UniProtKB - Q93074 (MED12_HUMAN)
Mediator of RNA polymerase II transcription subunit 12
MED12
Functioni
GO - Molecular functioni
- beta-catenin binding Source: InterPro
- chromatin binding Source: Ensembl
- nuclear receptor transcription coactivator activity Source: UniProtKB
- protein C-terminus binding Source: UniProtKB
- protein domain specific binding Source: UniProtKB
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: Ensembl
- thyroid hormone receptor binding Source: UniProtKB
- transcription coactivator activity Source: UniProtKB
- transcription coregulator activity Source: UniProtKB
- ubiquitin protein ligase activity Source: Ensembl
- vitamin D receptor binding Source: UniProtKB
GO - Biological processi
- axis elongation involved in somitogenesis Source: Ensembl
- canonical Wnt signaling pathway Source: Ensembl
- embryonic brain development Source: Ensembl
- embryonic neurocranium morphogenesis Source: Ensembl
- endoderm development Source: Ensembl
- heart development Source: Ensembl
- neural tube closure Source: Ensembl
- oligodendrocyte development Source: Ensembl
- positive regulation of transcription, DNA-templated Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: MGI
- positive regulation of transcription initiation from RNA polymerase II promoter Source: UniProtKB
- post-anal tail morphogenesis Source: Ensembl
- regulation of transcription by RNA polymerase II Source: GO_Central
- Schwann cell development Source: Ensembl
- spinal cord development Source: Ensembl
- stem cell population maintenance Source: Ensembl
- transcription initiation from RNA polymerase II promoter Source: Reactome
- Wnt signaling pathway, planar cell polarity pathway Source: Ensembl
Keywordsi
Molecular function | Activator, Repressor |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | Q93074 |
Reactomei | R-HSA-1989781, PPARA activates gene expression R-HSA-212436, Generic Transcription Pathway R-HSA-381340, Transcriptional regulation of white adipocyte differentiation |
SignaLinki | Q93074 |
SIGNORi | Q93074 |
Names & Taxonomyi
Protein namesi | Recommended name: Mediator of RNA polymerase II transcription subunit 12Alternative name(s): Activator-recruited cofactor 240 kDa component Short name: ARC240 CAG repeat protein 45 Mediator complex subunit 12 OPA-containing protein Thyroid hormone receptor-associated protein complex 230 kDa component Short name: Trap230 Trinucleotide repeat-containing gene 11 protein |
Gene namesi | Name:MED12 Synonyms:ARC240, CAGH45, HOPA, KIAA0192, TNRC11, TRAP230 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:11957, MED12 |
MIMi | 300188, gene |
neXtProti | NX_Q93074 |
VEuPathDBi | HostDB:ENSG00000184634.15 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- mediator complex Source: UniProtKB
- nucleoplasm Source: Reactome
- nucleus Source: UniProtKB
Other locations
- membrane Source: UniProtKB
- ubiquitin ligase complex Source: Ensembl
Keywords - Cellular componenti
NucleusPathology & Biotechi
Involvement in diseasei
Opitz-Kaveggia syndrome (OKS)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_033112 | 961 | R → W in OKS. 1 PublicationCorresponds to variant dbSNP:rs80338758EnsemblClinVar. | 1 |
Intellectual developmental disorder, X-linked, syndromic, Lujan-Fryns type (MRXSLF)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_037534 | 1007 | N → S in MRXSLF. 1 PublicationCorresponds to variant dbSNP:rs80338759EnsemblClinVar. | 1 |
Ohdo syndrome, X-linked (OHDOX)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_069770 | 1148 | R → H in OHDOX. 1 PublicationCorresponds to variant dbSNP:rs387907360EnsemblClinVar. | 1 | |
Natural variantiVAR_069771 | 1165 | S → P in OHDOX. 1 PublicationCorresponds to variant dbSNP:rs387907361EnsemblClinVar. | 1 | |
Natural variantiVAR_069772 | 1729 | H → N in OHDOX. 1 PublicationCorresponds to variant dbSNP:rs387907362EnsemblClinVar. | 1 |
Keywords - Diseasei
Disease variant, Mental retardationOrganism-specific databases
DisGeNETi | 9968 |
GeneReviewsi | MED12 |
MalaCardsi | MED12 |
MIMi | 300895, phenotype 305450, phenotype 309520, phenotype |
OpenTargetsi | ENSG00000184634 |
Orphaneti | 293707, Blepharophimosis-intellectual disability syndrome, MKB type 93932, FG syndrome type 1 776, X-linked intellectual disability with marfanoid habitus 777, X-linked non-syndromic intellectual disability |
PharmGKBi | PA36645 |
Miscellaneous databases
Pharosi | Q93074, Tbio |
Genetic variation databases
BioMutai | MED12 |
DMDMi | 209572775 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000096359 | 1 – 2177 | Mediator of RNA polymerase II transcription subunit 12Add BLAST | 2177 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 80 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 166 | PhosphotyrosineCombined sources | 1 | |
Modified residuei | 635 | PhosphoserineCombined sources | 1 | |
Modified residuei | 665 | PhosphoserineCombined sources | 1 | |
Modified residuei | 698 | PhosphoserineCombined sources | 1 | |
Modified residuei | 700 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1258 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1269 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1798 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 1899 | Asymmetric dimethylarginine; alternateBy similarity | 1 | |
Modified residuei | 1899 | Omega-N-methylarginine; alternateBy similarity | 1 | |
Modified residuei | 1910 | Omega-N-methylarginineBy similarity | 1 | |
Modified residuei | 1994 | Asymmetric dimethylarginineCombined sources | 1 | |
Modified residuei | 2015 | Asymmetric dimethylarginineCombined sources | 1 |
Keywords - PTMi
Acetylation, Methylation, PhosphoproteinProteomic databases
EPDi | Q93074 |
jPOSTi | Q93074 |
MassIVEi | Q93074 |
MaxQBi | Q93074 |
PaxDbi | Q93074 |
PeptideAtlasi | Q93074 |
PRIDEi | Q93074 |
ProteomicsDBi | 75701 [Q93074-1] 75702 [Q93074-2] 75703 [Q93074-3] |
PTM databases
iPTMneti | Q93074 |
PhosphoSitePlusi | Q93074 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000184634, Expressed in left adrenal gland and 213 other tissues |
ExpressionAtlasi | Q93074, baseline and differential |
Genevisiblei | Q93074, HS |
Organism-specific databases
HPAi | ENSG00000184634, Low tissue specificity |
Interactioni
Subunit structurei
Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
Also interacts with CTNNB1 and GLI3.
8 PublicationsBinary interactionsi
Hide detailsQ93074
With | #Exp. | IntAct |
---|---|---|
APLP1 [P51693] | 2 | EBI-394357,EBI-74648 |
APLP2 [Q06481] | 2 | EBI-394357,EBI-79306 |
APP [P05067] | 2 | EBI-394357,EBI-77613 |
MED4 [Q9NPJ6] | 6 | EBI-394357,EBI-394607 |
TGFBR2 [P37173] | 3 | EBI-394357,EBI-296151 |
GO - Molecular functioni
- beta-catenin binding Source: InterPro
- protein C-terminus binding Source: UniProtKB
- protein domain specific binding Source: UniProtKB
- thyroid hormone receptor binding Source: UniProtKB
- vitamin D receptor binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 115293, 138 interactors |
ComplexPortali | CPX-3232, CKM complex variant 1 CPX-3263, CKM complex variant 2 |
CORUMi | Q93074 |
DIPi | DIP-31459N |
IntActi | Q93074, 78 interactors |
MINTi | Q93074 |
STRINGi | 9606.ENSP00000363193 |
Miscellaneous databases
RNActi | Q93074, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1616 – 2051 | Interaction with CTNNB1 and GLI31 PublicationAdd BLAST | 436 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1732 – 1777 | Pro-richAdd BLAST | 46 | |
Compositional biasi | 1900 – 2168 | Gln-richAdd BLAST | 269 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG3598, Eukaryota |
GeneTreei | ENSGT00440000037505 |
HOGENOMi | CLU_000904_1_0_1 |
InParanoidi | Q93074 |
OMAi | VWLDTVA |
OrthoDBi | 15873at2759 |
PhylomeDBi | Q93074 |
TreeFami | TF324178 |
Family and domain databases
InterProi | View protein in InterPro IPR019035, Mediator_Med12 IPR021989, Mediator_Med12_catenin-bd IPR021990, Mediator_Med12_LCEWAV |
Pfami | View protein in Pfam PF09497, Med12, 1 hit PF12145, Med12-LCEWAV, 1 hit PF12144, Med12-PQL, 1 hit |
SMARTi | View protein in SMART SM01281, Med12, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAAFGILSYE HRPLKRPRLG PPDVYPQDPK QKEDELTALN VKQGFNNQPA
60 70 80 90 100
VSGDEHGSAK NVSFNPAKIS SNFSSIIAEK LRCNTLPDTG RRKPQVNQKD
110 120 130 140 150
NFWLVTARSQ SAINTWFTDL AGTKPLTQLA KKVPIFSKKE EVFGYLAKYT
160 170 180 190 200
VPVMRAAWLI KMTCAYYAAI SETKVKKRHV DPFMEWTQII TKYLWEQLQK
210 220 230 240 250
MAEYYRPGPA GSGGCGSTIG PLPHDVEVAI RQWDYTEKLA MFMFQDGMLD
260 270 280 290 300
RHEFLTWVLE CFEKIRPGED ELLKLLLPLL LRYSGEFVQS AYLSRRLAYF
310 320 330 340 350
CTRRLALQLD GVSSHSSHVI SAQSTSTLPT TPAPQPPTSS TPSTPFSDLL
360 370 380 390 400
MCPQHRPLVF GLSCILQTIL LCCPSALVWH YSLTDSRIKT GSPLDHLPIA
410 420 430 440 450
PSNLPMPEGN SAFTQQVRAK LREIEQQIKE RGQAVEVRWS FDKCQEATAG
460 470 480 490 500
FTIGRVLHTL EVLDSHSFER SDFSNSLDSL CNRIFGLGPS KDGHEISSDD
510 520 530 540 550
DAVVSLLCEW AVSCKRSGRH RAMVVAKLLE KRQAEIEAER CGESEAADEK
560 570 580 590 600
GSIASGSLSA PSAPIFQDVL LQFLDTQAPM LTDPRSESER VEFFNLVLLF
610 620 630 640 650
CELIRHDVFS HNMYTCTLIS RGDLAFGAPG PRPPSPFDDP ADDPEHKEAE
660 670 680 690 700
GSSSSKLEDP GLSESMDIDP SSSVLFEDME KPDFSLFSPT MPCEGKGSPS
710 720 730 740 750
PEKPDVEKEV KPPPKEKIEG TLGVLYDQPR HVQYATHFPI PQEESCSHEC
760 770 780 790 800
NQRLVVLFGV GKQRDDARHA IKKITKDILK VLNRKGTAET DQLAPIVPLN
810 820 830 840 850
PGDLTFLGGE DGQKRRRNRP EAFPTAEDIF AKFQHLSHYD QHQVTAQVSR
860 870 880 890 900
NVLEQITSFA LGMSYHLPLV QHVQFIFDLM EYSLSISGLI DFAIQLLNEL
910 920 930 940 950
SVVEAELLLK SSDLVGSYTT SLCLCIVAVL RHYHACLILN QDQMAQVFEG
960 970 980 990 1000
LCGVVKHGMN RSDGSSAERC ILAYLYDLYT SCSHLKNKFG ELFSDFCSKV
1010 1020 1030 1040 1050
KNTIYCNVEP SESNMRWAPE FMIDTLENPA AHTFTYTGLG KSLSENPANR
1060 1070 1080 1090 1100
YSFVCNALMH VCVGHHDPDR VNDIAILCAE LTGYCKSLSA EWLGVLKALC
1110 1120 1130 1140 1150
CSSNNGTCGF NDLLCNVDVS DLSFHDSLAT FVAILIARQC LLLEDLIRCA
1160 1170 1180 1190 1200
AIPSLLNAAC SEQDSEPGAR LTCRILLHLF KTPQLNPCQS DGNKPTVGIR
1210 1220 1230 1240 1250
SSCDRHLLAA SQNRIVDGAV FAVLKAVFVL GDAELKGSGF TVTGGTEELP
1260 1270 1280 1290 1300
EEEGGGGSGG RRQGGRNISV ETASLDVYAK YVLRSICQQE WVGERCLKSL
1310 1320 1330 1340 1350
CEDSNDLQDP VLSSAQAQRL MQLICYPHRL LDNEDGENPQ RQRIKRILQN
1360 1370 1380 1390 1400
LDQWTMRQSS LELQLMIKQT PNNEMNSLLE NIAKATIEVF QQSAETGSSS
1410 1420 1430 1440 1450
GSTASNMPSS SKTKPVLSSL ERSGVWLVAP LIAKLPTSVQ GHVLKAAGEE
1460 1470 1480 1490 1500
LEKGQHLGSS SRKERDRQKQ KSMSLLSQQP FLSLVLTCLK GQDEQREGLL
1510 1520 1530 1540 1550
TSLYSQVHQI VNNWRDDQYL DDCKPKQLMH EALKLRLNLV GGMFDTVQRS
1560 1570 1580 1590 1600
TQQTTEWAML LLEIIISGTV DMQSNNELFT TVLDMLSVLI NGTLAADMSS
1610 1620 1630 1640 1650
ISQGSMEENK RAYMNLAKKL QKELGERQSD SLEKVRQLLP LPKQTRDVIT
1660 1670 1680 1690 1700
CEPQGSLIDT KGNKIAGFDS IFKKEGLQVS TKQKISPWDL FEGLKPSAPL
1710 1720 1730 1740 1750
SWGWFGTVRV DRRVARGEEQ QRLLLYHTHL RPRPRAYYLE PLPLPPEDEE
1760 1770 1780 1790 1800
PPAPTLLEPE KKAPEPPKTD KPGAAPPSTE ERKKKSTKGK KRSQPATKTE
1810 1820 1830 1840 1850
DYGMGPGRSG PYGVTVPPDL LHHPNPGSIT HLNYRQGSIG LYTQNQPLPA
1860 1870 1880 1890 1900
GGPRVDPYRP VRLPMQKLPT RPTYPGVLPT TMTGVMGLEP SSYKTSVYRQ
1910 1920 1930 1940 1950
QQPAVPQGQR LRQQLQQSQG MLGQSSVHQM TPSSSYGLQT SQGYTPYVSH
1960 1970 1980 1990 2000
VGLQQHTGPA GTMVPPSYSS QPYQSTHPST NPTLVDPTRH LQQRPSGYVH
2010 2020 2030 2040 2050
QQAPTYGHGL TSTQRFSHQT LQQTPMISTM TPMSAQGVQA GVRSTAILPE
2060 2070 2080 2090 2100
QQQQQQQQQQ QQQQQQQQQQ QQQQQQYHIR QQQQQQILRQ QQQQQQQQQQ
2110 2120 2130 2140 2150
QQQQQQQQQQ QQQQQHQQQQ QQQAAPPQPQ PQSQPQFQRQ GLQQTQQQQQ
2160 2170
TAALVRQLQQ QLSNTQPQPS TNIFGRY
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ7Z3Z5 | Q7Z3Z5_HUMAN | Mediator of RNA polymerase II trans... | MED12 TNRC11, hCG_19960 | 2,027 | Annotation score: | ||
H7C191 | H7C191_HUMAN | Mediator of RNA polymerase II trans... | MED12 | 130 | Annotation score: | ||
H7C274 | H7C274_HUMAN | Mediator of RNA polymerase II trans... | MED12 | 251 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 16 | R → RPR in AAD22033 (PubMed:10198638).Curated | 1 | |
Sequence conflicti | 397 | Missing AA sequence (PubMed:10235266).Curated | 1 | |
Sequence conflicti | 1166 | E → V in AAD44162 (PubMed:10480376).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_033112 | 961 | R → W in OKS. 1 PublicationCorresponds to variant dbSNP:rs80338758EnsemblClinVar. | 1 | |
Natural variantiVAR_037534 | 1007 | N → S in MRXSLF. 1 PublicationCorresponds to variant dbSNP:rs80338759EnsemblClinVar. | 1 | |
Natural variantiVAR_069770 | 1148 | R → H in OHDOX. 1 PublicationCorresponds to variant dbSNP:rs387907360EnsemblClinVar. | 1 | |
Natural variantiVAR_069771 | 1165 | S → P in OHDOX. 1 PublicationCorresponds to variant dbSNP:rs387907361EnsemblClinVar. | 1 | |
Natural variantiVAR_046672 | 1392 | Q → R2 PublicationsCorresponds to variant dbSNP:rs1139013Ensembl. | 1 | |
Natural variantiVAR_069772 | 1729 | H → N in OHDOX. 1 PublicationCorresponds to variant dbSNP:rs387907362EnsemblClinVar. | 1 | |
Natural variantiVAR_074018 | 1974 | Q → H Found in a family with X-linked intellectual disability; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs879255528EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_035520 | 1916 | Q → QAKI in isoform 2. 1 Publication | 1 | |
Alternative sequenceiVSP_035521 | 1916 | Missing in isoform 3. 2 Publications | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF117755 mRNA Translation: AAD22033.1 Different initiation. AL590764 Genomic DNA No translation available. D83783 mRNA Translation: BAA12112.1 AF071309 mRNA Translation: AAC83163.1 AF132033 Genomic DNA Translation: AAD44162.1 U80742 mRNA Translation: AAB91440.1 |
CCDSi | CCDS43970.1 [Q93074-1] |
RefSeqi | NP_005111.2, NM_005120.2 [Q93074-1] |
Genome annotation databases
Ensembli | ENST00000374080; ENSP00000363193; ENSG00000184634 [Q93074-1] ENST00000374102; ENSP00000363215; ENSG00000184634 [Q93074-3] |
GeneIDi | 9968 |
KEGGi | hsa:9968 |
UCSCi | uc004dyy.4, human [Q93074-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF117755 mRNA Translation: AAD22033.1 Different initiation. AL590764 Genomic DNA No translation available. D83783 mRNA Translation: BAA12112.1 AF071309 mRNA Translation: AAC83163.1 AF132033 Genomic DNA Translation: AAD44162.1 U80742 mRNA Translation: AAB91440.1 |
CCDSi | CCDS43970.1 [Q93074-1] |
RefSeqi | NP_005111.2, NM_005120.2 [Q93074-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 115293, 138 interactors |
ComplexPortali | CPX-3232, CKM complex variant 1 CPX-3263, CKM complex variant 2 |
CORUMi | Q93074 |
DIPi | DIP-31459N |
IntActi | Q93074, 78 interactors |
MINTi | Q93074 |
STRINGi | 9606.ENSP00000363193 |
PTM databases
iPTMneti | Q93074 |
PhosphoSitePlusi | Q93074 |
Genetic variation databases
BioMutai | MED12 |
DMDMi | 209572775 |
Proteomic databases
EPDi | Q93074 |
jPOSTi | Q93074 |
MassIVEi | Q93074 |
MaxQBi | Q93074 |
PaxDbi | Q93074 |
PeptideAtlasi | Q93074 |
PRIDEi | Q93074 |
ProteomicsDBi | 75701 [Q93074-1] 75702 [Q93074-2] 75703 [Q93074-3] |
Protocols and materials databases
Antibodypediai | 562, 208 antibodies |
Genome annotation databases
Ensembli | ENST00000374080; ENSP00000363193; ENSG00000184634 [Q93074-1] ENST00000374102; ENSP00000363215; ENSG00000184634 [Q93074-3] |
GeneIDi | 9968 |
KEGGi | hsa:9968 |
UCSCi | uc004dyy.4, human [Q93074-1] |
Organism-specific databases
CTDi | 9968 |
DisGeNETi | 9968 |
GeneCardsi | MED12 |
GeneReviewsi | MED12 |
HGNCi | HGNC:11957, MED12 |
HPAi | ENSG00000184634, Low tissue specificity |
MalaCardsi | MED12 |
MIMi | 300188, gene 300895, phenotype 305450, phenotype 309520, phenotype |
neXtProti | NX_Q93074 |
OpenTargetsi | ENSG00000184634 |
Orphaneti | 293707, Blepharophimosis-intellectual disability syndrome, MKB type 93932, FG syndrome type 1 776, X-linked intellectual disability with marfanoid habitus 777, X-linked non-syndromic intellectual disability |
PharmGKBi | PA36645 |
VEuPathDBi | HostDB:ENSG00000184634.15 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3598, Eukaryota |
GeneTreei | ENSGT00440000037505 |
HOGENOMi | CLU_000904_1_0_1 |
InParanoidi | Q93074 |
OMAi | VWLDTVA |
OrthoDBi | 15873at2759 |
PhylomeDBi | Q93074 |
TreeFami | TF324178 |
Enzyme and pathway databases
PathwayCommonsi | Q93074 |
Reactomei | R-HSA-1989781, PPARA activates gene expression R-HSA-212436, Generic Transcription Pathway R-HSA-381340, Transcriptional regulation of white adipocyte differentiation |
SignaLinki | Q93074 |
SIGNORi | Q93074 |
Miscellaneous databases
BioGRID-ORCSi | 9968, 198 hits in 529 CRISPR screens |
ChiTaRSi | MED12, human |
GeneWikii | MED12 |
GenomeRNAii | 9968 |
Pharosi | Q93074, Tbio |
PROi | PR:Q93074 |
RNActi | Q93074, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000184634, Expressed in left adrenal gland and 213 other tissues |
ExpressionAtlasi | Q93074, baseline and differential |
Genevisiblei | Q93074, HS |
Family and domain databases
InterProi | View protein in InterPro IPR019035, Mediator_Med12 IPR021989, Mediator_Med12_catenin-bd IPR021990, Mediator_Med12_LCEWAV |
Pfami | View protein in Pfam PF09497, Med12, 1 hit PF12145, Med12-LCEWAV, 1 hit PF12144, Med12-PQL, 1 hit |
SMARTi | View protein in SMART SM01281, Med12, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MED12_HUMAN | |
Accessioni | Q93074Primary (citable) accession number: Q93074 Secondary accession number(s): O15410 Q9UND7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | October 14, 2008 | |
Last modified: | February 10, 2021 | |
This is version 200 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families