Segment polarity protein dishevelled homolog DVL-3

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• beta-catenin binding Source: BHF-UCL <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Protein phosphatase 2Calpha dephosphorylates axin and activates LEF-1-dependent transcription."
    Strovel E.T., Wu D., Sussman D.J.
    J Biol Chem 275:2399-2403(2000) [PubMed] [Europe PMC] [Abstract]
• frizzled binding Source: UniProtKB <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "Sequence requirement and subtype specificity in the high-affinity interaction between human frizzled and dishevelled proteins."
    Punchihewa C., Ferreira A.M., Cassell R., Rodrigues P., Fujii N.
    Protein Sci 18:994-1002(2009) [PubMed] [Europe PMC] [Abstract]
• protease binding Source: UniProtKBInferred from physical interactionⁱ
  • Ref.12

    "Loss of the tumor suppressor CYLD enhances Wnt/beta-catenin signaling through K63-linked ubiquitination of Dvl."
    Tauriello D.V., Haegebarth A., Kuper I., Edelmann M.J., Henraat M., Canninga-van Dijk M.R., Kessler B.M., Clevers H., Maurice M.M.
    Mol. Cell 37:607-619(2010) [PubMed] [Europe PMC] [Abstract]

    Cited for: UBIQUITINATION, DEUBIQUITINATION, INTERACTION WITH CYLD.
• Rac GTPase binding Source: ParkinsonsUK-UCLInferred from physical interactionⁱ
  • "Tiam1 regulates the Wnt/Dvl/Rac1 signaling pathway and the differentiation of midbrain dopaminergic neurons."
    Cajanek L., Ganji R.S., Henriques-Oliveira C., Theofilopoulos S., Konik P., Bryja V., Arenas E.
    Mol Cell Biol 33:59-70(2013) [PubMed] [Europe PMC] [Abstract]
• signaling receptor binding Source: BHF-UCLInferred from physical interactionⁱ
  • "Prickle-1 negatively regulates Wnt/beta-catenin pathway by promoting Dishevelled ubiquitination/degradation in liver cancer."
    Chan D.W., Chan C.Y., Yam J.W., Ching Y.P., Ng I.O.
    Gastroenterology 131:1218-1227(2006) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• beta-catenin destruction complex disassembly Source: Reactome
• canonical Wnt signaling pathway Source: BHF-UCLInferred from direct assayⁱ
  • "Protein phosphatase 2Calpha dephosphorylates axin and activates LEF-1-dependent transcription."
    Strovel E.T., Wu D., Sussman D.J.
    J Biol Chem 275:2399-2403(2000) [PubMed] [Europe PMC] [Abstract]
  • "Activation of p53 by Dishevelled independent of Wnt or planar polarity pathways."
    Ding V.W., Lin L.P., Chiang A.L., McCormick F.
    J Mol Med (Berl) 85:1281-1289(2007) [PubMed] [Europe PMC] [Abstract]
• intracellular signal transduction Source: InterPro
• negative regulation of canonical Wnt signaling pathway Source: Reactome
• non-canonical Wnt signaling pathway Source: BHF-UCL <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Activation of the non-canonical Dvl-Rac1-JNK pathway by Frizzled homologue 10 in human synovial sarcoma."
    Fukukawa C., Nagayama S., Tsunoda T., Toguchida J., Nakamura Y., Katagiri T.
    Oncogene 28:1110-1120(2009) [PubMed] [Europe PMC] [Abstract]
• non-canonical Wnt signaling pathway via JNK cascade Source: BHF-UCL
• planar cell polarity pathway involved in neural tube closure Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• positive regulation of GTPase activity Source: ParkinsonsUK-UCLInferred from direct assayⁱ
  • "Tiam1 regulates the Wnt/Dvl/Rac1 signaling pathway and the differentiation of midbrain dopaminergic neurons."
    Cajanek L., Ganji R.S., Henriques-Oliveira C., Theofilopoulos S., Konik P., Bryja V., Arenas E.
    Mol Cell Biol 33:59-70(2013) [PubMed] [Europe PMC] [Abstract]
• positive regulation of JUN kinase activity Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Activation of the non-canonical Dvl-Rac1-JNK pathway by Frizzled homologue 10 in human synovial sarcoma."
    Fukukawa C., Nagayama S., Tsunoda T., Toguchida J., Nakamura Y., Katagiri T.
    Oncogene 28:1110-1120(2009) [PubMed] [Europe PMC] [Abstract]
• positive regulation of neuron projection arborization Source: ARUK-UCL
• positive regulation of protein phosphorylation Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Helicobacter pylori-induced activation of beta-catenin involves low density lipoprotein receptor-related protein 6 and Dishevelled."
    Gnad T., Feoktistova M., Leverkus M., Lendeckel U., Naumann M.
    Mol Cancer 9:31-31(2010) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription, DNA-templated Source: BHF-UCLInferred from direct assayⁱ
  • "Protein phosphatase 2Calpha dephosphorylates axin and activates LEF-1-dependent transcription."
    Strovel E.T., Wu D., Sussman D.J.
    J Biol Chem 275:2399-2403(2000) [PubMed] [Europe PMC] [Abstract]
  • "Activation of p53 by Dishevelled independent of Wnt or planar polarity pathways."
    Ding V.W., Lin L.P., Chiang A.L., McCormick F.
    J Mol Med (Berl) 85:1281-1289(2007) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription by RNA polymerase II Source: BHF-UCLInferred from direct assayⁱ
  • Ref.9

    "Regulation of the Wnt signaling pathway by disabled-2 (Dab2)."
    Howe P.H.
    EMBO J. 22:3084-3094(2003) [PubMed] [Europe PMC] [Abstract]

    Cited for: INTERACTION WITH DAB2.
• protein stabilization Source: ParkinsonsUK-UCL <p>Inferred from Genetic Interaction</p> <p>Used to describe "traditional" genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • "Cytosolic TMEM88 promotes invasion and metastasis in lung cancer cells by binding DVLS."
    Zhang X., Yu X., Jiang G., Miao Y., Wang L., Zhang Y., Liu Y., Fan C., Lin X., Dong Q., Han Q., Zhao H., Han Y., Han X., Rong X., Ding S., Wang E., Wang E.
    Cancer Res 75:4527-4537(2015) [PubMed] [Europe PMC] [Abstract]
• regulation of cellular protein localization Source: ParkinsonsUK-UCLInferred from direct assayⁱ
  • "Mutations in the LRRK2 Roc-COR tandem domain link Parkinson's disease to Wnt signalling pathways."
    Sancho R.M., Law B.M., Harvey K.
    Hum Mol Genet 18:3955-3968(2009) [PubMed] [Europe PMC] [Abstract]
• response to drug Source: Ensembl
• Wnt signaling pathway, planar cell polarity pathway Source: BHF-UCLInferred from direct assayⁱ
  • Ref.9

    "Regulation of the Wnt signaling pathway by disabled-2 (Dab2)."
    Howe P.H.
    EMBO J. 22:3084-3094(2003) [PubMed] [Europe PMC] [Abstract]

    Cited for: INTERACTION WITH DAB2.

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseaseⁱ

Mutagenesis

Keywords - Diseaseⁱ

Organism-specific databases

Miscellaneous databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• beta-catenin binding Source: BHF-UCLInferred from direct assayⁱ
  • "Protein phosphatase 2Calpha dephosphorylates axin and activates LEF-1-dependent transcription."
    Strovel E.T., Wu D., Sussman D.J.
    J Biol Chem 275:2399-2403(2000) [PubMed] [Europe PMC] [Abstract]
• frizzled binding Source: UniProtKBInferred from physical interactionⁱ
  • "Sequence requirement and subtype specificity in the high-affinity interaction between human frizzled and dishevelled proteins."
    Punchihewa C., Ferreira A.M., Cassell R., Rodrigues P., Fujii N.
    Protein Sci 18:994-1002(2009) [PubMed] [Europe PMC] [Abstract]
• protease binding Source: UniProtKBInferred from physical interactionⁱ
  • Ref.12

    "Loss of the tumor suppressor CYLD enhances Wnt/beta-catenin signaling through K63-linked ubiquitination of Dvl."
    Tauriello D.V., Haegebarth A., Kuper I., Edelmann M.J., Henraat M., Canninga-van Dijk M.R., Kessler B.M., Clevers H., Maurice M.M.
    Mol. Cell 37:607-619(2010) [PubMed] [Europe PMC] [Abstract]

    Cited for: UBIQUITINATION, DEUBIQUITINATION, INTERACTION WITH CYLD.
• Rac GTPase binding Source: ParkinsonsUK-UCLInferred from physical interactionⁱ
  • "Tiam1 regulates the Wnt/Dvl/Rac1 signaling pathway and the differentiation of midbrain dopaminergic neurons."
    Cajanek L., Ganji R.S., Henriques-Oliveira C., Theofilopoulos S., Konik P., Bryja V., Arenas E.
    Mol Cell Biol 33:59-70(2013) [PubMed] [Europe PMC] [Abstract]
• signaling receptor binding Source: BHF-UCLInferred from physical interactionⁱ
  • "Prickle-1 negatively regulates Wnt/beta-catenin pathway by promoting Dishevelled ubiquitination/degradation in liver cancer."
    Chan D.W., Chan C.Y., Yam J.W., Ching Y.P., Ng I.O.
    Gastroenterology 131:1218-1227(2006) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

Chemistry databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MGETKIIYHL DGQETPYLVK LPLPAERVTL ADFKGVLQRP SYKFFFKSMD 
        60         70         80         90        100
DDFGVVKEEI SDDNAKLPCF NGRVVSWLVS AEGSHPDPAP FCADNPSELP 
       110        120        130        140        150
PPMERTGGIG DSRPPSFHPH AGGGSQENLD NDTETDSLVS AQRERPRRRD 
       160        170        180        190        200
GPEHATRLNG TAKGERRREP GGYDSSSTLM SSELETTSFF DSDEDDSTSR 
       210        220        230        240        250
FSSSTEQSSA SRLMRRHKRR RRKQKVSRIE RSSSFSSITD STMSLNIITV 
       260        270        280        290        300
TLNMEKYNFL GISIVGQSNE RGDGGIYIGS IMKGGAVAAD GRIEPGDMLL 
       310        320        330        340        350
QVNEINFENM SNDDAVRVLR EIVHKPGPIT LTVAKCWDPS PRGCFTLPRS 
       360        370        380        390        400
EPIRPIDPAA WVSHTAAMTG TFPAYGMSPS LSTITSTSSS ITSSIPDTER 
       410        420        430        440        450
LDDFHLSIHS DMAAIVKAMA SPESGLEVRD RMWLKITIPN AFIGSDVVDW 
       460        470        480        490        500
LYHNVEGFTD RREARKYASN LLKAGFIRHT VNKITFSEQC YYIFGDLCGN 
       510        520        530        540        550
MANLSLHDHD GSSGASDQDT LAPLPHPGAA PWPMAFPYQY PPPPHPYNPH 
       560        570        580        590        600
PGFPELGYSY GGGSASSQHS EGSRSSGSNR SGSDRRKEKD PKAGDSKSGG 
       610        620        630        640        650
SGSESDHTTR SSLRGPRERA PSERSGPAAS EHSHRSHHSL ASSLRSHHTH 
       660        670        680        690        700
PSYGPPGVPP LYGPPMLMMP PPPAAMGPPG APPGRDLASV PPELTASRQS 
       710 
FRMAMGNPSE FFVDVM                                      

        10         20         30         40         50
MGETKIIYHL DGQETPYLVK LPLPAERVTL ADFKGVLQRP SYKFFFKSMD 
        60         70         80         90        100
DDFGVVKEEI SDDNAKLPCF NGRVVSWLVS AEGSHPDPAP FCADNPSELP 
       110        120        130        140        150
PPMERTGGIG DSRPPSFHPH AGGGSQENLD NDTETDSLVS AQRERPRRRD 
       160        170        180        190        200
GPEHATRLNG TAKGERRREP GGYDSSSTLM SSELETTSFF DSDEDDSTSR 
       210        220        230        240        250
FSSSTEQSSA SRLMRRHKRR RRKQKVSRIE RSSSFSSITD STMSLNIITV 
       260        270        280        290        300
TLNMEKYNFL GISIVGQSNE RGDGGIYIGS IMKGGAVAAD GRIEPGDMLL 
       310        320        330        340        350
QVNEINFENM SNDDAVRVLR EIVHKPGPIT LTVAKCWDPS PRGCFTLPRT 
       360        370        380        390        400
MTGTFPAYGM SPSLSTITST SSSITSSIPD TERLDDFHLS IHSDMAAIVK 
       410        420        430        440        450
AMASPESGLE VRDRMWLKIT IPNAFIGSDV VDWLYHNVEG FTDRREARKY 
       460        470        480        490        500
ASNLLKAGFI RHTVNKITFS EQCYYIFGDL CGNMANLSLH DHDGSSGASD 
       510        520        530        540        550
QDTLAPLPHP GAAPWPMAFP YQYPPPPHPY NPHPGFPELG YSYGGGSASS 
       560        570        580        590        600
QHSEGSRSSG SNRSGSDRRK EKDPKAGDSK SGGSGSESDH TTRSSLRGPR 
       610        620        630        640        650
ERAPSERSGP AASEHSHRSH HSLASSLRSH HTHPSYGPPG VPPLYGPPML 
       660        670        680        690 
MMPPPPAAMG PPGAPPGRDL ASVPPELTAS RQSFRMAMGN PSEFFVDVM  

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautionⁱ

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. Human chromosome 3
   Human chromosome 3: entries, gene names and cross-references to MIM
2. Human polymorphisms and disease mutations
   Index of human polymorphisms and disease mutations
3. MIM cross-references
   Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
4. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references
5. SIMILARITY comments
   Index of protein domains and families
6. Human entries with polymorphisms or disease mutations
   List of human entries with polymorphisms or disease mutations