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Protein

Bifunctional protein PyrR

Gene

pyrR

Organism
Listeria innocua serovar 6a (strain ATCC BAA-680 / CLIP 11262)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon by binding in a uridine-dependent manner to specific sites on pyr mRNA. This disrupts an antiterminator hairpin in the RNA and favors formation of a downstream transcription terminator, leading to a reduced expression of downstream genes.UniRule annotation
Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.UniRule annotation

Catalytic activityi

UMP + diphosphate = uracil + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei139SubstrateBy similarity1
Binding sitei163SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, RNA-binding, Transferase
Biological processTranscription, Transcription regulation, Transcription termination

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional protein PyrRUniRule annotation
Including the following 2 domains:
Pyrimidine operon regulatory proteinUniRule annotation
Uracil phosphoribosyltransferaseUniRule annotation (EC:2.4.2.9UniRule annotation)
Short name:
UPRTaseUniRule annotation
Gene namesi
Name:pyrRUniRule annotation
Ordered Locus Names:lin1954
OrganismiListeria innocua serovar 6a (strain ATCC BAA-680 / CLIP 11262)
Taxonomic identifieri272626 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria
Proteomesi
  • UP000002513 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001830431 – 183Bifunctional protein PyrRAdd BLAST183

Proteomic databases

PRIDEiQ92AG8

Interactioni

Subunit structurei

Homodimer and homohexamer; in equilibrium.UniRule annotation

Protein-protein interaction databases

STRINGi272626.lin1954

Structurei

3D structure databases

ProteinModelPortaliQ92AG8
SMRiQ92AG8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni41 – 42Substrate-bindingBy similarity2
Regioni106 – 114Substrate bindingBy similarity9

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi102 – 114PRPP-bindingUniRule annotationAdd BLAST13

Sequence similaritiesi

Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108UK1 Bacteria
COG2065 LUCA
HOGENOMiHOG000245770
KOiK02825
OMAiRISHEIL
OrthoDBiPOG091H02JM

Family and domain databases

CDDicd06223 PRTases_typeI, 1 hit
HAMAPiMF_01219 PyrR, 1 hit
InterProiView protein in InterPro
IPR000836 PRibTrfase_dom
IPR029057 PRTase-like
IPR023050 PyrR
PfamiView protein in Pfam
PF00156 Pribosyltran, 1 hit
SUPFAMiSSF53271 SSF53271, 1 hit

Sequencei

Sequence statusi: Complete.

Q92AG8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQKQVVVMDE AAIKRALTRV SYEIIERNKG TKNLALVGIK TRGIYLAERL
60 70 80 90 100
HKRILEIEGI DVPVGDIDIT LYRDDLSFKD DKTREPAVHG TNIPFDINGK
110 120 130 140 150
KVVLVDDVLY TGRTVRAAMD ALMDVGRPAQ IHLAVLADRG HRELPIRADY
160 170 180
VGKNIPTSGN ERVEVRLTDV DHSEDAVIIN KNE
Length:183
Mass (Da):20,520
Last modified:December 1, 2001 - v1
Checksum:iBD0355266DE7340F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL596170 Genomic DNA Translation: CAC97184.1
PIRiAH1676
RefSeqiWP_003762971.1, NC_003212.1

Genome annotation databases

EnsemblBacteriaiCAC97184; CAC97184; CAC97184
KEGGilin:pyrR

Similar proteinsi

Entry informationi

Entry nameiPYRR_LISIN
AccessioniPrimary (citable) accession number: Q92AG8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2002
Last sequence update: December 1, 2001
Last modified: June 7, 2017
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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