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Entry version 175 (12 Aug 2020)
Sequence version 1 (01 Feb 1997)
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Protein

Lipoma-preferred partner

Gene

LPP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a structural role at sites of cell adhesion in maintaining cell shape and motility. In addition to these structural functions, it may also be implicated in signaling events and activation of gene transcription. May be involved in signal transduction from cell adhesion sites to the nucleus allowing successful integration of signals arising from soluble factors and cell-cell adhesion sites. Also suggested to serve as a scaffold protein upon which distinct protein complexes are assembled in the cytoplasm and in the nucleus.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • cell-cell adhesion Source: GO_Central

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator
Biological processCell adhesion
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q93052

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q93052

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Lipoma-preferred partner
Alternative name(s):
LIM domain-containing preferred translocation partner in lipoma
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LPP
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000145012.12

Human Gene Nomenclature Database

More...
HGNCi
HGNC:6679, LPP

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
600700, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q93052

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

A chromosomal aberration involving LPP is associated with a subclass of benign mesenchymal tumors known as lipomas. Translocation t(3;12)(q27-q28;q13-q15) with HMGA2 is shown in lipomas.
A chromosomal aberration involving LPP is associated with pulmonary chondroid hamartomas. Translocation t(3;12)(q27-q28;q14-q15) with HMGA2 is detected in pulmonary chondroid hamartomas.
A chromosomal aberration involving LPP is associated with parosteal lipomas. Translocation t(3;12)(q28;q14) with HMGA2 is also shown in one parosteal lipoma.
A chromosomal aberration involving LPP is associated with acute monoblastic leukemia. Translocation t(3;11)(q28;q23) with KMT2A/MLL1 is associated with acute monoblastic leukemia.

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi610T → A: Abolishes binding to SCRIB. 1 Publication1
Mutagenesisi612L → A: Abolishes binding to SCRIB. 1 Publication1

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei371 – 372Breakpoint for translocation to form HMGA2-LPP2
Sitei470 – 471Breakpoint for translocation to form HMGA2-LPP and KMT2A/MLL1-LPP2

Organism-specific databases

DisGeNET

More...
DisGeNETi
4026

MalaCards human disease database

More...
MalaCardsi
LPP

Open Targets

More...
OpenTargetsi
ENSG00000145012

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA30440

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q93052, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
LPP

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74751663

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000758321 – 612Lipoma-preferred partnerAdd BLAST612

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei108N6-acetyllysineBy similarity1
Modified residuei116PhosphoserineBy similarity1
Modified residuei151PhosphoserineBy similarity1
Modified residuei244PhosphotyrosineBy similarity1
Modified residuei301PhosphotyrosineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki327Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)Combined sources
Modified residuei333PhosphothreonineCombined sources1
Modified residuei375PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q93052

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q93052

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q93052

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q93052

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q93052

PeptideAtlas

More...
PeptideAtlasi
Q93052

PRoteomics IDEntifications database

More...
PRIDEi
Q93052

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
75690

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q93052, 3 sites, 1 O-linked glycan (3 sites)

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q93052

MetOSite database of methionine sulfoxide sites

More...
MetOSitei
Q93052

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q93052

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in a wide variety of tissues but no or very low expression in brain and peripheral leukocytes.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000145012, Expressed in saphenous vein and 253 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q93052, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q93052, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000145012, Tissue enhanced (smooth muscle, urinary bladder)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with VASP, with PDZ domains of SCRIB and with ACTN1/alpha-actinin.

4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
110208, 66 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q93052

Protein interaction database and analysis system

More...
IntActi
Q93052, 22 interactors

Molecular INTeraction database

More...
MINTi
Q93052

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000482472

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q93052, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q93052

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini414 – 473LIM zinc-binding 1PROSITE-ProRule annotationAdd BLAST60
Domaini474 – 534LIM zinc-binding 2PROSITE-ProRule annotationAdd BLAST61
Domaini535 – 603LIM zinc-binding 3PROSITE-ProRule annotationAdd BLAST69

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi41 – 370Pro-richAdd BLAST330

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the zyxin/ajuba family.Curated

Keywords - Domaini

LIM domain, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1701, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00940000156022

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q93052

KEGG Orthology (KO)

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KOi
K16676

Identification of Orthologs from Complete Genome Data

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OMAi
RYQDPYY

Database for complete collections of gene phylogenies

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PhylomeDBi
Q93052

TreeFam database of animal gene trees

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TreeFami
TF320310

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR028771, LPP
IPR001781, Znf_LIM

The PANTHER Classification System

More...
PANTHERi
PTHR24207:SF0, PTHR24207:SF0, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00412, LIM, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00132, LIM, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00478, LIM_DOMAIN_1, 2 hits
PS50023, LIM_DOMAIN_2, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 11 potential isoforms that are computationally mapped.Show allAlign All

Q93052-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSHPSWLPPK STGEPLGHVP ARMETTHSFG NPSISVSTQQ PPKKFAPVVA
60 70 80 90 100
PKPKYNPYKQ PGGEGDFLPP PPPPLDDSSA LPSISGNFPP PPPLDEEAFK
110 120 130 140 150
VQGNPGGKTL EERRSSLDAE IDSLTSILAD LECSSPYKPR PPQSSTGSTA
160 170 180 190 200
SPPVSTPVTG HKRMVIPNQP PLTATKKSTL KPQPAPQAGP IPVAPIGTLK
210 220 230 240 250
PQPQPVPASY TTASTSSRPT FNVQVKSAQP SPHYMAAPSS GQIYGSGPQG
260 270 280 290 300
YNTQPVPVSG QCPPPSTRGG MDYAYIPPPG LQPEPGYGYA PNQGRYYEGY
310 320 330 340 350
YAAGPGYGGR NDSDPTYGQQ GHPNTWKREP GYTPPGAGNQ NPPGMYPVTG
360 370 380 390 400
PKKTYITDPV SAPCAPPLQP KGGHSGQLGP SSVAPSFRPE DELEHLTKKM
410 420 430 440 450
LYDMENPPAD EYFGRCARCG ENVVGEGTGC TAMDQVFHVD CFTCIICNNK
460 470 480 490 500
LRGQPFYAVE KKAYCEPCYI NTLEQCNVCS KPIMERILRA TGKAYHPHCF
510 520 530 540 550
TCVMCHRSLD GIPFTVDAGG LIHCIEDFHK KFAPRCSVCK EPIMPAPGQE
560 570 580 590 600
ETVRIVALDR DFHVHCYRCE DCGGLLSEGD NQGCYPLDGH ILCKTCNSAR
610
IRVLTAKAST DL
Length:612
Mass (Da):65,746
Last modified:February 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i439CE0101FDE4DDD
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WZF1A0A087WZF1_HUMAN
Lipoma-preferred partner
LPP
590Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JXK9C9JXK9_HUMAN
Lipoma-preferred partner
LPP
252Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JUT4C9JUT4_HUMAN
LIM domain containing preferred tra...
LPP hCG_17155
428Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J1K7C9J1K7_HUMAN
Lipoma-preferred partner
LPP
93Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J3U9C9J3U9_HUMAN
Lipoma-preferred partner
LPP
66Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JT42C9JT42_HUMAN
Lipoma-preferred partner
LPP
65Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J4E3C9J4E3_HUMAN
Lipoma-preferred partner
LPP
151Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J5C8C9J5C8_HUMAN
Lipoma-preferred partner
LPP
111Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JIY7C9JIY7_HUMAN
Lipoma-preferred partner
LPP
57Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J2R5C9J2R5_HUMAN
Lipoma-preferred partner
LPP
52Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There is more potential isoformShow all

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_050150146T → A. Corresponds to variant dbSNP:rs35417432Ensembl.1
Natural variantiVAR_050151259S → P. Corresponds to variant dbSNP:rs35940579Ensembl.1
Natural variantiVAR_034070346Y → H. Corresponds to variant dbSNP:rs7645635Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
U49957 mRNA Translation: AAC50738.1
U49968 U49967 Genomic DNA Translation: AAC50739.1
CR457074 mRNA Translation: CAG33355.1
CH471052 Genomic DNA Translation: EAW78127.1
CH471052 Genomic DNA Translation: EAW78128.1
CH471052 Genomic DNA Translation: EAW78133.1
BC130584 mRNA Translation: AAI30585.1
AF393503 mRNA Translation: AAM73685.1 Different termination.

The Consensus CDS (CCDS) project

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CCDSi
CCDS3291.1

NCBI Reference Sequences

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RefSeqi
NP_001161143.1, NM_001167671.2
NP_005569.1, NM_005578.4
XP_005247503.1, XM_005247446.4
XP_005247507.1, XM_005247450.4
XP_005247508.1, XM_005247451.4
XP_005247510.1, XM_005247453.2
XP_011511122.1, XM_011512820.2
XP_011511129.1, XM_011512827.2
XP_011511130.1, XM_011512828.2
XP_011511133.1, XM_011512831.2
XP_011511135.1, XM_011512833.2
XP_011511136.1, XM_011512834.2
XP_016861866.1, XM_017006377.1
XP_016861867.1, XM_017006378.1
XP_016861868.1, XM_017006379.1
XP_016861869.1, XM_017006380.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000617246; ENSP00000478901; ENSG00000145012
ENST00000640853; ENSP00000491657; ENSG00000145012

Database of genes from NCBI RefSeq genomes

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GeneIDi
4026

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:4026

UCSC genome browser

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UCSCi
uc032sne.1, human

Keywords - Coding sequence diversityi

Chromosomal rearrangement, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U49957 mRNA Translation: AAC50738.1
U49968 U49967 Genomic DNA Translation: AAC50739.1
CR457074 mRNA Translation: CAG33355.1
CH471052 Genomic DNA Translation: EAW78127.1
CH471052 Genomic DNA Translation: EAW78128.1
CH471052 Genomic DNA Translation: EAW78133.1
BC130584 mRNA Translation: AAI30585.1
AF393503 mRNA Translation: AAM73685.1 Different termination.
CCDSiCCDS3291.1
RefSeqiNP_001161143.1, NM_001167671.2
NP_005569.1, NM_005578.4
XP_005247503.1, XM_005247446.4
XP_005247507.1, XM_005247450.4
XP_005247508.1, XM_005247451.4
XP_005247510.1, XM_005247453.2
XP_011511122.1, XM_011512820.2
XP_011511129.1, XM_011512827.2
XP_011511130.1, XM_011512828.2
XP_011511133.1, XM_011512831.2
XP_011511135.1, XM_011512833.2
XP_011511136.1, XM_011512834.2
XP_016861866.1, XM_017006377.1
XP_016861867.1, XM_017006378.1
XP_016861868.1, XM_017006379.1
XP_016861869.1, XM_017006380.1

3D structure databases

SMRiQ93052
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi110208, 66 interactors
CORUMiQ93052
IntActiQ93052, 22 interactors
MINTiQ93052
STRINGi9606.ENSP00000482472

PTM databases

GlyGeniQ93052, 3 sites, 1 O-linked glycan (3 sites)
iPTMnetiQ93052
MetOSiteiQ93052
PhosphoSitePlusiQ93052

Polymorphism and mutation databases

BioMutaiLPP
DMDMi74751663

Proteomic databases

EPDiQ93052
jPOSTiQ93052
MassIVEiQ93052
MaxQBiQ93052
PaxDbiQ93052
PeptideAtlasiQ93052
PRIDEiQ93052
ProteomicsDBi75690

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
2772, 246 antibodies

Genome annotation databases

EnsembliENST00000617246; ENSP00000478901; ENSG00000145012
ENST00000640853; ENSP00000491657; ENSG00000145012
GeneIDi4026
KEGGihsa:4026
UCSCiuc032sne.1, human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
4026
DisGeNETi4026
EuPathDBiHostDB:ENSG00000145012.12

GeneCards: human genes, protein and diseases

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GeneCardsi
LPP
HGNCiHGNC:6679, LPP
HPAiENSG00000145012, Tissue enhanced (smooth muscle, urinary bladder)
MalaCardsiLPP
MIMi600700, gene
neXtProtiNX_Q93052
OpenTargetsiENSG00000145012
PharmGKBiPA30440

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1701, Eukaryota
GeneTreeiENSGT00940000156022
InParanoidiQ93052
KOiK16676
OMAiRYQDPYY
PhylomeDBiQ93052
TreeFamiTF320310

Enzyme and pathway databases

PathwayCommonsiQ93052
SIGNORiQ93052

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
4026, 5 hits in 874 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
LPP, human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
LPP_(gene)

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
4026
PharosiQ93052, Tbio

Protein Ontology

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PROi
PR:Q93052
RNActiQ93052, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000145012, Expressed in saphenous vein and 253 other tissues
ExpressionAtlasiQ93052, baseline and differential
GenevisibleiQ93052, HS

Family and domain databases

InterProiView protein in InterPro
IPR028771, LPP
IPR001781, Znf_LIM
PANTHERiPTHR24207:SF0, PTHR24207:SF0, 1 hit
PfamiView protein in Pfam
PF00412, LIM, 3 hits
SMARTiView protein in SMART
SM00132, LIM, 3 hits
PROSITEiView protein in PROSITE
PS00478, LIM_DOMAIN_1, 2 hits
PS50023, LIM_DOMAIN_2, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLPP_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q93052
Secondary accession number(s): A1L4L6, D3DNV6, Q8NFX5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: February 1, 1997
Last modified: August 12, 2020
This is version 175 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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