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Protein

Protein GrpE

Gene

grpE

Organism
Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
Biological processStress response

Names & Taxonomyi

Protein namesi
Recommended name:
Protein GrpEUniRule annotation
Alternative name(s):
HSP-70 cofactorUniRule annotation
Gene namesi
Name:grpEUniRule annotation
Ordered Locus Names:R00378
ORF Names:SMc01142
OrganismiRhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Taxonomic identifieri266834 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
Proteomesi
  • UP000001976 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001138451 – 208Protein GrpEAdd BLAST208

Interactioni

Subunit structurei

Homodimer.UniRule annotation

GO - Molecular functioni

Protein-protein interaction databases

STRINGi266834.SMc01142

Structurei

3D structure databases

ProteinModelPortaliQ92SK0
SMRiQ92SK0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GrpE family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105K90 Bacteria
COG0576 LUCA
HOGENOMiHOG000252083
KOiK03687
OMAiYAYEKIA

Family and domain databases

CDDicd00446 GrpE, 1 hit
Gene3Di2.30.22.10, 1 hit
3.90.20.20, 1 hit
HAMAPiMF_01151 GrpE, 1 hit
InterProiView protein in InterPro
IPR000740 GrpE
IPR013805 GrpE_coiled_coil
IPR009012 GrpE_head
PANTHERiPTHR21237 PTHR21237, 1 hit
PfamiView protein in Pfam
PF01025 GrpE, 1 hit
PRINTSiPR00773 GRPEPROTEIN
SUPFAMiSSF51064 SSF51064, 1 hit
SSF58014 SSF58014, 1 hit
PROSITEiView protein in PROSITE
PS01071 GRPE, 1 hit

Sequencei

Sequence statusi: Complete.

Q92SK0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTDETNKNGP EAAAPEEFET AAEPQAAEKP EADASTTAPD PLELARAESA
60 70 80 90 100
ELRDKYLRLA AEMDNLRRRT ERDVKDAKSY SVAGFARDML AVSDNLRRAL
110 120 130 140 150
DAIPADAREA GDAGLKALIE GVEMTERSML AALERHGVKQ LDPTGQKFDP
160 170 180 190 200
NFHQAMFEVP NTEVPNNTVV QVVQAGYTIG ERVLRPAMVG VAKGGPKAAT

SESETPAA
Length:208
Mass (Da):22,362
Last modified:December 1, 2001 - v1
Checksum:iBCCEDA60FCF2F162
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591688 Genomic DNA Translation: CAC41815.1
RefSeqiNP_384484.1, NC_003047.1
WP_003527728.1, NC_003047.1

Genome annotation databases

EnsemblBacteriaiCAC41815; CAC41815; SMc01142
GeneIDi1232012
KEGGisme:SMc01142
PATRICifig|266834.11.peg.1750

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591688 Genomic DNA Translation: CAC41815.1
RefSeqiNP_384484.1, NC_003047.1
WP_003527728.1, NC_003047.1

3D structure databases

ProteinModelPortaliQ92SK0
SMRiQ92SK0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi266834.SMc01142

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC41815; CAC41815; SMc01142
GeneIDi1232012
KEGGisme:SMc01142
PATRICifig|266834.11.peg.1750

Phylogenomic databases

eggNOGiENOG4105K90 Bacteria
COG0576 LUCA
HOGENOMiHOG000252083
KOiK03687
OMAiYAYEKIA

Family and domain databases

CDDicd00446 GrpE, 1 hit
Gene3Di2.30.22.10, 1 hit
3.90.20.20, 1 hit
HAMAPiMF_01151 GrpE, 1 hit
InterProiView protein in InterPro
IPR000740 GrpE
IPR013805 GrpE_coiled_coil
IPR009012 GrpE_head
PANTHERiPTHR21237 PTHR21237, 1 hit
PfamiView protein in Pfam
PF01025 GrpE, 1 hit
PRINTSiPR00773 GRPEPROTEIN
SUPFAMiSSF51064 SSF51064, 1 hit
SSF58014 SSF58014, 1 hit
PROSITEiView protein in PROSITE
PS01071 GRPE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGRPE_RHIME
AccessioniPrimary (citable) accession number: Q92SK0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: December 1, 2001
Last modified: February 28, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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