TNFRSF25

Functionⁱ

Receptor for TNFSF12/APO3L/TWEAK. Interacts directly with the adapter TRADD. Mediates activation of NF-kappa-B and induces apoptosis. May play a role in regulating lymphocyte homeostasis.

GO - Molecular functionⁱ

signaling receptor activity
Source: UniProtKB
Non-traceable author statementⁱ
- Ref.5
  "LARD: a new lymphoid-specific death domain containing receptor regulated by alternative pre-mRNA splicing."
  Screaton G.R., Xu X.-N., Olsen A.L., Cowper A.E., Tan R., McMichael A.J., Bell J.I.
  Proc. Natl. Acad. Sci. U.S.A. 94:4615-4619(1997) [PubMed] [Europe PMC] [Abstract]
  Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3; 4; 5; 6; 7; 8; 9 AND 10).
tumor necrosis factor-activated receptor activity
Source: ProtInc
Traceable author statementⁱ
- Ref.12
  "TRAMP, a novel apoptosis-mediating receptor with sequence homology to tumor necrosis factor receptor 1 and Fas(Apo-1/CD95)."
  Bodmer J.-L., Burns K., Schneider P., Hofmann K., Steiner V., Thome M., Bornand T., Hahne M., Schroeter M., Wilson A., French L.E., Browning J.L., Macdonald H.R., Tschopp J.
  Immunity 6:79-88(1997) [PubMed] [Europe PMC] [Abstract]
  Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 4-417.

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Receptor
Biological process	Apoptosis

Enzyme and pathway databases

Reactomeⁱ	R-HSA-5669034 TNFs bind their physiological receptors
SIGNORⁱ	Q93038

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Tumor necrosis factor receptor superfamily member 25 Alternative name(s): Apo-3 Apoptosis-inducing receptor AIR Apoptosis-mediating receptor DR3 Apoptosis-mediating receptor TRAMP Death receptor 3 Lymphocyte-associated receptor of death Short name: LARD Protein WSL Protein WSL-1
Gene namesⁱ	Name:TNFRSF25 Synonyms:APO3, DDR3, DR3, TNFRSF12, WSL, WSL1 ORF Names:UNQ455/PRO779
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000215788.9
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:11910 TNFRSF25
MIMⁱ	603366 gene
neXtProtⁱ	NX_Q93038

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	25 – 199	ExtracellularSequence analysisAdd BLAST	175
Transmembraneⁱ	200 – 220	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	221 – 417	CytoplasmicSequence analysisAdd BLAST	197

Keywords - Cellular componentⁱ

Cell membrane, Membrane, Secreted

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	354	L → A: Suppresses homodimerization, TNFR1 interaction, and apoptosis induction. 1 Publication	1
Mutagenesisⁱ	356	L → A: Suppresses homodimerization, and TNFR1 interaction. 1 Publication	1
Mutagenesisⁱ	373	D → A: Suppresses homodimerization, and TNFR1 interaction. 1 Publication	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	8718
Open Targets More...OpenTargetsⁱ	ENSG00000215788
PharmGKBⁱ	PA36603

Polymorphism and mutation databases

BioMutaⁱ	TNFRSF25
DMDMⁱ	2501233

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 24	Sequence analysisAdd BLAST		24
ChainⁱPRO_0000034606	25 – 417	Tumor necrosis factor receptor superfamily member 25Add BLAST		393

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	35 ↔ 47	PROSITE-ProRule annotation
Disulfide bondⁱ	48 ↔ 61	PROSITE-ProRule annotation
Disulfide bondⁱ	51 ↔ 70	PROSITE-ProRule annotation
Glycosylationⁱ	67	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	73 ↔ 89	PROSITE-ProRule annotation
Disulfide bondⁱ	92 ↔ 107	PROSITE-ProRule annotation
Disulfide bondⁱ	95 ↔ 115	PROSITE-ProRule annotation
Glycosylationⁱ	106	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	117 ↔ 130	PROSITE-ProRule annotation
Disulfide bondⁱ	138 ↔ 155	PROSITE-ProRule annotation
Disulfide bondⁱ	141 ↔ 162	PROSITE-ProRule annotation
Disulfide bondⁱ	165 ↔ 176	PROSITE-ProRule annotation
Disulfide bondⁱ	179 ↔ 191	PROSITE-ProRule annotation
Disulfide bondⁱ	187 ↔ 195	PROSITE-ProRule annotation

Post-translational modificationⁱ

Glycosylated.Curated

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

jPOSTⁱ	Q93038
PeptideAtlas More...PeptideAtlasⁱ	Q93038
PRIDEⁱ	Q93038
ProteomicsDBⁱ	75674 75675 [Q93038-10] 75676 [Q93038-11] 75677 [Q93038-12] 75678 [Q93038-2] 75679 [Q93038-3] 75680 [Q93038-4] 75681 [Q93038-5] 75682 [Q93038-6] 75683 [Q93038-7] 75684 [Q93038-8] 75685 [Q93038-9]

PTM databases

iPTMnetⁱ	Q93038

iPTMnetⁱ

Q93038

Expressionⁱ

Tissue specificityⁱ

Abundantly expressed in thymocytes and lymphocytes. Detected in lymphocyte-rich tissues such as thymus, colon, intestine, and spleen. Also found in the prostate.

Gene expression databases

Bgeeⁱ	ENSG00000215788 Expressed in 180 organ(s), highest expression level in right hemisphere of cerebellum
ExpressionAtlasⁱ	Q93038 baseline and differential
Genevisibleⁱ	Q93038 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA069834

HPAⁱ

HPA069834

Interactionⁱ

Subunit structureⁱ

Homodimer. Interacts strongly via the death domains with TNFRSF1 and TRADD to activate at least two distinct signaling cascades, apoptosis and NF-kappa-B signaling. Interacts with BAG4.1 Publication

Protein-protein interaction databases

BioGridⁱ	114258, 11 interactors
Database of interacting proteins More...DIPⁱ	DIP-59563N
IntActⁱ	Q93038, 1 interactor
STRINGⁱ	9606.ENSP00000367013

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q93038
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	34 – 71	TNFR-Cys 1Add BLAST	38
Repeatⁱ	72 – 115	TNFR-Cys 2Add BLAST	44
Repeatⁱ	116 – 163	TNFR-Cys 3Add BLAST	48
Repeatⁱ	164 – 192	TNFR-Cys 4Add BLAST	29
Domainⁱ	332 – 413	DeathPROSITE-ProRule annotationAdd BLAST	82

Keywords - Domainⁱ

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

Ensembl GeneTree More...GeneTreeⁱ	ENSGT00940000161888
HOVERGENⁱ	HBG058493
InParanoidⁱ	Q93038
KEGG Orthology (KO) More...KOⁱ	K05160
OMAⁱ	RALHRHT
Database of Orthologous Groups More...OrthoDBⁱ	726174at2759
PhylomeDBⁱ	Q93038
TreeFamⁱ	TF333916

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd13420 TNFRSF25, 1 hit
InterProⁱ	View protein in InterPro IPR011029 DEATH-like_dom_sf IPR000488 Death_domain IPR001368 TNFR/NGFR_Cys_rich_reg IPR022329 TNFR_25 IPR034050 TNFRSF25_N
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00531 Death, 1 hit PF00020 TNFR_c6, 1 hit
PRINTSⁱ	PR01972 TNFACTORR25
SMARTⁱ	View protein in SMART SM00005 DEATH, 1 hit SM00208 TNFR, 2 hits
SUPFAMⁱ	SSF47986 SSF47986, 1 hit
PROSITEⁱ	View protein in PROSITE PS50017 DEATH_DOMAIN, 1 hit PS00652 TNFR_NGFR_1, 2 hits PS50050 TNFR_NGFR_2, 1 hit

Sequences (12+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 12 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 12 described isoforms and 3 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q93038-1) [UniParc]FASTA Add to basket

Also known as: WSL-1, LARD-1A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEQRPRGCAA VAAALLLVLL GARAQGGTRS PRCDCAGDFH KKIGLFCCRG 
        60         70         80         90        100
CPAGHYLKAP CTEPCGNSTC LVCPQDTFLA WENHHNSECA RCQACDEQAS 
       110        120        130        140        150
QVALENCSAV ADTRCGCKPG WFVECQVSQC VSSSPFYCQP CLDCGALHRH 
       160        170        180        190        200
TRLLCSRRDT DCGTCLPGFY EHGDGCVSCP TSTLGSCPER CAAVCGWRQM 
       210        220        230        240        250
FWVQVLLAGL VVPLLLGATL TYTYRHCWPH KPLVTADEAG MEALTPPPAT 
       260        270        280        290        300
HLSPLDSAHT LLAPPDSSEK ICTVQLVGNS WTPGYPETQE ALCPQVTWSW 
       310        320        330        340        350
DQLPSRALGP AAAPTLSPES PAGSPAMMLQ PGPQLYDVMD AVPARRWKEF 
       360        370        380        390        400
VRTLGLREAE IEAVEVEIGR FRDQQYEMLK RWRQQQPAGL GAVYAALERM 
       410 
GLDGCVEDLR SRLQRGP

Length:417

Mass (Da):45,385

Last modified:November 1, 1997 - v2

Checksum:ⁱ5226319DFDB46706

GO

Isoform 2 (identifier: Q93038-2) [UniParc]FASTA Add to basket

Also known as: LARD-1B

The sequence of this isoform differs from the canonical sequence as follows:
236-236: A → AA

« Hide

        10         20         30         40         50
MEQRPRGCAA VAAALLLVLL GARAQGGTRS PRCDCAGDFH KKIGLFCCRG 
        60         70         80         90        100
CPAGHYLKAP CTEPCGNSTC LVCPQDTFLA WENHHNSECA RCQACDEQAS 
       110        120        130        140        150
QVALENCSAV ADTRCGCKPG WFVECQVSQC VSSSPFYCQP CLDCGALHRH 
       160        170        180        190        200
TRLLCSRRDT DCGTCLPGFY EHGDGCVSCP TSTLGSCPER CAAVCGWRQM 
       210        220        230        240        250
FWVQVLLAGL VVPLLLGATL TYTYRHCWPH KPLVTAADEA GMEALTPPPA 
       260        270        280        290        300
THLSPLDSAH TLLAPPDSSE KICTVQLVGN SWTPGYPETQ EALCPQVTWS 
       310        320        330        340        350
WDQLPSRALG PAAAPTLSPE SPAGSPAMML QPGPQLYDVM DAVPARRWKE 
       360        370        380        390        400
FVRTLGLREA EIEAVEVEIG RFRDQQYEML KRWRQQQPAG LGAVYAALER 
       410 
MGLDGCVEDL RSRLQRGP

Show »

Length:418

Mass (Da):45,456

Checksum:ⁱ54B48F8B35C620E2

GO

Isoform 3 (identifier: Q93038-3) [UniParc]FASTA Add to basket

Also known as: WSL-S1, LARD-3

The sequence of this isoform differs from the canonical sequence as follows:
182-218: STLGSCPERCAAVCGWRQMFWVQVLLAGLVVPLLLGA → VLGPGAPGWPCGPPPAWGHPDLHIPPLLASQAPGYCR
219-417: Missing.

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        10         20         30         40         50
MEQRPRGCAA VAAALLLVLL GARAQGGTRS PRCDCAGDFH KKIGLFCCRG 
        60         70         80         90        100
CPAGHYLKAP CTEPCGNSTC LVCPQDTFLA WENHHNSECA RCQACDEQAS 
       110        120        130        140        150
QVALENCSAV ADTRCGCKPG WFVECQVSQC VSSSPFYCQP CLDCGALHRH 
       160        170        180        190        200
TRLLCSRRDT DCGTCLPGFY EHGDGCVSCP TVLGPGAPGW PCGPPPAWGH 
       210 
PDLHIPPLLA SQAPGYCR

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Show »

Length:218

Mass (Da):23,198

Checksum:ⁱ9B416919AFA442F6

GO

Isoform 4 (identifier: Q93038-4) [UniParc]FASTA Add to basket

Also known as: WSL-S2, LARD-2

The sequence of this isoform differs from the canonical sequence as follows:
200-253: MFWVQVLLAG...LTPPPATHLS → SRWCAGNARG...LWSPSCLGPP
254-417: Missing.

« Hide

        10         20         30         40         50
MEQRPRGCAA VAAALLLVLL GARAQGGTRS PRCDCAGDFH KKIGLFCCRG 
        60         70         80         90        100
CPAGHYLKAP CTEPCGNSTC LVCPQDTFLA WENHHNSECA RCQACDEQAS 
       110        120        130        140        150
QVALENCSAV ADTRCGCKPG WFVECQVSQC VSSSPFYCQP CLDCGALHRH 
       160        170        180        190        200
TRLLCSRRDT DCGTCLPGFY EHGDGCVSCP TSTLGSCPER CAAVCGWRQS 
       210        220        230        240        250
RWCAGNARGR TGMDRGEAGE EGGNHPTPTS CFQCSGSRCS WLALWSPSCL 

GPP

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Show »

Length:253

Mass (Da):27,004

Checksum:ⁱ50A06775B68FC3D7

GO

Isoform 5 (identifier: Q93038-5) [UniParc]FASTA Add to basket

Also known as: LARD-4, LARD-11

The sequence of this isoform differs from the canonical sequence as follows:
182-417: Missing.

« Hide

        10         20         30         40         50
MEQRPRGCAA VAAALLLVLL GARAQGGTRS PRCDCAGDFH KKIGLFCCRG 
        60         70         80         90        100
CPAGHYLKAP CTEPCGNSTC LVCPQDTFLA WENHHNSECA RCQACDEQAS 
       110        120        130        140        150
QVALENCSAV ADTRCGCKPG WFVECQVSQC VSSSPFYCQP CLDCGALHRH 
       160        170        180 
TRLLCSRRDT DCGTCLPGFY EHGDGCVSCP T

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Show »

Length:181

Mass (Da):19,432

Checksum:ⁱ59AAFEDBBB46E369

GO

Isoform 6 (identifier: Q93038-6) [UniParc]FASTA Add to basket

Also known as: LARD-5

The sequence of this isoform differs from the canonical sequence as follows:
54-98: Missing.
182-417: Missing.

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        10         20         30         40         50
MEQRPRGCAA VAAALLLVLL GARAQGGTRS PRCDCAGDFH KKIGLFCCRG 
        60         70         80         90        100
CPAASQVALE NCSAVADTRC GCKPGWFVEC QVSQCVSSSP FYCQPCLDCG 
       110        120        130 
ALHRHTRLLC SRRDTDCGTC LPGFYEHGDG CVSCPT

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Show »

Length:136

Mass (Da):14,439

Checksum:ⁱ6846913006EEE40A

GO

Isoform 7 (identifier: Q93038-7) [UniParc]FASTA Add to basket

Also known as: LARD-6

The sequence of this isoform differs from the canonical sequence as follows:
     54-98: Missing.
     156-171: SRRDTDCGTCLPGFYE → HPSVTLGQRPHPSSTS
     172-417: Missing.

« Hide

        10         20         30         40         50
MEQRPRGCAA VAAALLLVLL GARAQGGTRS PRCDCAGDFH KKIGLFCCRG 
        60         70         80         90        100
CPAASQVALE NCSAVADTRC GCKPGWFVEC QVSQCVSSSP FYCQPCLDCG 
       110        120 
ALHRHTRLLC HPSVTLGQRP HPSSTS

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Show »

Length:126

Mass (Da):13,349

Checksum:ⁱEBAC98D7FB3EDB68

GO

Isoform 8 (identifier: Q93038-8) [UniParc]FASTA Add to basket

Also known as: LARD-7

The sequence of this isoform differs from the canonical sequence as follows:
54-236: Missing.

« Hide

        10         20         30         40         50
MEQRPRGCAA VAAALLLVLL GARAQGGTRS PRCDCAGDFH KKIGLFCCRG 
        60         70         80         90        100
CPADEAGMEA LTPPPATHLS PLDSAHTLLA PPDSSEKICT VQLVGNSWTP 
       110        120        130        140        150
GYPETQEALC PQVTWSWDQL PSRALGPAAA PTLSPESPAG SPAMMLQPGP 
       160        170        180        190        200
QLYDVMDAVP ARRWKEFVRT LGLREAEIEA VEVEIGRFRD QQYEMLKRWR 
       210        220        230 
QQQPAGLGAV YAALERMGLD GCVEDLRSRL QRGP

Show »

Length:234

Mass (Da):25,373

Checksum:ⁱD082A4552EDF7531

GO

Isoform 9 (identifier: Q93038-9) [UniParc]FASTA Add to basket

Also known as: LARD-8

The sequence of this isoform differs from the canonical sequence as follows:
54-98: Missing.

« Hide

        10         20         30         40         50
MEQRPRGCAA VAAALLLVLL GARAQGGTRS PRCDCAGDFH KKIGLFCCRG 
        60         70         80         90        100
CPAASQVALE NCSAVADTRC GCKPGWFVEC QVSQCVSSSP FYCQPCLDCG 
       110        120        130        140        150
ALHRHTRLLC SRRDTDCGTC LPGFYEHGDG CVSCPTSTLG SCPERCAAVC 
       160        170        180        190        200
GWRQMFWVQV LLAGLVVPLL LGATLTYTYR HCWPHKPLVT ADEAGMEALT 
       210        220        230        240        250
PPPATHLSPL DSAHTLLAPP DSSEKICTVQ LVGNSWTPGY PETQEALCPQ 
       260        270        280        290        300
VTWSWDQLPS RALGPAAAPT LSPESPAGSP AMMLQPGPQL YDVMDAVPAR 
       310        320        330        340        350
RWKEFVRTLG LREAEIEAVE VEIGRFRDQQ YEMLKRWRQQ QPAGLGAVYA 
       360        370 
ALERMGLDGC VEDLRSRLQR GP

Show »

Length:372

Mass (Da):40,391

Checksum:ⁱD4F87353AB7F40F6

GO

Isoform 10 (identifier: Q93038-10) [UniParc]FASTA Add to basket

Also known as: LARD-9

The sequence of this isoform differs from the canonical sequence as follows:
200-237: MFWVQVLLAGLVVPLLLGATLTYTYRHCWPHKPLVTAD → N

« Hide

        10         20         30         40         50
MEQRPRGCAA VAAALLLVLL GARAQGGTRS PRCDCAGDFH KKIGLFCCRG 
        60         70         80         90        100
CPAGHYLKAP CTEPCGNSTC LVCPQDTFLA WENHHNSECA RCQACDEQAS 
       110        120        130        140        150
QVALENCSAV ADTRCGCKPG WFVECQVSQC VSSSPFYCQP CLDCGALHRH 
       160        170        180        190        200
TRLLCSRRDT DCGTCLPGFY EHGDGCVSCP TSTLGSCPER CAAVCGWRQN 
       210        220        230        240        250
EAGMEALTPP PATHLSPLDS AHTLLAPPDS SEKICTVQLV GNSWTPGYPE 
       260        270        280        290        300
TQEALCPQVT WSWDQLPSRA LGPAAAPTLS PESPAGSPAM MLQPGPQLYD 
       310        320        330        340        350
VMDAVPARRW KEFVRTLGLR EAEIEAVEVE IGRFRDQQYE MLKRWRQQQP 
       360        370        380
AGLGAVYAAL ERMGLDGCVE DLRSRLQRGP

Show »

Length:380

Mass (Da):41,193

Checksum:ⁱED19B586ADD947B7

GO

Isoform 11 (identifier: Q93038-11) [UniParc]FASTA Add to basket

Also known as: Beta

The sequence of this isoform differs from the canonical sequence as follows:
182-200: STLGSCPERCAAVCGWRQM → PPPSLAGAPWGAVQSAVPLSVAGGRVGV

« Hide

        10         20         30         40         50
MEQRPRGCAA VAAALLLVLL GARAQGGTRS PRCDCAGDFH KKIGLFCCRG 
        60         70         80         90        100
CPAGHYLKAP CTEPCGNSTC LVCPQDTFLA WENHHNSECA RCQACDEQAS 
       110        120        130        140        150
QVALENCSAV ADTRCGCKPG WFVECQVSQC VSSSPFYCQP CLDCGALHRH 
       160        170        180        190        200
TRLLCSRRDT DCGTCLPGFY EHGDGCVSCP TPPPSLAGAP WGAVQSAVPL 
       210        220        230        240        250
SVAGGRVGVF WVQVLLAGLV VPLLLGATLT YTYRHCWPHK PLVTADEAGM 
       260        270        280        290        300
EALTPPPATH LSPLDSAHTL LAPPDSSEKI CTVQLVGNSW TPGYPETQEA 
       310        320        330        340        350
LCPQVTWSWD QLPSRALGPA AAPTLSPESP AGSPAMMLQP GPQLYDVMDA 
       360        370        380        390        400
VPARRWKEFV RTLGLREAEI EAVEVEIGRF RDQQYEMLKR WRQQQPAGLG 
       410        420 
AVYAALERMG LDGCVEDLRS RLQRGP

Show »

Length:426

Mass (Da):45,928

Checksum:ⁱ292A9B2899F3AE1F

GO

Isoform 12 (identifier: Q93038-12) [UniParc]FASTA Add to basket

Also known as: Beta soluble

The sequence of this isoform differs from the canonical sequence as follows:
182-277: STLGSCPERC...SEKICTVQLV → PPPSLAGAPW...LASQAPGYCR
278-417: Missing.

« Hide

        10         20         30         40         50
MEQRPRGCAA VAAALLLVLL GARAQGGTRS PRCDCAGDFH KKIGLFCCRG 
        60         70         80         90        100
CPAGHYLKAP CTEPCGNSTC LVCPQDTFLA WENHHNSECA RCQACDEQAS 
       110        120        130        140        150
QVALENCSAV ADTRCGCKPG WFVECQVSQC VSSSPFYCQP CLDCGALHRH 
       160        170        180        190        200
TRLLCSRRDT DCGTCLPGFY EHGDGCVSCP TPPPSLAGAP WGAVQSAVPL 
       210        220        230        240        250
SVAGGRVGGV LGMRVGELGW TEGRRVRRGA TTQHPPAAFS VLGPGAPGWP 
       260        270 
CGPPPAWGHP DLHIPPLLAS QAPGYCR

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Show »

Length:277

Mass (Da):29,111

Checksum:ⁱ3D19F3E847BFC093

GO

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A3B3ISD9	A0A3B3ISD9_HUMAN	Tumor necrosis factor receptor supe... Tumor necrosis factor receptor superfamily member 25	TNFRSF25	373	Annotation score:
A0A0C4DGF3	A0A0C4DGF3_HUMAN	Tumor necrosis factor receptor supe... Tumor necrosis factor receptor superfamily member 25	TNFRSF25	253	Annotation score:
K7EJY9	K7EJY9_HUMAN	Tumor necrosis factor receptor supe... Tumor necrosis factor receptor superfamily member 25	TNFRSF25	45	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	4 – 6	RPR → AAA in AAC51192 (PubMed:9052839).Curated	3
Sequence conflictⁱ	4 – 6	RPR → AAA in AAC51193 (PubMed:9052839).Curated	3
Sequence conflictⁱ	60	P → H in AAB41435 (Ref. 13) Curated	1
Sequence conflictⁱ	167	P → L (PubMed:9052839).Curated	1
Sequence conflictⁱ	167	P → L (Ref. 13) Curated	1
Sequence conflictⁱ	312	A → R (PubMed:8934525).Curated	1
Sequence conflictⁱ	312	A → R (PubMed:9446802).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_018826	23	R → Q1 PublicationCorresponds to variant dbSNP:rs35771371Ensembl.	1
Natural variantⁱVAR_018827	159	D → G2 PublicationsCorresponds to variant dbSNP:rs11800462Ensembl.	1
Natural variantⁱVAR_018828	254	P → R1 PublicationCorresponds to variant dbSNP:rs34529016Ensembl.	1
Natural variantⁱVAR_011814	370	R → L. Corresponds to variant dbSNP:rs1064590Ensembl.	1
Natural variantⁱVAR_011815	381	R → H. Corresponds to variant dbSNP:rs1059333Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_006492	54 – 236	Missing in isoform 8. 1 PublicationAdd BLAST	183
Alternative sequenceⁱVSP_006491	54 – 98	Missing in isoform 6, isoform 7 and isoform 9. 1 PublicationAdd BLAST	45
Alternative sequenceⁱVSP_006493	156 – 171	SRRDT…PGFYE → HPSVTLGQRPHPSSTS in isoform 7. 1 PublicationAdd BLAST	16
Alternative sequenceⁱVSP_006494	172 – 417	Missing in isoform 7. 1 PublicationAdd BLAST	246
Alternative sequenceⁱVSP_006495	182 – 417	Missing in isoform 5 and isoform 6. 1 PublicationAdd BLAST	236
Alternative sequenceⁱVSP_006499	182 – 277	STLGS…TVQLV → PPPSLAGAPWGAVQSAVPLS VAGGRVGGVLGMRVGELGWT EGRRVRRGATTQHPPAAFSV LGPGAPGWPCGPPPAWGHPD LHIPPLLASQAPGYCR in isoform 12. 1 PublicationAdd BLAST	96
Alternative sequenceⁱVSP_006497	182 – 218	STLGS…LLLGA → VLGPGAPGWPCGPPPAWGHP DLHIPPLLASQAPGYCR in isoform 3. 2 PublicationsAdd BLAST	37
Alternative sequenceⁱVSP_006496	182 – 200	STLGS…GWRQM → PPPSLAGAPWGAVQSAVPLS VAGGRVGV in isoform 11. 1 PublicationAdd BLAST	19
Alternative sequenceⁱVSP_006501	200 – 253	MFWVQ…ATHLS → SRWCAGNARGRTGMDRGEAG EEGGNHPTPTSCFQCSGSRC SWLALWSPSCLGPP in isoform 4. 2 PublicationsAdd BLAST	54
Alternative sequenceⁱVSP_006503	200 – 237	MFWVQ…LVTAD → N in isoform 10. 2 PublicationsAdd BLAST	38
Alternative sequenceⁱVSP_006498	219 – 417	Missing in isoform 3. 2 PublicationsAdd BLAST	199
Alternative sequenceⁱVSP_006504	236	A → AA in isoform 2. 1 Publication	1
Alternative sequenceⁱVSP_006502	254 – 417	Missing in isoform 4. 2 PublicationsAdd BLAST	164
Alternative sequenceⁱVSP_006500	278 – 417	Missing in isoform 12. 1 PublicationAdd BLAST	140

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Y09392 mRNA Translation: CAA70561.1 Y09392 mRNA Translation: CAA70559.1 Y09392 mRNA Translation: CAA70560.1 U72763 mRNA Translation: AAC50819.1 U83599 Genomic DNA Translation: AAB41434.1 U83600 Genomic DNA Translation: AAB41435.1 U78029 mRNA Translation: AAB40918.1 U74611 mRNA Translation: AAB39714.1 U94501 mRNA Translation: AAC51306.1 U94504 mRNA Translation: AAC51309.1 U94502 mRNA Translation: AAC51307.1 U94503 mRNA Translation: AAC51308.1 U94505 mRNA Translation: AAC51310.1 U94506 mRNA Translation: AAC51311.1 U94507 mRNA Translation: AAC51312.1 U94508 mRNA Translation: AAC51313.1 U94509 mRNA Translation: AAC51314.1 U94510 mRNA Translation: AAC51315.1 U94512 mRNA Translation: AAC51316.1 U83598 mRNA Translation: AAB41433.1 AF026070 mRNA Translation: AAC39556.1 AF026071 mRNA Translation: AAB82288.1 AB051850 Genomic DNA Translation: BAB40662.1 AB051851 Genomic DNA Translation: BAB40663.1 AY358309 mRNA Translation: AAQ88676.1 AY254324 Genomic DNA Translation: AAO63495.1 U75380 mRNA Translation: AAC51192.1 AL158217 Genomic DNA No translation available. BC117189 mRNA Translation: AAI17190.1 BC143886 mRNA Translation: AAI43887.1 U75381 mRNA Translation: AAC51193.1 U83597 mRNA Translation: AAB41432.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS71.1 [Q93038-1] CCDS72.1 [Q93038-11] CCDS73.1 [Q93038-10] CCDS74.1 [Q93038-9] CCDS75.1 [Q93038-8]
NCBI Reference Sequences More...RefSeqⁱ	NP_001034753.1, NM_001039664.1 [Q93038-5] NP_003781.1, NM_003790.2 [Q93038-1] NP_683866.1, NM_148965.1 [Q93038-11] NP_683867.1, NM_148966.1 [Q93038-10] NP_683868.1, NM_148967.1 [Q93038-9] NP_683871.1, NM_148970.1 [Q93038-8]
UniGeneⁱ	Hs.462529

Genome annotation databases

Ensemblⁱ	ENST00000348333; ENSP00000314451; ENSG00000215788 [Q93038-9] ENST00000351748; ENSP00000326762; ENSG00000215788 [Q93038-8] ENST00000351959; ENSP00000337713; ENSG00000215788 [Q93038-10] ENST00000356876; ENSP00000349341; ENSG00000215788 [Q93038-1] ENST00000377782; ENSP00000367013; ENSG00000215788 [Q93038-11] ENST00000414040; ENSP00000404274; ENSG00000215788 [Q93038-3] ENST00000485036; ENSP00000431554; ENSG00000215788 [Q93038-12] ENST00000502588; ENSP00000423121; ENSG00000215788 [Q93038-6] ENST00000502730; ENSP00000421976; ENSG00000215788 [Q93038-7] ENST00000510563; ENSP00000424071; ENSG00000215788 [Q93038-5]
GeneIDⁱ	8718
KEGGⁱ	hsa:8718
UCSC genome browser More...UCSCⁱ	uc001ana.4 human [Q93038-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q93038-6	TNF receptor superfamily member 25		PANTR		372	UniRef100_H2RDZ3
Isoform 9 of Tumor necrosis factor receptor superfamily member 25		HUMAN		372
TNFRSF25 isoform 12		PANTR		136
Q93038-7	TNFRSF25 isoform 6		PANTR		126	UniRef100_A0A2J8KY34
Q93038-8	TNF receptor superfamily member 25		PANTR		234	UniRef100_A0A2I3RK20
Uncharacterized protein		PANPA		234

Protein	Similar proteins		Species	Score	Length	Source
Q93038	TNFRSF25 isoform 5		PONAB		421	UniRef90_Q93038
Uncharacterized protein		CERAT		420
Uncharacterized protein		MACNE		420
Uncharacterized protein		RHIRO		420
Uncharacterized protein		MACFA		420
+26
Q93038-3	TNFRSF25 isoform 8		PONAB		222	UniRef90_Q93038-3
TNFRSF25 isoform 7		PANTR		218
Uncharacterized protein		PANPA		188
Uncharacterized protein		RHIRO		188
Uncharacterized protein		PAPAN		188
+6
Q93038-4	Tumor necrosis factor receptor superfamily member 25		HUMAN		253	UniRef90_Q93038-4
TNFRSF25 isoform 5		PANTR		253
Q93038-5	Isoform 11 of Tumor necrosis factor receptor superfamily member 25		HUMAN		426	UniRef90_Q93038-11
Uncharacterized protein		Cebus capucinus imitator		428
TNF receptor superfamily member 25		CALJA		427
Uncharacterized protein		COLAP		426
Uncharacterized protein		PANPA		426
+15
Q93038-6	TNF receptor superfamily member 25		PANTR		372	UniRef90_H2RDZ3
Isoform 9 of Tumor necrosis factor receptor superfamily member 25		HUMAN		372
TNFRSF25 isoform 12		PONAB		376
Uncharacterized protein		PAPAN		375
Uncharacterized protein		MACNE		375
+17
Q93038-7	TNFRSF25 isoform 10		PONAB		130	UniRef90_A0A2J8US05
TNFRSF25 isoform 6		PANTR		126
Q93038-8	TNF receptor superfamily member 25		PANTR		234	UniRef90_A0A2I3RK20
Uncharacterized protein		PANPA		234
TNFRSF25 isoform 11		PONAB		238
Uncharacterized protein		RHIRO		237
Uncharacterized protein		NOMLE		234
+7
Q93038-10	TNFRSF25 isoform 7		PONAB		384	UniRef90_Q93038-10
Uncharacterized protein		MACMU		383
Uncharacterized protein		MANLE		383
Uncharacterized protein		CERAT		383
Uncharacterized protein		MACNE		383
+14
Q93038-12	TNFRSF25 isoform 1		PONAB		280	UniRef90_Q93038-12
TNFRSF25 isoform 2		PANTR		277
TNFRSF25 isoform 3		PONAB		263

Protein	Similar proteins		Species	Score	Length	Source
Q93038	TNFRSF25 isoform 5		PONAB		421	UniRef50_Q93038
Uncharacterized protein		RHIRO		420
Uncharacterized protein		MACNE		420
Uncharacterized protein		MACFA		420
Tumor necrosis factor receptor superfamily member 25 isoform 2		MACMU		420
+268
Q93038-3	TNFRSF25 isoform 8		PONAB		222	UniRef50_Q93038-3
TNFRSF25 isoform 7		PANTR		218
Uncharacterized protein		PAPAN		188
Uncharacterized protein		MACFA		188
Uncharacterized protein		MACNE		188
+7
Q93038-4	Isoform 12 of Tumor necrosis factor receptor superfamily member 25		HUMAN		277	UniRef50_Q93038-12
TNFRSF25 isoform 1		PONAB		280
TNFRSF25 isoform 2		PANTR		277
UPI000C814264		LOXAF		254
UPI000F440C5A		LAGOL		252
+6
Q93038-6	TNF receptor superfamily member 25		CANLF		385	UniRef50_F1Q452
tumor necrosis factor receptor superfamily member 25-like		BALAS		363
Uncharacterized protein		RHIRO		375
TNFRSF25 isoform 12		PONAB		376
Uncharacterized protein		MACMU		375
+46
Q93038-7	TNFRSF25 isoform 10		PONAB		130	UniRef50_A0A2J8US05
TNFRSF25 isoform 6		PANTR		126
Q93038-8	Uncharacterized protein		PONAB		289	UniRef50_H2N9A7
TNFRSF25		CEREH		314
tumor necrosis factor receptor superfamily member 25-like		LIPVE		278
Uncharacterized protein		NOMLE		234
Uncharacterized protein		RHIRO		237
+13

Cross-referencesⁱ

Web resourcesⁱ

NIEHS-SNPs

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Y09392 mRNA Translation: CAA70561.1 Y09392 mRNA Translation: CAA70559.1 Y09392 mRNA Translation: CAA70560.1 U72763 mRNA Translation: AAC50819.1 U83599 Genomic DNA Translation: AAB41434.1 U83600 Genomic DNA Translation: AAB41435.1 U78029 mRNA Translation: AAB40918.1 U74611 mRNA Translation: AAB39714.1 U94501 mRNA Translation: AAC51306.1 U94504 mRNA Translation: AAC51309.1 U94502 mRNA Translation: AAC51307.1 U94503 mRNA Translation: AAC51308.1 U94505 mRNA Translation: AAC51310.1 U94506 mRNA Translation: AAC51311.1 U94507 mRNA Translation: AAC51312.1 U94508 mRNA Translation: AAC51313.1 U94509 mRNA Translation: AAC51314.1 U94510 mRNA Translation: AAC51315.1 U94512 mRNA Translation: AAC51316.1 U83598 mRNA Translation: AAB41433.1 AF026070 mRNA Translation: AAC39556.1 AF026071 mRNA Translation: AAB82288.1 AB051850 Genomic DNA Translation: BAB40662.1 AB051851 Genomic DNA Translation: BAB40663.1 AY358309 mRNA Translation: AAQ88676.1 AY254324 Genomic DNA Translation: AAO63495.1 U75380 mRNA Translation: AAC51192.1 AL158217 Genomic DNA No translation available. BC117189 mRNA Translation: AAI17190.1 BC143886 mRNA Translation: AAI43887.1 U75381 mRNA Translation: AAC51193.1 U83597 mRNA Translation: AAB41432.1
CCDSⁱ	CCDS71.1 [Q93038-1] CCDS72.1 [Q93038-11] CCDS73.1 [Q93038-10] CCDS74.1 [Q93038-9] CCDS75.1 [Q93038-8]
RefSeqⁱ	NP_001034753.1, NM_001039664.1 [Q93038-5] NP_003781.1, NM_003790.2 [Q93038-1] NP_683866.1, NM_148965.1 [Q93038-11] NP_683867.1, NM_148966.1 [Q93038-10] NP_683868.1, NM_148967.1 [Q93038-9] NP_683871.1, NM_148970.1 [Q93038-8]
UniGeneⁱ	Hs.462529

3D structure databases

ProteinModelPortalⁱ	Q93038
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	114258, 11 interactors
DIPⁱ	DIP-59563N
IntActⁱ	Q93038, 1 interactor
STRINGⁱ	9606.ENSP00000367013

PTM databases

iPTMnetⁱ	Q93038

iPTMnetⁱ

Q93038

Polymorphism and mutation databases

BioMutaⁱ	TNFRSF25
DMDMⁱ	2501233

Proteomic databases

jPOSTⁱ	Q93038
PeptideAtlasⁱ	Q93038
PRIDEⁱ	Q93038
ProteomicsDBⁱ	75674 75675 [Q93038-10] 75676 [Q93038-11] 75677 [Q93038-12] 75678 [Q93038-2] 75679 [Q93038-3] 75680 [Q93038-4] 75681 [Q93038-5] 75682 [Q93038-6] 75683 [Q93038-7] 75684 [Q93038-8] 75685 [Q93038-9]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Organism-specific databases

CTDⁱ	8718
DisGeNETⁱ	8718
EuPathDBⁱ	HostDB:ENSG00000215788.9
GeneCardsⁱ	TNFRSF25
HGNCⁱ	HGNC:11910 TNFRSF25
HPAⁱ	HPA069834
MIMⁱ	603366 gene
neXtProtⁱ	NX_Q93038
OpenTargetsⁱ	ENSG00000215788
PharmGKBⁱ	PA36603
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

GeneTreeⁱ	ENSGT00940000161888
HOVERGENⁱ	HBG058493
InParanoidⁱ	Q93038
KOⁱ	K05160
OMAⁱ	RALHRHT
OrthoDBⁱ	726174at2759
PhylomeDBⁱ	Q93038
TreeFamⁱ	TF333916

Enzyme and pathway databases

Reactomeⁱ	R-HSA-5669034 TNFs bind their physiological receptors
SIGNORⁱ	Q93038

Miscellaneous databases

ChiTaRSⁱ	TNFRSF25 human
GeneWikiⁱ	TNFRSF25
GenomeRNAiⁱ	8718
Protein Ontology More...PROⁱ	PR:Q93038
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000215788 Expressed in 180 organ(s), highest expression level in right hemisphere of cerebellum
ExpressionAtlasⁱ	Q93038 baseline and differential
Genevisibleⁱ	Q93038 HS

Family and domain databases

CDDⁱ	cd13420 TNFRSF25, 1 hit
InterProⁱ	View protein in InterPro IPR011029 DEATH-like_dom_sf IPR000488 Death_domain IPR001368 TNFR/NGFR_Cys_rich_reg IPR022329 TNFR_25 IPR034050 TNFRSF25_N
Pfamⁱ	View protein in Pfam PF00531 Death, 1 hit PF00020 TNFR_c6, 1 hit
PRINTSⁱ	PR01972 TNFACTORR25
SMARTⁱ	View protein in SMART SM00005 DEATH, 1 hit SM00208 TNFR, 2 hits
SUPFAMⁱ	SSF47986 SSF47986, 1 hit
PROSITEⁱ	View protein in PROSITE PS50017 DEATH_DOMAIN, 1 hit PS00652 TNFR_NGFR_1, 2 hits PS50050 TNFR_NGFR_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TNR25_HUMAN
Accessionⁱ	Q93038Primary (citable) accession number: Q93038 Secondary accession number(s): B1ALX2 Q9UME5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
	Last sequence update:	November 1, 1997
	Last modified:	April 10, 2019
	This is version 181 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations

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UniProtKB - Q93038 (TNR25_HUMAN)

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Tumor necrosis factor receptor superfamily member 25

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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Keywords - Coding sequence diversityi

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Keywords - Cellular componentⁱ

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Keywords - PTMⁱ

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