Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 153 (17 Jun 2020)
Sequence version 2 (10 Feb 2009)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Immunoglobulin superfamily member 2

Gene

CD101

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role as inhibitor of T-cells proliferation induced by CD3. Inhibits expression of IL2RA on activated T-cells and secretion of IL2. Inhibits tyrosine kinases that are required for IL2 production and cellular proliferation. Inhibits phospholipase C-gamma-1/PLCG1 phosphorylation and subsequent CD3-induced changes in intracellular free calcium. Prevents nuclear translocation of nuclear factor of activated T-cell to the nucleus. Plays a role in the inhibition of T-cell proliferation via IL10 secretion by cutaneous dendritic cells. May be a marker of CD4+ CD56+ leukemic tumor cells.6 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-202433 Generation of second messenger molecules

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Immunoglobulin superfamily member 2
Short name:
IgSF2
Alternative name(s):
Cell surface glycoprotein V7
Glu-Trp-Ile EWI motif-containing protein 101
Short name:
EWI-101
CD_antigen: CD101
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CD101
Synonyms:EWI101, IGSF2, V7
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000134256.12

Human Gene Nomenclature Database

More...
HGNCi
HGNC:5949 CD101

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
604516 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q93033

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini21 – 954ExtracellularSequence analysisAdd BLAST934
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei955 – 975HelicalSequence analysisAdd BLAST21
Topological domaini976 – 1021CytoplasmicSequence analysisAdd BLAST46

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
9398

Open Targets

More...
OpenTargetsi
ENSG00000134256

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA29762

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q93033 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CD101

Domain mapping of disease mutations (DMDM)

More...
DMDMi
223590070

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 20Sequence analysisAdd BLAST20
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000025353921 – 1021Immunoglobulin superfamily member 2Add BLAST1001

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi43 ↔ 121PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi44N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi168 ↔ 249PROSITE-ProRule annotation
Disulfide bondi304 ↔ 377PROSITE-ProRule annotation
Glycosylationi322N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi434 ↔ 511PROSITE-ProRule annotation
Disulfide bondi562 ↔ 640PROSITE-ProRule annotation
Disulfide bondi697 ↔ 778PROSITE-ProRule annotation
Disulfide bondi834 ↔ 909PROSITE-ProRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q93033

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q93033

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q93033

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q93033

PeptideAtlas

More...
PeptideAtlasi
Q93033

PRoteomics IDEntifications database

More...
PRIDEi
Q93033

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
75672

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q93033

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q93033

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in lung, thymus and small intestine. Detected in cutaneous dendritic cells, activated T-cells, monocytes and granulocytes as well as with epithelial cells with dendritic morphology. Expressed in some leukemic cells, the CD4+ CD56+ blastic tumor cells, as well as in Langerhans cells from LCH (Langerhans cell histiocytosis) patients.5 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000134256 Expressed in leukocyte and 94 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q93033 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000134256 Tissue enhanced (blood, lung)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
114795, 3 interactors

Protein interaction database and analysis system

More...
IntActi
Q93033, 4 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000358482

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q93033 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini22 – 139Ig-like C2-type 1Add BLAST118
Domaini144 – 265Ig-like C2-type 2Add BLAST122
Domaini279 – 389Ig-like C2-type 3Add BLAST111
Domaini408 – 525Ig-like C2-type 4Add BLAST118
Domaini541 – 651Ig-like C2-type 5Add BLAST111
Domaini656 – 794Ig-like C2-type 6Add BLAST139
Domaini808 – 925Ig-like C2-type 7Add BLAST118

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi253 – 255EWI motif3

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IFBX Eukaryota
ENOG410YWQX LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161722

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_005187_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q93033

KEGG Orthology (KO)

More...
KOi
K06522

Identification of Orthologs from Complete Genome Data

More...
OMAi
KYGDEFH

Database of Orthologous Groups

More...
OrthoDBi
180654at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q93033

TreeFam database of animal gene trees

More...
TreeFami
TF332702

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 7 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002195 Dihydroorotase_CS
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR013106 Ig_V-set

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07679 I-set, 1 hit
PF07686 V-set, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00409 IG, 7 hits
SM00406 IGv, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726 SSF48726, 7 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50835 IG_LIKE, 7 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q93033-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGISYVASF FLLLTKLSIG QREVTVQKGP LFRAEGYPVS IGCNVTGHQG
60 70 80 90 100
PSEQHFQWSV YLPTNPTQEV QIISTKDAAF SYAVYTQRVR SGDVYVERVQ
110 120 130 140 150
GNSVLLHISK LQMKDAGEYE CHTPNTDEKY YGSYSAKTNL IVIPDTLSAT
160 170 180 190 200
MSSQTLGKEE GEPLALTCEA SKATAQHTHL SVTWYLTQDG GGSQATEIIS
210 220 230 240 250
LSKDFILVPG PLYTERFAAS DVQLNKLGPT TFRLSIERLQ SSDQGQLFCE
260 270 280 290 300
ATEWIQDPDE TWMFITKKQT DQTTLRIQPA VKDFQVNITA DSLFAEGKPL
310 320 330 340 350
ELVCLVVSSG RDPQLQGIWF FNGTEIAHID AGGVLGLKND YKERASQGEL
360 370 380 390 400
QVSKLGPKAF SLKIFSLGPE DEGAYRCVVA EVMKTRTGSW QVLQRKQSPD
410 420 430 440 450
SHVHLRKPAA RSVVMSTKNK QQVVWEGETL AFLCKAGGAE SPLSVSWWHI
460 470 480 490 500
PRDQTQPEFV AGMGQDGIVQ LGASYGVPSY HGNTRLEKMD WATFQLEITF
510 520 530 540 550
TAITDSGTYE CRVSEKSRNQ ARDLSWTQKI SVTVKSLESS LQVSLMSRQP
560 570 580 590 600
QVMLTNTFDL SCVVRAGYSD LKVPLTVTWQ FQPASSHIFH QLIRITHNGT
610 620 630 640 650
IEWGNFLSRF QKKTKVSQSL FRSQLLVHDA TEEETGVYQC EVEVYDRNSL
660 670 680 690 700
YNNRPPRASA ISHPLRIAVT LPESKLKVNS RSQVQELSIN SNTDIECSIL
710 720 730 740 750
SRSNGNLQLA IIWYFSPVST NASWLKILEM DQTNVIKTGD EFHTPQRKQK
760 770 780 790 800
FHTEKVSQDL FQLHILNVED SDRGKYHCAV EEWLLSTNGT WHKLGEKKSG
810 820 830 840 850
LTELKLKPTG SKVRVSKVYW TENVTEHREV AIRCSLESVG SSATLYSVMW
860 870 880 890 900
YWNRENSGSK LLVHLQHDGL LEYGEEGLRR HLHCYRSSST DFVLKLHQVE
910 920 930 940 950
MEDAGMYWCR VAEWQLHGHP SKWINQASDE SQRMVLTVLP SEPTLPSRIC
960 970 980 990 1000
SSAPLLYFLF ICPFVLLLLL LISLLCLYWK ARKLSTLRSN TRKEKALWVD
1010 1020
LKEAGGVTTN RREDEEEDEG N
Length:1,021
Mass (Da):115,109
Last modified:February 10, 2009 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i12A07C648D21EB91
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti91S → G in CAA83923 (PubMed:7722300).Curated1
Sequence conflicti129K → N in CAA83923 (PubMed:7722300).Curated1
Sequence conflicti135S → R in CAA83923 (PubMed:7722300).Curated1
Sequence conflicti352V → L in CAA83923 (PubMed:7722300).Curated1
Sequence conflicti684V → G in CAA83923 (PubMed:7722300).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_054434157G → S. Corresponds to variant dbSNP:rs34999087Ensembl.1
Natural variantiVAR_028371225N → S. Corresponds to variant dbSNP:rs3754112Ensembl.1
Natural variantiVAR_028372415M → V1 PublicationCorresponds to variant dbSNP:rs2249265Ensembl.1
Natural variantiVAR_028373518R → Q. Corresponds to variant dbSNP:rs17235766Ensembl.1
Natural variantiVAR_028374525S → R. Corresponds to variant dbSNP:rs17235773Ensembl.1
Natural variantiVAR_054435631T → S. Corresponds to variant dbSNP:rs34510762Ensembl.1
Natural variantiVAR_054436933R → Q. Corresponds to variant dbSNP:rs12093834Ensembl.1
Natural variantiVAR_054437955L → F. Corresponds to variant dbSNP:rs34223095Ensembl.1
Natural variantiVAR_028375965V → I. Corresponds to variant dbSNP:rs12097758Ensembl.1
Natural variantiVAR_028376988R → C. Corresponds to variant dbSNP:rs12067543Ensembl.1
Natural variantiVAR_054438992R → W. Corresponds to variant dbSNP:rs34248572Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z33642 mRNA Translation: CAA83923.1
AL445231 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS891.1

Protein sequence database of the Protein Information Resource

More...
PIRi
I39207

NCBI Reference Sequences

More...
RefSeqi
NP_001243035.1, NM_001256106.2
NP_001243038.1, NM_001256109.2
NP_004249.2, NM_004258.5

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000256652; ENSP00000256652; ENSG00000134256
ENST00000369470; ENSP00000358482; ENSG00000134256

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
9398

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:9398

UCSC genome browser

More...
UCSCi
uc010oxc.3 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z33642 mRNA Translation: CAA83923.1
AL445231 Genomic DNA No translation available.
CCDSiCCDS891.1
PIRiI39207
RefSeqiNP_001243035.1, NM_001256106.2
NP_001243038.1, NM_001256109.2
NP_004249.2, NM_004258.5

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi114795, 3 interactors
IntActiQ93033, 4 interactors
STRINGi9606.ENSP00000358482

PTM databases

iPTMnetiQ93033
PhosphoSitePlusiQ93033

Polymorphism and mutation databases

BioMutaiCD101
DMDMi223590070

Proteomic databases

EPDiQ93033
jPOSTiQ93033
MassIVEiQ93033
PaxDbiQ93033
PeptideAtlasiQ93033
PRIDEiQ93033
ProteomicsDBi75672

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
20186 358 antibodies

Genome annotation databases

EnsembliENST00000256652; ENSP00000256652; ENSG00000134256
ENST00000369470; ENSP00000358482; ENSG00000134256
GeneIDi9398
KEGGihsa:9398
UCSCiuc010oxc.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9398
DisGeNETi9398
EuPathDBiHostDB:ENSG00000134256.12

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CD101
HGNCiHGNC:5949 CD101
HPAiENSG00000134256 Tissue enhanced (blood, lung)
MIMi604516 gene
neXtProtiNX_Q93033
OpenTargetsiENSG00000134256
PharmGKBiPA29762

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IFBX Eukaryota
ENOG410YWQX LUCA
GeneTreeiENSGT00940000161722
HOGENOMiCLU_005187_0_0_1
InParanoidiQ93033
KOiK06522
OMAiKYGDEFH
OrthoDBi180654at2759
PhylomeDBiQ93033
TreeFamiTF332702

Enzyme and pathway databases

ReactomeiR-HSA-202433 Generation of second messenger molecules

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
9398 13 hits in 786 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CD101 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
IGSF2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
9398
PharosiQ93033 Tbio

Protein Ontology

More...
PROi
PR:Q93033
RNActiQ93033 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000134256 Expressed in leukocyte and 94 other tissues
GenevisibleiQ93033 HS

Family and domain databases

Gene3Di2.60.40.10, 7 hits
InterProiView protein in InterPro
IPR002195 Dihydroorotase_CS
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF07679 I-set, 1 hit
PF07686 V-set, 3 hits
SMARTiView protein in SMART
SM00409 IG, 7 hits
SM00406 IGv, 4 hits
SUPFAMiSSF48726 SSF48726, 7 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 7 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIGSF2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q93033
Secondary accession number(s): Q15856
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: February 10, 2009
Last modified: June 17, 2020
This is version 153 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again