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Protein

RNA-binding protein with multiple splicing

Gene

RBPMS

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a coactivator of transcriptional activity. Required to increase TGFB1/Smad-mediated transactivation. Acts through SMAD2, SMAD3 and SMAD4 to increase transcriptional activity. Increases phosphorylation of SMAD2 and SMAD3 on their C-terminal SSXS motif, possibly through recruitment of TGFBR1. Promotes the nuclear accumulation of SMAD2, SMAD3 and SMAD4 proteins (PubMed:26347403). Binds to poly(A) RNA (PubMed:17099224, PubMed:26347403).2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • poly(A) binding Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB
  • RNA binding Source: UniProtKB
  • snRNA stem-loop binding Source: GO_Central
  • transcription coactivator activity Source: UniProtKB

GO - Biological processi

  • mRNA splicing, via spliceosome Source: GO_Central
  • positive regulation of pathway-restricted SMAD protein phosphorylation Source: UniProtKB
  • positive regulation of SMAD protein signal transduction Source: UniProtKB
  • response to oxidative stress Source: UniProtKB
  • RNA processing Source: ProtInc

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, RNA-binding
Biological processTranscription, Transcription regulation

Protein family/group databases

MoonDB Database of extreme multifunctional and moonlighting proteins

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MoonDBi
Q93062 Predicted

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RNA-binding protein with multiple splicing
Short name:
RBP-MS
Alternative name(s):
Heart and RRM expressed sequence
Short name:
Hermes
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RBPMS
Synonyms:HERMES
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000157110.15

Human Gene Nomenclature Database

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HGNCi
HGNC:19097 RBPMS

Online Mendelian Inheritance in Man (OMIM)

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MIMi
601558 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q93062

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi27F → A: Abolishes RNA binding. 1 Publication1
Mutagenesisi36 – 38KPR → EPE: Impairs dimerization and RNA binding. 1 Publication3
Mutagenesisi65F → A: Abolishes RNA binding. 1 Publication1
Mutagenesisi97E → A: Abolishes RNA binding; when associated with A-100. 1 Publication1
Mutagenesisi100K → A: Abolishes RNA binding; when associated with A-97. 1 Publication1
Mutagenesisi100K → E: Abolishes RNA binding. 1 Publication1
Mutagenesisi103 – 104TK → AA: Abolishes RNA binding. 1 Publication2

Organism-specific databases

DisGeNET

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DisGeNETi
11030

Open Targets

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OpenTargetsi
ENSG00000157110

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA134985584

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
RBPMS

Domain mapping of disease mutations (DMDM)

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DMDMi
13124469

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000817931 – 196RNA-binding protein with multiple splicingAdd BLAST196

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
Modified residuei12PhosphothreonineBy similarity1
Modified residuei113PhosphothreonineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q93062

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q93062

MaxQB - The MaxQuant DataBase

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MaxQBi
Q93062

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q93062

PeptideAtlas

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PeptideAtlasi
Q93062

PRoteomics IDEntifications database

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PRIDEi
Q93062

ProteomicsDB human proteome resource

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ProteomicsDBi
75691
75692 [Q93062-2]
75693 [Q93062-3]
75694 [Q93062-4]
75695 [Q93062-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q93062

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q93062

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed, at various levels depending on the isoform and the tissue.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000157110 Expressed in 222 organ(s), highest expression level in lower esophagus muscularis layer

CleanEx database of gene expression profiles

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CleanExi
HS_RBPMS

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q93062 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q93062 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA056999

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer; each protein chain binds one RNA molecule via the external surface of the homodimer (PubMed:26347403). Interacts with SMAD2, SMAD3 and SMAD4; the interactions are direct (PubMed:17099224).2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei27Interaction with RNA1 Publication1
Sitei61Interaction with RNA1 Publication1

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
B2R5503EBI-740322,EBI-10175488
Q96EJ43EBI-740322,EBI-750454
ABCF3A0A0S2Z6453EBI-740343,EBI-16432404
ADAM15Q134443EBI-740322,EBI-77818
AESQ081173EBI-740322,EBI-717810
AESQ08117-24EBI-740343,EBI-11741437
AMMECR1Q9Y4X03EBI-740322,EBI-8583355
ANKMY1A0A0S2Z5963EBI-740343,EBI-16433724
ATXN1P542536EBI-740322,EBI-930964
BANPQ8N9N53EBI-740322,EBI-744695
BBS2Q9BXC93EBI-740322,EBI-748297
BCL6BA8KA133EBI-740322,EBI-10174813
BHLHE40O145033EBI-740322,EBI-711810
BOLLQ8N9W63EBI-740322,EBI-998198
C11orf87Q6NUJ23EBI-740322,EBI-6660291
C1orf94Q6P1W54EBI-740322,EBI-946029
C22orf39Q6P5X53EBI-740322,EBI-7317823
CAMK2BQ135543EBI-740322,EBI-1058722
CCNG1P519593EBI-740322,EBI-3905829
CCNKO759094EBI-740322,EBI-739806
CDC23Q9UJX24EBI-740322,EBI-396137
CRBNQ96SW23EBI-740322,EBI-2510250
CREB5Q02930-33EBI-740322,EBI-10192698
CRYBA1P058133EBI-740322,EBI-7043337
CSN3P074983EBI-740322,EBI-2602175
DAZAP2Q150386EBI-740343,EBI-724310
DCAF8Q5TAQ93EBI-740322,EBI-740686
DCDC2BA2VCK23EBI-740322,EBI-10173222
DCTN5Q9BTE13EBI-740322,EBI-747324
DMRT3Q9NQL93EBI-740322,EBI-9679045
DOK3Q7L5913EBI-740322,EBI-2834978
DOK6Q6PKX43EBI-740322,EBI-2880244
DPYSL4O145313EBI-740322,EBI-719542
DTX2Q86UW97EBI-740322,EBI-740376
EFEMP2O959673EBI-740322,EBI-743414
FAM124BQ9H5Z63EBI-740322,EBI-741626
FAM166BA8MTA8-24EBI-740343,EBI-12160437
FAM168AQ925675EBI-740322,EBI-7957930
FAM168AQ92567-24EBI-740343,EBI-11978259
FBF1Q8TES7-63EBI-740322,EBI-10244131
FBXL18Q96D163EBI-740322,EBI-744419
FNDC11Q9BVV23EBI-740322,EBI-744935
FOXC2Q999583EBI-740322,EBI-3956892
FOXP3Q9BZS14EBI-740322,EBI-983719
GCM2O756033EBI-740322,EBI-10188645
GLYCTKQ8IVS83EBI-740322,EBI-748515
GPATCH2LQ9NWQ43EBI-740322,EBI-5666657
GPS2Q132273EBI-740322,EBI-713355
GRAPQ135883EBI-740322,EBI-2847510
hCG_2008078Q8N4W54EBI-740343,EBI-11746188
hCG_20425B4DNA43EBI-740322,EBI-7399002
HEY2Q9UBP53EBI-740322,EBI-750630
HEYLQ9NQ874EBI-740322,EBI-751092
HNRNPLLQ8WVV93EBI-740322,EBI-535849
HOXA1P496393EBI-740322,EBI-740785
Hoxa1P090223EBI-740322,EBI-3957603From Mus musculus.
IGF2P013443EBI-740322,EBI-7178764
ILF3Q9NXX03EBI-740322,EBI-743980
INCA1Q0VD863EBI-740322,EBI-6509505
INIPQ9NRY23EBI-740322,EBI-2881520
IP6K2Q9UHH93EBI-740322,EBI-747509
KCTD9Q7L2733EBI-740322,EBI-4397613
KIAA1305Q96HR43EBI-740322,EBI-10288524
KIR2DL4Q997063EBI-740322,EBI-10294579
KPNA2P522923EBI-740322,EBI-349938
KRTAP12-2P599913EBI-740322,EBI-10176379
KRTAP19-5Q3LI724EBI-740322,EBI-1048945
KRTAP19-7Q3SYF94EBI-740343,EBI-10241353
KRTAP23-1A1A5803EBI-740322,EBI-10171734
KRTAP8-1Q8IUC23EBI-740322,EBI-10261141
LASP1Q14847-26EBI-740343,EBI-9088686
LGALS9CQ6DKI23EBI-740322,EBI-9088829
LINC00482Q8N8I63EBI-740322,EBI-10267998
LINC00588Q9Y4M83EBI-740322,EBI-10039207
LMO4P619683EBI-740322,EBI-2798728
LONRF1Q17RB83EBI-740322,EBI-2341787
LRRC75A-AS1Q8N1F13EBI-740322,EBI-2872544
MAGED1Q9Y5V33EBI-740322,EBI-716006
MCM5B1AHB03EBI-740322,EBI-10175425
MYOZ2Q9NPC63EBI-740322,EBI-746712
NAPRTQ6XQN63EBI-740322,EBI-10254872
NAPRTQ6XQN6-23EBI-740322,EBI-10254820
NEDD9Q145113EBI-740322,EBI-2108053
NR1D2Q6NSM03EBI-740322,EBI-10250949
OTX1P322424EBI-740322,EBI-740446
PATZ1Q9HBE1-45EBI-740343,EBI-11022007
PER1J3QSH93EBI-740322,EBI-10178671
PER1Q6IN513EBI-740322,EBI-10250187
PHF1O431894EBI-740322,EBI-530034
PIH1D1Q9NWS03EBI-740322,EBI-357318
PIN1Q135264EBI-740322,EBI-714158
PITX1P783374EBI-740322,EBI-748265
POGZQ7Z3K34EBI-740343,EBI-1389308
POM121Q96HA14EBI-740322,EBI-739990
PP9974P095653EBI-740322,EBI-10196507
PRKAA1Q131313EBI-740322,EBI-1181405
PRKAA2P546463EBI-740322,EBI-1383852
PRR20CP864793EBI-740322,EBI-10172814
QKIQ96PU85EBI-740322,EBI-945792
R3HDM2Q9Y2K5-23EBI-740322,EBI-10326419
RBFOX1Q9NWB13EBI-740322,EBI-945906
RBPMS2Q6ZRY44EBI-740343,EBI-11987469
RDH12Q96NR83EBI-740343,EBI-3916363
RHOBTB3O949553EBI-740322,EBI-2367123
RHOXF2Q9BQY46EBI-740322,EBI-372094
RIPPLY1Q0D2K33EBI-740322,EBI-10226430
ROR2A1L4F53EBI-740322,EBI-10172778
RTP5Q14D333EBI-740322,EBI-10217913
RUSC1Q9BVN23EBI-740322,EBI-6257312
SBF2Q86WG53EBI-740322,EBI-2683289
SEMA4GQ9NTN9-33EBI-740322,EBI-9089805
SH3RF2Q08AM83EBI-740322,EBI-10225873
SIRPB1O00241-23EBI-740322,EBI-10179231
SMRP1Q8NCR63EBI-740322,EBI-10269322
SMUG1Q53HV72EBI-740322,EBI-749970
SMUG1Q53HV7-24EBI-740343,EBI-12275818
SNRPBP14678-23EBI-740322,EBI-372475
SNRPCQ5TAL43EBI-740322,EBI-10246938
SPATA46Q5T0L33EBI-740322,EBI-750105
SPATA8Q6RVD64EBI-740322,EBI-8635958
SPG7Q9UQ903EBI-740322,EBI-717201
STRBPA0A0S2Z5K83EBI-740343,EBI-16433759
STRBPQ96SI94EBI-740322,EBI-740355
TBX6O959473EBI-740322,EBI-2824328
TENT2Q6PIY73EBI-740322,EBI-2802204
TEX37Q96LM64EBI-740322,EBI-743976
TFGQ927343EBI-740322,EBI-357061
TIE1P355903EBI-740322,EBI-2256865
TINAGL1Q9GZM7-33EBI-740322,EBI-10303636
TMSB4XQ0P5Q03EBI-740322,EBI-10226570
TOLLIPQ6FIE93EBI-740322,EBI-10249783
TOLLIPQ9H0E24EBI-740322,EBI-74615
TOR1AIP2Q9H4963EBI-740322,EBI-2510146
TTLL10Q6ZVT03EBI-740322,EBI-7844656
TUSC2O758963EBI-740322,EBI-1052725
VENTXO952313EBI-740322,EBI-10191303
VHLLQ6RSH73EBI-740322,EBI-10254232
VPS37CA5D8V63EBI-740322,EBI-2559305
WDR90Q96KV73EBI-740322,EBI-9478492
WDYHV1Q96HA83EBI-740322,EBI-741158
ZBTB32A0A0C4DGF15EBI-740343,EBI-10188476
ZC3H10Q96K804EBI-740322,EBI-742550
ZNF385CQ66K413EBI-740322,EBI-8651919
ZNF488Q96MN93EBI-740322,EBI-948288
ZNF581Q9P0T46EBI-740343,EBI-745520

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
116220, 207 interactors

Protein interaction database and analysis system

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IntActi
Q93062, 267 interactors

Molecular INTeraction database

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MINTi
Q93062

STRING: functional protein association networks

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STRINGi
9606.ENSP00000340176

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1196
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BNYmodel-A15-111[»]
5CYJX-ray1.79A/B14-111[»]
5DETX-ray1.95A/B14-111[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q93062

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q93062

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini24 – 101RRMPROSITE-ProRule annotationAdd BLAST78

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni98 – 105Interaction with RNA1 Publication8

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The RRM domain is necessary for interaction with SMAD4. Both the RRM domain and the C-terminus are required for TGFB1/Smad-mediated transactivation activity.

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1457 Eukaryota
ENOG410XSBT LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000159617

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000017369

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG069897

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q93062

Identification of Orthologs from Complete Genome Data

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OMAi
FITREPY

Database of Orthologous Groups

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OrthoDBi
1368991at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q93062

TreeFam database of animal gene trees

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TreeFami
TF351070

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.30.70.330, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom

Pfam protein domain database

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Pfami
View protein in Pfam
PF00076 RRM_1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00360 RRM, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF54928 SSF54928, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50102 RRM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 5 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform A (identifier: Q93062-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNNGGKAEKE NTPSEANLQE EEVRTLFVSG LPLDIKPREL YLLFRPFKGY
60 70 80 90 100
EGSLIKLTSK QPVGFVSFDS RSEAEAAKNA LNGIRFDPEI PQTLRLEFAK
110 120 130 140 150
ANTKMAKNKL VGTPNPSTPL PNTVPQFIAR EPYELTVPAL YPSSPEVWAP
160 170 180 190
YPLYPAELAP ALPPPAFTYP ASLHAQMRWL PPSEATSQGW KSRQFC
Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Length:196
Mass (Da):21,802
Last modified:February 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i05DD964E62F8F88C
GO
Isoform B (identifier: Q93062-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     177-196: MRWLPPSEATSQGWKSRQFC → LCEGQTVRRSHPLSAPSPDSASLAWFPV

Show »
Length:204
Mass (Da):22,416
Checksum:i60382A7EC1D4672F
GO
Isoform C (identifier: Q93062-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     177-196: MRWLPPSEATSQGWKSRQFC → CFSPEAKPNTPVFCPLLQQIRFVSGNVFVTYQPTADQQRELPC

Show »
Length:219
Mass (Da):24,277
Checksum:i700E9B9FA7682FAD
GO
Isoform D (identifier: Q93062-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     133-196: YELTVPALYPSSPEVWAPYPLYPAELAPALPPPAFTYPASLHAQMRWLPPSEATSQGWKSRQFC → LGGANEHGERQ

Show »
Length:143
Mass (Da):15,794
Checksum:i86DDB14345784716
GO
Isoform E (identifier: Q93062-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     133-176: Missing.

Show »
Length:152
Mass (Da):17,022
Checksum:iB62DC25BB6EFB888
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B4E3T4B4E3T4_HUMAN
HCG2043421, isoform CRA_c
RBPMS hCG_2043421
224Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RJ31E5RJ31_HUMAN
RNA-binding protein with multiple-s...
RBPMS
120Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RJD7E5RJD7_HUMAN
RNA-binding protein with multiple-s...
RBPMS
49Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RFP4E5RFP4_HUMAN
RNA-binding protein with multiple-s...
RBPMS
115Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YBU9H0YBU9_HUMAN
RNA-binding protein with multiple-s...
RBPMS
119Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YC46H0YC46_HUMAN
RNA-binding protein with multiple-s...
RBPMS
113Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_005815133 – 196YELTV…SRQFC → LGGANEHGERQ in isoform D. 1 PublicationAdd BLAST64
Alternative sequenceiVSP_005816133 – 176Missing in isoform E. 1 PublicationAdd BLAST44
Alternative sequenceiVSP_005813177 – 196MRWLP…SRQFC → LCEGQTVRRSHPLSAPSPDS ASLAWFPV in isoform B. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_005814177 – 196MRWLP…SRQFC → CFSPEAKPNTPVFCPLLQQI RFVSGNVFVTYQPTADQQRE LPC in isoform C. 2 PublicationsAdd BLAST20

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
D84110 mRNA Translation: BAA12228.1
D84107 mRNA Translation: BAA12225.1
D84108 mRNA Translation: BAA12226.1
D84109 mRNA Translation: BAA12227.1
D84111 mRNA Translation: BAA12229.1
CH471080 Genomic DNA Translation: EAW63451.1
CH471080 Genomic DNA Translation: EAW63453.1
BC003608 mRNA Translation: AAH03608.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS34875.1 [Q93062-2]
CCDS34876.1 [Q93062-3]
CCDS6077.1 [Q93062-1]

Protein sequence database of the Protein Information Resource

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PIRi
JC6127

NCBI Reference Sequences

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RefSeqi
NP_001008710.1, NM_001008710.2 [Q93062-1]
NP_001008711.1, NM_001008711.2 [Q93062-2]
NP_001008712.1, NM_001008712.2 [Q93062-3]
NP_006858.1, NM_006867.3 [Q93062-1]
XP_016868475.1, XM_017012986.1 [Q93062-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.334587

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000287771; ENSP00000287771; ENSG00000157110 [Q93062-2]
ENST00000320203; ENSP00000318102; ENSG00000157110 [Q93062-1]
ENST00000339877; ENSP00000340176; ENSG00000157110 [Q93062-3]
ENST00000397323; ENSP00000380486; ENSG00000157110 [Q93062-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
11030

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:11030

UCSC genome browser

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UCSCi
uc003xib.5 human [Q93062-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D84110 mRNA Translation: BAA12228.1
D84107 mRNA Translation: BAA12225.1
D84108 mRNA Translation: BAA12226.1
D84109 mRNA Translation: BAA12227.1
D84111 mRNA Translation: BAA12229.1
CH471080 Genomic DNA Translation: EAW63451.1
CH471080 Genomic DNA Translation: EAW63453.1
BC003608 mRNA Translation: AAH03608.1
CCDSiCCDS34875.1 [Q93062-2]
CCDS34876.1 [Q93062-3]
CCDS6077.1 [Q93062-1]
PIRiJC6127
RefSeqiNP_001008710.1, NM_001008710.2 [Q93062-1]
NP_001008711.1, NM_001008711.2 [Q93062-2]
NP_001008712.1, NM_001008712.2 [Q93062-3]
NP_006858.1, NM_006867.3 [Q93062-1]
XP_016868475.1, XM_017012986.1 [Q93062-1]
UniGeneiHs.334587

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BNYmodel-A15-111[»]
5CYJX-ray1.79A/B14-111[»]
5DETX-ray1.95A/B14-111[»]
ProteinModelPortaliQ93062
SMRiQ93062
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116220, 207 interactors
IntActiQ93062, 267 interactors
MINTiQ93062
STRINGi9606.ENSP00000340176

Protein family/group databases

MoonDBiQ93062 Predicted

PTM databases

iPTMnetiQ93062
PhosphoSitePlusiQ93062

Polymorphism and mutation databases

BioMutaiRBPMS
DMDMi13124469

Proteomic databases

EPDiQ93062
jPOSTiQ93062
MaxQBiQ93062
PaxDbiQ93062
PeptideAtlasiQ93062
PRIDEiQ93062
ProteomicsDBi75691
75692 [Q93062-2]
75693 [Q93062-3]
75694 [Q93062-4]
75695 [Q93062-5]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000287771; ENSP00000287771; ENSG00000157110 [Q93062-2]
ENST00000320203; ENSP00000318102; ENSG00000157110 [Q93062-1]
ENST00000339877; ENSP00000340176; ENSG00000157110 [Q93062-3]
ENST00000397323; ENSP00000380486; ENSG00000157110 [Q93062-1]
GeneIDi11030
KEGGihsa:11030
UCSCiuc003xib.5 human [Q93062-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
11030
DisGeNETi11030
EuPathDBiHostDB:ENSG00000157110.15

GeneCards: human genes, protein and diseases

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GeneCardsi
RBPMS
HGNCiHGNC:19097 RBPMS
HPAiHPA056999
MIMi601558 gene
neXtProtiNX_Q93062
OpenTargetsiENSG00000157110
PharmGKBiPA134985584

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1457 Eukaryota
ENOG410XSBT LUCA
GeneTreeiENSGT00940000159617
HOGENOMiHOG000017369
HOVERGENiHBG069897
InParanoidiQ93062
OMAiFITREPY
OrthoDBi1368991at2759
PhylomeDBiQ93062
TreeFamiTF351070

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
RBPMS human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
RBPMS

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
11030

Protein Ontology

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PROi
PR:Q93062

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000157110 Expressed in 222 organ(s), highest expression level in lower esophagus muscularis layer
CleanExiHS_RBPMS
ExpressionAtlasiQ93062 baseline and differential
GenevisibleiQ93062 HS

Family and domain databases

Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PfamiView protein in Pfam
PF00076 RRM_1, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRBPMS_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q93062
Secondary accession number(s): D3DSU9
, Q92516, Q92517, Q92518, Q96J26
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: February 1, 1997
Last modified: January 16, 2019
This is version 176 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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