylarginineBy similarity1
Modified residuei1994Asymmetric dimethylarginineCombined sources1
Modified residuei2015Asymmetric dimethylarginineCombined sources1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDiQ93074
MaxQBiQ93074
PaxDbiQ93074
PeptideAtlasiQ93074
PRIDEiQ93074
ProteomicsDBi75701
75702 [Q93074-2]
75703 [Q93074-3]

PTM databases

iPTMnetiQ93074
PhosphoSitePlusiQ93074

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiENSG00000184634 Expressed in 200 organ(s), highest expression level in left adrenal gland
CleanExiHS_MED12
ExpressionAtlasiQ93074 baseline and differential
GenevisibleiQ93074 HS

Organism-specific databases

HPAiHPA003184
HPA003185

Interactioni

Subunit structurei

Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. Also interacts with CTNNB1 and GLI3.8 Publications

Binary interactionsi

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi115293, 90 interactors
ComplexPortaliCPX-3232 CKM complex variant 1
CPX-3263 CKM complex variant 2
CORUMiQ93074
DIPiDIP-31459N
IntActiQ93074, 70 interactors
MINTiQ93074
STRINGi9606.ENSP00000363193

Structurei

3D structure databases

ProteinModelPortaliQ93074
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1616 – 2051Interaction with CTNNB1 and GLI31 PublicationAdd BLAST436

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1732 – 1777Pro-richAdd BLAST46
Compositional biasi1900 – 2168Gln-richAdd BLAST269

Sequence similaritiesi

Belongs to the Mediator complex subunit 12 family.Curated

Phylogenomic databases

eggNOGiENOG410ISJR Eukaryota
ENOG41119EY LUCA
GeneTreeiENSGT00440000037505
HOGENOMiHOG000231423
HOVERGENiHBG052447
InParanoidiQ93074
KOiK15162
OMAiMICYPEA
OrthoDBiEOG091G00I6
PhylomeDBiQ93074
TreeFamiTF324178

Family and domain databases

InterProiView protein in InterPro
IPR019035 Mediator_Med12
IPR021989 Mediator_Med12_catenin-bd
IPR021990 Mediator_Med12_LCEWAV
PfamiView protein in Pfam
PF09497 Med12, 1 hit
PF12145 Med12-LCEWAV, 1 hit
PF12144 Med12-PQL, 1 hit
SMARTiView protein in SMART
SM01281 Med12, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q93074-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAFGILSYE HRPLKRPRLG PPDVYPQDPK QKEDELTALN VKQGFNNQPA 
        60         70         80         90        100
VSGDEHGSAK NVSFNPAKIS SNFSSIIAEK LRCNTLPDTG RRKPQVNQKD 
       110        120        130        140        150
NFWLVTARSQ SAINTWFTDL AGTKPLTQLA KKVPIFSKKE EVFGYLAKYT 
       160        170        180        190        200
VPVMRAAWLI KMTCAYYAAI SETKVKKRHV DPFMEWTQII TKYLWEQLQK 
       210        220        230        240        250
MAEYYRPGPA GSGGCGSTIG PLPHDVEVAI RQWDYTEKLA MFMFQDGMLD 
       260        270        280        290        300
RHEFLTWVLE CFEKIRPGED ELLKLLLPLL LRYSGEFVQS AYLSRRLAYF 
       310        320        330        340        350
CTRRLALQLD GVSSHSSHVI SAQSTSTLPT TPAPQPPTSS TPSTPFSDLL 
       360        370        380        390        400
MCPQHRPLVF GLSCILQTIL LCCPSALVWH YSLTDSRIKT GSPLDHLPIA 
       410        420        430        440        450
PSNLPMPEGN SAFTQQVRAK LREIEQQIKE RGQAVEVRWS FDKCQEATAG 
       460        470        480        490        500
FTIGRVLHTL EVLDSHSFER SDFSNSLDSL CNRIFGLGPS KDGHEISSDD 
       510        520        530        540        550
DAVVSLLCEW AVSCKRSGRH RAMVVAKLLE KRQAEIEAER CGESEAADEK 
       560        570        580        590        600
GSIASGSLSA PSAPIFQDVL LQFLDTQAPM LTDPRSESER VEFFNLVLLF 
       610        620        630        640        650
CELIRHDVFS HNMYTCTLIS RGDLAFGAPG PRPPSPFDDP ADDPEHKEAE 
       660        670        680        690        700
GSSSSKLEDP GLSESMDIDP SSSVLFEDME KPDFSLFSPT MPCEGKGSPS 
       710        720        730        740        750
PEKPDVEKEV KPPPKEKIEG TLGVLYDQPR HVQYATHFPI PQEESCSHEC 
       760        770        780        790        800
NQRLVVLFGV GKQRDDARHA IKKITKDILK VLNRKGTAET DQLAPIVPLN 
       810        820        830        840        850
PGDLTFLGGE DGQKRRRNRP EAFPTAEDIF AKFQHLSHYD QHQVTAQVSR 
       860        870        880        890        900
NVLEQITSFA LGMSYHLPLV QHVQFIFDLM EYSLSISGLI DFAIQLLNEL 
       910        920        930        940        950
SVVEAELLLK SSDLVGSYTT SLCLCIVAVL RHYHACLILN QDQMAQVFEG 
       960        970        980        990       1000
LCGVVKHGMN RSDGSSAERC ILAYLYDLYT SCSHLKNKFG ELFSDFCSKV 
      1010       1020       1030       1040       1050
KNTIYCNVEP SESNMRWAPE FMIDTLENPA AHTFTYTGLG KSLSENPANR 
      1060       1070       1080       1090       1100
YSFVCNALMH VCVGHHDPDR VNDIAILCAE LTGYCKSLSA EWLGVLKALC 
      1110       1120       1130       1140       1150
CSSNNGTCGF NDLLCNVDVS DLSFHDSLAT FVAILIARQC LLLEDLIRCA 
      1160       1170       1180       1190       1200
AIPSLLNAAC SEQDSEPGAR LTCRILLHLF KTPQLNPCQS DGNKPTVGIR 
      1210       1220       1230       1240       1250
SSCDRHLLAA SQNRIVDGAV FAVLKAVFVL GDAELKGSGF TVTGGTEELP 
      1260       1270       1280       1290       1300
EEEGGGGSGG RRQGGRNISV ETASLDVYAK YVLRSICQQE WVGERCLKSL 
      1310       1320       1330       1340       1350
CEDSNDLQDP VLSSAQAQRL MQLICYPHRL LDNEDGENPQ RQRIKRILQN 
      1360       1370       1380       1390       1400
LDQWTMRQSS LELQLMIKQT PNNEMNSLLE NIAKATIEVF QQSAETGSSS 
      1410       1420       1430       1440       1450
GSTASNMPSS SKTKPVLSSL ERSGVWLVAP LIAKLPTSVQ GHVLKAAGEE 
      1460       1470       1480       1490       1500
LEKGQHLGSS SRKERDRQKQ KSMSLLSQQP FLSLVLTCLK GQDEQREGLL 
      1510       1520       1530       1540       1550
TSLYSQVHQI VNNWRDDQYL DDCKPKQLMH EALKLRLNLV GGMFDTVQRS 
      1560       1570       1580       1590       1600
TQQTTEWAML LLEIIISGTV DMQSNNELFT TVLDMLSVLI NGTLAADMSS 
      1610       1620       1630       1640       1650
ISQGSMEENK RAYMNLAKKL QKELGERQSD SLEKVRQLLP LPKQTRDVIT 
      1660       1670       1680       1690       1700
CEPQGSLIDT KGNKIAGFDS IFKKEGLQVS TKQKISPWDL FEGLKPSAPL 
      1710       1720       1730       1740       1750
SWGWFGTVRV DRRVARGEEQ QRLLLYHTHL RPRPRAYYLE PLPLPPEDEE 
      1760       1770       1780       1790       1800
PPAPTLLEPE KKAPEPPKTD KPGAAPPSTE ERKKKSTKGK KRSQPATKTE 
      1810       1820       1830       1840       1850
DYGMGPGRSG PYGVTVPPDL LHHPNPGSIT HLNYRQGSIG LYTQNQPLPA 
      1860       1870       1880       1890       1900
GGPRVDPYRP VRLPMQKLPT RPTYPGVLPT TMTGVMGLEP SSYKTSVYRQ 
      1910       1920       1930       1940       1950
QQPAVPQGQR LRQQLQQSQG MLGQSSVHQM TPSSSYGLQT SQGYTPYVSH 
      1960       1970       1980       1990       2000
VGLQQHTGPA GTMVPPSYSS QPYQSTHPST NPTLVDPTRH LQQRPSGYVH 
      2010       2020       2030       2040       2050
QQAPTYGHGL TSTQRFSHQT LQQTPMISTM TPMSAQGVQA GVRSTAILPE 
      2060       2070       2080       2090       2100
QQQQQQQQQQ QQQQQQQQQQ QQQQQQYHIR QQQQQQILRQ QQQQQQQQQQ 
      2110       2120       2130       2140       2150
QQQQQQQQQQ QQQQQHQQQQ QQQAAPPQPQ PQSQPQFQRQ GLQQTQQQQQ 
      2160       2170 
TAALVRQLQQ QLSNTQPQPS TNIFGRY
Length:2,177
Mass (Da):243,081
Last modified:October 14, 2008 - v4
Checksum:i7492B07BA0F6EA9D
GO
Isoform 2 (identifier: Q93074-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1916-1916: Q → QAKI

Show »
Length:2,180
Mass (Da):243,394
Checksum:i22DB2ABC4A1CCA6B
GO
Isoform 3 (identifier: Q93074-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1916-1916: Missing.

Note: No experimental confirmation available.
Show »
Length:2,176
Mass (Da):242,953
Checksum:i440A5E60BA3E7273
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q7Z3Z5Q7Z3Z5_HUMAN
Mediator of RNA polymerase II trans...
MED12 TNRC11, hCG_19960
2,027Annotation score:
H7C191H7C191_HUMAN
Mediator of RNA polymerase II trans...
MED12
130Annotation score:
H7C274H7C274_HUMAN
Mediator of RNA polymerase II trans...
MED12
251Annotation score:

Sequence cautioni

The sequence AAD22033 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti16R → RPR in AAD22033 (PubMed:10198638).Curated1
Sequence conflicti397Missing AA sequence (PubMed:10235266).Curated1
Sequence conflicti1166E → V in AAD44162 (PubMed:10480376).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_033112961R → W in OKS. 1 PublicationCorresponds to variant dbSNP:rs80338758EnsemblClinVar.1
Natural variantiVAR_0375341007N → S in LUJFRYS. 1 PublicationCorresponds to variant dbSNP:rs80338759EnsemblClinVar.1
Natural variantiVAR_0697701148R → H in OHDOX. 1 PublicationCorresponds to variant dbSNP:rs387907360EnsemblClinVar.1
Natural variantiVAR_0697711165S → P in OHDOX. 1 PublicationCorresponds to variant dbSNP:rs387907361EnsemblClinVar.1
Natural variantiVAR_0466721392Q → R2 PublicationsCorresponds to variant dbSNP:rs1139013Ensembl.1
Natural variantiVAR_0697721729H → N in OHDOX. 1 PublicationCorresponds to variant dbSNP:rs387907362EnsemblClinVar.1
Natural variantiVAR_0740181974Q → H Found in a family with X-linked intellectual disability; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs879255528EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0355201916Q → QAKI in isoform 2. 1 Publication1
Alternative sequenceiVSP_0355211916Missing in isoform 3. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF117755 mRNA Translation: AAD22033.1 Different initiation.
AL590764 Genomic DNA No translation available.
D83783 mRNA Translation: BAA12112.1
AF071309 mRNA Translation: AAC83163.1
AF132033 Genomic DNA Translation: AAD44162.1
U80742 mRNA Translation: AAB91440.1
CCDSiCCDS43970.1 [Q93074-1]
RefSeqiNP_005111.2, NM_005120.2 [Q93074-1]
UniGeneiHs.409226

Genome annotation databases

EnsembliENST00000374080; ENSP00000363193; ENSG00000184634 [Q93074-1]
ENST00000374102; ENSP00000363215; ENSG00000184634 [Q93074-3]
GeneIDi9968
KEGGihsa:9968
UCSCiuc004dyy.4 human [Q93074-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF117755 mRNA Translation: AAD22033.1 Different initiation.
AL590764 Genomic DNA No translation available.
D83783 mRNA Translation: BAA12112.1
AF071309 mRNA Translation: AAC83163.1
AF132033 Genomic DNA Translation: AAD44162.1
U80742 mRNA Translation: AAB91440.1
CCDSiCCDS43970.1 [Q93074-1]
RefSeqiNP_005111.2, NM_005120.2 [Q93074-1]
UniGeneiHs.409226

3D structure databases

ProteinModelPortaliQ93074
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115293, 90 interactors
ComplexPortaliCPX-3232 CKM complex variant 1
CPX-3263 CKM complex variant 2
CORUMiQ93074
DIPiDIP-31459N
IntActiQ93074, 70 interactors
MINTiQ93074
STRINGi9606.ENSP00000363193

PTM databases

iPTMnetiQ93074
PhosphoSitePlusiQ93074

Polymorphism and mutation databases

BioMutaiMED12
DMDMi209572775

Proteomic databases

EPDiQ93074
MaxQBiQ93074
PaxDbiQ93074
PeptideAtlasiQ93074
PRIDEiQ93074
ProteomicsDBi75701
75702 [Q93074-2]
75703 [Q93074-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000374080; ENSP00000363193; ENSG00000184634 [Q93074-1]
ENST00000374102; ENSP00000363215; ENSG00000184634 [Q93074-3]
GeneIDi9968
KEGGihsa:9968
UCSCiuc004dyy.4 human [Q93074-1]

Organism-specific databases

CTDi9968
DisGeNETi9968
EuPathDBiHostDB:ENSG00000184634.15
GeneCardsiMED12
GeneReviewsiMED12
HGNCiHGNC:11957 MED12
HPAiHPA003184
HPA003185
MalaCardsiMED12
MIMi300188 gene
300895 phenotype
305450 phenotype
309520 phenotype
neXtProtiNX_Q93074
OpenTargetsiENSG00000184634
Orphaneti293707 Blepharophimosis-intellectual disability syndrome, MKB type
93932 FG syndrome type 1
776 X-linked intellectual disability with marfanoid habitus
777 X-linked non-syndromic intellectual disability
PharmGKBiPA36645
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410ISJR Eukaryota
ENOG41119EY LUCA
GeneTreeiENSGT00440000037505
HOGENOMiHOG000231423
HOVERGENiHBG052447
InParanoidiQ93074
KOiK15162
OMAiMICYPEA
OrthoDBiEOG091G00I6
PhylomeDBiQ93074
TreeFamiTF324178

Enzyme and pathway databases

ReactomeiR-HSA-1989781 PPARA activates gene expression
R-HSA-212436 Generic Transcription Pathway
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation
SignaLinkiQ93074
SIGNORiQ93074

Miscellaneous databases

ChiTaRSiMED12 human
GeneWikiiMED12
GenomeRNAii9968
PROiPR:Q93074
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000184634 Expressed in 200 organ(s), highest expression level in left adrenal gland
CleanExiHS_MED12
ExpressionAtlasiQ93074 baseline and differential
GenevisibleiQ93074 HS

Family and domain databases

InterProiView protein in InterPro
IPR019035 Mediator_Med12
IPR021989 Mediator_Med12_catenin-bd
IPR021990 Mediator_Med12_LCEWAV
PfamiView protein in Pfam
PF09497 Med12, 1 hit
PF12145 Med12-LCEWAV, 1 hit
PF12144 Med12-PQL, 1 hit
SMARTiView protein in SMART
SM01281 Med12, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMED12_HUMAN
AccessioniPrimary (citable) accession number: Q93074
Secondary accession number(s): O15410
, O75557, Q9UHV6, Q9UND7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: October 14, 2008
Last modified: November 7, 2018
This is version 183 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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