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UniProtKB - Q92994 (TF3B_HUMAN)

Entry version 184 (29 Sep 2021)
Sequence version 1 (01 Feb 1997)
Previous versions | rss
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Protein

Transcription factor IIIB 90 kDa subunit

Gene

BRF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

General activator of RNA polymerase which utilizes different TFIIIB complexes at structurally distinct promoters. The isoform 1 is involved in the transcription of tRNA, adenovirus VA1, 7SL and 5S RNA. Isoform 2 is required for transcription of the U6 promoter.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi6ZincPROSITE-ProRule annotation1
Metal bindingi9ZincPROSITE-ProRule annotation1
Metal bindingi25ZincPROSITE-ProRule annotation1
Metal bindingi28ZincPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri2 – 33TFIIB-typePROSITE-ProRule annotationAdd BLAST32

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q92994

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-749476, RNA Polymerase III Abortive And Retractive Initiation
R-HSA-76061, RNA Polymerase III Transcription Initiation From Type 1 Promoter
R-HSA-76066, RNA Polymerase III Transcription Initiation From Type 2 Promoter

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transcription factor IIIB 90 kDa subunit
Short name:
TFIIIB90
Short name:
hTFIIIB90
Alternative name(s):
B-related factor 1
Short name:
BRF-1
Short name:
hBRF
TAF3B2
TATA box-binding protein-associated factor, RNA polymerase III, subunit 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:BRF1
Synonyms:BRF, GTF3B, TAF3B2, TAF3C
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:11551, BRF1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		604902, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q92994

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000185024

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Cerebellofaciodental syndrome (CFDS)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive disorder characterized by cerebellar hypoplasia, delayed development and intellectual disability, as well as facial dysmorphic features, short stature, microcephaly, and dental anomalies.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_072710223R → W in CFDS. 1 PublicationCorresponds to variant dbSNP:rs370270828EnsemblClinVar.1
Natural variantiVAR_072711226S → L in CFDS. 1 PublicationCorresponds to variant dbSNP:rs606231416EnsemblClinVar.1
Natural variantiVAR_072712259T → M in CFDS. 1 PublicationCorresponds to variant dbSNP:rs373957300EnsemblClinVar.1
Natural variantiVAR_072713292P → H in CFDS. 1 PublicationCorresponds to variant dbSNP:rs606231450EnsemblClinVar.1

Keywords - Diseasei

Disease variant, Dwarfism, Mental retardation

Organism-specific databases

DisGeNET

More...DisGeNETi		2972

MalaCards human disease database

More...MalaCardsi		BRF1
MIMi616202, phenotype

Open Targets

More...OpenTargetsi		ENSG00000185024

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		444072, Cerebellar-facial-dental syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA164741296

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q92994, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL4523421

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		BRF1

Domain mapping of disease mutations (DMDM)

More...DMDMi		20455319

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001193471 – 677Transcription factor IIIB 90 kDa subunitAdd BLAST677

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei365PhosphothreonineCombined sources1
Modified residuei450PhosphoserineCombined sources1
Modified residuei553PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q92994

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q92994

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q92994

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q92994

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q92994

PeptideAtlas

More...PeptideAtlasi		Q92994

PRoteomics IDEntifications database

More...PRIDEi		Q92994

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		27032
30432
75658 [Q92994-1]
75659 [Q92994-2]
75660 [Q92994-3]
75661 [Q92994-4]
75662 [Q92994-5]
75663 [Q92994-6]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q92994

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q92994

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000185024, Expressed in sural nerve and 184 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q92994, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q92994, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000185024, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

TFIIIB comprises at least the TATA-binding protein (TBP) and the B-related factor 1 (BRF1/TFIIIB90).

Interacts with BDP1 (PubMed:14592981).

Interacts with MAF1 (PubMed:18377933).

2 Publications

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		109227, 80 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q92994

Protein interaction database and analysis system

More...IntActi		Q92994, 12 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000448323

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q92994, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q92994

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati91 – 1721Add BLAST82
Repeati185 – 2692Add BLAST85

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni340 – 368DisorderedSequence analysisAdd BLAST29
Regioni385 – 413DisorderedSequence analysisAdd BLAST29
Regioni501 – 521DisorderedSequence analysisAdd BLAST21
Regioni544 – 653DisorderedSequence analysisAdd BLAST110

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi639 – 653Acidic residuesSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TFIIB family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri2 – 33TFIIB-typePROSITE-ProRule annotationAdd BLAST32

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1598, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000010349

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_010293_2_3_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q92994

Identification of Orthologs from Complete Genome Data

More...OMAi		MHNFRRT

Database of Orthologous Groups

More...OrthoDBi		412601at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q92994

TreeFam database of animal gene trees

More...TreeFami		TF324046

Family and domain databases

Conserved Domains Database

More...CDDi		cd00043, CYCLIN, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR029529, Brf1
IPR011665, BRF1_TBP-bd_dom
IPR013763, Cyclin-like
IPR036915, Cyclin-like_sf
IPR000812, TFIIB
IPR013150, TFIIB_cyclin
IPR013137, Znf_TFIIB

The PANTHER Classification System

More...PANTHERi		PTHR11618, PTHR11618, 1 hit
PTHR11618:SF4, PTHR11618:SF4, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF07741, BRF1, 1 hit
PF08271, TF_Zn_Ribbon, 1 hit
PF00382, TFIIB, 2 hits

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00685, TIFACTORIIB

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00385, CYCLIN, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47954, SSF47954, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51134, ZF_TFIIB, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (9+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 9 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 9 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q92994-1) [UniParc]FASTAAdd to basket
Also known as: hBRF1

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTGRVCRGCG GTDIELDAAR GDAVCTACGS VLEDNIIVSE VQFVESSGGG 
        60         70         80         90        100
SSAVGQFVSL DGAGKTPTLG GGFHVNLGKE SRAQTLQNGR RHIHHLGNQL 
       110        120        130        140        150
QLNQHCLDTA FNFFKMAVSR HLTRGRKMAH VIAACLYLVC RTEGTPHMLL 
       160        170        180        190        200
DLSDLLQVNV YVLGKTFLLL ARELCINAPA IDPCLYIPRF AHLLEFGEKN 
       210        220        230        240        250
HEVSMTALRL LQRMKRDWMH TGRRPSGLCG AALLVAARMH DFRRTVKEVI 
       260        270        280        290        300
SVVKVCESTL RKRLTEFEDT PTSQLTIDEF MKIDLEEECD PPSYTAGQRK 
       310        320        330        340        350
LRMKQLEQVL SKKLEEVEGE ISSYQDAIEI ELENSRPKAK GGLASLAKDG 
       360        370        380        390        400
STEDTASSLC GEEDTEDEEL EAAASHLNKD LYRELLGGAP GSSEAAGSPE 
       410        420        430        440        450
WGGRPPALGS LLDPLPTAAS LGISDSIREC ISSQSSDPKD ASGDGELDLS 
       460        470        480        490        500
GIDDLEIDRY ILNESEARVK AELWMRENAE YLREQREKEA RIAKEKELGI 
       510        520        530        540        550
YKEHKPKKSC KRREPIQAST AREAIEKMLE QKKISSKINY SVLRGLSSAG 
       560        570        580        590        600
GGSPHREDAQ PEHSASARKL SRRRTPASRS GADPVTSVGK RLRPLVSTQP 
       610        620        630        640        650
AKKVATGEAL LPSSPTLGAE PARPQAVLVE SGPVSYHADE EADEEEPDEE 
       660        670 
DGEPCVSALQ MMGSNDYGCD GDEDDGY
Length:677
Mass (Da):73,840
Last modified:February 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5866304B879EC1DE
GO
Isoform 2 (identifier: Q92994-2) [UniParc]FASTAAdd to basket
Also known as: hBRF2

The sequence of this isoform differs from the canonical sequence as follows:
     1-204: Missing.
     293-338: SYTAGQRKLR...EIELENSRPK → IEEGGQTEAR...CGRGGFTLCP
     339-677: Missing.

Show »
Length:134
Mass (Da):15,159
Checksum:i0F56B878F16C484B
GO
Isoform 3 (identifier: Q92994-3) [UniParc]FASTAAdd to basket
Also known as: hBRF3

The sequence of this isoform differs from the canonical sequence as follows:
     1-204: Missing.

Show »
Length:473
Mass (Da):51,798
Checksum:iEF95D8EDB737C5C4
GO
Isoform 4 (identifier: Q92994-4) [UniParc]FASTAAdd to basket
Also known as: hBRF4

The sequence of this isoform differs from the canonical sequence as follows:
     159-242: NVYVLGKTFL...LLVAARMHDF → DSLRPASFPT...HLPMLGTVGC
     243-677: Missing.

Show »
Length:242
Mass (Da):25,922
Checksum:iB6FC691408BA8E26
GO
Isoform 5 (identifier: Q92994-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     63-89: Missing.

Show »
Length:650
Mass (Da):71,119
Checksum:iEC6958C644660237
GO
Isoform 6 (identifier: Q92994-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     159-208: NVYVLGKTFL...KNHEVSMTAL → DSLRPASFPT...CPVRKFWSVG
     209-677: Missing.

Show »
Length:208
Mass (Da):22,309
Checksum:i8761AE32A65FFE89
GO
Isoform 7 (identifier: Q92994-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-115: Missing.

Show »
Length:562
Mass (Da):61,812
Checksum:i9C25CDA5DFE0F90E
GO
Isoform 8 (identifier: Q92994-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-115: Missing.
     459-459: R → RRDLSMPRCAKAKSQPHFPVLAQ

Show »
Length:584
Mass (Da):64,275
Checksum:i9365EBA805C92B88
GO
Isoform 9 (identifier: Q92994-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-238: Missing.

Show »
Length:439
Mass (Da):47,978
Checksum:i340FA6DDD52479DC
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8VS45F8VS45_HUMAN
Transcription factor IIIB 90 kDa su...
BRF1
234Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VWT8F8VWT8_HUMAN
Transcription factor IIIB 90 kDa su...
BRF1
155Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q3SYD7Q3SYD7_HUMAN
BRF1 protein
BRF1
161Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A3KN61A3KN61_HUMAN
BRF1 protein
BRF1
184Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6VUY7F6VUY7_HUMAN
Transcription factor IIIB 90 kDa su...
BRF1
134Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YIV6H0YIV6_HUMAN
Transcription factor IIIB 90 kDa su...
BRF1
185Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VWY1F8VWY1_HUMAN
Transcription factor IIIB 90 kDa su...
BRF1
45Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VXJ4F8VXJ4_HUMAN
Transcription factor IIIB 90 kDa su...
BRF1
63Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W123F8W123_HUMAN
Transcription factor IIIB 90 kDa su...
BRF1
14Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC50170 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti88N → D in AAC50170 (PubMed:7624363).Curated1
Sequence conflicti151D → V in AAC50170 (PubMed:7624363).Curated1
Sequence conflicti224R → G in AAC50170 (PubMed:7624363).Curated1
Sequence conflicti231A → G in AAC50170 (PubMed:7624363).Curated1
Sequence conflicti339 – 340AK → R in AAC50170 (PubMed:7624363).Curated2
Sequence conflicti437D → N in BAH11919 (PubMed:14702039).Curated1
Sequence conflicti446E → G in BAG53298 (PubMed:14702039).Curated1
Sequence conflicti594P → T in AAC50170 (PubMed:7624363).Curated1
Sequence conflicti618G → E in AAC50170 (PubMed:7624363).Curated1
Sequence conflicti640E → G in BAG53298 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_072710223R → W in CFDS. 1 PublicationCorresponds to variant dbSNP:rs370270828EnsemblClinVar.1
Natural variantiVAR_072711226S → L in CFDS. 1 PublicationCorresponds to variant dbSNP:rs606231416EnsemblClinVar.1
Natural variantiVAR_072712259T → M in CFDS. 1 PublicationCorresponds to variant dbSNP:rs373957300EnsemblClinVar.1
Natural variantiVAR_072713292P → H in CFDS. 1 PublicationCorresponds to variant dbSNP:rs606231450EnsemblClinVar.1
Natural variantiVAR_035723542V → M in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs371981699Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0450451 – 238Missing in isoform 9. 1 PublicationAdd BLAST238
Alternative sequenceiVSP_0063961 – 204Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST204
Alternative sequenceiVSP_0442441 – 115Missing in isoform 7 and isoform 8. 1 PublicationAdd BLAST115
Alternative sequenceiVSP_01469763 – 89Missing in isoform 5. 1 PublicationAdd BLAST27
Alternative sequenceiVSP_006399159 – 242NVYVL…RMHDF → DSLRPASFPTWGCDLGVVTR VVTGVYPRCASRISVAGLCC LPSQEVLVCRMRGLHDMGVT VRDLWECGSPWQEGHLPMLG TVGC in isoform 4. 1 PublicationAdd BLAST84
Alternative sequenceiVSP_043835159 – 208NVYVL…SMTAL → DSLRPASFPTWGCDLGVVTR VVTGVYPRCLHASQWPVCAA CPVRKFWSVG in isoform 6. 1 PublicationAdd BLAST50
Alternative sequenceiVSP_043836209 – 677Missing in isoform 6. 1 PublicationAdd BLAST469
Alternative sequenceiVSP_006400243 – 677Missing in isoform 4. 1 PublicationAdd BLAST435
Alternative sequenceiVSP_006397293 – 338SYTAG…NSRPK → IEEGGQTEAREPPQASSWEG PSTTRRRSQLWHGCPGCGRG GFTLCP in isoform 2. 2 PublicationsAdd BLAST46
Alternative sequenceiVSP_006398339 – 677Missing in isoform 2. 2 PublicationsAdd BLAST339
Alternative sequenceiVSP_045046459R → RRDLSMPRCAKAKSQPHFPV LAQ in isoform 8. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U28838 mRNA Translation: AAC50170.1 Frameshift.
U75276 mRNA Translation: AAB38876.1
AJ297406 mRNA Translation: CAC04512.1
AJ297407 mRNA Translation: CAC04513.1
AJ297408 mRNA Translation: CAC04514.1
AK096471 mRNA Translation: BAG53298.1
AK294899 mRNA Translation: BAH11919.1
AK295579 mRNA Translation: BAG58477.1
AL512355 Genomic DNA No translation available.
CH471061 Genomic DNA Translation: EAW81908.1
CH471061 Genomic DNA Translation: EAW81911.1
BC016743 mRNA Translation: AAH16743.1
BC071637 mRNA Translation: AAH71637.1
BC086856 mRNA Translation: AAH86856.1
BC103859 mRNA Translation: AAI03860.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS10001.1 [Q92994-1]
CCDS42001.1 [Q92994-3]
CCDS55949.1 [Q92994-9]
CCDS55950.1 [Q92994-7]
CCDS55951.1 [Q92994-8]
CCDS55952.1 [Q92994-5]
CCDS55953.1 [Q92994-6]

Protein sequence database of the Protein Information Resource

More...PIRi		I39065

NCBI Reference Sequences

More...RefSeqi		NP_001229715.1, NM_001242786.1 [Q92994-8]
NP_001229716.1, NM_001242787.1 [Q92994-7]
NP_001229717.1, NM_001242788.1 [Q92994-5]
NP_001229718.1, NM_001242789.1 [Q92994-9]
NP_001229719.1, NM_001242790.1 [Q92994-6]
NP_001510.2, NM_001519.3 [Q92994-1]
NP_663718.1, NM_145685.2 [Q92994-3]
XP_005267620.1, XM_005267563.3 [Q92994-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000327359; ENSP00000329029; ENSG00000185024 [Q92994-7]
ENST00000379937; ENSP00000369269; ENSG00000185024 [Q92994-5]
ENST00000392557; ENSP00000376340; ENSG00000185024 [Q92994-3]
ENST00000440513; ENSP00000388877; ENSG00000185024 [Q92994-8]
ENST00000446501; ENSP00000389859; ENSG00000185024 [Q92994-9]
ENST00000547530; ENSP00000448387; ENSG00000185024 [Q92994-1]
ENST00000548421; ENSP00000446707; ENSG00000185024 [Q92994-6]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		2972

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:2972

UCSC genome browser

More...UCSCi		uc001yql.3, human [Q92994-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28838 mRNA Translation: AAC50170.1 Frameshift.
U75276 mRNA Translation: AAB38876.1
AJ297406 mRNA Translation: CAC04512.1
AJ297407 mRNA Translation: CAC04513.1
AJ297408 mRNA Translation: CAC04514.1
AK096471 mRNA Translation: BAG53298.1
AK294899 mRNA Translation: BAH11919.1
AK295579 mRNA Translation: BAG58477.1
AL512355 Genomic DNA No translation available.
CH471061 Genomic DNA Translation: EAW81908.1
CH471061 Genomic DNA Translation: EAW81911.1
BC016743 mRNA Translation: AAH16743.1
BC071637 mRNA Translation: AAH71637.1
BC086856 mRNA Translation: AAH86856.1
BC103859 mRNA Translation: AAI03860.1
CCDSiCCDS10001.1 [Q92994-1]
CCDS42001.1 [Q92994-3]
CCDS55949.1 [Q92994-9]
CCDS55950.1 [Q92994-7]
CCDS55951.1 [Q92994-8]
CCDS55952.1 [Q92994-5]
CCDS55953.1 [Q92994-6]
PIRiI39065
RefSeqiNP_001229715.1, NM_001242786.1 [Q92994-8]
NP_001229716.1, NM_001242787.1 [Q92994-7]
NP_001229717.1, NM_001242788.1 [Q92994-5]
NP_001229718.1, NM_001242789.1 [Q92994-9]
NP_001229719.1, NM_001242790.1 [Q92994-6]
NP_001510.2, NM_001519.3 [Q92994-1]
NP_663718.1, NM_145685.2 [Q92994-3]
XP_005267620.1, XM_005267563.3 [Q92994-3]

3D structure databases

SMRiQ92994
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi109227, 80 interactors
CORUMiQ92994
IntActiQ92994, 12 interactors
STRINGi9606.ENSP00000448323

Chemistry databases

ChEMBLiCHEMBL4523421

PTM databases

iPTMnetiQ92994
PhosphoSitePlusiQ92994

Genetic variation databases

BioMutaiBRF1
DMDMi20455319

Proteomic databases

EPDiQ92994
jPOSTiQ92994
MassIVEiQ92994
MaxQBiQ92994
PaxDbiQ92994
PeptideAtlasiQ92994
PRIDEiQ92994
ProteomicsDBi27032
30432
75658 [Q92994-1]
75659 [Q92994-2]
75660 [Q92994-3]
75661 [Q92994-4]
75662 [Q92994-5]
75663 [Q92994-6]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		14980, 247 antibodies

The DNASU plasmid repository

More...DNASUi		2972

Genome annotation databases

EnsembliENST00000327359; ENSP00000329029; ENSG00000185024 [Q92994-7]
ENST00000379937; ENSP00000369269; ENSG00000185024 [Q92994-5]
ENST00000392557; ENSP00000376340; ENSG00000185024 [Q92994-3]
ENST00000440513; ENSP00000388877; ENSG00000185024 [Q92994-8]
ENST00000446501; ENSP00000389859; ENSG00000185024 [Q92994-9]
ENST00000547530; ENSP00000448387; ENSG00000185024 [Q92994-1]
ENST00000548421; ENSP00000446707; ENSG00000185024 [Q92994-6]
GeneIDi2972
KEGGihsa:2972
UCSCiuc001yql.3, human [Q92994-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		2972
DisGeNETi2972

GeneCards: human genes, protein and diseases

More...GeneCardsi		BRF1
HGNCiHGNC:11551, BRF1
HPAiENSG00000185024, Low tissue specificity
MalaCardsiBRF1
MIMi604902, gene
616202, phenotype
neXtProtiNX_Q92994
OpenTargetsiENSG00000185024
Orphaneti444072, Cerebellar-facial-dental syndrome
PharmGKBiPA164741296
VEuPathDBiHostDB:ENSG00000185024

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1598, Eukaryota
GeneTreeiENSGT00390000010349
HOGENOMiCLU_010293_2_3_1
InParanoidiQ92994
OMAiMHNFRRT
OrthoDBi412601at2759
PhylomeDBiQ92994
TreeFamiTF324046

Enzyme and pathway databases

PathwayCommonsiQ92994
ReactomeiR-HSA-749476, RNA Polymerase III Abortive And Retractive Initiation
R-HSA-76061, RNA Polymerase III Transcription Initiation From Type 1 Promoter
R-HSA-76066, RNA Polymerase III Transcription Initiation From Type 2 Promoter

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		2972, 762 hits in 1024 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		BRF1, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		BRF1_(gene)

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		2972
PharosiQ92994, Tbio

Protein Ontology

More...PROi		PR:Q92994
RNActiQ92994, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000185024, Expressed in sural nerve and 184 other tissues
ExpressionAtlasiQ92994, baseline and differential
GenevisibleiQ92994, HS

Family and domain databases

CDDicd00043, CYCLIN, 2 hits
InterProiView protein in InterPro
IPR029529, Brf1
IPR011665, BRF1_TBP-bd_dom
IPR013763, Cyclin-like
IPR036915, Cyclin-like_sf
IPR000812, TFIIB
IPR013150, TFIIB_cyclin
IPR013137, Znf_TFIIB
PANTHERiPTHR11618, PTHR11618, 1 hit
PTHR11618:SF4, PTHR11618:SF4, 1 hit
PfamiView protein in Pfam
PF07741, BRF1, 1 hit
PF08271, TF_Zn_Ribbon, 1 hit
PF00382, TFIIB, 2 hits
PRINTSiPR00685, TIFACTORIIB
SMARTiView protein in SMART
SM00385, CYCLIN, 2 hits
SUPFAMiSSF47954, SSF47954, 2 hits
PROSITEiView protein in PROSITE
PS51134, ZF_TFIIB, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTF3B_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q92994
Secondary accession number(s): B3KU36
, B4DIG5, B7Z2N3, F5H5Z7, F8WA46, Q13223, Q3SYD9, Q5PR24, Q6IQ02, Q96KX3, Q9HCW6, Q9HCW7, Q9HCW8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: February 1, 1997
Last modified: September 29, 2021
This is version 184 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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