UniProtKB - Q92VB9 (HIUH1_RHIME)
Protein
5-hydroxyisourate hydrolase 1
Gene
RB0789
Organism
Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Status
Functioni
Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU).By similarity
Miscellaneous
HIU hydrolysis also occurs spontaneously, but more slowly.
Catalytic activityi
- EC:3.5.2.17
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 14 | SubstrateBy similarity | 1 | |
Binding sitei | 52 | SubstrateBy similarity | 1 | |
Binding sitei | 120 | SubstrateBy similarity | 1 |
GO - Molecular functioni
- hydroxyisourate hydrolase activity Source: UniProtKB-EC
GO - Biological processi
- purine nucleobase metabolic process Source: UniProtKB-KW
Keywordsi
Molecular function | Hydrolase |
Biological process | Purine metabolism |
Names & Taxonomyi
Protein namesi | Recommended name: 5-hydroxyisourate hydrolase 1 (EC:3.5.2.17)Short name: HIU hydrolase 1 Short name: HIUHase 1 |
Gene namesi | Ordered Locus Names:RB0789 ORF Names:SMb21285 |
Encoded oni | Plasmid pSymB (megaplasmid 2) |
Organismi | Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti) |
Taxonomic identifieri | 266834 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Rhizobiaceae › Sinorhizobium/Ensifer group › Sinorhizobium › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000050616 | 1 – 123 | 5-hydroxyisourate hydrolase 1Add BLAST | 123 |
Interactioni
Subunit structurei
Homotetramer.
By similarityProtein-protein interaction databases
STRINGi | 266834.SM_b21285 |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | COG2351, Bacteria |
HOGENOMi | CLU_115536_1_1_5 |
OMAi | MFRIDNG |
Family and domain databases
Gene3Di | 2.60.40.180, 1 hit |
InterProi | View protein in InterPro IPR014306, Hydroxyisourate_hydrolase IPR023418, Thyroxine_BS IPR000895, Transthyretin/HIU_hydrolase IPR023416, Transthyretin/HIU_hydrolase_d IPR036817, Transthyretin/HIU_hydrolase_sf IPR023419, Transthyretin_CS |
PANTHERi | PTHR10395, PTHR10395, 1 hit |
Pfami | View protein in Pfam PF00576, Transthyretin, 1 hit |
PRINTSi | PR00189, TRNSTHYRETIN |
SUPFAMi | SSF49472, SSF49472, 1 hit |
TIGRFAMsi | TIGR02962, hdxy_isourate, 1 hit |
PROSITEi | View protein in PROSITE PS00768, TRANSTHYRETIN_1, 1 hit PS00769, TRANSTHYRETIN_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q92VB9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MQVQDGTPGR LTTHVLDTAS GRPASNLRID LYRIEGERPE LLSSTRTNDD
60 70 80 90 100
GRCDAPLLNG STMETGTYEL RFHAGEYLGT AAERGANPFL DVIPIRFGIA
110 120
DRAAHYHVPL LLSPYGYSTY RGS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL591985 Genomic DNA Translation: CAC49189.1 |
PIRi | E95940 |
RefSeqi | NP_437329.1, NC_003078.1 WP_010975645.1, NC_003078.1 |
Genome annotation databases
EnsemblBacteriai | CAC49189; CAC49189; SM_b21285 |
GeneIDi | 25013732 |
KEGGi | sme:SM_b21285 |
PATRICi | fig|266834.11.peg.5719 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL591985 Genomic DNA Translation: CAC49189.1 |
PIRi | E95940 |
RefSeqi | NP_437329.1, NC_003078.1 WP_010975645.1, NC_003078.1 |
3D structure databases
SMRi | Q92VB9 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 266834.SM_b21285 |
Genome annotation databases
EnsemblBacteriai | CAC49189; CAC49189; SM_b21285 |
GeneIDi | 25013732 |
KEGGi | sme:SM_b21285 |
PATRICi | fig|266834.11.peg.5719 |
Phylogenomic databases
eggNOGi | COG2351, Bacteria |
HOGENOMi | CLU_115536_1_1_5 |
OMAi | MFRIDNG |
Miscellaneous databases
PROi | PR:Q92VB9 |
Family and domain databases
Gene3Di | 2.60.40.180, 1 hit |
InterProi | View protein in InterPro IPR014306, Hydroxyisourate_hydrolase IPR023418, Thyroxine_BS IPR000895, Transthyretin/HIU_hydrolase IPR023416, Transthyretin/HIU_hydrolase_d IPR036817, Transthyretin/HIU_hydrolase_sf IPR023419, Transthyretin_CS |
PANTHERi | PTHR10395, PTHR10395, 1 hit |
Pfami | View protein in Pfam PF00576, Transthyretin, 1 hit |
PRINTSi | PR00189, TRNSTHYRETIN |
SUPFAMi | SSF49472, SSF49472, 1 hit |
TIGRFAMsi | TIGR02962, hdxy_isourate, 1 hit |
PROSITEi | View protein in PROSITE PS00768, TRANSTHYRETIN_1, 1 hit PS00769, TRANSTHYRETIN_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | HIUH1_RHIME | |
Accessioni | Q92VB9Primary (citable) accession number: Q92VB9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 2, 2002 |
Last sequence update: | December 1, 2001 | |
Last modified: | December 2, 2020 | |
This is version 96 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Plasmid, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families