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Protein

D-alanine--D-alanine ligase

Gene

ddl

Organism
Rickettsia conorii (strain ATCC VR-613 / Malish 7)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cell wall formation.UniRule annotation

Catalytic activityi

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.UniRule annotation

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 2 magnesium or manganese ions per subunit.By similarity

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi268Magnesium or manganese 1UniRule annotation1
Metal bindingi282Magnesium or manganese 1UniRule annotation1
Metal bindingi282Magnesium or manganese 2UniRule annotation1
Metal bindingi284Magnesium or manganese 2UniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi147 – 199ATPUniRule annotationAdd BLAST53

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processCell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis
LigandATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRCON272944:G1FZG-554-MONOMER
UniPathwayiUPA00219

Names & Taxonomyi

Protein namesi
Recommended name:
D-alanine--D-alanine ligaseUniRule annotation (EC:6.3.2.4UniRule annotation)
Alternative name(s):
D-Ala-D-Ala ligaseUniRule annotation
D-alanylalanine synthetaseUniRule annotation
Gene namesi
Name:ddlUniRule annotation
Synonyms:ddlB
Ordered Locus Names:RC0333
OrganismiRickettsia conorii (strain ATCC VR-613 / Malish 7)
Taxonomic identifieri272944 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
Proteomesi
  • UP000000816 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001778651 – 321D-alanine--D-alanine ligaseAdd BLAST321

Structurei

3D structure databases

ProteinModelPortaliQ92IT7
SMRiQ92IT7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini121 – 315ATP-graspUniRule annotationAdd BLAST195

Sequence similaritiesi

Belongs to the D-alanine--D-alanine ligase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000011592
KOiK01921
OMAiYETKYTE
OrthoDBiPOG091H00GT

Family and domain databases

Gene3Di3.30.1490.20, 1 hit
HAMAPiMF_00047 Dala_Dala_lig, 1 hit
InterProiView protein in InterPro
IPR011761 ATP-grasp
IPR013815 ATP_grasp_subdomain_1
IPR000291 D-Ala_lig_Van_CS
IPR005905 D_ala_D_ala
IPR011095 Dala_Dala_lig_C
IPR011127 Dala_Dala_lig_N
IPR016185 PreATP-grasp_dom_sf
PfamiView protein in Pfam
PF07478 Dala_Dala_lig_C, 1 hit
PF01820 Dala_Dala_lig_N, 1 hit
PIRSFiPIRSF039102 Ddl/VanB, 1 hit
SUPFAMiSSF52440 SSF52440, 1 hit
TIGRFAMsiTIGR01205 D_ala_D_alaTIGR, 1 hit
PROSITEiView protein in PROSITE
PS50975 ATP_GRASP, 1 hit
PS00843 DALA_DALA_LIGASE_1, 1 hit
PS00844 DALA_DALA_LIGASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q92IT7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHKYQTHWVE HSIVKILSST GKKHIALMAG GMSAEREVSL VSSEGVSKAL
60 70 80 90 100
IELGYRVTFI DMGADIAVRL QEIKPDIVFN CLHGTYGEDG CLPGLLNIMR
110 120 130 140 150
IPYTHSGVLS SALAFDKIHS RIWFLTNNIN MAEGIVVNKS DNIKNDPMKR
160 170 180 190 200
PYVIKPLTQG SSIGVEVIFA EDDFNFADYD FPYGDQVIIE QYIKGRELQV
210 220 230 240 250
AVLNGKALGA LEIKLLKNRF YDYETKYTEG FADHLCPAPL PANLYEKLLI
260 270 280 290 300
ESEKIYKTMN CKGPARAEFI LEEQTNKLYA LEINTHPGMM PLSIVPEIAA
310 320
YAGINFTNLI EEIIKTASFE S
Length:321
Mass (Da):35,931
Last modified:December 1, 2001 - v1
Checksum:i7D1DF04C1EAAB40E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006914 Genomic DNA Translation: AAL02871.1
PIRiE97741
RefSeqiWP_010976988.1, NC_003103.1

Genome annotation databases

EnsemblBacteriaiAAL02871; AAL02871; RC0333
GeneIDi928536
KEGGirco:RC0333
PATRICifig|272944.4.peg.382

Similar proteinsi

Entry informationi

Entry nameiDDL_RICCN
AccessioniPrimary (citable) accession number: Q92IT7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 2, 2002
Last sequence update: December 1, 2001
Last modified: February 28, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Rickettsia conorii
    (strain Malish 7): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

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