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Protein

Immunoglobulin superfamily member 2

Gene

CD101

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role as inhibitor of T-cells proliferation induced by CD3. Inhibits expression of IL2RA on activated T-cells and secretion of IL2. Inhibits tyrosine kinases that are required for IL2 production and cellular proliferation. Inhibits phospholipase C-gamma-1/PLCG1 phosphorylation and subsequent CD3-induced changes in intracellular free calcium. Prevents nuclear translocation of nuclear factor of activated T-cell to the nucleus. Plays a role in the inhibition of T-cell proliferation via IL10 secretion by cutaneous dendritic cells. May be a marker of CD4+ CD56+ leukemic tumor cells.6 Publications

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-202433 Generation of second messenger molecules

Names & Taxonomyi

Protein namesi
Recommended name:
Immunoglobulin superfamily member 2
Short name:
IgSF2
Alternative name(s):
Cell surface glycoprotein V7
Glu-Trp-Ile EWI motif-containing protein 101
Short name:
EWI-101
CD_antigen: CD101
Gene namesi
Name:CD101
Synonyms:EWI101, IGSF2, V7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000134256.12
HGNCiHGNC:5949 CD101
MIMi604516 gene
neXtProtiNX_Q93033

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini21 – 954ExtracellularSequence analysisAdd BLAST934
Transmembranei955 – 975HelicalSequence analysisAdd BLAST21
Topological domaini976 – 1021CytoplasmicSequence analysisAdd BLAST46

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi9398
OpenTargetsiENSG00000134256
PharmGKBiPA29762

Polymorphism and mutation databases

DMDMi223590070

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000025353921 – 1021Immunoglobulin superfamily member 2Add BLAST1001

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi43 ↔ 121PROSITE-ProRule annotation
Glycosylationi44N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi168 ↔ 249PROSITE-ProRule annotation
Disulfide bondi304 ↔ 377PROSITE-ProRule annotation
Glycosylationi322N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi434 ↔ 511PROSITE-ProRule annotation
Disulfide bondi562 ↔ 640PROSITE-ProRule annotation
Disulfide bondi697 ↔ 778PROSITE-ProRule annotation
Disulfide bondi834 ↔ 909PROSITE-ProRule annotation

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ93033
PaxDbiQ93033
PeptideAtlasiQ93033
PRIDEiQ93033
ProteomicsDBi75672

PTM databases

iPTMnetiQ93033
PhosphoSitePlusiQ93033

Expressioni

Tissue specificityi

Expressed in lung, thymus and small intestine. Detected in cutaneous dendritic cells, activated T-cells, monocytes and granulocytes as well as with epithelial cells with dendritic morphology. Expressed in some leukemic cells, the CD4+ CD56+ blastic tumor cells, as well as in Langerhans cells from LCH (Langerhans cell histiocytosis) patients.5 Publications

Gene expression databases

BgeeiENSG00000134256 Expressed in 95 organ(s), highest expression level in leukocyte
CleanExiHS_IGSF2
GenevisibleiQ93033 HS

Organism-specific databases

HPAiHPA049527
HPA057763

Interactioni

Protein-protein interaction databases

BioGridi114795, 3 interactors
IntActiQ93033, 4 interactors
STRINGi9606.ENSP00000256652

Structurei

3D structure databases

ProteinModelPortaliQ93033
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 139Ig-like C2-type 1Add BLAST118
Domaini144 – 265Ig-like C2-type 2Add BLAST122
Domaini279 – 389Ig-like C2-type 3Add BLAST111
Domaini408 – 525Ig-like C2-type 4Add BLAST118
Domaini541 – 651Ig-like C2-type 5Add BLAST111
Domaini656 – 794Ig-like C2-type 6Add BLAST139
Domaini808 – 925Ig-like C2-type 7Add BLAST118

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi253 – 255EWI motif3

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFBX Eukaryota
ENOG410YWQX LUCA
GeneTreeiENSGT00390000010278
HOGENOMiHOG000293322
HOVERGENiHBG107997
InParanoidiQ93033
KOiK06522
OMAiQAVWEGE
OrthoDBiEOG091G00OL
PhylomeDBiQ93033
TreeFamiTF332702

Family and domain databases

Gene3Di2.60.40.10, 7 hits
InterProiView protein in InterPro
IPR002195 Dihydroorotase_CS
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF07679 I-set, 1 hit
PF07686 V-set, 3 hits
SMARTiView protein in SMART
SM00409 IG, 7 hits
SM00406 IGv, 4 hits
SUPFAMiSSF48726 SSF48726, 7 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 7 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q93033-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGISYVASF FLLLTKLSIG QREVTVQKGP LFRAEGYPVS IGCNVTGHQG
60 70 80 90 100
PSEQHFQWSV YLPTNPTQEV QIISTKDAAF SYAVYTQRVR SGDVYVERVQ
110 120 130 140 150
GNSVLLHISK LQMKDAGEYE CHTPNTDEKY YGSYSAKTNL IVIPDTLSAT
160 170 180 190 200
MSSQTLGKEE GEPLALTCEA SKATAQHTHL SVTWYLTQDG GGSQATEIIS
210 220 230 240 250
LSKDFILVPG PLYTERFAAS DVQLNKLGPT TFRLSIERLQ SSDQGQLFCE
260 270 280 290 300
ATEWIQDPDE TWMFITKKQT DQTTLRIQPA VKDFQVNITA DSLFAEGKPL
310 320 330 340 350
ELVCLVVSSG RDPQLQGIWF FNGTEIAHID AGGVLGLKND YKERASQGEL
360 370 380 390 400
QVSKLGPKAF SLKIFSLGPE DEGAYRCVVA EVMKTRTGSW QVLQRKQSPD
410 420 430 440 450
SHVHLRKPAA RSVVMSTKNK QQVVWEGETL AFLCKAGGAE SPLSVSWWHI
460 470 480 490 500
PRDQTQPEFV AGMGQDGIVQ LGASYGVPSY HGNTRLEKMD WATFQLEITF
510 520 530 540 550
TAITDSGTYE CRVSEKSRNQ ARDLSWTQKI SVTVKSLESS LQVSLMSRQP
560 570 580 590 600
QVMLTNTFDL SCVVRAGYSD LKVPLTVTWQ FQPASSHIFH QLIRITHNGT
610 620 630 640 650
IEWGNFLSRF QKKTKVSQSL FRSQLLVHDA TEEETGVYQC EVEVYDRNSL
660 670 680 690 700
YNNRPPRASA ISHPLRIAVT LPESKLKVNS RSQVQELSIN SNTDIECSIL
710 720 730 740 750
SRSNGNLQLA IIWYFSPVST NASWLKILEM DQTNVIKTGD EFHTPQRKQK
760 770 780 790 800
FHTEKVSQDL FQLHILNVED SDRGKYHCAV EEWLLSTNGT WHKLGEKKSG
810 820 830 840 850
LTELKLKPTG SKVRVSKVYW TENVTEHREV AIRCSLESVG SSATLYSVMW
860 870 880 890 900
YWNRENSGSK LLVHLQHDGL LEYGEEGLRR HLHCYRSSST DFVLKLHQVE
910 920 930 940 950
MEDAGMYWCR VAEWQLHGHP SKWINQASDE SQRMVLTVLP SEPTLPSRIC
960 970 980 990 1000
SSAPLLYFLF ICPFVLLLLL LISLLCLYWK ARKLSTLRSN TRKEKALWVD
1010 1020
LKEAGGVTTN RREDEEEDEG N
Length:1,021
Mass (Da):115,109
Last modified:February 10, 2009 - v2
Checksum:i12A07C648D21EB91
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti91S → G in CAA83923 (PubMed:7722300).Curated1
Sequence conflicti129K → N in CAA83923 (PubMed:7722300).Curated1
Sequence conflicti135S → R in CAA83923 (PubMed:7722300).Curated1
Sequence conflicti352V → L in CAA83923 (PubMed:7722300).Curated1
Sequence conflicti684V → G in CAA83923 (PubMed:7722300).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_054434157G → S. Corresponds to variant dbSNP:rs34999087Ensembl.1
Natural variantiVAR_028371225N → S. Corresponds to variant dbSNP:rs3754112Ensembl.1
Natural variantiVAR_028372415M → V1 PublicationCorresponds to variant dbSNP:rs2249265Ensembl.1
Natural variantiVAR_028373518R → Q. Corresponds to variant dbSNP:rs17235766Ensembl.1
Natural variantiVAR_028374525S → R. Corresponds to variant dbSNP:rs17235773Ensembl.1
Natural variantiVAR_054435631T → S. Corresponds to variant dbSNP:rs34510762Ensembl.1
Natural variantiVAR_054436933R → Q. Corresponds to variant dbSNP:rs12093834Ensembl.1
Natural variantiVAR_054437955L → F. Corresponds to variant dbSNP:rs34223095Ensembl.1
Natural variantiVAR_028375965V → I. Corresponds to variant dbSNP:rs12097758Ensembl.1
Natural variantiVAR_028376988R → C. Corresponds to variant dbSNP:rs12067543Ensembl.1
Natural variantiVAR_054438992R → W. Corresponds to variant dbSNP:rs34248572Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z33642 mRNA Translation: CAA83923.1
AL445231 Genomic DNA No translation available.
CCDSiCCDS891.1
PIRiI39207
RefSeqiNP_001243035.1, NM_001256106.2
NP_001243038.1, NM_001256109.2
NP_004249.2, NM_004258.5
UniGeneiHs.654598

Genome annotation databases

EnsembliENST00000256652; ENSP00000256652; ENSG00000134256
ENST00000369470; ENSP00000358482; ENSG00000134256
GeneIDi9398
KEGGihsa:9398
UCSCiuc010oxc.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z33642 mRNA Translation: CAA83923.1
AL445231 Genomic DNA No translation available.
CCDSiCCDS891.1
PIRiI39207
RefSeqiNP_001243035.1, NM_001256106.2
NP_001243038.1, NM_001256109.2
NP_004249.2, NM_004258.5
UniGeneiHs.654598

3D structure databases

ProteinModelPortaliQ93033
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114795, 3 interactors
IntActiQ93033, 4 interactors
STRINGi9606.ENSP00000256652

PTM databases

iPTMnetiQ93033
PhosphoSitePlusiQ93033

Polymorphism and mutation databases

DMDMi223590070

Proteomic databases

EPDiQ93033
PaxDbiQ93033
PeptideAtlasiQ93033
PRIDEiQ93033
ProteomicsDBi75672

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000256652; ENSP00000256652; ENSG00000134256
ENST00000369470; ENSP00000358482; ENSG00000134256
GeneIDi9398
KEGGihsa:9398
UCSCiuc010oxc.3 human

Organism-specific databases

CTDi9398
DisGeNETi9398
EuPathDBiHostDB:ENSG00000134256.12
GeneCardsiCD101
H-InvDBiHIX0028852
HGNCiHGNC:5949 CD101
HPAiHPA049527
HPA057763
MIMi604516 gene
neXtProtiNX_Q93033
OpenTargetsiENSG00000134256
PharmGKBiPA29762
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFBX Eukaryota
ENOG410YWQX LUCA
GeneTreeiENSGT00390000010278
HOGENOMiHOG000293322
HOVERGENiHBG107997
InParanoidiQ93033
KOiK06522
OMAiQAVWEGE
OrthoDBiEOG091G00OL
PhylomeDBiQ93033
TreeFamiTF332702

Enzyme and pathway databases

ReactomeiR-HSA-202433 Generation of second messenger molecules

Miscellaneous databases

ChiTaRSiCD101 human
GeneWikiiIGSF2
GenomeRNAii9398
PROiPR:Q93033
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000134256 Expressed in 95 organ(s), highest expression level in leukocyte
CleanExiHS_IGSF2
GenevisibleiQ93033 HS

Family and domain databases

Gene3Di2.60.40.10, 7 hits
InterProiView protein in InterPro
IPR002195 Dihydroorotase_CS
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF07679 I-set, 1 hit
PF07686 V-set, 3 hits
SMARTiView protein in SMART
SM00409 IG, 7 hits
SM00406 IGv, 4 hits
SUPFAMiSSF48726 SSF48726, 7 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 7 hits
ProtoNetiSearch...

Entry informationi

Entry nameiIGSF2_HUMAN
AccessioniPrimary (citable) accession number: Q93033
Secondary accession number(s): Q15856
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: February 10, 2009
Last modified: November 7, 2018
This is version 141 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
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