Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Succinate dehydrogenase flavoprotein subunit

Gene

sdhA

Organism
Rickettsia conorii (strain ATCC VR-613 / Malish 7)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Succinate + a quinone = fumarate + a quinol.By similarity

Cofactori

FADBy similarity

Pathwayi: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes fumarate from succinate (bacterial route).By similarity
Proteins known to be involved in this subpathway in this organism are:
  1. Succinate dehydrogenase flavoprotein subunit (sdhA), Succinate dehydrogenase iron-sulfur subunit (sdhB)
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes fumarate from succinate (bacterial route), the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei225FADBy similarity1
Binding sitei246SubstrateBy similarity1
Binding sitei258SubstrateBy similarity1
Active sitei290Proton acceptorBy similarity1
Binding sitei357SubstrateBy similarity1
Binding sitei391FADBy similarity1
Binding sitei402SubstrateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi18 – 23FADBy similarity6
Nucleotide bindingi41 – 56FADBy similarityAdd BLAST16
Nucleotide bindingi407 – 408FADBy similarity2

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Transport, Tricarboxylic acid cycle
LigandFAD, Flavoprotein

Enzyme and pathway databases

BioCyciRCON272944:G1FZG-272-MONOMER
UniPathwayi
UPA00223;UER01005

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate dehydrogenase flavoprotein subunit (EC:1.3.5.1By similarity)
Gene namesi
Name:sdhA
Ordered Locus Names:RC0170
OrganismiRickettsia conorii (strain ATCC VR-613 / Malish 7)
Taxonomic identifieri272944 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
Proteomesi
  • UP000000816 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001586561 – 596Succinate dehydrogenase flavoprotein subunitAdd BLAST596

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei49Tele-8alpha-FAD histidineBy similarity1

Proteomic databases

PRIDEiQ92J97

Interactioni

Subunit structurei

Part of an enzyme complex containing four subunits: a flavoprotein, an iron-sulfur, cytochrome b-556, and a hydrophobic anchor protein.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ92J97
SMRiQ92J97
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000160475
KOiK00239
OMAiGDSPWEH
OrthoDBiPOG091H02TE

Family and domain databases

Gene3Di3.50.50.60, 2 hits
3.90.700.10, 1 hit
InterProiView protein in InterPro
IPR003953 FAD-binding_2
IPR036188 FAD/NAD-bd_sf
IPR003952 FRD_SDH_FAD_BS
IPR037099 Fum_R/Succ_DH_flav-like_C_sf
IPR015939 Fum_Rdtase/Succ_DH_flav-like_C
IPR027477 Succ_DH/fumarate_Rdtase_cat_sf
IPR011281 Succ_DH_flav_su_fwd
IPR014006 Succ_Dhase_FrdA_Gneg
PfamiView protein in Pfam
PF00890 FAD_binding_2, 1 hit
PF02910 Succ_DH_flav_C, 1 hit
SUPFAMiSSF46977 SSF46977, 1 hit
SSF51905 SSF51905, 2 hits
SSF56425 SSF56425, 1 hit
TIGRFAMsiTIGR01816 sdhA_forward, 1 hit
TIGR01812 sdhA_frdA_Gneg, 1 hit
PROSITEiView protein in PROSITE
PS00504 FRD_SDH_FAD_BINDING, 1 hit

Sequencei

Sequence statusi: Complete.

Q92J97-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTKAYNIIHH KFDVVVVGAG GAGLRSAFGM AKEGLNTACI TKLFPTRSHT
60 70 80 90 100
VAAQGGISAA LGNMGEDDWR WHMYDTVKGS DWLGDQDAIE YMCKNAPDAI
110 120 130 140 150
LELEHYGVPF SRTEEGKIYQ RPFGGMTTEY GKGKAAQRTC AAADRTGHAI
160 170 180 190 200
LHTLYQQSLK HKVQFFVEYF AIDLLMEDGE CRGVVAWNLD DGSLHCFRAH
210 220 230 240 250
NVVLATGGYG RAYFSATSAH TCTGDGGGMA IRAGLPLQDM EFVQFHPTGI
260 270 280 290 300
YSAGCLITEG ARGEGGYLVN ANGERFMERY APAAKDLASR DVVSRAMTIE
310 320 330 340 350
IREGRGVGEH KDHVFLHLNH LSPEILHSRL PGISETAKIF AGVDVTKEPI
360 370 380 390 400
PVLPTVHYNM GGIPTNYHGQ VIIKDGKNHN SVVKGLMAIG EAACVSVHGA
410 420 430 440 450
NRLGSNSLLD LVVFGRSSAL KAAELIKPAS PHRSIKEESL EKIINRFDKV
460 470 480 490 500
RHANGNILVA ELRLKMQRTM QSHASVFRTQ EVLDEGAGMI SEIRSGYKDI
510 520 530 540 550
KINDKSLIWN SDLVEALELD NLLDQALVTV YSAAARKESR GAHAREDYPD
560 570 580 590
RNDEDWMKHT LSSIDEAGKV VLDYKPVTLT TLTDEVTAVP PVKRVY
Length:596
Mass (Da):65,291
Last modified:December 1, 2001 - v1
Checksum:iF313CE9506A7DA10
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006914 Genomic DNA Translation: AAL02708.1
PIRiB97721
RefSeqiWP_010976845.1, NC_003103.1

Genome annotation databases

EnsemblBacteriaiAAL02708; AAL02708; RC0170
GeneIDi928018
KEGGirco:RC0170
PATRICifig|272944.4.peg.199

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006914 Genomic DNA Translation: AAL02708.1
PIRiB97721
RefSeqiWP_010976845.1, NC_003103.1

3D structure databases

ProteinModelPortaliQ92J97
SMRiQ92J97
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ92J97

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL02708; AAL02708; RC0170
GeneIDi928018
KEGGirco:RC0170
PATRICifig|272944.4.peg.199

Phylogenomic databases

HOGENOMiHOG000160475
KOiK00239
OMAiGDSPWEH
OrthoDBiPOG091H02TE

Enzyme and pathway databases

UniPathwayi
UPA00223;UER01005

BioCyciRCON272944:G1FZG-272-MONOMER

Family and domain databases

Gene3Di3.50.50.60, 2 hits
3.90.700.10, 1 hit
InterProiView protein in InterPro
IPR003953 FAD-binding_2
IPR036188 FAD/NAD-bd_sf
IPR003952 FRD_SDH_FAD_BS
IPR037099 Fum_R/Succ_DH_flav-like_C_sf
IPR015939 Fum_Rdtase/Succ_DH_flav-like_C
IPR027477 Succ_DH/fumarate_Rdtase_cat_sf
IPR011281 Succ_DH_flav_su_fwd
IPR014006 Succ_Dhase_FrdA_Gneg
PfamiView protein in Pfam
PF00890 FAD_binding_2, 1 hit
PF02910 Succ_DH_flav_C, 1 hit
SUPFAMiSSF46977 SSF46977, 1 hit
SSF51905 SSF51905, 2 hits
SSF56425 SSF56425, 1 hit
TIGRFAMsiTIGR01816 sdhA_forward, 1 hit
TIGR01812 sdhA_frdA_Gneg, 1 hit
PROSITEiView protein in PROSITE
PS00504 FRD_SDH_FAD_BINDING, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSDHA_RICCN
AccessioniPrimary (citable) accession number: Q92J97
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: December 1, 2001
Last modified: May 23, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. Rickettsia conorii
    (strain Malish 7): entries and gene names
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again