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Protein

Pyruvate dehydrogenase E1 component subunit beta

Gene

pdhB

Organism
Rickettsia conorii (strain ATCC VR-613 / Malish 7)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).By similarity

Catalytic activityi

Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2.

Cofactori

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei59Thiamine pyrophosphateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processGlycolysis
LigandPyruvate, Thiamine pyrophosphate

Enzyme and pathway databases

BioCyciRCON272944:G1FZG-581-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate dehydrogenase E1 component subunit beta (EC:1.2.4.1)
Gene namesi
Name:pdhB
Ordered Locus Names:RC0348
OrganismiRickettsia conorii (strain ATCC VR-613 / Malish 7)
Taxonomic identifieri272944 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
Proteomesi
  • UP000000816 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001622261 – 326Pyruvate dehydrogenase E1 component subunit betaAdd BLAST326

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta chain.

Structurei

3D structure databases

ProteinModelPortaliQ92IS2
SMRiQ92IS2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

HOGENOMiHOG000281450
KOiK00162
OMAiSRMRHHC
OrthoDBiPOG091H04FE

Family and domain databases

Gene3Di3.40.50.920, 1 hit
InterProiView protein in InterPro
IPR027110 PDHB
IPR029061 THDP-binding
IPR009014 Transketo_C/PFOR_II
IPR005475 Transketolase-like_Pyr-bd
IPR033248 Transketolase_C
PANTHERiPTHR11624:SF94 PTHR11624:SF94, 1 hit
PfamiView protein in Pfam
PF02779 Transket_pyr, 1 hit
PF02780 Transketolase_C, 1 hit
SMARTiView protein in SMART
SM00861 Transket_pyr, 1 hit
SUPFAMiSSF52518 SSF52518, 1 hit
SSF52922 SSF52922, 1 hit

Sequencei

Sequence statusi: Complete.

Q92IS2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQITVREALR DAMQEEMIRD DKVFVIGEEV AEYQGAYKVT QGLLEQFGPK
60 70 80 90 100
RVIDTPITEY GFAGLAVGAA FAGLRPIVEF MTFNFAMQAF DHIVNSAAKT
110 120 130 140 150
HYMSGGQVKC PIVFRGPNGA ASRVAAQHSQ NYTACYSHIP GLKVVAPYSA
160 170 180 190 200
EDHKGLMLTA IRDDNPVVFL ENEILYGHSF DVPKTIEPIP FGQAKILREG
210 220 230 240 250
SSVTIVTFSI QVKLALDAAN FVQNDNIDCE VIDLRTIKPL DTETIIESVK
260 270 280 290 300
KTNRLVVVEE GWFFAGVGAS IASIVMKEAF DYLDAPIEIV SGKDLPLPYA
310 320
VNLETLALPS ESDVIEAVKK VCYYSI
Length:326
Mass (Da):35,821
Last modified:December 1, 2001 - v1
Checksum:i21A97CE0774EA9AE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006914 Genomic DNA Translation: AAL02886.1
PIRiD97743
RefSeqiWP_010977003.1, NC_003103.1

Genome annotation databases

EnsemblBacteriaiAAL02886; AAL02886; RC0348
GeneIDi928543
KEGGirco:RC0348
PATRICifig|272944.4.peg.396

Similar proteinsi

Entry informationi

Entry nameiODPB_RICCN
AccessioniPrimary (citable) accession number: Q92IS2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 16, 2003
Last sequence update: December 1, 2001
Last modified: February 28, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia conorii
    (strain Malish 7): entries and gene names

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