DVL3

Functionⁱ

Involved in the signal transduction pathway mediated by multiple Wnt genes.By similarity

GO - Molecular functionⁱ

beta-catenin binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 10644691
frizzled binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 19388021
protease binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 20227366
protein heterodimerization activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 19137009
Rac GTPase binding
Source: ParkinsonsUK-UCL
Inferred from physical interactionⁱ
- 23109420
signaling receptor binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 17030191

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

beta-catenin destruction complex disassembly Source: Reactome
canonical Wnt signaling pathway
Source: BHF-UCL
Inferred from direct assayⁱ
- 10644691
- 17593335
intracellular signal transduction Source: InterPro
negative regulation of canonical Wnt signaling pathway Source: Reactome
non-canonical Wnt signaling pathway
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 19137009
non-canonical Wnt signaling pathway via JNK cascade Source: BHF-UCL
planar cell polarity pathway involved in neural tube closure
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of GTPase activity
Source: ParkinsonsUK-UCL
Inferred from direct assayⁱ
- 23109420
positive regulation of JUN kinase activity
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 19137009
positive regulation of neuron projection arborization Source: ARUK-UCL
positive regulation of protein phosphorylation
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 20137080
positive regulation of transcription, DNA-templated
Source: BHF-UCL
Inferred from direct assayⁱ
protein stabilization
Source: ParkinsonsUK-UCL
Inferred from genetic interactionⁱ
- 26359454
regulation of cellular protein localization
Source: ParkinsonsUK-UCL
Inferred from direct assayⁱ
- 19625296
Wnt signaling pathway, planar cell polarity pathway
Source: BHF-UCL
Inferred from direct assayⁱ
- 12805222

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Developmental protein
Biological process	Wnt signaling pathway

Enzyme and pathway databases

Reactomeⁱ	R-HSA-201681 TCF dependent signaling in response to WNT R-HSA-201688 WNT mediated activation of DVL R-HSA-4086400 PCP/CE pathway R-HSA-4641258 Degradation of DVL R-HSA-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-5368598 Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5663220 RHO GTPases Activate Formins
SignaLinkⁱ	Q92997
SIGNORⁱ	Q92997

Protein family/group databases

MoonDBⁱ	Q92997 Predicted

MoonDBⁱ

Q92997 Predicted

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Segment polarity protein dishevelled homolog DVL-3 Short name: Dishevelled-3 Alternative name(s): DSH homolog 3
Gene namesⁱ	Name:DVL3 Synonyms:KIAA0208
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 3

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000161202.17
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:3087 DVL3
MIMⁱ	601368 gene
neXtProtⁱ	NX_Q92997

Keywords - Cellular componentⁱ

Cytoplasm

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Robinow syndrome, autosomal dominant 3 (DRS3)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA form of Robinow syndrome, a rare skeletal dysplasia syndrome characterized by dysmorphic features resembling a fetal face, mesomelic limb shortening, genital hypoplasia, renal anomalies, and costovertebral segmentation defects.

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	271	R → K: Localizes to plasma membranes. 1 Publication	1
Mutagenesisⁱ	342	R → K: No effect on subcellular location. 1 Publication	1
Mutagenesisⁱ	614	R → K: Localizes to plasma membranes. 1 Publication	1

Keywords - Diseaseⁱ

Dwarfism

Organism-specific databases

DisGeNET More...DisGeNETⁱ	1857
MalaCards human disease database More...MalaCardsⁱ	DVL3
MIMⁱ	616894 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000161202
Orphanetⁱ	3107 Autosomal dominant Robinow syndrome
PharmGKBⁱ	PA27543

Chemistry databases

ChEMBLⁱ	CHEMBL6028

ChEMBLⁱ

CHEMBL6028

Polymorphism and mutation databases

BioMutaⁱ	DVL3
DMDMⁱ	6919875

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000145749	1 – 716	Segment polarity protein dishevelled homolog DVL-3Add BLAST		716

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	27	Omega-N-methylarginine1 Publication	1
Modified residueⁱ	48	PhosphoserineCombined sources	1
Modified residueⁱ	125	PhosphoserineCombined sources	1
Modified residueⁱ	192	PhosphoserineCombined sources1 Publication	1
Modified residueⁱ	212	Omega-N-methylarginine1 Publication	1
Modified residueⁱ	271	Asymmetric dimethylarginine; by PRMT1; alternate1 Publication	1
Modified residueⁱ	271	Symmetric dimethylarginine; by PRMT7; alternate1 Publication	1
Modified residueⁱ	342	Omega-N-methylarginine; alternate2 Publications	1
Modified residueⁱ	342	Symmetric dimethylarginine; by PRMT7; alternate2 Publications	1
Modified residueⁱ	346	Phosphothreonine1 Publication	1
Modified residueⁱ	614	Symmetric dimethylarginine; by PRMT71 Publication	1
Modified residueⁱ	697	PhosphoserineCombined sources	1
Modified residueⁱ	698	Dimethylated arginine; alternate1 Publication	1
Modified residueⁱ	698	Omega-N-methylarginine; alternate1 Publication	1
Modified residueⁱ	700	Phosphoserine1 Publication	1

Post-translational modificationⁱ

Ubiquitinated. Deubiquitinated by CYLD, which acts on 'Lys-63'-linked ubiquitin chains.1 Publication

Phosphorylated by CSNK1D.2 Publications

Keywords - PTMⁱ

Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q92997
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q92997
PaxDbⁱ	Q92997
PeptideAtlas More...PeptideAtlasⁱ	Q92997
PRIDEⁱ	Q92997
ProteomicsDBⁱ	75666

PTM databases

iPTMnetⁱ	Q92997
PhosphoSitePlusⁱ	Q92997

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000161202 Expressed in 231 organ(s), highest expression level in lower esophagus muscularis layer
CleanExⁱ	HS_DVL3
ExpressionAtlasⁱ	Q92997 baseline and differential
Genevisibleⁱ	Q92997 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB046486 HPA058265

HPAⁱ

CAB046486
HPA058265

Interactionⁱ

Subunit structureⁱ

Interacts (via the PDZ domain) with the C-terminal regions of VANGL1 and VANGL2 (By similarity). Interacts (via the region containing both the PDZ and DEP domains) with LRRFIP2; the DIX domain may inhibit this interaction. Interacts with CYLD, CEP164 and DAB2. Interacts with DCDC2. Interacts with FOXK1 and FOXK2 (PubMed:25805136). Interacts with DAAM2 (By similarity).By similarity6 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
ADAP1	O75689	3	EBI-739789,EBI-714732
BAHD1	Q8TBE0	3	EBI-739789,EBI-742750
CEP164	Q9UPV0	5	EBI-739789,EBI-3937015
CSNK1D	P48730	4	EBI-739789,EBI-751621
CSNK1E	P49674	8	EBI-739789,EBI-749343
Dab2	P98078	2	EBI-739789,EBI-1391846	From Mus musculus.
DVL1	O14640	5	EBI-739789,EBI-723489
DVL1	Q86TH3	4	EBI-739789,EBI-10185025
FAM13C	Q8NE31	3	EBI-739789,EBI-751248
KCTD7	Q96MP8-2	4	EBI-739789,EBI-11954971
KLF3	P57682	3	EBI-739789,EBI-8472267
KLHL12	Q53G59	3	EBI-739789,EBI-740929
LRRFIP2	Q9Y608	2	EBI-739789,EBI-1023718
LRRK2	Q5S007	4	EBI-739789,EBI-5323863
NOL12	Q9UGY1	3	EBI-739789,EBI-716098
NXF1	Q9UBU9	3	EBI-739789,EBI-398874
PITX1	P78337	3	EBI-739789,EBI-748265
PRICKLE1	Q96MT3	3	EBI-739789,EBI-2348662
PRPF3	O43395	2	EBI-739789,EBI-744322
RWDD2B	P57060	3	EBI-739789,EBI-724442
SIRT1	Q96EB6	3	EBI-739789,EBI-1802965
STOM	P27105	3	EBI-739789,EBI-1211440
SYT6	Q5T7P8-2	5	EBI-739789,EBI-10246152
TNFAIP8L1	Q8WVP5	3	EBI-739789,EBI-752102
UTP3	Q9NQZ2	3	EBI-739789,EBI-714067
YTHDC1	Q96MU7	5	EBI-739789,EBI-2849854
ZBTB48	P10074	3	EBI-739789,EBI-744864
ZNF264	Q14C61	3	EBI-739789,EBI-2826570
ZNF408	Q9H9D4	3	EBI-739789,EBI-347633
ZNF697	Q8N508	3	EBI-739789,EBI-10265733
ZNF774	Q6NX45	4	EBI-739789,EBI-10251462

GO - Molecular functionⁱ

beta-catenin binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 10644691
frizzled binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 19388021
protease binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 20227366
protein heterodimerization activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 19137009
Rac GTPase binding
Source: ParkinsonsUK-UCL
Inferred from physical interactionⁱ
- 23109420
signaling receptor binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 17030191

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	108190, 100 interactors
Database of interacting proteins More...DIPⁱ	DIP-34509N
IntActⁱ	Q92997, 189 interactors
Molecular INTeraction database More...MINTⁱ	Q92997
STRINGⁱ	9606.ENSP00000316054

Chemistry databases

BindingDBⁱ

Q92997

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q92997
SMRⁱ	Q92997
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	1 – 82	DIXPROSITE-ProRule annotationAdd BLAST	82
Domainⁱ	249 – 321	PDZPROSITE-ProRule annotationAdd BLAST	73
Domainⁱ	422 – 496	DEPPROSITE-ProRule annotationAdd BLAST	75

Sequence similaritiesⁱ

Belongs to the DSH family.Curated

Phylogenomic databases

eggNOGⁱ	KOG3571 Eukaryota ENOG410Y5G4 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000013552
HOGENOMⁱ	HOG000017084
HOVERGENⁱ	HBG005542
InParanoidⁱ	Q92997
KEGG Orthology (KO) More...KOⁱ	K02353
OMAⁱ	TNQSDNC
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G041O
PhylomeDBⁱ	Q92997
TreeFamⁱ	TF318198

Family and domain databases

Gene3Dⁱ	1.10.10.10, 1 hit 3.10.20.380, 1 hit
InterProⁱ	View protein in InterPro IPR000591 DEP_dom IPR024580 Dishevelled_C-dom IPR008339 Dishevelled_fam IPR003351 Dishevelled_protein_dom IPR001158 DIX IPR038207 DIX_dom_sf IPR015506 Dsh/Dvl-rel IPR008342 DVL3 IPR001478 PDZ IPR036034 PDZ_sf IPR029071 Ubiquitin-like_domsf IPR036388 WH-like_DNA-bd_sf IPR036390 WH_DNA-bd_sf
PANTHERⁱ	PTHR10878 PTHR10878, 1 hit PTHR10878:SF6 PTHR10878:SF6, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00610 DEP, 1 hit PF02377 Dishevelled, 1 hit PF00778 DIX, 1 hit PF12316 Dsh_C, 1 hit PF00595 PDZ, 1 hit
PRINTSⁱ	PR01760 DISHEVELLED PR01763 DISHEVELLED3
SMARTⁱ	View protein in SMART SM00021 DAX, 1 hit SM00049 DEP, 1 hit SM00228 PDZ, 1 hit
SUPFAMⁱ	SSF46785 SSF46785, 1 hit SSF50156 SSF50156, 1 hit SSF54236 SSF54236, 1 hit
PROSITEⁱ	View protein in PROSITE PS50186 DEP, 1 hit PS50841 DIX, 1 hit PS50106 PDZ, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q92997-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGETKIIYHL DGQETPYLVK LPLPAERVTL ADFKGVLQRP SYKFFFKSMD 
        60         70         80         90        100
DDFGVVKEEI SDDNAKLPCF NGRVVSWLVS AEGSHPDPAP FCADNPSELP 
       110        120        130        140        150
PPMERTGGIG DSRPPSFHPH AGGGSQENLD NDTETDSLVS AQRERPRRRD 
       160        170        180        190        200
GPEHATRLNG TAKGERRREP GGYDSSSTLM SSELETTSFF DSDEDDSTSR 
       210        220        230        240        250
FSSSTEQSSA SRLMRRHKRR RRKQKVSRIE RSSSFSSITD STMSLNIITV 
       260        270        280        290        300
TLNMEKYNFL GISIVGQSNE RGDGGIYIGS IMKGGAVAAD GRIEPGDMLL 
       310        320        330        340        350
QVNEINFENM SNDDAVRVLR EIVHKPGPIT LTVAKCWDPS PRGCFTLPRS 
       360        370        380        390        400
EPIRPIDPAA WVSHTAAMTG TFPAYGMSPS LSTITSTSSS ITSSIPDTER 
       410        420        430        440        450
LDDFHLSIHS DMAAIVKAMA SPESGLEVRD RMWLKITIPN AFIGSDVVDW 
       460        470        480        490        500
LYHNVEGFTD RREARKYASN LLKAGFIRHT VNKITFSEQC YYIFGDLCGN 
       510        520        530        540        550
MANLSLHDHD GSSGASDQDT LAPLPHPGAA PWPMAFPYQY PPPPHPYNPH 
       560        570        580        590        600
PGFPELGYSY GGGSASSQHS EGSRSSGSNR SGSDRRKEKD PKAGDSKSGG 
       610        620        630        640        650
SGSESDHTTR SSLRGPRERA PSERSGPAAS EHSHRSHHSL ASSLRSHHTH 
       660        670        680        690        700
PSYGPPGVPP LYGPPMLMMP PPPAAMGPPG APPGRDLASV PPELTASRQS 
       710 
FRMAMGNPSE FFVDVM

Length:716

Mass (Da):78,055

Last modified:May 30, 2000 - v2

Checksum:ⁱB1A55EBF9507D06E

GO

Isoform 2 (identifier: Q92997-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
350-367: SEPIRPIDPAAWVSHTAA → T

« Hide

        10         20         30         40         50
MGETKIIYHL DGQETPYLVK LPLPAERVTL ADFKGVLQRP SYKFFFKSMD 
        60         70         80         90        100
DDFGVVKEEI SDDNAKLPCF NGRVVSWLVS AEGSHPDPAP FCADNPSELP 
       110        120        130        140        150
PPMERTGGIG DSRPPSFHPH AGGGSQENLD NDTETDSLVS AQRERPRRRD 
       160        170        180        190        200
GPEHATRLNG TAKGERRREP GGYDSSSTLM SSELETTSFF DSDEDDSTSR 
       210        220        230        240        250
FSSSTEQSSA SRLMRRHKRR RRKQKVSRIE RSSSFSSITD STMSLNIITV 
       260        270        280        290        300
TLNMEKYNFL GISIVGQSNE RGDGGIYIGS IMKGGAVAAD GRIEPGDMLL 
       310        320        330        340        350
QVNEINFENM SNDDAVRVLR EIVHKPGPIT LTVAKCWDPS PRGCFTLPRT 
       360        370        380        390        400
MTGTFPAYGM SPSLSTITST SSSITSSIPD TERLDDFHLS IHSDMAAIVK 
       410        420        430        440        450
AMASPESGLE VRDRMWLKIT IPNAFIGSDV VDWLYHNVEG FTDRREARKY 
       460        470        480        490        500
ASNLLKAGFI RHTVNKITFS EQCYYIFGDL CGNMANLSLH DHDGSSGASD 
       510        520        530        540        550
QDTLAPLPHP GAAPWPMAFP YQYPPPPHPY NPHPGFPELG YSYGGGSASS 
       560        570        580        590        600
QHSEGSRSSG SNRSGSDRRK EKDPKAGDSK SGGSGSESDH TTRSSLRGPR 
       610        620        630        640        650
ERAPSERSGP AASEHSHRSH HSLASSLRSH HTHPSYGPPG VPPLYGPPML 
       660        670        680        690 
MMPPPPAAMG PPGAPPGRDL ASVPPELTAS RQSFRMAMGN PSEFFVDVM

Note: No experimental confirmation available.

Show »

Length:699

Mass (Da):76,256

Checksum:ⁱAD4CB18FDB88AA63

GO

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

F8WCF1	F8WCF1_HUMAN	Segment polarity protein dishevelle... Segment polarity protein dishevelled homolog DVL-3	DVL3	77	Annotation score:
C9K0P9	C9K0P9_HUMAN	Segment polarity protein dishevelle... Segment polarity protein dishevelled homolog DVL-3	DVL3	220	Annotation score:

Sequence cautionⁱ

The sequence BAA13199 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	2	G → D in AAB47447 (PubMed:8817329).Curated	1
Sequence conflictⁱ	76	S → Y in AAB84228 (PubMed:9344861).Curated	1
Sequence conflictⁱ	102	P → S in AAB47447 (PubMed:8817329).Curated	1
Sequence conflictⁱ	151	G → W in AAB47447 (PubMed:8817329).Curated	1
Sequence conflictⁱ	182	S → R in AAB47447 (PubMed:8817329).Curated	1
Sequence conflictⁱ	218	K → N in AAB47447 (PubMed:8817329).Curated	1
Sequence conflictⁱ	222	R → W in AAB47447 (PubMed:8817329).Curated	1
Sequence conflictⁱ	230	E → D in AAB47447 (PubMed:8817329).Curated	1
Sequence conflictⁱ	233	S → C in AAB47447 (PubMed:8817329).Curated	1
Sequence conflictⁱ	236	S → T in AAB47447 (PubMed:8817329).Curated	1
Sequence conflictⁱ	239	T → S in AAB47447 (PubMed:8817329).Curated	1
Sequence conflictⁱ	242	T → A in AAB47447 (PubMed:8817329).Curated	1
Sequence conflictⁱ	303	N → K in AAB47447 (PubMed:8817329).Curated	1
Sequence conflictⁱ	431	R → C in AAB47447 (PubMed:8817329).Curated	1
Sequence conflictⁱ	450	W → C in AAB47447 (PubMed:8817329).Curated	1
Sequence conflictⁱ	465	R → P in AAB47447 (PubMed:8817329).Curated	1
Sequence conflictⁱ	472	L → V in AAB47447 (PubMed:8817329).Curated	1
Sequence conflictⁱ	543	P → R in AAB65244 (PubMed:9192851).Curated	1
Sequence conflictⁱ	553 – 554	FP → LG in AAB65244 (PubMed:9192851).Curated	2
Sequence conflictⁱ	629	A → T in AAB47447 (PubMed:8817329).Curated	1
Sequence conflictⁱ	633	S → I in AAB47447 (PubMed:8817329).Curated	1
Sequence conflictⁱ	682 – 716	PPGRD…FVDVM → LRAATWPQCPRN in BAA13199 (PubMed:9039502).CuratedAdd BLAST	35

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_036116	216	R → T in a breast cancer sample; somatic mutation. 1 Publication		1
Natural variantⁱVAR_025519	433	W → L1 PublicationCorresponds to variant dbSNP:rs17853048Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_053371	350 – 367	SEPIR…SHTAA → T in isoform 2. 1 PublicationAdd BLAST		18

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U49262 mRNA Translation: AAB47447.1 U75651 mRNA Translation: AAB84228.1 AF006013 mRNA Translation: AAB65244.1 D86963 mRNA Translation: BAA13199.2 Different initiation. AK304686 mRNA Translation: BAG65457.1 AC131235 Genomic DNA No translation available. CH471052 Genomic DNA Translation: EAW78295.1 CH471052 Genomic DNA Translation: EAW78296.1 BC032459 mRNA Translation: AAH32459.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS3253.1 [Q92997-1]
PIRⁱ	JC5763
NCBI Reference Sequences More...RefSeqⁱ	NP_004414.3, NM_004423.3 [Q92997-1]
UniGeneⁱ	Hs.388116

Genome annotation databases

Ensemblⁱ	ENST00000313143; ENSP00000316054; ENSG00000161202 [Q92997-1] ENST00000431765; ENSP00000405885; ENSG00000161202 [Q92997-2]
GeneIDⁱ	1857
KEGGⁱ	hsa:1857
UCSC genome browser More...UCSCⁱ	uc003fms.4 human [Q92997-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q92997	DVL3 isoform 1		PANTR		716	UniRef100_Q92997
Uncharacterized protein		COLAP		716
Uncharacterized protein		CERAT		716
Uncharacterized protein		CHLSB		716
Uncharacterized protein		RHIBE		716
+4
Q92997-2	DVL3 isoform 3		PANTR		699	UniRef100_A0A2J8M5B9

Protein	Similar proteins		Species	Score	Length	Source
Q92997	Segment polarity protein dishevelled homolog DVL-3		MOUSE		716	UniRef90_Q92997
DVL3 isoform 1		PANTR		716
Uncharacterized protein		COLAP		716
Uncharacterized protein		CERAT		716
Uncharacterized protein		CHLSB		716
+216

Protein	Similar proteins		Species	Score	Length	Source
Q92997	Segment polarity protein dishevelled homolog DVL-1	)	MOUSE		695	UniRef50_P51141
Segment polarity protein dishevelled homolog DVL-1		RAT		695
Segment polarity protein dishevelled homolog DVL-1		HUMAN		695
Segment polarity protein dishevelled homolog DVL-2	)	XENLA		736
Segment polarity protein dishevelled homolog DVL-2		XENTR		732
+1028

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U49262 mRNA Translation: AAB47447.1 U75651 mRNA Translation: AAB84228.1 AF006013 mRNA Translation: AAB65244.1 D86963 mRNA Translation: BAA13199.2 Different initiation. AK304686 mRNA Translation: BAG65457.1 AC131235 Genomic DNA No translation available. CH471052 Genomic DNA Translation: EAW78295.1 CH471052 Genomic DNA Translation: EAW78296.1 BC032459 mRNA Translation: AAH32459.1
CCDSⁱ	CCDS3253.1 [Q92997-1]
PIRⁱ	JC5763
RefSeqⁱ	NP_004414.3, NM_004423.3 [Q92997-1]
UniGeneⁱ	Hs.388116

3D structure databases

ProteinModelPortalⁱ	Q92997
SMRⁱ	Q92997
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	108190, 100 interactors
DIPⁱ	DIP-34509N
IntActⁱ	Q92997, 189 interactors
MINTⁱ	Q92997
STRINGⁱ	9606.ENSP00000316054

Chemistry databases

BindingDBⁱ	Q92997
ChEMBLⁱ	CHEMBL6028

Protein family/group databases

MoonDBⁱ	Q92997 Predicted

MoonDBⁱ

Q92997 Predicted

PTM databases

iPTMnetⁱ	Q92997
PhosphoSitePlusⁱ	Q92997

Polymorphism and mutation databases

BioMutaⁱ	DVL3
DMDMⁱ	6919875

Proteomic databases

EPDⁱ	Q92997
MaxQBⁱ	Q92997
PaxDbⁱ	Q92997
PeptideAtlasⁱ	Q92997
PRIDEⁱ	Q92997
ProteomicsDBⁱ	75666

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	1857
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000313143; ENSP00000316054; ENSG00000161202 [Q92997-1] ENST00000431765; ENSP00000405885; ENSG00000161202 [Q92997-2]
GeneIDⁱ	1857
KEGGⁱ	hsa:1857
UCSCⁱ	uc003fms.4 human [Q92997-1]

Organism-specific databases

CTDⁱ	1857
DisGeNETⁱ	1857
EuPathDBⁱ	HostDB:ENSG00000161202.17
GeneCardsⁱ	DVL3
HGNCⁱ	HGNC:3087 DVL3
HPAⁱ	CAB046486 HPA058265
MalaCardsⁱ	DVL3
MIMⁱ	601368 gene 616894 phenotype
neXtProtⁱ	NX_Q92997
OpenTargetsⁱ	ENSG00000161202
Orphanetⁱ	3107 Autosomal dominant Robinow syndrome
PharmGKBⁱ	PA27543
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3571 Eukaryota ENOG410Y5G4 LUCA
GeneTreeⁱ	ENSGT00390000013552
HOGENOMⁱ	HOG000017084
HOVERGENⁱ	HBG005542
InParanoidⁱ	Q92997
KOⁱ	K02353
OMAⁱ	TNQSDNC
OrthoDBⁱ	EOG091G041O
PhylomeDBⁱ	Q92997
TreeFamⁱ	TF318198

Enzyme and pathway databases

Reactomeⁱ	R-HSA-201681 TCF dependent signaling in response to WNT R-HSA-201688 WNT mediated activation of DVL R-HSA-4086400 PCP/CE pathway R-HSA-4641258 Degradation of DVL R-HSA-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-5368598 Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5663220 RHO GTPases Activate Formins
SignaLinkⁱ	Q92997
SIGNORⁱ	Q92997

Miscellaneous databases

ChiTaRSⁱ	DVL3 human
GeneWikiⁱ	DVL3
GenomeRNAiⁱ	1857
Protein Ontology More...PROⁱ	PR:Q92997
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000161202 Expressed in 231 organ(s), highest expression level in lower esophagus muscularis layer
CleanExⁱ	HS_DVL3
ExpressionAtlasⁱ	Q92997 baseline and differential
Genevisibleⁱ	Q92997 HS

Family and domain databases

Gene3Dⁱ	1.10.10.10, 1 hit 3.10.20.380, 1 hit
InterProⁱ	View protein in InterPro IPR000591 DEP_dom IPR024580 Dishevelled_C-dom IPR008339 Dishevelled_fam IPR003351 Dishevelled_protein_dom IPR001158 DIX IPR038207 DIX_dom_sf IPR015506 Dsh/Dvl-rel IPR008342 DVL3 IPR001478 PDZ IPR036034 PDZ_sf IPR029071 Ubiquitin-like_domsf IPR036388 WH-like_DNA-bd_sf IPR036390 WH_DNA-bd_sf
PANTHERⁱ	PTHR10878 PTHR10878, 1 hit PTHR10878:SF6 PTHR10878:SF6, 1 hit
Pfamⁱ	View protein in Pfam PF00610 DEP, 1 hit PF02377 Dishevelled, 1 hit PF00778 DIX, 1 hit PF12316 Dsh_C, 1 hit PF00595 PDZ, 1 hit
PRINTSⁱ	PR01760 DISHEVELLED PR01763 DISHEVELLED3
SMARTⁱ	View protein in SMART SM00021 DAX, 1 hit SM00049 DEP, 1 hit SM00228 PDZ, 1 hit
SUPFAMⁱ	SSF46785 SSF46785, 1 hit SSF50156 SSF50156, 1 hit SSF54236 SSF54236, 1 hit
PROSITEⁱ	View protein in PROSITE PS50186 DEP, 1 hit PS50841 DIX, 1 hit PS50106 PDZ, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	DVL3_HUMAN
Accessionⁱ	Q92997Primary (citable) accession number: Q92997 Secondary accession number(s): B4E3E5 , D3DNT0, O14642, Q13531, Q8N5E9, Q92607
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
	Last sequence update:	May 30, 2000
	Last modified:	November 7, 2018
	This is version 185 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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UniProtKB - Q92997 (DVL3_HUMAN)

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Segment polarity protein dishevelled homolog DVL-3

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ