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UniProtKB - Q92997 (DVL3_HUMAN)

Entry version 198 (17 Jun 2020)
Sequence version 2 (30 May 2000)
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Protein

Segment polarity protein dishevelled homolog DVL-3

Gene

DVL3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in the signal transduction pathway mediated by multiple Wnt genes.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processWnt signaling pathway

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-201681 TCF dependent signaling in response to WNT
R-HSA-201688 WNT mediated activation of DVL
R-HSA-4086400 PCP/CE pathway
R-HSA-4641258 Degradation of DVL
R-HSA-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane
R-HSA-5368598 Negative regulation of TCF-dependent signaling by DVL-interacting proteins
R-HSA-5663220 RHO GTPases Activate Formins

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q92997

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q92997

Protein family/group databases

MoonDB Database of extreme multifunctional and moonlighting proteins

More...MoonDBi		Q92997 Predicted

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Segment polarity protein dishevelled homolog DVL-3
Short name:
Dishevelled-3
Alternative name(s):
DSH homolog 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DVL3
Synonyms:KIAA0208
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000161202.17

Human Gene Nomenclature Database

More...HGNCi		HGNC:3087 DVL3

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		601368 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q92997

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Robinow syndrome, autosomal dominant 3 (DRS3)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of Robinow syndrome, a rare skeletal dysplasia syndrome characterized by dysmorphic features resembling a fetal face, mesomelic limb shortening, genital hypoplasia, renal anomalies, and costovertebral segmentation defects.
Related information in OMIM

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi271R → K: Localizes to plasma membranes. 1 Publication1
Mutagenesisi342R → K: No effect on subcellular location. 1 Publication1
Mutagenesisi614R → K: Localizes to plasma membranes. 1 Publication1

Keywords - Diseasei

Dwarfism

Organism-specific databases

DisGeNET

More...DisGeNETi		1857

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...GeneReviewsi		DVL3

MalaCards human disease database

More...MalaCardsi		DVL3
MIMi616894 phenotype

Open Targets

More...OpenTargetsi		ENSG00000161202

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		3107 Autosomal dominant Robinow syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA27543

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q92997 Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL6028

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		DVL3

Domain mapping of disease mutations (DMDM)

More...DMDMi		6919875

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001457491 – 716Segment polarity protein dishevelled homolog DVL-3Add BLAST716

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei27Omega-N-methylarginine1 Publication1
Modified residuei48PhosphoserineCombined sources1
Modified residuei125PhosphoserineCombined sources1
Modified residuei192PhosphoserineCombined sources1 Publication1
Modified residuei212Omega-N-methylarginine1 Publication1
Modified residuei271Asymmetric dimethylarginine; by PRMT1; alternate1 Publication1
Modified residuei271Symmetric dimethylarginine; by PRMT7; alternate1 Publication1
Modified residuei342Omega-N-methylarginine; alternate2 Publications1
Modified residuei342Symmetric dimethylarginine; by PRMT7; alternate2 Publications1
Modified residuei346Phosphothreonine1 Publication1
Modified residuei614Symmetric dimethylarginine; by PRMT71 Publication1
Modified residuei697PhosphoserineCombined sources1
Modified residuei698Dimethylated arginine; alternate1 Publication1
Modified residuei698Omega-N-methylarginine; alternate1 Publication1
Modified residuei700Phosphoserine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Ubiquitinated. Deubiquitinated by CYLD, which acts on 'Lys-63'-linked ubiquitin chains.1 Publication
Phosphorylated by CSNK1D.2 Publications
Arginine methylation may function as a switch in regulation of function in Wnt signaling.2 Publications

Keywords - PTMi

Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q92997

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q92997

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q92997

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q92997

PeptideAtlas

More...PeptideAtlasi		Q92997

PRoteomics IDEntifications database

More...PRIDEi		Q92997

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		5895
75666 [Q92997-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q92997

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q92997

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000161202 Expressed in lower esophagus muscularis layer and 230 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q92997 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q92997 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000161202 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via the PDZ domain) with the C-terminal regions of VANGL1 and VANGL2 (By similarity).

Interacts (via the region containing both the PDZ and DEP domains) with LRRFIP2; the DIX domain may inhibit this interaction.

Interacts with CYLD, CEP164 and DAB2.

Interacts with DCDC2.

Interacts with FOXK1 and FOXK2 (PubMed:25805136).

Interacts with DAAM2 (By similarity).

By similarity6 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q92997
With#Exp.IntAct
ABT1 [Q9ULW3]5EBI-739789,EBI-2602396
ADAP1 [O75689]3EBI-739789,EBI-714732
AKAP17A [Q02040]3EBI-739789,EBI-1042725
ANKRD36B - isoform 4 [Q8N2N9-4]3EBI-739789,EBI-12170453
AP3M1 [Q9Y2T2]3EBI-739789,EBI-2371151
BAHD1 [Q8TBE0]4EBI-739789,EBI-742750
BEND7 - isoform 2 [Q8N7W2-2]5EBI-739789,EBI-10181188
BHLHE40 [O14503]3EBI-739789,EBI-711810
CBX8 [Q9HC52]3EBI-739789,EBI-712912
CCNL1 [Q9UK58]3EBI-739789,EBI-2836773
CDYL2 [Q8N8U2]3EBI-739789,EBI-8467076
CEP164 [Q9UPV0]5EBI-739789,EBI-3937015
CEP57L1 [Q8IYX8]3EBI-739789,EBI-1104570
CEP70 [Q8NHQ1]3EBI-739789,EBI-739624
CEP76 [Q8TAP6]3EBI-739789,EBI-742887
CLK1 - isoform 3 [P49759-3]3EBI-739789,EBI-11981867
CSNK1D [P48730]4EBI-739789,EBI-751621
CSNK1E [P49674]9EBI-739789,EBI-749343
CSNK2A1 [P68400]4EBI-739789,EBI-347804
CT45A10 [P0DMU9]3EBI-739789,EBI-12153495
CT45A3 [Q8NHU0]3EBI-739789,EBI-8643558
CYSRT1 [A8MQ03]3EBI-739789,EBI-3867333
DVL1 [O14640]5EBI-739789,EBI-723489
DVL1 [Q86TH3]3EBI-739789,EBI-10185025
EIF1B [O60739]3EBI-739789,EBI-1043343
EIF3D [O15371]3EBI-739789,EBI-353818
FAM13C [Q8NE31]3EBI-739789,EBI-751248
FAM90A1 [Q86YD7]3EBI-739789,EBI-6658203
FARS2 [O95363]3EBI-739789,EBI-2513774
FGF16 [O43320]3EBI-739789,EBI-11479104
FLACC1 - isoform 2 [Q96Q35-2]3EBI-739789,EBI-11533409
GADD45GIP1 [Q8TAE8]3EBI-739789,EBI-372506
HOMER3 [Q9NSC5]3EBI-739789,EBI-748420
HOXA5 [P20719]3EBI-739789,EBI-8470697
HOXC5 [Q00444]3EBI-739789,EBI-11955357
HOXC8 [P31273]3EBI-739789,EBI-1752118
INO80B [Q9C086]3EBI-739789,EBI-715611
KAZN - isoform 2 [Q674X7-2]3EBI-739789,EBI-12024294
KCTD10 [Q9H3F6]3EBI-739789,EBI-2505886
KCTD7 - isoform 2 [Q96MP8-2]3EBI-739789,EBI-11954971
KLF1 [Q13351]3EBI-739789,EBI-8284732
KLF15 [Q9UIH9]5EBI-739789,EBI-2796400
KLF3 [P57682]3EBI-739789,EBI-8472267
KLF4 [O43474]3EBI-739789,EBI-7232405
KLHL12 [Q53G59]4EBI-739789,EBI-740929
LENG8 [Q96PV6]3EBI-739789,EBI-739546
LONRF1 [Q17RB8]3EBI-739789,EBI-2341787
LRRFIP2 [Q9Y608]2EBI-739789,EBI-1023718
LRRK2 [Q5S007]4EBI-739789,EBI-5323863
LUZP4 [Q9P127]3EBI-739789,EBI-10198848
MAB21L3 [Q8N8X9]3EBI-739789,EBI-10268010
MAGEB4 [O15481]3EBI-739789,EBI-751857
MAGOHB [Q96A72]3EBI-739789,EBI-746778
MMTAG2 [Q9BU76]3EBI-739789,EBI-742459
NFYA - isoform Short [P23511-2]3EBI-739789,EBI-11061759
NKD1 [Q969G9]3EBI-739789,EBI-1538217
NOL12 [Q9UGY1]3EBI-739789,EBI-716098
NXF1 [Q9UBU9]3EBI-739789,EBI-398874
PATZ1 - isoform 4 [Q9HBE1-4]3EBI-739789,EBI-11022007
PHF19 [Q5T6S3]3EBI-739789,EBI-2339674
PITX1 [P78337]4EBI-739789,EBI-748265
PLAGL2 [Q9UPG8]3EBI-739789,EBI-2876622
PNKP [Q96T60]3EBI-739789,EBI-1045072
PPP1R16B [Q96T49]3EBI-739789,EBI-10293968
PRICKLE1 [Q96MT3]3EBI-739789,EBI-2348662
PRKAA2 [P54646]3EBI-739789,EBI-1383852
PRPF18 [Q99633]3EBI-739789,EBI-2798416
PRPF3 [O43395]2EBI-739789,EBI-744322
PRPF31 [Q8WWY3]3EBI-739789,EBI-1567797
PRPF38A [Q8NAV1]3EBI-739789,EBI-715374
PRR13 [Q9NZ81]3EBI-739789,EBI-740924
PRR20D [P86480]3EBI-739789,EBI-12754095
PSME3 [P61289]3EBI-739789,EBI-355546
RBM15B - isoform 2 [Q8NDT2-2]3EBI-739789,EBI-10269922
RBM39 [Q14498]3EBI-739789,EBI-395290
RNF151 [Q2KHN1]3EBI-739789,EBI-12002474
RPL11 - isoform 2 [P62913-2]3EBI-739789,EBI-11027771
RRP8 [O43159]3EBI-739789,EBI-2008793
RWDD2B [P57060]3EBI-739789,EBI-724442
SAP30L [Q9HAJ7]3EBI-739789,EBI-2340040
SHFL - isoform 4 [Q9NUL5-4]3EBI-739789,EBI-11955083
SIRT1 [Q96EB6]3EBI-739789,EBI-1802965
SNIP1 [Q8TAD8]3EBI-739789,EBI-749336
SNX22 - isoform 2 [Q96L94-2]3EBI-739789,EBI-12310305
SORBS3 [O60504]3EBI-739789,EBI-741237
STOM [P27105]3EBI-739789,EBI-1211440
SUV39H1 [O43463]3EBI-739789,EBI-349968
SYT6 - isoform 2 [Q5T7P8-2]6EBI-739789,EBI-10246152
SYTL4 [Q96C24]3EBI-739789,EBI-747142
TBPL1 [P62380]3EBI-739789,EBI-716225
TCEA2 [Q15560]3EBI-739789,EBI-710310
TCEANC - isoform 2 [Q8N8B7-2]3EBI-739789,EBI-11955057
TFG [Q92734]3EBI-739789,EBI-357061
THAP7 [Q9BT49]3EBI-739789,EBI-741350
TLE5 - isoform 2 [Q08117-2]3EBI-739789,EBI-11741437
TNFAIP8L1 [Q8WVP5]6EBI-739789,EBI-752102
TNP1 [P09430]3EBI-739789,EBI-10196343
TRAF2 [Q12933]3EBI-739789,EBI-355744
TRIM41 [Q8WV44]3EBI-739789,EBI-725997
TSN [Q15631]3EBI-739789,EBI-1044160
TSPYL [Q6FI91]3EBI-739789,EBI-723389
TSPYL6 [Q8N831]3EBI-739789,EBI-12023322
UTP3 [Q9NQZ2]3EBI-739789,EBI-714067
VAX1 - isoform 2 [Q5SQQ9-2]3EBI-739789,EBI-12227803
WDR25 - isoform 2 [Q64LD2-2]3EBI-739789,EBI-12032042
XPA [P23025]3EBI-739789,EBI-295222
YTHDC1 [Q96MU7]6EBI-739789,EBI-2849854
ZBTB24 [O43167]3EBI-739789,EBI-744471
ZBTB26 [Q9HCK0]3EBI-739789,EBI-3918996
ZBTB47 [Q9UFB7]3EBI-739789,EBI-7781767
ZBTB48 [P10074]4EBI-739789,EBI-744864
ZBTB8A [Q96BR9]3EBI-739789,EBI-742740
ZFP57 - isoform 3 [Q9NU63-3]3EBI-739789,EBI-12879708
ZNF165 [P49910]3EBI-739789,EBI-741694
ZNF2 [Q9BSG1]3EBI-739789,EBI-8489229
ZNF264 [O43296]3EBI-739789,EBI-4395808
ZNF264 [Q14C61]3EBI-739789,EBI-2826570
ZNF319 [Q9P2F9]3EBI-739789,EBI-11993110
ZNF408 [Q9H9D4]4EBI-739789,EBI-347633
ZNF417 [Q8TAU3]3EBI-739789,EBI-740727
ZNF441 [Q8N8Z8]3EBI-739789,EBI-17216366
ZNF444 - isoform 2 [Q8N0Y2-2]3EBI-739789,EBI-12010736
ZNF497 [Q6ZNH5]3EBI-739789,EBI-10486136
ZNF552 [Q9H707]3EBI-739789,EBI-2555731
ZNF581 [Q9P0T4]3EBI-739789,EBI-745520
ZNF648 [Q5T619]3EBI-739789,EBI-11985915
ZNF696 [Q9H7X3]3EBI-739789,EBI-11090299
ZNF697 [Q8N508]3EBI-739789,EBI-10265733
ZNF699 [Q32M78]3EBI-739789,EBI-10217363
ZNF71 [Q9NQZ8]3EBI-739789,EBI-7138235
ZNF764 [Q96H86]3EBI-739789,EBI-745775
ZNF774 [Q6NX45]6EBI-739789,EBI-10251462
ZNF775 [Q96BV0]3EBI-739789,EBI-7149881
ZNF792 [Q3KQV3]3EBI-739789,EBI-10240849
ZNF821 - isoform 2 [O75541-2]3EBI-739789,EBI-14544035
ZNF837 [Q96EG3]3EBI-739789,EBI-11962574
ZRSR2 [Q15696]3EBI-739789,EBI-6657923
ZSCAN21 [Q9Y5A6]3EBI-739789,EBI-10281938
ZSCAN22 [P10073]3EBI-739789,EBI-10178224
ZSCAN25 - isoform 2 [Q6NSZ9-2]3EBI-739789,EBI-14650477
Dab2 [P98078] from Mus musculus.2EBI-739789,EBI-1391846

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		108190, 109 interactors

Database of interacting proteins

More...DIPi		DIP-34509N

Protein interaction database and analysis system

More...IntActi		Q92997, 207 interactors

Molecular INTeraction database

More...MINTi		Q92997

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000316054

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q92997

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q92997 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q92997

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 82DIXPROSITE-ProRule annotationAdd BLAST82
Domaini249 – 321PDZPROSITE-ProRule annotationAdd BLAST73
Domaini422 – 496DEPPROSITE-ProRule annotationAdd BLAST75

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DSH family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3571 Eukaryota
ENOG410Y5G4 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00950000182903

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_012601_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q92997

KEGG Orthology (KO)

More...KOi		K02353

Identification of Orthologs from Complete Genome Data

More...OMAi		HHQKMMG

Database of Orthologous Groups

More...OrthoDBi		474724at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q92997

TreeFam database of animal gene trees

More...TreeFami		TF318198

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.10.10, 1 hit
2.30.42.10, 1 hit
3.10.20.380, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000591 DEP_dom
IPR024580 Dishevelled_C-dom
IPR008339 Dishevelled_fam
IPR003351 Dishevelled_protein_dom
IPR001158 DIX
IPR038207 DIX_dom_sf
IPR015506 Dsh/Dvl-rel
IPR008342 DVL3
IPR001478 PDZ
IPR036034 PDZ_sf
IPR029071 Ubiquitin-like_domsf
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf

The PANTHER Classification System

More...PANTHERi		PTHR10878 PTHR10878, 1 hit
PTHR10878:SF6 PTHR10878:SF6, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00610 DEP, 1 hit
PF02377 Dishevelled, 1 hit
PF00778 DIX, 1 hit
PF12316 Dsh_C, 1 hit
PF00595 PDZ, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01760 DISHEVELLED
PR01763 DISHEVELLED3

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00021 DAX, 1 hit
SM00049 DEP, 1 hit
SM00228 PDZ, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF46785 SSF46785, 1 hit
SSF50156 SSF50156, 1 hit
SSF54236 SSF54236, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50186 DEP, 1 hit
PS50841 DIX, 1 hit
PS50106 PDZ, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q92997-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGETKIIYHL DGQETPYLVK LPLPAERVTL ADFKGVLQRP SYKFFFKSMD 
        60         70         80         90        100
DDFGVVKEEI SDDNAKLPCF NGRVVSWLVS AEGSHPDPAP FCADNPSELP 
       110        120        130        140        150
PPMERTGGIG DSRPPSFHPH AGGGSQENLD NDTETDSLVS AQRERPRRRD 
       160        170        180        190        200
GPEHATRLNG TAKGERRREP GGYDSSSTLM SSELETTSFF DSDEDDSTSR 
       210        220        230        240        250
FSSSTEQSSA SRLMRRHKRR RRKQKVSRIE RSSSFSSITD STMSLNIITV 
       260        270        280        290        300
TLNMEKYNFL GISIVGQSNE RGDGGIYIGS IMKGGAVAAD GRIEPGDMLL 
       310        320        330        340        350
QVNEINFENM SNDDAVRVLR EIVHKPGPIT LTVAKCWDPS PRGCFTLPRS 
       360        370        380        390        400
EPIRPIDPAA WVSHTAAMTG TFPAYGMSPS LSTITSTSSS ITSSIPDTER 
       410        420        430        440        450
LDDFHLSIHS DMAAIVKAMA SPESGLEVRD RMWLKITIPN AFIGSDVVDW 
       460        470        480        490        500
LYHNVEGFTD RREARKYASN LLKAGFIRHT VNKITFSEQC YYIFGDLCGN 
       510        520        530        540        550
MANLSLHDHD GSSGASDQDT LAPLPHPGAA PWPMAFPYQY PPPPHPYNPH 
       560        570        580        590        600
PGFPELGYSY GGGSASSQHS EGSRSSGSNR SGSDRRKEKD PKAGDSKSGG 
       610        620        630        640        650
SGSESDHTTR SSLRGPRERA PSERSGPAAS EHSHRSHHSL ASSLRSHHTH 
       660        670        680        690        700
PSYGPPGVPP LYGPPMLMMP PPPAAMGPPG APPGRDLASV PPELTASRQS 
       710 
FRMAMGNPSE FFVDVM
Length:716
Mass (Da):78,055
Last modified:May 30, 2000 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB1A55EBF9507D06E
GO
Isoform 2 (identifier: Q92997-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     350-367: SEPIRPIDPAAWVSHTAA → T

Show »
Length:699
Mass (Da):76,256
Checksum:iAD4CB18FDB88AA63
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A3B3ITC6A0A3B3ITC6_HUMAN
Segment polarity protein dishevelle...
DVL3
131Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WCF1F8WCF1_HUMAN
Segment polarity protein dishevelle...
DVL3
77Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3ISG4A0A3B3ISG4_HUMAN
Segment polarity protein dishevelle...
DVL3
99Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA13199 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti2G → D in AAB47447 (PubMed:8817329).Curated1
Sequence conflicti76S → Y in AAB84228 (PubMed:9344861).Curated1
Sequence conflicti102P → S in AAB47447 (PubMed:8817329).Curated1
Sequence conflicti151G → W in AAB47447 (PubMed:8817329).Curated1
Sequence conflicti182S → R in AAB47447 (PubMed:8817329).Curated1
Sequence conflicti218K → N in AAB47447 (PubMed:8817329).Curated1
Sequence conflicti222R → W in AAB47447 (PubMed:8817329).Curated1
Sequence conflicti230E → D in AAB47447 (PubMed:8817329).Curated1
Sequence conflicti233S → C in AAB47447 (PubMed:8817329).Curated1
Sequence conflicti236S → T in AAB47447 (PubMed:8817329).Curated1
Sequence conflicti239T → S in AAB47447 (PubMed:8817329).Curated1
Sequence conflicti242T → A in AAB47447 (PubMed:8817329).Curated1
Sequence conflicti303N → K in AAB47447 (PubMed:8817329).Curated1
Sequence conflicti431R → C in AAB47447 (PubMed:8817329).Curated1
Sequence conflicti450W → C in AAB47447 (PubMed:8817329).Curated1
Sequence conflicti465R → P in AAB47447 (PubMed:8817329).Curated1
Sequence conflicti472L → V in AAB47447 (PubMed:8817329).Curated1
Sequence conflicti543P → R in AAB65244 (PubMed:9192851).Curated1
Sequence conflicti553 – 554FP → LG in AAB65244 (PubMed:9192851).Curated2
Sequence conflicti629A → T in AAB47447 (PubMed:8817329).Curated1
Sequence conflicti633S → I in AAB47447 (PubMed:8817329).Curated1
Sequence conflicti682 – 716PPGRD…FVDVM → LRAATWPQCPRN in BAA13199 (PubMed:9039502).CuratedAdd BLAST35

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_036116216R → T in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_025519433W → L1 PublicationCorresponds to variant dbSNP:rs17853048Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_053371350 – 367SEPIR…SHTAA → T in isoform 2. 1 PublicationAdd BLAST18

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U49262 mRNA Translation: AAB47447.1
U75651 mRNA Translation: AAB84228.1
AF006013 mRNA Translation: AAB65244.1
D86963 mRNA Translation: BAA13199.2 Different initiation.
AK304686 mRNA Translation: BAG65457.1
AC131235 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW78295.1
CH471052 Genomic DNA Translation: EAW78296.1
BC032459 mRNA Translation: AAH32459.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS3253.1 [Q92997-1]

Protein sequence database of the Protein Information Resource

More...PIRi		JC5763

NCBI Reference Sequences

More...RefSeqi		NP_004414.3, NM_004423.3 [Q92997-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000313143; ENSP00000316054; ENSG00000161202 [Q92997-1]
ENST00000431765; ENSP00000405885; ENSG00000161202 [Q92997-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		1857

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:1857

UCSC genome browser

More...UCSCi		uc003fms.4 human [Q92997-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U49262 mRNA Translation: AAB47447.1
U75651 mRNA Translation: AAB84228.1
AF006013 mRNA Translation: AAB65244.1
D86963 mRNA Translation: BAA13199.2 Different initiation.
AK304686 mRNA Translation: BAG65457.1
AC131235 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW78295.1
CH471052 Genomic DNA Translation: EAW78296.1
BC032459 mRNA Translation: AAH32459.1
CCDSiCCDS3253.1 [Q92997-1]
PIRiJC5763
RefSeqiNP_004414.3, NM_004423.3 [Q92997-1]

3D structure databases

SMRiQ92997
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi108190, 109 interactors
DIPiDIP-34509N
IntActiQ92997, 207 interactors
MINTiQ92997
STRINGi9606.ENSP00000316054

Chemistry databases

BindingDBiQ92997
ChEMBLiCHEMBL6028

Protein family/group databases

MoonDBiQ92997 Predicted

PTM databases

iPTMnetiQ92997
PhosphoSitePlusiQ92997

Polymorphism and mutation databases

BioMutaiDVL3
DMDMi6919875

Proteomic databases

jPOSTiQ92997
MassIVEiQ92997
MaxQBiQ92997
PaxDbiQ92997
PeptideAtlasiQ92997
PRIDEiQ92997
ProteomicsDBi5895
75666 [Q92997-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		33790 298 antibodies

The DNASU plasmid repository

More...DNASUi		1857

Genome annotation databases

EnsembliENST00000313143; ENSP00000316054; ENSG00000161202 [Q92997-1]
ENST00000431765; ENSP00000405885; ENSG00000161202 [Q92997-2]
GeneIDi1857
KEGGihsa:1857
UCSCiuc003fms.4 human [Q92997-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		1857
DisGeNETi1857
EuPathDBiHostDB:ENSG00000161202.17

GeneCards: human genes, protein and diseases

More...GeneCardsi		DVL3
GeneReviewsiDVL3
HGNCiHGNC:3087 DVL3
HPAiENSG00000161202 Low tissue specificity
MalaCardsiDVL3
MIMi601368 gene
616894 phenotype
neXtProtiNX_Q92997
OpenTargetsiENSG00000161202
Orphaneti3107 Autosomal dominant Robinow syndrome
PharmGKBiPA27543

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3571 Eukaryota
ENOG410Y5G4 LUCA
GeneTreeiENSGT00950000182903
HOGENOMiCLU_012601_1_0_1
InParanoidiQ92997
KOiK02353
OMAiHHQKMMG
OrthoDBi474724at2759
PhylomeDBiQ92997
TreeFamiTF318198

Enzyme and pathway databases

ReactomeiR-HSA-201681 TCF dependent signaling in response to WNT
R-HSA-201688 WNT mediated activation of DVL
R-HSA-4086400 PCP/CE pathway
R-HSA-4641258 Degradation of DVL
R-HSA-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane
R-HSA-5368598 Negative regulation of TCF-dependent signaling by DVL-interacting proteins
R-HSA-5663220 RHO GTPases Activate Formins
SignaLinkiQ92997
SIGNORiQ92997

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		1857 4 hits in 786 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		DVL3 human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		DVL3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		1857
PharosiQ92997 Tbio

Protein Ontology

More...PROi		PR:Q92997
RNActiQ92997 protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000161202 Expressed in lower esophagus muscularis layer and 230 other tissues
ExpressionAtlasiQ92997 baseline and differential
GenevisibleiQ92997 HS

Family and domain databases

Gene3Di1.10.10.10, 1 hit
2.30.42.10, 1 hit
3.10.20.380, 1 hit
InterProiView protein in InterPro
IPR000591 DEP_dom
IPR024580 Dishevelled_C-dom
IPR008339 Dishevelled_fam
IPR003351 Dishevelled_protein_dom
IPR001158 DIX
IPR038207 DIX_dom_sf
IPR015506 Dsh/Dvl-rel
IPR008342 DVL3
IPR001478 PDZ
IPR036034 PDZ_sf
IPR029071 Ubiquitin-like_domsf
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PANTHERiPTHR10878 PTHR10878, 1 hit
PTHR10878:SF6 PTHR10878:SF6, 1 hit
PfamiView protein in Pfam
PF00610 DEP, 1 hit
PF02377 Dishevelled, 1 hit
PF00778 DIX, 1 hit
PF12316 Dsh_C, 1 hit
PF00595 PDZ, 1 hit
PRINTSiPR01760 DISHEVELLED
PR01763 DISHEVELLED3
SMARTiView protein in SMART
SM00021 DAX, 1 hit
SM00049 DEP, 1 hit
SM00228 PDZ, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF50156 SSF50156, 1 hit
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50186 DEP, 1 hit
PS50841 DIX, 1 hit
PS50106 PDZ, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDVL3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q92997
Secondary accession number(s): B4E3E5
, D3DNT0, O14642, Q13531, Q8N5E9, Q92607
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: June 17, 2020
This is version 198 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
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