UniProtKB - Q93062 (RBPMS_HUMAN)
RNA-binding protein with multiple splicing
RBPMS
Functioni
Acts as a coactivator of transcriptional activity. Required to increase TGFB1/Smad-mediated transactivation. Acts through SMAD2, SMAD3 and SMAD4 to increase transcriptional activity. Increases phosphorylation of SMAD2 and SMAD3 on their C-terminal SSXS motif, possibly through recruitment of TGFBR1. Promotes the nuclear accumulation of SMAD2, SMAD3 and SMAD4 proteins (PubMed:26347403).
Binds to poly(A) RNA (PubMed:17099224, PubMed:26347403).
2 PublicationsGO - Molecular functioni
- mRNA binding Source: GO_Central
- poly(A) binding Source: UniProtKB
- protein homodimerization activity Source: UniProtKB
- RNA binding Source: UniProtKB
- transcription coactivator activity Source: UniProtKB
GO - Biological processi
- positive regulation of pathway-restricted SMAD protein phosphorylation Source: UniProtKB
- positive regulation of SMAD protein signal transduction Source: UniProtKB
- response to oxidative stress Source: UniProtKB
- RNA processing Source: ProtInc
Keywordsi
Molecular function | Activator, RNA-binding |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | Q93062 |
SignaLinki | Q93062 |
SIGNORi | Q93062 |
Protein family/group databases
MoonDBi | Q93062, Predicted |
Names & Taxonomyi
Protein namesi | Recommended name: RNA-binding protein with multiple splicingShort name: RBP-MS Alternative name(s): Heart and RRM expressed sequence Short name: Hermes |
Gene namesi | Name:RBPMS Synonyms:HERMES |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:19097, RBPMS |
MIMi | 601558, gene |
neXtProti | NX_Q93062 |
VEuPathDBi | HostDB:ENSG00000157110 |
Subcellular locationi
Cytosol
- cytosol Source: HPA
Nucleus
- nucleoplasm Source: HPA
Other locations
- cytoplasmic stress granule Source: UniProtKB
- P-body Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 27 | F → A: Abolishes RNA binding. 1 Publication | 1 | |
Mutagenesisi | 36 – 38 | KPR → EPE: Impairs dimerization and RNA binding. 1 Publication | 3 | |
Mutagenesisi | 65 | F → A: Abolishes RNA binding. 1 Publication | 1 | |
Mutagenesisi | 97 | E → A: Abolishes RNA binding; when associated with A-100. 1 Publication | 1 | |
Mutagenesisi | 100 | K → A: Abolishes RNA binding; when associated with A-97. 1 Publication | 1 | |
Mutagenesisi | 100 | K → E: Abolishes RNA binding. 1 Publication | 1 | |
Mutagenesisi | 103 – 104 | TK → AA: Abolishes RNA binding. 1 Publication | 2 |
Organism-specific databases
DisGeNETi | 11030 |
OpenTargetsi | ENSG00000157110 |
PharmGKBi | PA134985584 |
Miscellaneous databases
Pharosi | Q93062, Tbio |
Genetic variation databases
BioMutai | RBPMS |
DMDMi | 13124469 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000081793 | 1 – 196 | RNA-binding protein with multiple splicingAdd BLAST | 196 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineCombined sources | 1 | |
Modified residuei | 12 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 113 | PhosphothreonineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
jPOSTi | Q93062 |
MassIVEi | Q93062 |
MaxQBi | Q93062 |
PaxDbi | Q93062 |
PeptideAtlasi | Q93062 |
PRIDEi | Q93062 |
ProteomicsDBi | 75691 [Q93062-1] 75692 [Q93062-2] 75693 [Q93062-3] 75694 [Q93062-4] 75695 [Q93062-5] |
PTM databases
GlyGeni | Q93062, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q93062 |
PhosphoSitePlusi | Q93062 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000157110, Expressed in lower esophagus muscularis layer and 234 other tissues |
ExpressionAtlasi | Q93062, baseline and differential |
Genevisiblei | Q93062, HS |
Organism-specific databases
HPAi | ENSG00000157110, Low tissue specificity |
Interactioni
Subunit structurei
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 27 | Interaction with RNA1 Publication | 1 | |
Sitei | 61 | Interaction with RNA1 Publication | 1 |
Binary interactionsi
Q93062
Isoform C [Q93062-3]
GO - Molecular functioni
- protein homodimerization activity Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 116220, 297 interactors |
IntActi | Q93062, 281 interactors |
MINTi | Q93062 |
STRINGi | 9606.ENSP00000340176 |
Miscellaneous databases
RNActi | Q93062, protein |
Structurei
Secondary structure
3D structure databases
BMRBi | Q93062 |
SMRi | Q93062 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 24 – 101 | RRMPROSITE-ProRule annotationAdd BLAST | 78 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 98 – 105 | Interaction with RNA1 Publication | 8 |
Domaini
Phylogenomic databases
eggNOGi | KOG1457, Eukaryota |
GeneTreei | ENSGT00940000159617 |
HOGENOMi | CLU_099973_1_1_1 |
InParanoidi | Q93062 |
OMAi | FIAREPX |
OrthoDBi | 1368991at2759 |
PhylomeDBi | Q93062 |
TreeFami | TF351070 |
Family and domain databases
Gene3Di | 3.30.70.330, 1 hit |
InterProi | View protein in InterPro IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR000504, RRM_dom |
Pfami | View protein in Pfam PF00076, RRM_1, 1 hit |
SMARTi | View protein in SMART SM00360, RRM, 1 hit |
SUPFAMi | SSF54928, SSF54928, 1 hit |
PROSITEi | View protein in PROSITE PS50102, RRM, 1 hit |
s (5+)i Sequence
Sequence statusi: Complete.
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 5 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MNNGGKAEKE NTPSEANLQE EEVRTLFVSG LPLDIKPREL YLLFRPFKGY
60 70 80 90 100
EGSLIKLTSK QPVGFVSFDS RSEAEAAKNA LNGIRFDPEI PQTLRLEFAK
110 120 130 140 150
ANTKMAKNKL VGTPNPSTPL PNTVPQFIAR EPYELTVPAL YPSSPEVWAP
160 170 180 190
YPLYPAELAP ALPPPAFTYP ASLHAQMRWL PPSEATSQGW KSRQFC
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketB4E3T4 | B4E3T4_HUMAN | HCG2043421, isoform CRA_c | RBPMS hCG_2043421 | 224 | Annotation score: | ||
E5RJ31 | E5RJ31_HUMAN | RNA-binding protein with multiple-s... | RBPMS | 120 | Annotation score: | ||
E5RJD7 | E5RJD7_HUMAN | RNA-binding protein with multiple-s... | RBPMS | 49 | Annotation score: | ||
E5RFP4 | E5RFP4_HUMAN | RNA-binding protein with multiple-s... | RBPMS | 115 | Annotation score: | ||
H0YBU9 | H0YBU9_HUMAN | RNA-binding protein with multiple-s... | RBPMS | 119 | Annotation score: | ||
H0YC46 | H0YC46_HUMAN | RNA-binding protein with multiple-s... | RBPMS | 113 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_005815 | 133 – 196 | YELTV…SRQFC → LGGANEHGERQ in isoform D. 1 PublicationAdd BLAST | 64 | |
Alternative sequenceiVSP_005816 | 133 – 176 | Missing in isoform E. 1 PublicationAdd BLAST | 44 | |
Alternative sequenceiVSP_005813 | 177 – 196 | MRWLP…SRQFC → LCEGQTVRRSHPLSAPSPDS ASLAWFPV in isoform B. 1 PublicationAdd BLAST | 20 | |
Alternative sequenceiVSP_005814 | 177 – 196 | MRWLP…SRQFC → CFSPEAKPNTPVFCPLLQQI RFVSGNVFVTYQPTADQQRE LPC in isoform C. 2 PublicationsAdd BLAST | 20 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D84110 mRNA Translation: BAA12228.1 D84107 mRNA Translation: BAA12225.1 D84108 mRNA Translation: BAA12226.1 D84109 mRNA Translation: BAA12227.1 D84111 mRNA Translation: BAA12229.1 CH471080 Genomic DNA Translation: EAW63451.1 CH471080 Genomic DNA Translation: EAW63453.1 BC003608 mRNA Translation: AAH03608.1 |
CCDSi | CCDS34875.1 [Q93062-2] CCDS34876.1 [Q93062-3] CCDS6077.1 [Q93062-1] |
PIRi | JC6127 |
RefSeqi | NP_001008710.1, NM_001008710.2 [Q93062-1] NP_001008711.1, NM_001008711.2 [Q93062-2] NP_001008712.1, NM_001008712.2 [Q93062-3] NP_006858.1, NM_006867.3 [Q93062-1] XP_016868475.1, XM_017012986.1 [Q93062-1] |
Genome annotation databases
Ensembli | ENST00000287771; ENSP00000287771; ENSG00000157110 [Q93062-2] ENST00000320203; ENSP00000318102; ENSG00000157110 ENST00000339877; ENSP00000340176; ENSG00000157110 [Q93062-3] ENST00000397323; ENSP00000380486; ENSG00000157110 |
GeneIDi | 11030 |
KEGGi | hsa:11030 |
MANE-Selecti | ENST00000397323.9; ENSP00000380486.4; NM_001008710.3; NP_001008710.1 |
UCSCi | uc003xib.5, human [Q93062-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D84110 mRNA Translation: BAA12228.1 D84107 mRNA Translation: BAA12225.1 D84108 mRNA Translation: BAA12226.1 D84109 mRNA Translation: BAA12227.1 D84111 mRNA Translation: BAA12229.1 CH471080 Genomic DNA Translation: EAW63451.1 CH471080 Genomic DNA Translation: EAW63453.1 BC003608 mRNA Translation: AAH03608.1 |
CCDSi | CCDS34875.1 [Q93062-2] CCDS34876.1 [Q93062-3] CCDS6077.1 [Q93062-1] |
PIRi | JC6127 |
RefSeqi | NP_001008710.1, NM_001008710.2 [Q93062-1] NP_001008711.1, NM_001008711.2 [Q93062-2] NP_001008712.1, NM_001008712.2 [Q93062-3] NP_006858.1, NM_006867.3 [Q93062-1] XP_016868475.1, XM_017012986.1 [Q93062-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5CYJ | X-ray | 1.79 | A/B | 14-111 | [»] | |
5DET | X-ray | 1.95 | A/B | 14-111 | [»] | |
BMRBi | Q93062 | |||||
SMRi | Q93062 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 116220, 297 interactors |
IntActi | Q93062, 281 interactors |
MINTi | Q93062 |
STRINGi | 9606.ENSP00000340176 |
Protein family/group databases
MoonDBi | Q93062, Predicted |
PTM databases
GlyGeni | Q93062, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q93062 |
PhosphoSitePlusi | Q93062 |
Genetic variation databases
BioMutai | RBPMS |
DMDMi | 13124469 |
Proteomic databases
jPOSTi | Q93062 |
MassIVEi | Q93062 |
MaxQBi | Q93062 |
PaxDbi | Q93062 |
PeptideAtlasi | Q93062 |
PRIDEi | Q93062 |
ProteomicsDBi | 75691 [Q93062-1] 75692 [Q93062-2] 75693 [Q93062-3] 75694 [Q93062-4] 75695 [Q93062-5] |
Protocols and materials databases
Antibodypediai | 23209, 442 antibodies from 30 providers |
DNASUi | 11030 |
Genome annotation databases
Ensembli | ENST00000287771; ENSP00000287771; ENSG00000157110 [Q93062-2] ENST00000320203; ENSP00000318102; ENSG00000157110 ENST00000339877; ENSP00000340176; ENSG00000157110 [Q93062-3] ENST00000397323; ENSP00000380486; ENSG00000157110 |
GeneIDi | 11030 |
KEGGi | hsa:11030 |
MANE-Selecti | ENST00000397323.9; ENSP00000380486.4; NM_001008710.3; NP_001008710.1 |
UCSCi | uc003xib.5, human [Q93062-1] |
Organism-specific databases
CTDi | 11030 |
DisGeNETi | 11030 |
GeneCardsi | RBPMS |
HGNCi | HGNC:19097, RBPMS |
HPAi | ENSG00000157110, Low tissue specificity |
MIMi | 601558, gene |
neXtProti | NX_Q93062 |
OpenTargetsi | ENSG00000157110 |
PharmGKBi | PA134985584 |
VEuPathDBi | HostDB:ENSG00000157110 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1457, Eukaryota |
GeneTreei | ENSGT00940000159617 |
HOGENOMi | CLU_099973_1_1_1 |
InParanoidi | Q93062 |
OMAi | FIAREPX |
OrthoDBi | 1368991at2759 |
PhylomeDBi | Q93062 |
TreeFami | TF351070 |
Enzyme and pathway databases
PathwayCommonsi | Q93062 |
SignaLinki | Q93062 |
SIGNORi | Q93062 |
Miscellaneous databases
BioGRID-ORCSi | 11030, 10 hits in 1042 CRISPR screens |
ChiTaRSi | RBPMS, human |
GeneWikii | RBPMS |
GenomeRNAii | 11030 |
Pharosi | Q93062, Tbio |
PROi | PR:Q93062 |
RNActi | Q93062, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000157110, Expressed in lower esophagus muscularis layer and 234 other tissues |
ExpressionAtlasi | Q93062, baseline and differential |
Genevisiblei | Q93062, HS |
Family and domain databases
Gene3Di | 3.30.70.330, 1 hit |
InterProi | View protein in InterPro IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR000504, RRM_dom |
Pfami | View protein in Pfam PF00076, RRM_1, 1 hit |
SMARTi | View protein in SMART SM00360, RRM, 1 hit |
SUPFAMi | SSF54928, SSF54928, 1 hit |
PROSITEi | View protein in PROSITE PS50102, RRM, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | RBPMS_HUMAN | |
Accessioni | Q93062Primary (citable) accession number: Q93062 Secondary accession number(s): D3DSU9 Q96J26 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 21, 2001 |
Last sequence update: | February 1, 1997 | |
Last modified: | February 23, 2022 | |
This is version 196 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 8
Human chromosome 8: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references