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Protein

Acetate kinase 2

Gene

ackA2

Organism
Listeria innocua serovar 6a (strain ATCC BAA-680 / CLIP 11262)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.UniRule annotation

Catalytic activityi

ATP + acetate = ADP + acetyl phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Mg2+. Can also accept Mn2+.UniRule annotation

Pathwayi: acetyl-CoA biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes acetyl-CoA from acetate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Acetate kinase 1 (ackA1), Acetate kinase 2 (ackA2)
  2. no protein annotated in this organism
This subpathway is part of the pathway acetyl-CoA biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetyl-CoA from acetate, the pathway acetyl-CoA biosynthesis and in Metabolic intermediate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi8MagnesiumUniRule annotation1
Binding sitei15ATPUniRule annotation1
Binding sitei89SubstrateUniRule annotation1
Active sitei146Proton donor/acceptorUniRule annotation1
Sitei178Transition state stabilizerUniRule annotation1
Sitei239Transition state stabilizerUniRule annotation1
Metal bindingi380MagnesiumUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi206 – 210ATPUniRule annotation5
Nucleotide bindingi281 – 283ATPUniRule annotation3
Nucleotide bindingi329 – 333ATPUniRule annotation5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayi
UPA00340;UER00458

Names & Taxonomyi

Protein namesi
Recommended name:
Acetate kinase 2UniRule annotation (EC:2.7.2.1UniRule annotation)
Alternative name(s):
Acetokinase 2UniRule annotation
Gene namesi
Name:ackA2UniRule annotation
Ordered Locus Names:lin1132
OrganismiListeria innocua serovar 6a (strain ATCC BAA-680 / CLIP 11262)
Taxonomic identifieri272626 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria
Proteomesi
  • UP000002513 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001075761 – 397Acetate kinase 2Add BLAST397

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi272626.lin1132

Structurei

3D structure databases

ProteinModelPortaliQ92CN9
SMRiQ92CN9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acetokinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C6H Bacteria
COG0282 LUCA
HOGENOMiHOG000288398
KOiK00925
OMAiFMMQKEN
OrthoDBiPOG091H02K4

Family and domain databases

HAMAPiMF_00020 Acetate_kinase, 1 hit
InterProiView protein in InterPro
IPR004372 Ac/propionate_kinase
IPR000890 Aliphatic_acid_kin_short-chain
IPR023865 Aliphatic_acid_kinase_CS
PANTHERiPTHR21060 PTHR21060, 1 hit
PfamiView protein in Pfam
PF00871 Acetate_kinase, 1 hit
PIRSFiPIRSF000722 Acetate_prop_kin, 1 hit
PRINTSiPR00471 ACETATEKNASE
TIGRFAMsiTIGR00016 ackA, 1 hit
PROSITEiView protein in PROSITE
PS01075 ACETATE_KINASE_1, 1 hit
PS01076 ACETATE_KINASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q92CN9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MHKIMAINAG SSSLKFQIFT MPGEEVLVKG LIERIGLPDA IFNMSFQNEK
60 70 80 90 100
IKETRAINNH GEAVEILLEQ LKTHQVINDL NEITGVGHRV AHGGEAFVSS
110 120 130 140 150
CIVTDDVVKG IEDVTSLAPL HNPANIIGIK TFRELLPNAV SVAVFDTAFH
160 170 180 190 200
QTIPEENFLY ALPYELYEKH HIRKYGFHGT SHKYVAGKAA EVLKKPLEKL
210 220 230 240 250
KIISCHLGNG ASVCAIEAGK SVNTSMGFTP NAGLMMGTRS GTIDATIIPY
260 270 280 290 300
LVDELGYSLD EVTHMMSSES GVLGVSGISS DFRDIEIAAN EGNSRALLTL
310 320 330 340 350
RMFTGQICNY IGAYASAMNG CDALLFTAGV GENSPLIRKM VTEQLSYLGV
360 370 380 390
TCNVTKNNAG DMIISNDDEA VKVCIIPTNE ELMIARDVEK YTKQTIS
Length:397
Mass (Da):43,115
Last modified:December 1, 2001 - v1
Checksum:i5822544EF92CBF51
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL596167 Genomic DNA Translation: CAC96363.1
PIRiAC1574
RefSeqiWP_010990790.1, NC_003212.1

Genome annotation databases

EnsemblBacteriaiCAC96363; CAC96363; CAC96363
KEGGilin:AckA2

Similar proteinsi

Entry informationi

Entry nameiACKA2_LISIN
AccessioniPrimary (citable) accession number: Q92CN9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: December 1, 2001
Last modified: June 7, 2017
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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