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Protein

Pyruvate dehydrogenase E1 component subunit alpha

Gene

pdhA

Organism
Rickettsia conorii (strain ATCC VR-613 / Malish 7)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).By similarity

Catalytic activityi

Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2.

Cofactori

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processGlycolysis
LigandPyruvate, Thiamine pyrophosphate

Enzyme and pathway databases

BioCyciRCON272944:G1FZG-577-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate dehydrogenase E1 component subunit alpha (EC:1.2.4.1)
Gene namesi
Name:pdhA
Ordered Locus Names:RC0347
OrganismiRickettsia conorii (strain ATCC VR-613 / Malish 7)
Taxonomic identifieri272944 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
Proteomesi
  • UP000000816 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001622031 – 326Pyruvate dehydrogenase E1 component subunit alphaAdd BLAST326

Proteomic databases

PRIDEiQ92IS3

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta chain.

Structurei

3D structure databases

ProteinModelPortaliQ92IS3
SMRiQ92IS3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

HOGENOMiHOG000281336
KOiK00161
OMAiYRSHGFT
OrthoDBiPOG091H04RI

Family and domain databases

InterProiView protein in InterPro
IPR001017 DH_E1
IPR017597 Pyrv_DH_E1_asu_subgrp-y
IPR029061 THDP-binding
PfamiView protein in Pfam
PF00676 E1_dh, 1 hit
SUPFAMiSSF52518 SSF52518, 1 hit
TIGRFAMsiTIGR03182 PDH_E1_alph_y, 1 hit

Sequencei

Sequence statusi: Complete.

Q92IS3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDIKLGKYKP TKEEYIKSFK DMLLLRRFEE KCGQLYGMGE IGGFCHLYIG
60 70 80 90 100
QEAVISAIDM VKQKGDSTIT SYRDHAHIIL AGTEPKYVLA ELMGRATGCS
110 120 130 140 150
KGKGGSMHLF NVPNKFYGGH GIVGAQVPIG TGLAFVEKYN DTHNICFTFL
160 170 180 190 200
GDGAVNQGQV YEAFNMAALW GLPVVYIIEN NEYSMGTSVA RSTFMRDLYK
210 220 230 240 250
KGASFGIKGF QLDGMDFEEM YDGSKQAAEY VRENSFPLIL EVKTYRYRGH
260 270 280 290 300
SMSDPAKYRS KEEVEQYKER DPLVIIRKTI LDNKYVTEAD LKAIEQSVKE
310 320
IVKEAVEFSE NSPLPDEGEL YTQVYC
Length:326
Mass (Da):36,736
Last modified:December 1, 2001 - v1
Checksum:iBC588D2C9EFFABD9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006914 Genomic DNA Translation: AAL02885.1
PIRiC97743
RefSeqiWP_010977002.1, NC_003103.1

Genome annotation databases

EnsemblBacteriaiAAL02885; AAL02885; RC0347
GeneIDi927514
KEGGirco:RC0347
PATRICifig|272944.4.peg.395

Similar proteinsi

Entry informationi

Entry nameiODPA_RICCN
AccessioniPrimary (citable) accession number: Q92IS3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 16, 2003
Last sequence update: December 1, 2001
Last modified: May 23, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia conorii
    (strain Malish 7): entries and gene names

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