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Protein

Stathmin-2

Gene

STMN2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulator of microtubule stability. When phosphorylated by MAPK8, stabilizes microtubules and consequently controls neurite length in cortical neurons. In the developing brain, negatively regulates the rate of exit from multipolar stage and retards radial migration from the ventricular zone (By similarity).By similarity

GO - Molecular functioni

  • calcium-dependent protein binding Source: UniProtKB
  • tubulin binding Source: GO_Central

GO - Biological processi

Enzyme and pathway databases

SignaLinkiQ93045
SIGNORiQ93045

Names & Taxonomyi

Protein namesi
Recommended name:
Stathmin-2
Alternative name(s):
Superior cervical ganglion-10 protein
Short name:
Protein SCG10
Gene namesi
Name:STMN2
Synonyms:SCG10, SCGN10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000104435.13
HGNCiHGNC:10577 STMN2
MIMi600621 gene
neXtProtiNX_Q93045

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Endosome, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi11075
OpenTargetsiENSG00000104435
PharmGKBiPA35540

Polymorphism and mutation databases

BioMutaiSTMN2
DMDMi51704330

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001823961 – 179Stathmin-2Add BLAST179

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei16PhosphoserineSequence analysis1
Lipidationi22S-palmitoyl cysteine1 Publication1
Lipidationi24S-palmitoyl cysteine1 Publication1
Modified residuei50PhosphoserineSequence analysisBy similarity1
Modified residuei62PhosphoserineCombined sources1
Modified residuei73PhosphoserineBy similarity1
Modified residuei97PhosphoserineSequence analysisBy similarity1

Post-translational modificationi

Sumoylated.1 Publication
Phosphorylated mostly by MAPK8, but also by MAPK9 and MAPK10 in the developing brain cortex.By similarity
N-terminal palmitoylation promotes specific anchoring to the cytosolic leaflet of Golgi membranes and subsequent vesicular trafficking along dendrites and axons. Neuronal Stathmins are substrates for palmitoyltransferases ZDHHC3, ZDHHC7 and ZDHHC15.1 Publication

Keywords - PTMi

Lipoprotein, Palmitate, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ93045
MaxQBiQ93045
PaxDbiQ93045
PeptideAtlasiQ93045
PRIDEiQ93045
ProteomicsDBi75686

PTM databases

iPTMnetiQ93045
PhosphoSitePlusiQ93045

Expressioni

Tissue specificityi

Neuron specific.

Gene expression databases

BgeeiENSG00000104435 Expressed in 166 organ(s), highest expression level in frontal cortex
CleanExiHS_STMN2
ExpressionAtlasiQ93045 baseline and differential
GenevisibleiQ93045 HS

Organism-specific databases

HPAiHPA026922

Interactioni

Subunit structurei

Interacts with MAPK8 (By similarity). Interacts with ITM2C. Interacts with KIF1BP. Interacts (via the N-terminal region) with CIB1 (via C-terminal region); the interaction is direct, occurs in a calcium-dependent manner and attenuates the neurite outgrowth inhibition of STMN2.By similarity3 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi116258, 36 interactors
IntActiQ93045, 18 interactors
MINTiQ93045
STRINGi9606.ENSP00000429243

Structurei

3D structure databases

ProteinModelPortaliQ93045
SMRiQ93045
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini38 – 179SLDPROSITE-ProRule annotationAdd BLAST142

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 26Membrane attachmentSequence analysisAdd BLAST26
Regioni39 – 96Regulatory/phosphorylation domainSequence analysisAdd BLAST58

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili75 – 179Sequence analysisAdd BLAST105

Sequence similaritiesi

Belongs to the stathmin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IJ9S Eukaryota
ENOG410YFK3 LUCA
GeneTreeiENSGT00390000003691
HOGENOMiHOG000013197
HOVERGENiHBG054037
InParanoidiQ93045
OMAiMKMDQIK
OrthoDBiEOG091G0Y2U
PhylomeDBiQ93045
TreeFamiTF326935

Family and domain databases

InterProiView protein in InterPro
IPR026729 Stathmin-2
IPR030514 Stathmin_CS
IPR000956 Stathmin_fam
IPR036002 Stathmin_sf
PANTHERiPTHR10104 PTHR10104, 1 hit
PTHR10104:SF18 PTHR10104:SF18, 1 hit
PfamiView protein in Pfam
PF00836 Stathmin, 1 hit
PIRSFiPIRSF002285 Stathmin, 1 hit
PRINTSiPR00345 STATHMIN
SUPFAMiSSF101494 SSF101494, 1 hit
PROSITEiView protein in PROSITE
PS00563 STATHMIN_1, 1 hit
PS01041 STATHMIN_2, 1 hit
PS51663 STATHMIN_3, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q93045-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAKTAMAYKE KMKELSMLSL ICSCFYPEPR NINIYTYDDM EVKQINKRAS
60 70 80 90 100
GQAFELILKP PSPISEAPRT LASPKKKDLS LEEIQKKLEA AEERRKSQEA
110 120 130 140 150
QVLKQLAEKR EHEREVLQKA LEENNNFSKM AEEKLILKME QIKENREANL
160 170
AAIIERLQEK ERHAAEVRRN KELQVELSG
Length:179
Mass (Da):20,828
Last modified:August 31, 2004 - v3
Checksum:iF9A258A1B57E620D
GO
Isoform 2 (identifier: Q93045-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     161-179: ERHAAEVRRNKELQVELSG → LVKFISSELKESIESQFLELQREGEKQ

Note: No experimental confirmation available.
Show »
Length:187
Mass (Da):21,802
Checksum:i79F9F10FF182FD01
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E5RGX5E5RGX5_HUMAN
Stathmin
STMN2
168Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti92E → G in AAB36428 (PubMed:8622778).Curated1
Sequence conflicti122E → G in BAA23326 (Ref. 2) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_045047161 – 179ERHAA…VELSG → LVKFISSELKESIESQFLEL QREGEKQ in isoform 2. 1 PublicationAdd BLAST19

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S82024 mRNA Translation: AAB36428.1
D50375 mRNA Translation: BAA23326.1
BT020034 mRNA Translation: AAV38837.1
CR456833 mRNA Translation: CAG33114.1
AK292737 mRNA Translation: BAF85426.1
AC016240 Genomic DNA No translation available.
AC025599 Genomic DNA No translation available.
CH471068 Genomic DNA Translation: EAW87064.1
CH471068 Genomic DNA Translation: EAW87065.1
BC006302 mRNA Translation: AAH06302.1
BQ069488 mRNA No translation available.
CCDSiCCDS43748.1 [Q93045-1]
CCDS56542.1 [Q93045-2]
RefSeqiNP_001186143.1, NM_001199214.1 [Q93045-2]
NP_008960.2, NM_007029.3 [Q93045-1]
UniGeneiHs.521651

Genome annotation databases

EnsembliENST00000220876; ENSP00000220876; ENSG00000104435 [Q93045-1]
ENST00000518111; ENSP00000429243; ENSG00000104435 [Q93045-2]
GeneIDi11075
KEGGihsa:11075
UCSCiuc003ybj.3 human [Q93045-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S82024 mRNA Translation: AAB36428.1
D50375 mRNA Translation: BAA23326.1
BT020034 mRNA Translation: AAV38837.1
CR456833 mRNA Translation: CAG33114.1
AK292737 mRNA Translation: BAF85426.1
AC016240 Genomic DNA No translation available.
AC025599 Genomic DNA No translation available.
CH471068 Genomic DNA Translation: EAW87064.1
CH471068 Genomic DNA Translation: EAW87065.1
BC006302 mRNA Translation: AAH06302.1
BQ069488 mRNA No translation available.
CCDSiCCDS43748.1 [Q93045-1]
CCDS56542.1 [Q93045-2]
RefSeqiNP_001186143.1, NM_001199214.1 [Q93045-2]
NP_008960.2, NM_007029.3 [Q93045-1]
UniGeneiHs.521651

3D structure databases

ProteinModelPortaliQ93045
SMRiQ93045
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116258, 36 interactors
IntActiQ93045, 18 interactors
MINTiQ93045
STRINGi9606.ENSP00000429243

PTM databases

iPTMnetiQ93045
PhosphoSitePlusiQ93045

Polymorphism and mutation databases

BioMutaiSTMN2
DMDMi51704330

Proteomic databases

EPDiQ93045
MaxQBiQ93045
PaxDbiQ93045
PeptideAtlasiQ93045
PRIDEiQ93045
ProteomicsDBi75686

Protocols and materials databases

DNASUi11075
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000220876; ENSP00000220876; ENSG00000104435 [Q93045-1]
ENST00000518111; ENSP00000429243; ENSG00000104435 [Q93045-2]
GeneIDi11075
KEGGihsa:11075
UCSCiuc003ybj.3 human [Q93045-1]

Organism-specific databases

CTDi11075
DisGeNETi11075
EuPathDBiHostDB:ENSG00000104435.13
GeneCardsiSTMN2
HGNCiHGNC:10577 STMN2
HPAiHPA026922
MIMi600621 gene
neXtProtiNX_Q93045
OpenTargetsiENSG00000104435
PharmGKBiPA35540
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJ9S Eukaryota
ENOG410YFK3 LUCA
GeneTreeiENSGT00390000003691
HOGENOMiHOG000013197
HOVERGENiHBG054037
InParanoidiQ93045
OMAiMKMDQIK
OrthoDBiEOG091G0Y2U
PhylomeDBiQ93045
TreeFamiTF326935

Enzyme and pathway databases

SignaLinkiQ93045
SIGNORiQ93045

Miscellaneous databases

ChiTaRSiSTMN2 human
GeneWikiiSTMN2
GenomeRNAii11075
PROiPR:Q93045
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000104435 Expressed in 166 organ(s), highest expression level in frontal cortex
CleanExiHS_STMN2
ExpressionAtlasiQ93045 baseline and differential
GenevisibleiQ93045 HS

Family and domain databases

InterProiView protein in InterPro
IPR026729 Stathmin-2
IPR030514 Stathmin_CS
IPR000956 Stathmin_fam
IPR036002 Stathmin_sf
PANTHERiPTHR10104 PTHR10104, 1 hit
PTHR10104:SF18 PTHR10104:SF18, 1 hit
PfamiView protein in Pfam
PF00836 Stathmin, 1 hit
PIRSFiPIRSF002285 Stathmin, 1 hit
PRINTSiPR00345 STATHMIN
SUPFAMiSSF101494 SSF101494, 1 hit
PROSITEiView protein in PROSITE
PS00563 STATHMIN_1, 1 hit
PS01041 STATHMIN_2, 1 hit
PS51663 STATHMIN_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSTMN2_HUMAN
AccessioniPrimary (citable) accession number: Q93045
Secondary accession number(s): A8K9M2
, G3V110, O14952, Q6PK68
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: August 31, 2004
Last modified: November 7, 2018
This is version 163 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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