Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

N-alpha-acetyltransferase 80

Gene

NAA80

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

N-alpha-acetyltransferase that specifically mediates the acetylation of the acidic amino terminus of processed forms of beta- and gamma-actin (ACTB and ACTG, respectively) (PubMed:30028079, PubMed:29581253). N-terminal acetylation of processed beta- and gamma-actin regulates actin filament depolymerization and elongation (PubMed:29581253). In vivo, preferentially displays N-terminal acetyltransferase activity towards acid N-terminal sequences starting with Asp-Asp-Asp and Glu-Glu-Glu (PubMed:30028079, PubMed:29581253). In vitro, shows high activity towards Met-Asp-Glu-Leu and Met-Asp-Asp-Asp (PubMed:10644992, PubMed:29581307). May act as a tumor suppressor (PubMed:10644992).4 Publications

Catalytic activityi

Acetyl-CoA + an N-terminal L-aspartyl-L-aspartyl-L-aspartyl-[protein] = an N-terminal N(alpha)-acetyl-L-aspartyl-L-aspartyl-L-aspartyl-[protein] + CoA.2 Publications
Acetyl-CoA + an N-terminal L-glutamyl-L-glutamyl-L-glutamyl-[protein] = an N-terminal N(alpha)-acetyl-L-glutamyl-L-glutamyl-L-glutamyl-[protein] + CoA.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei85SubstrateBy similarity1
Binding sitei179Acetyl-CoABy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
N-alpha-acetyltransferase 80 (EC:2.3.1.-3 Publications)
Short name:
HsNAAA801 Publication
Alternative name(s):
N-acetyltransferase 61 Publication
Protein fusion-21 Publication
Short name:
Protein fus-21 Publication
Gene namesi
Name:NAA801 PublicationImported
Synonyms:FUS21 Publication, NAT61 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000243477.5
HGNCiHGNC:30252 NAA80
MIMi607073 gene
neXtProtiNX_Q93015

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi83W → F in NAA80mut; abolished acetyltransferase activity; when associated with Q-148, D-151 and F-183. 1 Publication1
Mutagenesisi148R → Q in NAA80mut; abolished acetyltransferase activity; when associated with F-83, D-151 and F-183. 1 Publication1
Mutagenesisi151G → D in NAA80mut; abolished acetyltransferase activity; when associated with F-83, Q-148 and F-183. 1 Publication1
Mutagenesisi183Y → F in NAA80mut; abolished acetyltransferase activity; when associated with F-83, Q-148 and D-151. 1 Publication1

Keywords - Diseasei

Tumor suppressor

Organism-specific databases

DisGeNETi24142
OpenTargetsiENSG00000243477
PharmGKBiPA134979782

Polymorphism and mutation databases

BioMutaiNAT6
DMDMi25008833

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000745361 – 286N-alpha-acetyltransferase 80Add BLAST286

Proteomic databases

EPDiQ93015
MaxQBiQ93015
PaxDbiQ93015
PeptideAtlasiQ93015
PRIDEiQ93015
ProteomicsDBi75670
75671 [Q93015-2]

PTM databases

iPTMnetiQ93015
PhosphoSitePlusiQ93015

Expressioni

Tissue specificityi

Strongly expressed in heart and skeletal muscle, followed by brain and pancreas, with weak expression in kidney, liver, and lung and no expression in placenta.1 Publication

Gene expression databases

BgeeiENSG00000243477 Expressed in 120 organ(s), highest expression level in right testis
ExpressionAtlasiQ93015 baseline and differential
GenevisibleiQ93015 HS

Organism-specific databases

HPAiHPA039576

Interactioni

Protein-protein interaction databases

BioGridi117293, 2 interactors
IntActiQ93015, 4 interactors
STRINGi9606.ENSP00000346927

Structurei

3D structure databases

ProteinModelPortaliQ93015
SMRiQ93015
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini60 – 207N-acetyltransferasePROSITE-ProRule annotationAdd BLAST148

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni90 – 93Substrate bindingBy similarity4
Regioni141 – 143Acetyl-CoA bindingBy similarity3
Regioni149 – 154Acetyl-CoA bindingBy similarity6

Sequence similaritiesi

Belongs to the acetyltransferase family.Curated

Phylogenomic databases

eggNOGiENOG410IS85 Eukaryota
ENOG4111U9V LUCA
GeneTreeiENSGT00390000000980
HOGENOMiHOG000113734
HOVERGENiHBG031735
InParanoidiQ93015
OMAiGCPIFWM
OrthoDBiEOG091G0SQB
PhylomeDBiQ93015
TreeFamiTF106312

Family and domain databases

InterProiView protein in InterPro
IPR016181 Acyl_CoA_acyltransferase
IPR000182 GNAT_dom
IPR039840 NAT6
PANTHERiPTHR13538:SF4 PTHR13538:SF4, 1 hit
PfamiView protein in Pfam
PF00583 Acetyltransf_1, 1 hit
SUPFAMiSSF55729 SSF55729, 1 hit
PROSITEiView protein in PROSITE
PS51186 GNAT, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q93015-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MELILSTSPA ELTLDPACQP KLPLDSTCQP EMTFNPGPTE LTLDPEHQPE
60 70 80 90 100
ETPAPSLAEL TLEPVHRRPE LLDACADLIN DQWPRSRTSR LHSLGQSSDA
110 120 130 140 150
FPLCLMLLSP HPTLEAAPVV VGHARLSRVL NQPQSLLVET VVVARALRGR
160 170 180 190 200
GFGRRLMEGL EVFARARGFR KLHLTTHDQV HFYTHLGYQL GEPVQGLVFT
210 220 230 240 250
SRRLPATLLN AFPTAPSPRP PRKAPNLTAQ AAPRGPKGPP LPPPPPLPEC
260 270 280
LTISPPVPSG PPSKSLLETQ YQNVRGRPIF WMEKDI
Length:286
Mass (Da):31,445
Last modified:June 1, 1998 - v2
Checksum:iA755E2E3367625DB
GO
Isoform 2 (identifier: Q93015-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MQELTLSPGPAKLTPTLDPTHRM

Show »
Length:308
Mass (Da):33,831
Checksum:i09A5F1F976681DB5
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J451C9J451_HUMAN
N-alpha-acetyltransferase 80
NAA80
57Annotation score:
C9JL88C9JL88_HUMAN
N-alpha-acetyltransferase 80
NAA80
86Annotation score:
A0A1D5RMQ1A0A1D5RMQ1_HUMAN
N-alpha-acetyltransferase 80
NAA80
9Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_014224145R → S in non-small cell lung cancer cell lines. 1 Publication1
Natural variantiVAR_014225207T → S in non-small cell lung cancer cell lines. 1 PublicationCorresponds to variant dbSNP:rs200439690Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0371871M → MQELTLSPGPAKLTPTLDPT HRM in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF040706 mRNA Translation: AAC70913.1
AF040705 mRNA Translation: AAC70912.1
U73167 Genomic DNA Translation: AAC02732.1
BC004483 mRNA Translation: AAH04483.2
CCDSiCCDS43095.1 [Q93015-2]
CCDS56258.1 [Q93015-1]
RefSeqiNP_001186945.1, NM_001200016.1 [Q93015-1]
NP_001186947.1, NM_001200018.1 [Q93015-1]
NP_036323.2, NM_012191.3 [Q93015-2]
UniGeneiHs.129910
Hs.736942

Genome annotation databases

EnsembliENST00000354862; ENSP00000346927; ENSG00000243477 [Q93015-2]
ENST00000417393; ENSP00000391893; ENSG00000243477 [Q93015-1]
ENST00000443094; ENSP00000410610; ENSG00000243477 [Q93015-1]
ENST00000443842; ENSP00000400559; ENSG00000243477 [Q93015-1]
GeneIDi24142
KEGGihsa:24142
UCSCiuc003czi.4 human [Q93015-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF040706 mRNA Translation: AAC70913.1
AF040705 mRNA Translation: AAC70912.1
U73167 Genomic DNA Translation: AAC02732.1
BC004483 mRNA Translation: AAH04483.2
CCDSiCCDS43095.1 [Q93015-2]
CCDS56258.1 [Q93015-1]
RefSeqiNP_001186945.1, NM_001200016.1 [Q93015-1]
NP_001186947.1, NM_001200018.1 [Q93015-1]
NP_036323.2, NM_012191.3 [Q93015-2]
UniGeneiHs.129910
Hs.736942

3D structure databases

ProteinModelPortaliQ93015
SMRiQ93015
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117293, 2 interactors
IntActiQ93015, 4 interactors
STRINGi9606.ENSP00000346927

PTM databases

iPTMnetiQ93015
PhosphoSitePlusiQ93015

Polymorphism and mutation databases

BioMutaiNAT6
DMDMi25008833

Proteomic databases

EPDiQ93015
MaxQBiQ93015
PaxDbiQ93015
PeptideAtlasiQ93015
PRIDEiQ93015
ProteomicsDBi75670
75671 [Q93015-2]

Protocols and materials databases

DNASUi24142
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000354862; ENSP00000346927; ENSG00000243477 [Q93015-2]
ENST00000417393; ENSP00000391893; ENSG00000243477 [Q93015-1]
ENST00000443094; ENSP00000410610; ENSG00000243477 [Q93015-1]
ENST00000443842; ENSP00000400559; ENSG00000243477 [Q93015-1]
GeneIDi24142
KEGGihsa:24142
UCSCiuc003czi.4 human [Q93015-1]

Organism-specific databases

CTDi24142
DisGeNETi24142
EuPathDBiHostDB:ENSG00000243477.5
GeneCardsiNAA80
HGNCiHGNC:30252 NAA80
HPAiHPA039576
MIMi607073 gene
neXtProtiNX_Q93015
OpenTargetsiENSG00000243477
PharmGKBiPA134979782
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IS85 Eukaryota
ENOG4111U9V LUCA
GeneTreeiENSGT00390000000980
HOGENOMiHOG000113734
HOVERGENiHBG031735
InParanoidiQ93015
OMAiGCPIFWM
OrthoDBiEOG091G0SQB
PhylomeDBiQ93015
TreeFamiTF106312

Miscellaneous databases

GenomeRNAii24142
PROiPR:Q93015
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000243477 Expressed in 120 organ(s), highest expression level in right testis
ExpressionAtlasiQ93015 baseline and differential
GenevisibleiQ93015 HS

Family and domain databases

InterProiView protein in InterPro
IPR016181 Acyl_CoA_acyltransferase
IPR000182 GNAT_dom
IPR039840 NAT6
PANTHERiPTHR13538:SF4 PTHR13538:SF4, 1 hit
PfamiView protein in Pfam
PF00583 Acetyltransf_1, 1 hit
SUPFAMiSSF55729 SSF55729, 1 hit
PROSITEiView protein in PROSITE
PS51186 GNAT, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNAA80_HUMAN
AccessioniPrimary (citable) accession number: Q93015
Secondary accession number(s): Q93014
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: June 1, 1998
Last modified: November 7, 2018
This is version 141 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again